SELECTION GUIDE DISTRIBUTION HEALTHCARE SOLUTIONS. Drug Delivery Devices
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1 SELECTION GUIDE DISTRIBUTION HEALTHCARE SOLUTIONS Drug Delivery Devices
2 Healthcare professionals use drug delivery devices everyday to administer IV therapy, inhalations and injections to patients. Performance and reliability is paramount. When your goal is to select the perfect material for rigid or flexible components of medical devices, we can help. In the earliest phases of the product development lifestyle, we will recommend medical grade materials able to withstand cracking, crazing or discoloration despite constant exposure to harsh disinfectants and aggressive drugs. PolyOne Distribution is here to assist you in material selection, offer manufacturing support, and navigate regulatory processes.
3 RIGID COMPONENTS: IV THERAPY, INHALATION & INJECTION (IV y-sites, drip chambers, syringe bodies, valves, luers, spikes, caps, plungers, gears, actuators) Copolyester, PBT & PC/PET Blends Rigid Component Solution Needs: Copolyester Eastman Tritan (Copolyester) High chemical resistance to oncology drugs and carrier solvents, lipids, and disinfectants; clarity; no color shift after gamma/e-beam sterilization; free of BPA, BPS, halogens; high bond strength to tubing Materials compliant with ISO & USP Class VI, if required Polybutylene Terephthalate (PBT) DuPont Crastin (PBT) Excellent surface appearance; good printability; low extractables and volatiles; excellent gamma sterilization performance; good chemical resistance; alternative to nylon for low moisture uptake and dimensional stability; low wear/low friction Devices resistant to cracking with exposure to lipids, drugs &/or hand oils Components that retain mechanical & aesthetic integrity after sterilization Polycarbonate/ Polyester (PC/PET) PC & PMMA Polycarbonate (PC) PolyMethyl Methacrylate (PMMA) Trinseo EMERGE (PC/PET) Covestro Makrolon (PC) Trinseo CALIBRE & CALIBRE MEGARAD (PC) Altuglas Plexiglas SG Acrylics & Luctor (PMMA) Chemical resistance to hospital disinfectants; UL94 V-0 and HB options; ISO tested Clarity; excellent impact resistance; lipid and gamma resistant options; sterilizable by gamma, EtO, e-beam and steam Transparent and opaque; lipid and gamma resistant options; sterilizable by gamma, e-beam, and EtO; Animal-Derivative Free and ISO tested Easy processing; BPA free; transparency; impact resistance; chemical resistance; sterilizable by gamma and EtO Components that exhibit long-lasting bond strength PA (Nylon), Rigid TPU & Rigid PVC & PVC Blends DuPont Zytel (PA66) Good toughness; chemical resistance and colorability; excellent stiffness and strength; acceptable EtO, gamma, e-beam, and autoclave sterilization High quality resins with proven performance in drug delivery devices Polyamide (Nylon, PA) DuPont Zytel (PA612) Arkema Rilsan MED (PA11) & Rilsamid MED (PA12) Good toughness and colorability; acceptable EtO and autoclave sterilization (limited gamma/e-beam sterilization performance); improved dimensional stability; chemical resistance; reduced aqueous extractables versus PA66 Chemical resistance; transparent and opaque; easy processing; creep resistance; temperature resistance; BPA-free; sterilizable by gamma, EtO and steam Rigid Polyurethane Covestro Texin Biocompatible; excellent chemical resistance; bondable to polar substrates like PC; sterilizable by gamma, EtO, e-beam and dry heat; rigid 65 to 80 Shore D grades Rigid Polyvinyl Chloride (PVC) PolyOne Resilience HC (PVC) Excellent chemical resistance; physical integrity after chemical/cleaner exposure; inherently flame retardant; color branding available; excellent solvent bonding to PVC tubing Rigid Polyvinyl Chloride/ABS (PVC/ABS) PolyOne HTX (PVC/ABS) High temperature resistance; excellent chemical resistance; physical integrity after chemical/cleaner exposure; inherently flame retardant; color branding available; excellent solvent bonding to PVC tubing
