Curriculum Vitae. Strong background in writing and reviewing grants and manuscripts.

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1 Curriculum Vitae Marinella G. Sandros, Ph.D. McGill University Dept. of Biomedical Engineering 3775 University St. Rm. 314A Montreal, QC H3A 2B4 Office: FAX: PROFESSIONAL PROFILE Experience in teaching undergraduate students (5 yrs) and biomedical engineering graduate students (3yrs) in a class room setting. Strong background in writing and reviewing grants and manuscripts. Enhancing the limit of detection of biomolecules for surface plasmon resonance imaging using quantum dots. Used correlative light and electron microscopy to determine the fate of polyelectrolytes in porcine arteries. Enhanced biointerfacing properties of InGaP quantum dots by covalently binding them to chitosan polymer. Developed a new polymer based multifunctional vehicle for sirna delivery. An accomplished independent researcher in a multidisciplinary laboratory with several high impact journal publications. Research collaborations with medical doctors and pharmacologists. Developed a new reagentless nanobiosensor for single molecule detection. Innovative, superior and effective supervisory skills, experience in managing and assisting numerous students projects throughout my PhD and Post-doctoral studies. EDUCATION

2 Post-Doctoral Studies, Biomedical Engineering, McGill University, Montreal, QC, 05/2006-Present Project: The application of quantum dots as a tool for monitoring polymer diffusion and sirna delivery; also, enhancing surface Plasmon resonance imaging signal. Advisor: Prof. Maryam Tabrizian PhD, Bioinorganic Chemistry, Wayne State University, Detroit, MI, 05/2006 Thesis Title: A New Method for Designing Protein-Based Reagentless Nanobiosensor Advisor: Prof. David E. Benson B.Sc. Honors Chemistry, Minor in German Studies University of Windsor, Windsor, ON, 05/2001 Thesis Title: Early transition metal-phosphinimide olefin polymerization catalysts. Advisor: Prof. Douglas W. Stephan RESEARCH EXPERIENCE 2001-Present Developed a robust and stable multifunctional sirna delivery system with both targeting and tracking abilities. Covalently binding chitosan polymers to InGaP@ZnS quantum dots for enhanced interfacing properties with cells and tissue. To track the release behaviour of polyelectrolytes multilayers of chitosan and hyaluronic acid within an artery using confocal and electron microscopy. Designing a reagentless protein-based nanobiosensor for selective small molecules detection using conformational dependent interactions between a redox active metal complex ion Ru II and the surface of a CdSe nanoparticle. Protein Chemistry: Protein Growth and purification via column chromatography, French press, SDS and acrylamide gels. Cell culture techniques and western blot analysis. Recombinant DNA technology: subcloning, point mutations and sequencing.

3 Synthesis of organic, coordination, and organometallic compounds and semiconducting nanoparticles. Expertise in maintaining and handling air-sensitive materials using glove box, anaerobic bag, and Schlenk line techniques. Routine use of Powder X-ray Diffraction (PXRD), Ultraviolet-Visible (UV-Vis), Fluorescence, Atomic Force Microscopy (AFM) and Transmission Electron Microscopy (TEM) to determine structure, particle size and the morphology of nanoparticles. Frequent use of Mass Assisted Lazer Desorption Ionization (MALDI), Proton Nuclear Magnetic Resonance (H NMR), Cyclic Voltammetry, Fourier Transform Infrared Red (FT-IR), Quartz Crystal Microbalance-Dissipation (QCM-D), Confocal Microscope and High Performance Liquid Chromatography (HPLC), Surface Plasmon Resonance Imaging (SPRi). ACADEMIC CLUBS 2006-Present Member of the Canadian Biomaterial Society (CBS) Member of the American Chemical Society (ACS) Member of PHI LAMBDA UPSILON (PLU) (National Honorary Chemical Society): ALPHA PSI CHAPTER - Wayne State University President of Phi Lambda Upsilon ( ) LANGUAGES National Chairperson of Recruitment ( ) English French Arabic ACADEMIC HONORS AND AWARDS 2006

