Minimizing Ethylene Oxide and Glutaraldehyde Use Marcy Yeshnow ski Tetra Tech EM Inc.
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1 Take Home Messages Minimizing Ethylene Oxide and Glutaraldehyde Use Marcy Yeshnow ski Tetra Tech EM Inc. 1. Balance sporicidal, virucidal, and bactericidal effectiveness vs. human health effects and environmental toxicity of wastes 2. Check material co mpatibi lity with delicate medical devices and equipment repair costs 3. Consider cost per cycle, useful life of product, and cycle time First Consider the Device* Critical Enters sterile tissue or vascular system (e.g., surgical instruments, cardiac and urinary catheters, implants) Semi-Critical Contacts mucous membranes or non-intact skin (e.g., endoscopes, respiratory therapy and anesthesia equipment, diaphram rings) Non-Critical Contacts intact skin (e.g., bedpans, blood pressure cuffs, crutches) *Spaudling sc hem e Sterilization: Which Determines 1 Validated process used to render a pr oduct fr ee of all for ms of viable mircr oor ganisms. Disinfection: Destr uction of pathogenic and other kinds of micr oor ganisms by ther mal or chemical means. Destroys most recognized pathogenic microorganisms, but not necessarily all microbial forms, such as bacterial spores. 1 Rutala, W.A., Draft Guidelines for Disinfection and Sterilization in Healthcare Facilities, HICPAC 2b, CDC 02/20/2002 1
2 Reprocessing Algorithm* Is Is the the instrument reu reusa sable? Discard Discard th the dispo disposabl sable instrum instrument ent after after one one use. use. Is the Is the re u sa b le? re u sa b le? Can the Can the be be thoroughly thoroughly cle a n e d? cle a n e d? Will heat Will heat damage the damage the?? Discard the disposable Discard the disposable in stru me n t a f te r o n e u se. in stru me n t a f te r o n e u se. Replace the reusable ins tru ment Replace the reusable ins tru ment with a disposable. with a disposable. Use pres surized stea m Use pres surized stea m or dry heat sterili zation. or dry heat sterili zation. Disposable Instruments Sterilized Can Can the the instrument be be tho thorou roughly cleaned? Replace the the re reusa usable in inst strum rumen ent t with with a disposable iinstrument. High Lev el Disinfected Does the Does the have long, thin have long, thin Use a cold liquid s terilant. Use a cold liquid s terilant. Use a low- tempe rature gas, Use a low- tempe rature gas, plasma, or vapor sterili zation. plasma, or vapor sterili zation. Will Will heat heat damag damage the the instrument? Use Use pressurized steam steam or or dry dry heat heat sterilization. Can Can the the instrument be be tho thorou roughly cleaned? Replace the the re reusa usable in inst strum rumen ent t with with a disposable iinstrument. Will Will heat heat damag damage the the instrument? Use Use pressurized steam steam or or dry dry heat heat sterilization. Will Will heat heat damag damage the the instrument? Use Use pressurized steam steam or or dry dry heat heat sterilization. Does Does tthe he instrument have have lo long, tthin hin Use Use a lo low- w-tem tempe perature gas, gas, plasma, or or vapor vapor sterilization. Does Does tthe he instrument have have lo long, tthin hin Use Use a lo low- w-tem tempe perature gas, gas, plasma, or or vapor vapor sterilization. Use Use a col cold liquid liquid st sterilan erilant. t. 2
3 Reprocessing Algorithm* Ethylene Oxide and Glutaraldehyde Is the Is the re u sa b le? re u sa b le? Can the Can the be be thoroughly thoroughly cle a n e d? cle a n e d? Discard the disposable Discard the disposable in stru me n t a f te r o n e u se. in stru me n t a f te r o n e u se. Replace the reusable ins tru ment Replace the reusable ins tru ment with a disposable. with a disposable. Disposable Instruments Ethylene Oxide (EtO) is a sterilant, glutaraldehyde is a high-level disinfectant Will heat Will heat damage the damage the?? Use pres surized stea m Use pres surized stea m or dry heat sterili zation. or dry heat sterili zation. Sterilized Both do not damage heatand moisture-sensitive instruments High Lev el Disinfected Does the Does the have long, thin have long, thin Use a cold liquid s terilant. Use a cold liquid s terilant. Use a low- tempe rature gas, Use a low- tempe rature gas, plasma, or vapor sterili zation. plasma, or vapor sterili zation. Should be managed in a centralized area Why Eliminate EtO? 3-Step Approach to Eliminating EtO Known carcinogen Probable teratogen Neurotoxin May damage CNS Increasing regulatory concerns 1EtO Use Inventory 2Evaluate methods of eliminating EtO sterilization for each instrument 3 Establi sh a working g roup to ensure sterilization standards aren t compromised 3
4 EtO Alternatives Steris System Considerations Steris (Steris Corporation) Peracetic acid sterilant but Just In Time approach Not a drop-in replacement Sterrad (Johnson & Johnson Corporation) Plasma-phase hydrogen peroxide sterilant but Some manufacturer limitations Pr os Sterilizer -- if scope used within 2 hours and processed in covered tray (high level disinfected if alcohol purged and forcedair dried) Small footprint Closed, automated system Cons Must use S-20 concentrate in System 1/P6000 processor only Cannot process ERCP scopes Materials incompatibility with Olympus GI scopes Irritant -- may not bring relief to those suffering from asthma or other respiratory sensitization Highly toxic material, Class II combustible, Class II Unstable, Class II or III organic peroxide Higher repair costs with other flexible and rigid scopes Sterrad Decision Tree 1. Is the reprocessable medical device made of the follow ing materials? Aluminum Brass Delrin Acetal Resin Ethylvinyl Acetate Glass Kraton Polymers Neoprene Nylon Polycarbonate Polyethylene Polyetherimide Polymethyl methacrylate Polyphenylene sulfone Polypropylene Polystyrene Polyurethane Polyvinyl chloride Silicone elastomers Stainless Steel Teflon Titanium Items T Recommended for Sterrad Processing Non-Sterrad instrument mats and trays Any item that is not completely dry Items or materials that absorb liquids 4
