REFERENCE CODE GDME1016FPR PUBLICATION DATE JULY 2013 HERNIA REPAIR CURRENT AND FUTURE PLAYERS
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1 REFERENCE CODE GDME1016FPR PUBLICATION DATE JULY 2013 HERNIA REPAIR
2 List of Tables List of Figures Introduction Catalyst Competitive Assessment Overview Large Pore Meshes Overview Angimesh R2 (Angiologica) Assumesh (Assut Europe) Cristalene (Abiss Analytical Biosurgical Systems) Hexapro Mesh (Agency for Medical Innovation) Optilene Mesh (B. Braun) Omyra Mesh (B. Braun) Prolene Soft Mesh (Ethicon) ProLite Ultra Mesh (Atrium Medical) Soft Mesh (C. R. Bard) Surgimesh 1 & 2 and XLIGHT (Aspide Medical) Surgimesh PET 2D (Aspide Medical) Surgimesh WN (Aspide Medical)
3 Ultrapro Mesh (Ethicon) Vypro Mesh (Ethicon) Small Pore Meshes Overview Bard Mesh (C.R. Bard) Surgipro Flatsheet Mesh (Covidien) Premilene Mesh (B. Braun) Prolene Mesh (Ethicon) ProLite Mesh (Atrium Medical) Repol Angimesh (Angiologica) Composite Meshes Overview DDome (Cousin Biotech) B-Foil (Assut Europe) Biomesh CA.B.S Air Composite (Cousin Biotech) C-QUR Mesh (Atrium Medical) C-QUR TacShield (Atrium Medical) C-QUR V-Patch (Atrium Medical) C-QUR CentriFX (Atrium Medical) C-QUR FX Mesh (Atrium Medical) Composix Mesh (C.R. Bard) Parietex Composite (Covidien) Parietex ProGrip Self Fixating Mesh (Covidien)
4 Sorbimesh (Assut Europe) Surgimesh Cible (Aspide Medical) Surgimesh Diablo (Aspide Medical) Surgimesh M.O.P.P. (Aspide Medical) Surgimesh XB (Aspide Medical) Ultrapro Mesh (Ethicon) D Meshes Overview DMax Mesh (C.R. Bard) Bio-A Hernia Plug (W. L. Gore & Associates) Laparomesh (Assut Europe) Perfix Plug (C.R. Bard) ProLoop Mesh (Atrium Medical) Surgimesh Easyplug (Aspide Medical) Surgimesh PET 3D (Aspide Medical) Surgimesh XD (Aspide Medical) Repol Plug Cap (Angiologica) Biologic Hernia Meshes Overview AlloDerm Regenerative Tissue Matrix (LifeCell) Allomax Surgical Graft (Davol) Biodesign Hernia Graft (Cook Medical) Permacol Surgical Implant (Covidien)
5 3.6.6 Strattice (LifeCell) Pipeline Products Overview Clinical Trial Analysis Overview Trials to Watch Current and Future Players Trends in Corporate Strategy Company Profiles Abiss Analytic Biosurgical Solutions AMI: Agency for Medical Innovation Angiologica Aspide Medical Assut Europe Atrium Medical B. Braun Surgical Cook Medical Cousin Biotech Covidien C.R. Bard Ethicon FEG Textiltechnik mbh Proxy Biomedical
6 TEI Biosciences W. L. Gore & Associates Appendix Bibliography Abbreviations Report Methodology Overview Coverage Primary Research Secondary Research Forecasting Methodology General Surgeons and Herniologists Included in this Study About the Authors Joseph A. Gregory, Analyst, Surgical Devices Derek Archila, MBA, Director of Research and Analysis, Medical Devices Global Head of Healthcare Bonnie Bain, Ph.D., Global Head of Healthcare About MediPoint About GlobalData Disclaimer
7 1.1 List of Tables Table 1: Hernia Mesh Classifications Table 2: Large Pore SWOT Analysis, Table 3: Product Profile Angimesh R Table 4: Product Profile Assumesh Table 5: Product Profile Cristalene Table 6: Product Profile Hexapro Mesh Table 7: Product Profile Optilene Mesh Table 8: Product Profile Optilene Mesh LP Table 9: Product Profile Optilene Mesh Elastic Table 10: Product Profile Omyra Mesh Table 11: Product Profile Prolene Soft Mesh Table 12: Product Profile ProLite Ultra Mesh Table 13: Product Profile Soft Mesh Table 14: Product Profile Surgimesh 1 & 2 and XLIGHT Table 15: Product Profile Surgimesh PET 2D Table 16: Product Profile Surgimesh WN Table 17: Product Profile Ultrapro Mesh Table 18: Product Profile Vypro Mesh Table 19: Small Pore SWOT Analysis, Table 20: Product Profile Bard Mesh Table 21: Product Profile Surgipro Flatsheet Mesh Table 22: Product Profile Premilene Mesh Table 23: Product Profile Premilene Mesh Plug
