Mobile Health Monitoring Enabled by Wearable Microfluidic Sensing. Micro-Nano Innovations Laboratory
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1 Mobile Health Monitoring Enabled by Wearable Microfluidic Sensing Tingrui Pan, Ph.D. Director, Center for Nano and Micro-Manufacturing (CNM²) Associate Professor, Department of Biomedical Engineering University of California, Davis Founder of TacSense, LLC Micro-Nano Innovations Laboratory Bio Printing Micro and Nano Innovations (MiNI) Laboratory Digital Chemistry Precision Medicine Flexible, Wearable, Adaptive Devices 1
2 Emerging Flexible Electronics Smart Watches Pebble Watch What do they promise? Fitness Track Sleep Track Blood Pulse Blood Pressure Oxygen Level Emotion Moto 360 Samsung Gear Apple Watch 2
3 Smart Wristbands Microsoft Band Nike Fuelband What do they promise? Fitness Track Sleep Track Blood Pulse Blood Pressure Oxygen Level Emotion Fitbit Charge MisFit Shine Jawbone UP Garmin VivoFit Smart Glasses Augmented Reality for Medicine Oculus Rift 3
4 Smart Textiles Reebok MC10 CheckLight Footlogger Athos Smart Textiles MIMO Baby Monitor Raiing 4
5 Smart Bandages/Tattoos Measure EEG (UIUC) Measure Oxygenation (MGH) Measure Ionic Concentration (UC) Measure Temperature /Infection (UIUC) Generate Bio-Electricity (UCSD) Measure Metabolism Artificial Skins Skin Replacement 1 Health Monitoring 2 1 from Someya-Sekitani Group, downloaded online 2 from John Rogers Group, downloaded online 3 from Someya-Sekitani Group, downloaded online Robotic Interface 3 5
6 Ubiquitous Internet of Everything 6
7 Microfluidic Interfacial Capacitive Sensing Microfluidic Interfacial Capacitive Sensing (MICS) The world s most sensitive capacitive pressure sensor enabled by a microfluidic interfacial sensing principle Microfluidic Interfacial Capacitive Sensing MICS Advantages: Ultrahigh pressure sensitivity; Ultraprecise mech resolution; True optical transparency (as good as touchscreen); Excellent mechanical flexibility Outstanding adaptability and integratability (for wearable applications); Fast response time (>1,000Hz); Ultrathin microstructure (<200µm); Massively scalability and manufacturability (compatible with existing manufacturing processes). 7
8 Microfluidic Interfacial Capacitive Sensing Single-Element MIST (1 st Generation, 2011) Continuous MIST Array (3 rd Generation, 2013) Discrete MIST Array (2 nd Generation, 2012) App 1: Pressure-Sensitive Touchscreen 8
9 App 1: Pressure-Sensitive Touchscreen App 1: Pressure-Sensitive Touchscreen Apple s Force Sensitive Touchscreen Patent (2014) Apple Watch (2015) 9
10 App 2: Wearable Pressure Monitoring Wearable MICS Array for Pulse Pressure Mapping App 2: Wearable Pressure Monitoring Key features: Unprecedented sensitivity and accuracy; Flexible ultrathin profile with soft construct; Mass producibility with low cost. 10
11 App 2: Wearable Pressure Monitoring App 2: Wearable Pressure Monitoring Dicrotic notch Unpublished data (2015) 11
12 App 2: Wearable Pressure Monitoring Advanced Features: Heart Rate Upstroke Time Systolic Pressure Mean Arterial Pressure Diastolic Pressure Pulse Wave Velocity Home Monitoring (Muscular Artery Stenosis) Central Systolic Pressure Peripheral Argument Index Telemedical Clinical Solution App 2: Wearable Pressure Monitoring Video Link 12
13 App 3: Artificial Tactile Sensing Artificial Tactile Sense for Robotic Prosthetics B R A I L L E App 3: Artificial Tactile Sensing 3D Tactile Force Sense 13
14 App 3: Artificial Tactile Sensing Frequency Response App 3: Artificial Tactile Sensing Mouse on the Fingertip 14
15 Micro-Nano Innovations (MiNI) Laboratory Nanomaterials MiNI Lab MiNI Members Nanofabrication Bio-Inspiration Genome Building Nano Characterization Questions to Acknowledgement Team Members Dr. Baoqing Nie ( ) Dr. Siyuan Xing (2009-) Jinzhen Fan (2011-) Ruya Li (2012-) Jiannan Li (2012-) Joshua DeOtte (2012-) Dr. Gaomai Yang (2013-) Dr. Baoqing Li (2013-) Zijie Zhu (2013-) Yan Zhang (2013-) Zhichao Zhang (2014-) Dan Fong (2014-) Dr. Yahui Yang (2014-) Aaron Cohen (2015-) Howard Tseng (2015-) Laboratory Website Collaborators Dr. James Brandt (UC Davis) Dr. Willy Chi (UC Davis) Dr. Leah Krubitzer (UC Davis) Dr. Kit Lam (UC Davis) Dr. Scott Simon (UC Davis) Dr. Chris Spadaccini (LLNL) Dr. Reinhard Warnking (Guided) Dr. Bill Wu (Cynoware) Dr. Min Zhao (UC Davis) Grant Sponsors NSF ECCS, CMMI, DBI and EFRI NIH NCI, NEI and NIEHS DOD PCRP UC Proof-of-Concept Grant Xerox Foundation Tahoe Research Institute UC CITRIS 15
16 Welcome to Micro-Nano Innovations (MiNI) Laboratory Microfluidics Interfaces Nanomaterials Innovations 16
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