5 Sterrad Decision Tree Sterrad Decision Tree 2. Does the reprocessable medical device have a lumen? If no, contact medical device manufacturer for information If y es, continue to next question. If no, contact medical device manufacturer for information If y es, continue to next question. Sterrad Decision Tree 3. Is the lumen made of stainless steel, polyethylene, or Teflon? If no, continue with processing. If y es, continue to next question. Items T Recommended for Sterrad Processing Items whose design permits the surfaces to collapse onto each other unless some method is used to keep the surfaces separ ated. Devices with internal parts, such as sealed bearings, that cannot be immersed Lumen lengths and diameter limitations Ultimately, consult the Compatible Device list 5
6 Sterrad Decision Tree EtO Alternatives 4. Proc eed w ith processing if the lumen conforms to the dimensions listed below : Teflon/Polyethylene Inside Diameter Length 6 mm or larger 310 mm or shorter Single Stainless Steel Lumen Inside Diameter Length 1 mm or larger 125 mm or shorter 2 mm or larger 250 mm or shorter 3 mm or larger 400 mm or shorter Sterilization Process EtO Sterrad Steris Cycle Time 17 hours 50 minutes 30 minutes Cycle s per Shift Cost per foot 3 $11 - $12 $8.50 ~ $6 per cycle Non-EtO Technology Costs Sterrad Processor $65,000 to $130,000 $216 to $265 per case ($43 to $53 per cassette, or $9 to $10 per cycle) Steris Processor $18,200 $128 per case, $7 per cycle Costs/Benefits Not Quantified Transaction cost of reductio n effort Value of quicker sterilization time Increased availability of instruments Instrument upgrade/replacement costs Eliminate s chance of EtO incident 6
7 Disinfection Levels Cold Liquid Disinfection Methods High-level Capable of killing bacterial spores, and is ther efor e ex pected to kill all other microorganisms Intermediate-level Destroy s all v egetative bacteria, including tuberc le bac illi, viruses, and fungus spores Low-level Destroy s all v egetative bacteria ( exc ept tuberc le bac illi), som e v ir uses and fungi Glutar aldehyde Cetylcide-G (3.2%) Cidex (2.4, 2.5, 3.4%) MedSci (3%) Metricide (2.5, 2.6, 3.4%) Omnicide (2.4, 3.4%) Procide (2.4%) Rapidcide (2.5%) Sporicidin (1.12/1.93% glut/phenol) Wavicide-01 (2.5%) Hydr ogen Per oxide Sporox (7.5%) Hydr ogen Per oxide/ Peroxyacetic Acid EndoSpor Plus (7.5/0.23%) Peract 20 (1.0/0.08%) or tho-phthalaldehyde Cidex OPA (0.55%) Peroxyacetic Acid Steris S-20 (35%) Disadvantages of Glutaraldehyde Severe irritant - may cause asthma and respiratory sensitization (although not canc er or reproductive harm) Skin sensitizer Low exposure limits 0.2 ppm NIOSH REL 0.05 ppm ACGIH TLV Proposed ppm Ceiling Limit in CA OPA vs. Glutaraldehyde Low vapor pressure therefore minim al inhalation risk Switch can be accomplished relatively quickly compared to installing engineering controls No reg ulatory or recommended exposur e limits so no assoc iated monitor ing Reduces disinfec tion tim e to 12 min. m anual and 5 min. automated processing (from 20 min. for glutaraldehy de) Allows twic e the disinfection cyc les bef ore solution failure 7
8 OPA Considerations Time Out: Comparing Cycle Times Unknown long-ter m health effects or cr oss-sensitivity to other aldehydes No validated air sampling method Pr ecautionar y principle r equir es same engineer ing contr ols as glutar aldehyde 4 times the cost of glutaraldehyde Glutaraldehyde ($5 per bottle) 20 minutes per cycle = 24 cycles per 8 hour shift Cidex OPA ($25 per bottle) 12 minutes per cycle ( manual) = 40 cycles per 8 hour shift 5 minute s per cycle (autom ated) = 96 cycles per 8 hour shift Benefits of Quicker Process Time Increased availability of instruments and medical devices Decreased inventory requirements Inc reased personnel availability Relative Cost Considerations $20 Difference in cost of OPA vs. glutaraldehyde-based products $15K Cost of each reprocessor Patients get treated sooner! $30K Cost of each endoscope 8
9 The Built Environment Scope Wash Room Scope Wash Room Isolation of cleaning and disinfection pr ocess fr om clinical procedure areas Separ ation of clean and dirty areas Pr ocess flow fr om dirty to clean, with no cross-over encour aged between the two Engineering controls of vapor-generating activities and equipment Safety equipment (eyewash, shower, spill containment, emer gency shut-off) Local Exhaust Ventilation Take Home Messages 1. Balance sporicidal, virucidal, and bactericidal effectiveness vs. human health effects and environmental toxicity of wastes 2. Check material co mpatibi lity with delicate medical devices and equipment repair costs 3. Consider cost per cycle, useful life of product, and cycle time 9
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