National and Targeted Health-Based Monitoring Activities Under Canada s Chemicals Management Plan

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Plan Canadian Public Health Association 2012

Yome Chemicals Surveillance Bureau Healthy

1 National and Targeted Health-Based Monitoring Activities Under Canada s Chemicals Management Plan Canadian Public Health Association 2012 Conference June 13, 2012 Edmonton, AB Julie Yome Chemicals Surveillance Bureau Healthy Environments and Consumer Safety Branch Health Canada

2 Chemicals Management Plan In 2006, the Government of Canada launched the Chemicals Management Plan (CMP) to advance and improve the management of chemical substances and safeguard the health of Canadians. Risk Assessment Research Monitoring & Surveillance Reporting, Communication & Cooperation Risk Management Compliance, Promotion & Enforcement 2 1

3 Monitoring and Surveillance Activities Under the CMP Theme 1: National Biomonitoring Canadian Health Measures Survey Maternal-Infant Research on Environmental Chemicals Northern Contaminants Program First Nations Biomonitoring Initiative Theme 2: Targeted Population Biomonitoring Children s exposure to lead Plastics & personal care products in pregnancy Arsenic in targeted geographic areas Children s exposure to phthalates in indoor air Acrylamide exposure in adolescents Theme 3: Biomonitoring Supportive Research Biomonitoring equivalent development Toxicokinetic modelling of pyrethroids Dermal absorption studies Analytical tools to biomonitor nanomaterials Theme 4: Targeted Environmental Monitoring Metals, pesticides, & flame retardants in house dust National indoor air survey Children s dietary exposure to plasticizers National drinking water survey 3 2

Partners Statistics Canada Health Canada Public Health Agency of Canada Canadian Health Measures Survey (CHMS) National health survey that collects information on the general health and lifestyles of

4 Partners Statistics Canada Health Canada Public Health Agency of Canada Canadian Health Measures Survey (CHMS) National health survey that collects information on the general health and lifestyles of Canadians to provide information on chronic and infectious disease, physical fitness, nutrition, and other factors that influence health Health questionnaire (home interview) Direct measurements (mobile examination centre) Timeline Cycle 1 biomonitoring Cycle 2 report expected report published Cycle 1 Dates: Mar 2007 Feb 2009 Sites: 15 Ages: 6-79 yrs (n = 5,600) Environmental chemicals: 91 Cycle 3 Dates: Jan 2012 Dec 2013 Sites: 16 Ages: 3-79 yrs (n = 5,700) Environmental chemicals: 95 (~40% new) Cycle 2 Dates: Sept 2009 Dec 2011 Sites: 18 Ages: 3-79 yrs (n = 6,300) Environmental chemicals: 94 (~60% new) Cycle 4 Dates: Jan 2014 Dec 2015 Sites: TBD Ages: 3-79 yrs (n = 5,700) Environmental chemicals: 95 (same as Cycle 3) 4 3

5 Canadian Health Measures Survey (CHMS) Biomonitoring Substances Flame Retardants PCBs Organochlorines & POPs CYCLE 1 Chlorophenols Phthalates Perfluorinated Compounds CYCLE 2 Smoking Status CYCLE 2 Current Use Pesticides Environmental Phenols Metals & Trace Elements Benzene Metabolites Parabens VOCs Acrylamide Dioxins/Furans CYCLE 3 PAHs Flame Retardants PCBs Organochlorines & POPs CYCLE 3 CYCLE 1 CYCLE 2 CYCLES 3 & 4 5 4

CHMS CYCLE 1 Blood Lead Levels in Canadians (2007-2009) Geometric Mean and 95 th Percentile Geometric mean blood lead concentration (μg/dl) 95 th

6 CHMS CYCLE 1 Blood Lead Levels in Canadians ( ) Geometric Mean and 95 th Percentile Geometric mean blood lead concentration (μg/dl) 95 th Percentile Age (years) M+F 6-79 M+F 6-79 M F 6-11 M F M F M F M F Canada Health Survey Canadian Health Measures Survey

7 CHMS CYCLE 1 Blood Total Mercury Levels in Canadians ( ) Geometric mean blood mercury concentration (μg/l) F 6-15 Geometric Mean and 95 th Percentile Proposed blood guidance level (8 μg/l) for children and women of childbearing age* F M 6-18 Age (years) Blood guidance level for general adult population (20 μg/l) F M th Percentile * Legrand et al

Maternal-Infant Research on Environmental Chemicals National biomonitoring study of pregnant women and their infants Principal Investigators Tye Arbuckle, Health Canada William Fraser, Université de

8 Maternal-Infant Research on Environmental Chemicals National biomonitoring study of pregnant women and their infants Principal Investigators Tye Arbuckle, Health Canada William Fraser, Université de Montréal Objectives To assess what pregnancy health risks, if any, are associated with exposure to heavy metals (lead, cadmium, arsenic, and mercury) To obtain baseline data on maternal and neonatal exposure to priority environmental chemicals (via biomonitoring) To establish time-trends for concentrations of environmental chemicals in human milk 8 7

9 MIREC Study Design Design A national-level pregnancy cohort: Data collection: Results expected in ,000 pregnant women and their infants recruited during 1st trimester and followed until 8 weeks after delivery 10 clinical sites across Canada 9 8

Northern Contaminants Program (NCP) Established in 1991 in response to concerns about human exposure to elevated levels of contaminants in wildlife species important to traditional diets of northern

10 Northern Contaminants Program (NCP) Established in 1991 in response to concerns about human exposure to elevated levels of contaminants in wildlife species important to traditional diets of northern Aboriginal peoples Key Objectives Reduce/eliminate contaminants in traditional/country foods Support informed decision making on food use for individuals and communities Approach Government/stakeholder partnership Biomonitoring studies over several years in various Canadian Arctic communities Focus on metals (Pb, Cd, Hg, etc.) and persistent organic pollutants (PCBs, emerging flame retardants, etc.) 10 9

11 Maternal Blood Contaminant Levels in Arctic Canada PCB 153 concentrations (µg/kg plasma lipid) in the blood of mothers from three Canadian Arctic Regions 11 11

For Additional Information Julie Yome Chemicals Surveillance Bureau Healthy Environments and Consumer Safety Branch Health Canada Ottawa, Canada Telephone: (613) 960-1790 Email: julie.yome@hc-sc.gc.

12 For Additional Information Julie Yome Chemicals Surveillance Bureau Healthy Environments and Consumer Safety Branch Health Canada Ottawa, Canada Telephone: (613) Human Biomonitoring of Environmental Chemicals The Canadian Health Measures Survey Maternal-Infant Research on Environmental Chemicals Northern Contaminants Program

State-based Biomonitoring Programs and NHANES Exposure Data

State-based Biomonitoring Programs and NHANES Exposure Data Kristin Dortch, MS Project Officer, State Biomonitoring Cooperative Agreement Division of Laboratory Sciences Association of Public Health Laboratories