INL s role in the European Nanomedicine innovation chain

Transcription

1 NANOMED PLATFORM CONF, Madrid March 24, 2015 INL s role in the European Nanomedicine innovation chain First Q: What is INL? Prof Lars Montelius Director General, INL 1

2 Creating value at nanoscale The International Iberian Nanotechnology Laboratory Avenida Mestre José Veiga BRAGA, PORTUGAL 2005 : P-S RI 2006 : Legal statutes 2008 : UN /Constr : Personnel 2

3 INL: the project Total site area: ca. 47,000 m 2 Total buildings area: ca. 26,000 m 2 Main scientific bdg: ca. 22,000 m 2 Social Building (Hostel, Gym and Nursery) Incubator Area INL Campus Main Scientific Building 8 Laboratories 7,500 m 2, Cleanroom 1000 m 2, Auditorium and other public areas 4,800 m 2, technical areas 3,500 m 2, Administrative areas 700 m2.

4 Modern infrastructure

5 Scientific Building The scientific infrastructure comprises central laboratories (providing services for the INL resident research personnel and visiting scientists) and specialized laboratories associated with individual Principal Investigators (PIs) or research groups and research topics. TheScientific building includes: Cleanroom, High Accuracy Laboratory, Wet and Dry PI laboratories, Biochemistry laboratory and other support labs. Central Bio Lab High Accuracy Laboratories Dry Labs (Floor 0) Wet Labs (Floor 1) "Clean room" Social Building 22 rooms Nursery Gym

6 A nice atmosphere 6

7 INL: Our Offer(s)! Science offer Technology offer Health Food& Environment ICT Energy Nanofabrication & Processes Exploratory Nanomaterials Synthesis Joao G Carlos R WORLDWIDE Characterisation NETWORK Facilities Bio & Cell Laboratory Nanotechnology System & IC Design Solutions Dmitri P Marta P Joao P INL-X Laboratory Ines P Begona E Ricardo F Sascha S

8 INL: Our Offer(s)! Science offer Technology offer Funding Logics Collaboration - regional - H bilateral Associated R&D&I projects Internal R&D&I projects Extended RDI Research&Development &Innovation Contracted research Technology provider Expert for hire Business Logics INL Innovation System

9 INL Operations- in short! INL Operations Explore Deploy Articulate Explore Excellence in research & being brave enough to create new knowledge, explore the unknown and break boundaries. Change paradigms, invents new fields and open opportunities Breakthroughs that lead to new products and processes that bring benefit to society.? The INL Innovation Systems Business model Conferences External Relations IPR Policy & Portfolio INL strives to embrace the concept of excellence, to prepare for the unexpected and to be sufficiently dynamic and adaptable in order to foster ambitious and ingenious breakthroughs that will tackle challenges of today and those not yet imagined. Articulation Clarification Science for Society Meaningfulness 9

10 Valley of death Research Market Research Society ARTICULATION! 10

11 What are you doing? I am cutting stone!..and you: What are you doing? I am building a cathedral! 11

12 Valley of death Research Market Research ARTICULATION! Society Scientific Social Responsitivity 12

13 Creating a vibrant society The INL International Advanced Projects Program The INL International Visiting Scholar Program The INL International Fellow Program The INL International PhD Program The INL International Incubator Program The INL International Industrial Program The INL Colloquium Program Annual INL Scientific Symposium 13

14 WELCOME TO INL Lars Montelius, Prof, Dr, Dr hc Director General

15 The role for INL The Role for INL in the NanoMedicine Innovation Chain Q1: How can INL play a role? Q2: Through Innovation? 15

16 Innovation: 16

17 Development of a new diagnostic tool for epithelial tumors Epithelial cell contractility - Depends on the assembly and dynamics of the cellular skeleton (=cytoskeleton). - Hypercontractility of the cytoskeleton correlates with epithelial tumor proliferation and metastasis. Epithelial cell cytoskeleton Structure Physical-Chemistry Prediction of cell contraction rate Identification of molecular traits that affect both contraction and metastatic potential Cytoskeleton Braga, April 24 th, 2014 ines.m.pinto@inl.int

18 ENVIRONMENT MONITORING, SECURITY AND FOOD QUALITY CONTROL Project: DETECTION OF WATERBORNE TOXINS IN FOOD AND WATER FOR HUMAN CONSUMPTION Diagnostic markers for vulnerable atherosclerotic plaques Need: Coronary Angiography detects flow blockage and other atherosclerotic plaques: vulnerable or stable? Project Concept Cardiac Catheterization: Optical coherence tomography Vulnerable? Biomarkers for vulnerability validation in human coronary arteries x lumen Vulnerable plaque Stable plaque In- house testing mockup (mimicking in vivo scenario) marina.brito@inl.int

19 Magnetoresistive Platform for Medical Diagnosis Development of surface biochemistry Production of magnetic nanoparticles Microfabrication of MR sensor Design of microelectronic board: chip control and read-out Microfluidic system design and fabrication Verónica Romão