8 Table 24: Product Profile Prolene Mesh Table 25: Product Profile ProLite Mesh Table 26: Product Profile Repol Angimesh Table 27: Composite Meshes SWOT Analysis, Table 28: Product Profile 4DDome Table 29: Product Profile B-Foil Table 30: Product Profile Biomesh CA.B.S. Air Composite Table 31: Product Profile C-QUR Mesh Table 32: Product Profile C-QUR TacShield Table 33: Product Profile C-QUR V-Patch Table 34: Product Profile C-QUR CentriFX Table 35: Product Profile C-QUR FX Mesh Table 36: Product Profile Composix Mesh Table 37: Product Profile Parietex Composite Table 38: Product Profile Parietex ProGrip Self Fixating Mesh Table 39: Product Profile Sorbimesh Table 40: Product Profile Surgimesh Cible Table 41: Product Profile Surgimesh Diablo Table 42: Product Profile Surgimesh M.O.P.P Table 43: Product Profile Surgimesh XB Table 44: Product Profile Ultrapro Mesh Table 45: 3D Meshes SWOT Analysis, Table 46: Product Profile 3DMax Mesh Table 47: Product Profile Bio-A Hernia Plug
9 Table 48: Product Profile Laparomesh Table 49: Product Profile Perfix Plug Table 50: Product Profile ProLoop FX Mesh Table 51: Product Profile Easyplug Table 52: Product Profile Surgimesh PET 3D Table 53: Product Profile Surgimesh XD Table 54: Product Profile Repol Plug Cap Table 55: Biological Meshes SWOT Analysis, Table 56: Product Profile AlloDerm Regenerative Tissue Matrix Table 57: Product Profile Allomax Surgical Graft Table 58: Product Profile Biodesign Hernia Graft Table 59: Product Profile Permacol Surgical Implant Table 60: Product Profile Strattice Table 61: Company Portfolio Abyss Analytic Biosurgical Solutions Table 62: Abyss Analytic Biosurgical Solutions SWOT Analysis, Table 63: Company Portfolio AMI: Agency for Medical Innovation Table 64: AMI: Agency for Medical Innovation SWOT Analysis, Table 65: Company Portfolio Angiologica Table 66: Angiologica SWOT Analysis, Table 67: Company Portfolio Aspide Medical Table 68: Aspide Medical SWOT Analysis, Table 69: Company Portfolio Assut Europe Table 70: Assut Europe SWOT Analysis, Table 71: Company Portfolio Atrium Medical
10 Table 72: Atrium Medical SWOT Analysis, Table 73: Company Portfolio B. Braun Table 74: B. Braun SWOT Analysis, Table 75: Company Portfolio Cook Medical Table 76: Cook Medical SWOT Analysis, Table 77: Company Portfolio Cousin Biotech Table 78: Cousin Biotech SWOT Analysis, Table 79: Company Portfolio Covidien Table 80: Covidien SWOT Analysis, Table 81: Company Portfolio C. R. Bard Table 82: C. R. Bard SWOT Analysis, Table 83: Company Portfolio Ethicon Table 84: Ethicon SWOT Analysis, Table 85: Company Portfolio FEG Textiltechnik Table 86: FEG Textiltechnik SWOT Analysis, Table 87: Company Portfolio Proxy Biomedical Table 88: Proxy Biomedical SWOT Analysis, Table 89: Company Portfolio TEI Biosciences Table 90: TEI Biosciences SWOT Analysis, Table 91: Company Portfolio W. L. Gore & Associates Table 92: W. L. Gore & Associates SWOT Analysis,
11 1.2 List of Figures Figure 1: Global Company Market Share, Large Pore Meshes, Figure 2: Structure of Angimesh R Figure 3: Structure of Assumesh Figure 4: Structure of Cristalene Figure 5: Structure of Hexapro Mesh Figure 6: Structure of Optilene Mesh Figure 7: Structure of Optilene Mesh LP Figure 8: Structure of Optilene Mesh Elastic Figure 9: Structure of Omyra Mesh Figure 10: Structure of Prolene Soft Mesh Figure 11: Structure of ProLite Ultra Mesh Figure 12: Structure of Soft Mesh Figure 13: Structure of Surgimesh 1 & 2 and XLIGHT Figure 14: Structure of Surgimesh PET 2D Figure 15: Structure of Surgimesh WN Figure 16: Structure of Ultrapro Mesh Figure 17: Structure of Vypro Mesh Figure 18: Global Company Market Share, Small Pore Meshes, Figure 19: Structure of Bard Mesh Figure 20: Structure of Surgipro Flatsheet Mesh Figure 21: Structure of Premilene Mesh Figure 22: Structure of Premilene Mesh Plug Figure 23: Structure of Prolene Mesh
