FP7 REGPOT Project coordinator: Srećko Gajović

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1 Combining Stem Cells and Biomaterials for Brain Repair - Unlocking the Potential of the Existing Brain Research through Innovative In Vivo Molecular Imaging FP7 REGPOT Project coordinator: Srećko Gajović

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3 GlowBrain history REINFORCING A CENTER FOR LASER MICROSCOPY AND CELL PROFILING FOR REGIONAL NETWORKING NEUROIMAGE REVEALING GENE FUNCTIONS IN BRAIN THROUGH PHENOTYPE ANALYSIS OF MOUSE MUTANTS PHENOBRAIN Stem Cell Applications for Brain Repair unlocking the Potential of the Existing Mouse Brain Research through Innovative Imaging of Bioluminescence Reporters GlowBrain Stem Cell Applications for Brain Repair unlocking the Potential of the Existing Mouse Brain Research through Innovative In vivo Molecular Imaging GlowBrain Success! Stem Cell Applications and Biomaterials for Brain Repair unlocking the Potential of the Existing Mouse Brain Research through Innovative In vivo Molecular Imaging GlowBrain

4 Objective of the REGPOT call Stimulating the realisation of the full research potential of the enlarged Union by unlocking and developing existing or emerging excellence in the EU's Convergence regions and Outermost regions, and helping to strengthen the potential of their researchers to successfully participate in research activities at European Union level.

5 Special requests competitiveness, jobs, sustainable growth and social progress it is necessary they advance scientific discovery and innovation and improve management of intellectual property (IP)

6 Result 14.5 points 5 for scientific excellence 5 for implementation and management 4.5 for impact The IPR strategy potential to exploit research results needs more justification.

7 What is GlowBrain?

8 Brain damage is irreparable Mary Free Bed Rehabilitation Hospital physical therapist assistant, Glenn Tamminga, helps stroke patient Ben walk using an FES foot drop unit.

9 Regenerative medicine

10 Contribution to the substantial change in medicine

11 The main objective of GlowBrain is To introduce a synergic combination of stem cells, biomaterials and in vivo imaging aiming to transform the existing mouse brain research in the cutting edge innovative facility for regenerative medicine

12 University of Zagreb School of Medicine (UNIZAG) and its part Croatian Institute for Brain Research (CIBR) as research entity hosting GlowBrain University of Zagreb School of Medicine Croatian Institute for Brain Research - high quality research and teaching entity of significant scientific and organizational size

13 Mouse brain research at CIBR as a foundation for GlowBrain (1) mouse facility, (2) neuroanatomy platform, (3) neurodevelopmental platform, (4) microscopy platform, (5) molecular biology platform, (6) behavioral platform, plus two platforms under construction (7) stem cell platform (8) biomaterials platform GlowBrain project aims to complete two platforms under construction (i.e. 7 and 8) and to add (9) in vivo molecular imaging.

14 Experienced scientists of CIBR which would realize GlowBrain gender balance of experienced researchers is approx. 50% - 50% the majority of experienced researchers are in mid 40 s, i.e. at the top potential of their careers.

15 Action plan to increase the attractiveness of the research performed in order to gain national, international and private funding to coordinate scientific activities of the Institution as whole in order to accumulate knowledge and expertise necessary to attack major scientific problems to support innovations and generation of new intellectual property to orientate toward societal needs and envisage the research program which is timely and needed

16 The main objective of GlowBrain is To introduce a synergic combination of stem cells, biomaterials and in vivo imaging aiming to transform the existing mouse brain research in the cutting edge innovative facility for regenerative medicine

17 GlowBrain three main pillars A) stem cells, B) biomaterials and C) in vivo animal imaging system.

18 GlowBrain Main S&T objective is to introduce a novel approach for stem cell based therapy of nervous system by using the biomaterials to enhance and control stem cells, and by in vivo monitoring of stem cell behavior after transplantation through complementary combination of two imaging modalities - bioluminescent imaging (BLI) and magnetic resonance imaging (MRI).

19 Participant No.: Participant organisation name: Country: 1 (Coordinator) University of Zagreb School of Medicine (UniZAG) Croatia 2 (Partnering organisation) Lund University Lund Stem Cell Center (LSCC) Sweden 3 (Partnering organisation) Max Planck Institute for Neurological Research (MPINR) Germany 4 (Partnering organisation) Paracelsus Medical University (PMU) Austria 5 (Partnering organisation) Marche Polytechnic University (UNIVPM) Italy 6 (Partnering organisation) Prague Institute of Macromolecular Chemistry (PIMC) Czech Republic 7 (Partnering organisation) Semmelweis University (SEMU) Hungary 8 (Partnering organisation) University of Minho (UMINHO) Portugal

20 WP1 WP2 WP3 WP4 WP5 WP6 WP7 Coordination and management Exchange of know-how and experience Recruitment of the experienced researchers Acquisition and upgrading of research equipment Intelectual property and innovation capacity building Dissemination and promotional activities Ex-post Evaluation of UniZAG research potential

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22 Current results Experienced scientist employed Equipment chosen and partially functional Secondements and collaboration with partners ongoing Management structure functional RegMed established Public manifestation The night when brains are glowing organised

23 5 day follow up of stroke + intracerebral injection of PBS

24 The Night When Brains Are Glowing September 20, 2013

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31 Brain damage COULD BE REPARABLE Mary Free Bed Rehabilitation Hospital physical therapist assistant, Glenn Tamminga, helps stroke patient Ben walk using an FES foot drop unit.

32 Additional resources likes already! Project web page atia Aminated movie What is GlowBrain?