4 RIGID COMPONENTS: IV THERAPY, INHALATION & INJECTION (cont.) (IV y-sites, drip chambers, syringe bodies, valves, luers, spikes, caps, plungers, gears, actuators) Styrenics & PC/ABS Blends Rigid Component Solution Needs: Trinseo MAGNUM (ABS) & STYRON (PS) Opaque; custom colors; excellent impact and flow; low residuals; ISO tested Materials compliant with ISO & USP Class VI, if required Devices resistant to cracking with exposure to lipids, drugs &/or hand oils Components that retain mechanical & aesthetic integrity after sterilization Components that exhibit long-lasting bond strength High quality resins with proven performance in drug delivery devices Styrenics Polycarbonate/ ABS (PC/ABS) POM (Acetal), PP & PE Polyoxymethylene (Acetal, POM) INEOS Styrolution NAS (SMMA) INEOS Styrolution Zylar & Clearblend (MBS) INEOS Styrolution Lustran (SAN) INEOS Styrolution Styrolux (SBC) INEOS Styrolution Terlux HD (MABS) INEOS Styrolution Lustran & Novodur HD (ABS) Covestro Bayblend (PC/ABS) Trinseo EMERGE (PC/ABS) DuPont Delrin (POM) Sparkling clarity; color neutrality; good rigidity; easy processing; no pre-drying needed; excellent alcohol resistance Exceptional toughness; excellent clarity; low specific gravity; no pre-drying needed; excellent thermal stability; superior chemical resistance Rigid; heat resistant; outstanding transparency; good overall chemical resistance; superior processing; good scratch resistance Good transparency and excellent toughness; easy and versatile processing; great for adding toughness to styrenic polymer blends Good clarity; good heat and overall chemical resistance; good impact strength; good solvent bonding to PVC; outstanding surface quality Opaque appearance; outstanding chemical resistance; high impact strength; excellent balance of properties; ease of processability; bondable Opaque; excellent mechanical and thermal properties; toughness; rigidity; dimensional stability; easy processing; sterilizable by gamma, e-beam and EtO Opaque; high toughness; high flow; easy processing; sterilizable by gamma, e-beam, and EtO; ISO tested Excellent low wear/low friction; excellent surface appearance; good chemical resistance; alternative to nylon for low moisture uptake and dimensional stability; acceptable for EtO and autoclave sterilization (not recommended for gamma/e-beam sterilization) Flint Hills (PP) Polypropylene (PP) & Polyethylene (PE) Pinnacle (PP) Dow Health+ Polymers (PE) Good strength and stiffness; easy processing; sterilizable grades available Lyondellbasell (PP) & (PE)
5 FLEXIBLE COMPONENTS: IV THERAPY, INHALATION & INJECTION (o-rings, plunger seals, gaskets, spring seals, soft-touch overmolds, etc.) TPE, TPC-ET, TPU, TPV & Flexible PVC Flexible Component Solution Needs: PolyOne Versaflex HC Series (TPE) Proven healthcare solutions with hardness ranges Shore A; autoclave, radiation and EtO sterilizable; good ambient and elevated compression set properties Materials compliant with ISO & USP Class VI, if required Elastomers (TPE) PolyOne Versaflex HC Overmolding Series (TPE) Proven healthcare solutions with hardness ranges Shore A; autoclave, radiation and EtO sterilizable; bondable to PC, ABS, PVC, COPE, PP, HIPS and others Optimum sealing force & compression set for gaskets & valves Polyester Elastomers (TPC-ET) Arkema Pebax MED (TPE) DuPont Hytrel (TPC-ET) Sterilizable by gamma and EtO; low energy return; soft touch; chemical resistance; overmolding material BPA-free; excellent flex fatigue and toughness; low temperature flexibility; good chemical resistance Comfortable, easy to hold & operate devices Flow control Polyurethane PolyOne NEU Specialty Engineered Materials Covestro Texin Biocompatible; various durometer ranges; autoclave, radiation and EtO sterilizable Biocompatible; soft touch; sterilizable; good chemical and abrasion resistance and toughness; excellent bonding to polar substrates like PC; 70 to 95 Shore A grades Vulcanizate (TPV) PolyOne Versalloy (TPV) Exxon Mobil Santoprene (TPV) Proven healthcare solutions with hardness ranges Shore A; autoclave, radiation and EtO sterilizable; natural and colorable; smooth texture; bonds to PP Durable sealing performance; elastic recovery; excellent chemical resistance; compliance with medical standards Flexible Polyvinyl Chloride (PVC) PolyOne Geon (PVC) Engineered exclusively for the healthcare market; transparent and opaque colors; radiopaque grades available; durometer range from 55A to 40D; gamma and EtO sterilizable Thermoset Silicone Elastomers Thermoset Silicone Elastomers/ Liquid Silicone Rubber (LSR) Dow Corning Silicone Elastomers Biocompatible; non-irritating and non-sensitization; sterilizable; made without plasticizers, phthalates or latex SBC Styrene Butadiene Copolymer (SBC) INEOS Styrolution Styroflex (SBC) Rubber-like mechanics; outstanding resilience; toughness and transparency; extremely high elasticity; excellent bonding to other polymers