12 Figure 24: Structure of ProLite Mesh Figure 25: Structure of Repol Angimesh Figure 26: Global Company Market Share, Composite Meshes, Figure 27: Structure of the 4DDome Figure 28: Structure of B-Foil Figure 29: Structure of the Biomesh CA.B.S. Air Composite Figure 30: Structure of C-QUR Mesh Figure 31: Structure of C-QUR TacShield Figure 32: Structure of C-QUR V-Patch Figure 33: Structure of C-QUR CentriFX Figure 34: Structure of C-QUR FX Mesh Figure 35: Structure of Composix Mesh Figure 36: Structure of Parietex Composite Figure 37: Structure of Parietex ProGrip Self Fixating Mesh Figure 38: Structure of Sorbimesh Figure 39: Structure of Surgimesh Cible Figure 40: Structure of Surgimesh Diablo Figure 41: Structure of Surgimesh M.O.P.P Figure 42: Structure of Surgimesh XB Figure 43: Structure of Ultrapro Mesh Figure 44: Global Company Market Share, Composite Meshes, Figure 45: Structure of the 3DMax Mesh Figure 46: Structure of the Bio-A Hernia Plug Figure 47: Structure of Laparomesh
13 Figure 48: Structure of Perfix Plug Figure 49: Structure of ProLoop Mesh Figure 50: Structure of Surgimesh Easyplug Standard Figure 51: Structure of Surgimesh WN Easyplug Figure 52: Structure of Surgimesh WN Easyplug No Touch Figure 53: Structure of Surgimesh PET 3D Figure 54: Structure of Surgimesh XD Figure 55: Structure of Repol Plug Cap Figure 56: Global Company Market Share, Biological Meshes, Figure 57: Structure of the AlloDerm Regenerative Tissue Matrix Figure 58: Structure of the Allomax Surgical Graft Figure 59: Structure of the Biodesign Hernia Graft Figure 60: Structure of the Permacol Surgical Implant
14 Introduction 2 Introduction Hernia is a term used to describe the protrusion of an internal organ or tissue through a weak portion of a muscle or connective tissue. The majority of hernias occur in the abdomen, where they are caused by a combination of increased abdominal pressure and a weakness in a particular portion of the abdomen (which is often present at birth). Certain conditions such as obesity and persistent coughing can cause an increase in intra-abdominal pressure and contribute to hernia development. There are several types and subtypes of hernias, classified based on their location, pathophysiology, and the presence of the condition or contributing factors at birth. There are three hernia types that essentially comprise the entire hernia market, inguinal (71%), umbilical (14%), and incisional (4.7%) (Dabbas et al., 2011). While another form of hernia, epigastric, was found to have a slightly higher prevalence than incisional (6.6%), it is not the focal point of medical and There are three hernia types that essentially comprise the entire hernia market, inguinal (71%), umbilical (14%), and incisional (4.7%) industry research as incisional hernia repairs are. Inguinal hernias occur when intra-abdominal contents protrude through a weak spot in the abdominal wall near the groin. Incisional hernias develop after an incision from an abdominal surgery does not properly heal. Umbilical hernias are protrusions of intra-abdominal contents through the abdominal wall near the naval region. The most common symptom with these types of hernias is persistent pain, which is present in varying degrees. Since the various types of hernias differ in patients by severity, the amount of resultant pain can range from nonexistent to debilitating. Currently, a debate exists amongst surgeons over whether to surgically manage a hernia upon its diagnosis or to wait until the hernia begins producing debilitating symptoms. Thus the percentage of patients with a particular type of hernia that are surgically managed varies between geographies. 14