4 Esther & Stanley Kirschner Graduate Award for superior academic achievement in Inorganic Chemistry Teaching Citation award for the Chemistry Department Convocation, Wayne State University Teaching Citation award for the Chemistry Department Convocation, Wayne State University University of Windsor entrance scholarship JOURNAL PUBLICATIONS Azari F, Sandros MG, Tabrizian M Self-assembled Multifunctional Nanoplexes for Gene Inhibitory Therapy submitted to ACSNano. Behrendt M, Sandros MG, McKinney A, McDonald K, Tabrizian M, Maysinger D Imaging and organelle distribution of fluorescent InGaP/ZnS nanoparticles in glial cells Nanomedicine, 4(7), , Sandros MG, Behrendt M, McKinney A, Maysinger D, Tabrizian M Chitosanmodified InGaP/ZnS nanoparticles for live cell imaging of glia ICCM-17 Proceedings, Sandros MG, Behrendt M, Maysinger D, Tabrizian M InGaP@ZnS-Enriched Chitosan Nanoparticles: A Versatile Fluorescent Probe for Deep Tissue Imaging Advanced Functional Materials 17(18), , Aryal BP, Neupane KP, Sandros MG, Benson DE Metallothioneins initiate semiconducting nanoparticle cellular toxicity Small 2(10), , Sandros MG, Shete V, Benson DE Selective, Reversible, Reagentless Maltose Biosensing with Core-Shell Semiconducting Nanoparticles" The Analyst, 131, 229, 2006 Sandros MG, Gao D, Benson DE A Modular Nanoparticle-Based System for Reagentless Small Molecule Biosensing J. Am. Chem. Soc., 127 (35), , 2005.

5 Sandros MG, Gao D, Gokdemir C, Benson DE General, high-affinity approach for the synthesis of fluorophore appended protein nanoparticle assemblies Chem. Commun. (22), , BOOK CHAPTERS & REVIEWS Sandros MG, Tabrizian M Drug-Eluting Stents Devices: Clinical Relevance and Perspective New Technologies in Vascular Biomaterials, Fundamentals about Stents II, ESVB, EURPROT: Strasbourg, France 15, , Sandros MG, Sarraf CB, Tabrizian M Prodrugs in Cardiovascular Therapy Molecules, 13(5), , 2008 PRESENTATIONS 7 th International Conference on Pathways, Networks and Systems Medicine, Corfu, Greece 2009 InGaP/ZnS quantum dots: assessing their uptake in glial cells and application as bioimaging tools for monitoring bioactive coating internalization in porcine arteries Poster Presentation Sandros MG, Behrendt M, Maysinger D, Tabrizian M. EST-EMBO Symposium Biological Surfaces and Interfaces, Sant Feliu de Guixols, Spain 2007 Coating with chitosan improves the interfacing properties of InGaP@ZnS QDs with biological surfaces Poster Presentation Sandros MG, Behrendt M, Maysinger D, Tabrizian M. 26 th Canadian Biomaterial Society Conference, London, ON May 2007 Chitosan nanoparticles encapsulated with InGaP@ZnS Quantum Dots as a nontoxic bioimaging tool Poster Presentation Sandros MG, Behrendt M, Maysinger D, Tabrizian M. 7 th Annual Graduate Student Research Symposium, Wayne State University, Detroit, MI, October 2005 A New Method for Designing Protein-Based Reagentless Nanobiosensor Oral Presentation-**Won Best Talk** Sandros MG, Benson DE 6 th Annual Graduate Student Research Symposium, Wayne State University, Detroit, MI, October 2004 Maltose-Responsive Protein Nanoparticles: Using

6 Ligand Gated Electron Transfer Poster - **Won Best Poster** Sandros MG, Benson DE Gordon Research Conference-Biological Inorganic Chemistry, Ventura, CA, January Maltose-Responsive Protein Nanoparticles: Using Ligand Gated Electron Transfer Poster Sandros MG, Benson DE. Midwest Metal Meeting, University of Michigan, Ann Arbor, MI, June 2004 Maltose-Responsive Protein Nanoparticles: Using Ligand Gated Electron Transfer Poster Sandros MG, Benson DE. INVITED SPEAKER American Association of Clinical Chemistry, Henry Ford Hospital, Detroit, MI September 2004 Maltose-Responsive Protein Nanoparticles: Using Ligand Gated Electron Transfer Oral Presentation Sandros MG, Benson DE UNIVERSITY SERVICES 2009 Student Research Day, McGill University, Montreal, QC. o Duties: Judged posters presented by first and second year medical students. INDUSTRIAL EXPERIENCES Cordis Corporation (Johnson & Johnson Company) o Duties: Participated in assessing thrombogenecity on two types of cordis stents through the measurement of fibrinogen adsorption and platelet adhesion in an ex-vivo porcine model.

NINT Supporting Innovative Ideas through Nanotechnology

NINT Supporting Innovative Ideas through Nanotechnology (Capabilities and Expertise) Dr. Marianna Kulka, PhD Group Leader, NINT National Research Council Marianna.kulka@nrc.ca National Institute for Nanotechnology