20 Nanoparticles for cancer treatment with hyperthermia 1 - MNP + protein 2 - MNP + protein + mab Add recognition molecule (ex. mab) 4 - Magnetic field application 5 Magnetic heating 3 Specific binding Cell death membrane Cancer Treatment vania.vilasboas@visitor.inl.int

21 Magnetic Resonance Imaging Cell tracking of stem cells in brain isquemia therapies (in collaboration with CHUS, Santiago de Compostela) Healthy animal (without cells- MNPs) Healthy animal (1x10 6 cells- MNPs) Ischemic animals (1x10 6 cells- MNPs) cells) Images from partner Clinical Neurosciences Group (LINC), CHUS

22 Magnetic Imaging and Spectroscopy Magnetrodes Development a new generation of tools for local magnetic imaging and spectroscopy at the neuron scale in order to model the electromagnetic response of a neuron. 50µm thick electrodes - Detecting the magnetic field generated by the currents in the low-frequency signals <1kHz - Detecting the Nuclear Magnetic Resonance (NMR) signal for the chemical analysis of the area concerned (few 100 µm3); MHz range signals CEA-Saclay (probes), INESC-MN (probes), Aalto Univ.(modelling), ESI-Frankfurt (in vivo), CNRS-Gift sur Yvette (in vitro)

23 The role for INL The Role for INL in the NanoMedicine Innovation Chain Q1: How can INL play a role? Q2: Through Innovation? Q3: Radical Innovation? 23

24 Radical Innovation Let me talk about a learning experience: A sector having had - and still is of - large importance for todays society! A sector where standardisation is absolutely instrumental! And a sector that is about to go through a spectacular change! Which one? 24

25 Radical Innovation The lighting sector is very big lighting has been one of the disruptive technologies that have built our modern society... 25

26 .but the lighting sector has been (forced to be) rather stupid!!!...just more or less light! 6 am 17 pm 10 am 12 am 21 pm 23 pm.we know well that natural lighting is nice and...& changing...

27 Plants feels better if they get the right light HPS- lampa Heliospectra s LED- lampa Heliospectra cooperate with Swedeponic that harvest for Santa Maria.

28

29

30 The role of nano & KETs for Regional Development Circadian rhythm and health 30

31 Radical Innovation Photoreceptor Cells in the Retina visual Cones are concentrated in the fovea Image forming High resolution Retina Blood vessels Fovea Optic Nerve Iris Lens Cornea Pupil biological iprgcs are widely distributed Higher sensitivity in lower retina Large receptive fields Light from above is more effective visual biological 31

32 Radical Innovation Health & Wellbeing! St. Katharina Improved quality of life for resident dementia patients Location: Vienna, AU! Lessons learned: Conversations Social Activities 32

33 Radical Innovation Education & Productivity! In der Alten Forst Dynamic school lighting Location: Hamburg, Germany! Lessons learned: 35% increase in reading speed 45% drop in frequency of errors 76% reduction in hyperactivity 33

34 We are right now entering a new paradigm! Solid State Lighting: LED Past: More or less Color temp Static Presently:. Wavelengths Dynamic Smart Lighting Saves energy Sustainability Last long time Architectur & Design Future: Obviously values are created beyond sustainability!! Interactive, intelligent, active Smart Living Light

35 The spotify of (digital) light! What is it? And who will create it?

36 The role for INL The Role for INL in the NanoMedicine Innovation Chain Q1: How can INL play a role? Q2: Through Innovation? Q3: Radical Innovation? As a neutral Hub for Iberian efforts? 36

37 Nanomedicine platform Where is nanomedicine going? Ageing population! Bringing together actors - creating a large enough critical mass! Big Data- history & experiences Multi-sickness panorama! Obesity! So, what is called for? Life styles! Pandemics! Clean Water! Food supply! Urbanisation! A Health System Ceiling! A holistic translational Health perspective! Cross-KET & Smart Specialisation ESFRI - proposal EuroScience Corridor! 37

38 The role for INL The Role for INL in the NanoMedicine Innovation Chain Q1: How can INL play a role? Q2: Through Innovation? Q3: Radical Innovation? As a neutral Hub for Iberian efforts? 38

39 Creating societal value Summary International Iberian Nanotechnology Laboratory 1) Location: Braga- Portugal 2) Status: Intergovernmental Organization 3) Built area: 26,000 m2 4) Total Staff: ~ 400 people (100) 5) Research Space: 40 PI labs (15) Braga 39

40 Strategic plan VISION: Become the world wide hub for nanotechnology addressing society s grand challenges MISSION: Perform interdisciplinary cutting edge research, deploy and articulate nanotechnology - all for the benefits of society. 40

41 WELCOME TO INL Thank you for Your attention! Lars Montelius, Prof, Dr, Dr hc Director General