15 Introduction When discussing those patients that decide to undergo surgical interventions for their hernia, the topic will typically turn towards the method of operation. We are in the midst of a tidal shift from the standard method of open repair to the technically difficult method of laparoscopic repair. The laparoscopic approach has been shown to decrease hospital stays but is characterized by a longer learning curve and the potential for serious complications (Salameh et al., 2002). Additionally, the procedure has been shown to decrease recurrence rates and reduce postoperative pain (Liem et al., 1997). With this transition to a minimally invasive technique comes the utilization of a new type of mesh. This report focuses on the adoption patterns in hernia mesh and surgical techniques in 10 major global markets (the United States, France, Germany, Italy, Spain, the United Kingdom, Japan, Brazil, China and India) presently and through Catalyst The advancement of hernia repair has been hallmarked by three significant shifts in surgical treatment. The first was the transition from the tension techniques, which involved the use of sutures to tie adjacent tissue layers together, to a tension-free technique that incorporated flat sheets of mesh to bridge the defect. The second transition was the overwhelming adoption of large pore meshes in replacement of small pore meshes. Both shifts were prompted by improvements in patient outcomes. The third transition is currently underway as surgeons adopt the laparoscopic technique over the standard open technique. Instead of a large abdominal incision, a laparoscopic repair involves several small incisions in the abdominal cavity. Clinical trials have found favorable outcomes for both patients and surgeons, including lower recurrence rates, lower post-operative pain rates and a decreased recovery time. This transition is significant to medical device manufacturers because it affects the types of meshes that surgeons will be using in the future. This means that certain mesh products from a company s portfolio will become less utilized in favor of other products that are more applicable to the needs of minimally invasive surgery. As more players enter the market and operations become international, it is increasingly imperative that companies understand how to properly adapt to growing trends in order to succeed. This report examines the implications of this transition and discusses how medical device companies can capitalize on it to gain market share. 15
16 Appendix 6.7 About MediPoint MediPoint is the flagship product for GlobalData s Medical team. Each MediPoint report is built from the ground up by our team of healthcare analysts in the US and UK. Each report includes input from experienced physicians and leading Key Opinion Leaders (KOL). Running throughout each report in the series, What Physicians Think quotes provide a unique insight into how healthcare professionals are reacting to events within the industry, and what their responses could mean for industry strategists. 6.8 About GlobalData GlobalData is a leading global provider of business intelligence in the Healthcare industry. GlobalData provides its clients with up-to-date information and analysis on the latest developments in drug research, disease analysis, and clinical research and development. Our integrated business intelligence solutions include a range of interactive online databases, analytical tools, reports and forecasts. Our analysis is supported by a 24/7 client support and analyst team. GlobalData has offices in New York, Boston, London, India and Singapore. 6.9 Disclaimer All Rights Reserved. No part of this publication may be reproduced, stored in a retrieval system or transmitted in any form by any means, electronic, mechanical, photocopying, recording or otherwise, without the prior permission of the publisher, GlobalData. The facts of this report are believed to be correct at the time of publication but cannot be guaranteed. Please note that the findings, conclusions and recommendations that GlobalData delivers will be based on information gathered in good faith from both primary and secondary sources, whose accuracy we are not always in a position to guarantee. As such GlobalData can accept no liability whatsoever for actions taken based on any information that may subsequently prove to be incorrect. 166
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