6 CUSTOM POLYONE SOLUTIONS FOR DRUG DELIVERY Custom Solution Needs PolyOne Custom Solutions Specialized materials to meet unique application requirements PolyOne Trilliant Healthcare products are a line of customized solutions specific for regulated medical devices; color branding expertise FDA-registered pre-colored resins and masterbatch options; color coding for safety and brand recognition PolyOne collaborates with key material suppliers to provide FDA-approved pre-colored resins PolyOne OnColor HC Plus offers customizable color masterbatch solutions pre-certified for biocompatibility using ISO and USP Class VI test protocol Reduced growth of microbes PolyOne WithStand additive technologies inhibit growth of microbes that often cause odor, staining and loss of mechanical properties
7 POLYONE DISTRIBUTION Healthcare Supplier Line Card You face a unique set of challenges when designing parts for the healthcare industry. In addition to maintaining an effective manufacturing and supply chain operation, you re challenged with designing products that must meet strict regulatory and quality assurance standards. At PolyOne Distribution, we help you achieve these goals with our comprehensive portfolio of leading suppliers, on-time delivery and a host of services focused on helping you succeed. RESOURCES
8 PATIENT FIRST HEALTHCARE SOLUTIONS To deliver patient safety, security and comfort, start with PolyOne healthcare materials and solutions. Your focus is on developing medical devices that greatly improve patient outcomes, so you know that there is no room for product development shortcuts. High-stakes healthcare applications demand the best in materials science. PolyOne Distribution provides you more than the world s most advanced polymer materials. We help you streamline design, manufacturing and supply chain processes, including navigating regulatory demands and beyond. DRUG DELIVERY DEVICES THAT DELIVER When it comes to administering life-saving drugs, your devices need to properly perform every time. With the right polymers, your devices will not only resist cracking, but can also bring greater comfort to both the patient and physician. IV y-site Luers Needleless Valves Stopcocks & Connectors Drip Chambers Syringes Inhalers Injector Pens POLYONE Copyright 2018, PolyOne Corporation. PolyOne makes no representations, guarantees, or warranties of any kind with respect to the information contained in this document about its accuracy, suitability for particular applications, or the results obtained or obtainable using the information. Some of the information arises from laboratory work with small-scale equipment which may not provide a reliable indication of performance or properties obtained or obtainable on larger-scale equipment. Values reported as typical or stated without a range do not state minimum or maximum properties; consult your sales representative for property ranges and min/max specifications. Processing conditions can cause material properties to shift from the values stated in the information. PolyOne makes no warranties or guarantees respecting suitability of either PolyOne s products or the information for your process or end-use application. You have the responsibility to conduct full-scale end-product performance testing to determine suitability in your application, and you assume all risk and liability arising from your use of the information and/or use or handling of any product. POLYONE MAKES NO WARRANTIES, EXPRESS OR IMPLIED, INCLUDING, BUT NOT LIMITED TO, IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE, either with respect to the information or products reflected by the information. This literature shall NOT operate as permission, recommendation, or inducement to practice any patented invention without permission of the patent owner. Makrolon, Apec, Bayblend, Makroblend, and Texin are trademarks of the Covestro Group. Trinseo STYRON Polystyrene Resins are available in Europe and Asia Pacific only. In North America, STYRON Polystyrene is available through a joint venture with Americas Styrenics.
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