1. Identification of the substance/mixture and of the company/undertaking
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1 1. Identification of the substance/mixture and of the company/undertaking Designation : Imukin, liquid (Bulk), <= 0,1 % Synonyms : Active ingredient: Interferon gamma-1b Imukin solution for injection, Immukin solution for injection, Immukine solution for injection Identified uses : Solution for production of finished medicinal products. Company : Boehringer Ing. Pharma GmbH & Co.KG Binger Str Ingelheim am Rhein Telephone : / Telefax number : / address : gefahr@boehringer-ingelheim.com Information providing : Quality & Environmental Health & Safety division Emergency information : (+49) (0)61 32 / (24 h) 2. Hazards Identification Classification according to Regulation (EC) No. 1272/2008: This product is a non-hazardous solution of single components and need not be labelled according to EC-Directive 1999/45/EC, as amended. 3. Composition/Information on Ingredients Hazardous ingredients Chemical name Classification GHS classification Concentration Polypeptide of 143 amino acids <= 0,1% Molecular formula: C734-H1166-N204-O216-S5 CAS-No Molecular weight: 16464,88 Chemical name Classification GHS classification Concentration Non-hazardous galenic >= 99% excipients Page 1 from 6
2 4. First-aid Measures General advice : Remove from exposure, lie down. Immediately remove contaminated clothing. If danger of loss of consciousness, place patient in recovery position and transport accordingly. Apply artificial respiration if necessary. First aid personnel should pay attention to their own safety. Eye contact : Immediately wash affected eyes for at least 15 minutes under running water with eyelids held open, consult an eye specialist. Skin contact : Wash off thoroughly with ample water. Seek medical attention. Inhalation : Keep patient calm, remove to fresh air, seek medical attention. Ingestion : Rinse mouth immediately and then drink plenty of water, seek medical attention. Notes to physician Treatment : Observe the summary of product characteristics of proprietary medicinal products 5. Fire-fighting Measures Suitable extinguishing media : Use extinguishing measures to suit surroundings., Water, Dry chemical, Foam, carbon dioxide Hazards during fire-fighting : In case of fire and/or explosion do not breathe fumes. Can be released in case of fire:, nitrogen oxides, Carbon oxides, Sulphur oxides Protective equipment for fire-fighting : Wear self-contained breathing apparatus and chemicalprotective clothing. Further information : Collect separately contaminated extinguishing water, do not allow to reach sewage or effluent systems. Dispose of fire debris and contaminated extinguishing water in accordance with official regulations. 6. Accidental Release Measures Personal precautions : Wear protective equipment. Keep unprotected persons away. Ensure adequate ventilation. Environmental precautions : Do not discharge into drains/surface waters/groundwater. Methods for cleaning-up or taking-up : For large amounts: Pump off product. For residues: Contain with absorbent material (e.g. sand, silica gel, acid binder, general purpose binder, sawdust). Pack in tightly closed containers for disposal. Additional information : High risk of slipping due to leakage/spillage of product. 7. Handling and Storage Handling Advice on safe handling : Ensure thorough ventilation of stores and work areas. Do not open until use. Hints for protection against fire and explosion : No hazards which require special first aid measures Page 2 from 6
3 Hygienic measures : General safety and hygiene measures. Hands and/or face should be washed before breaks and at the end of the shift. Store work clothing separately. Storage Requirements for storage rooms and vessels Advice on storage compatibility Storage class according to VCI : Protect from heat and direct sunlight. Keep container tightly closed. Jointless smooth floor : Keep away from food, drink and animal feedingstuffs. Advice on Segregation : 12 Non Combustible Liquids 8. Exposure controls/personal protections Exposure controls Personal protective equipment Respiratory protection : Not required; except in case of aerosol formation. Hand protection : Chemical safety glove category III (EN 374). Glove material: Nitrile rubber, Layer thickness: 0.43 mm (f.e. Camatril green, Article No.732, Company KCL). Resistance (permeability): Level 6 (480 min). Eye protection : Safety glasses with side-shields (frame goggles) (EN 166) Body protection : Laboratory: laboratory coat; factory: disposable Overall. Additional information : Only use protective equipment in accordance with national/international regulations. Follow the national regulations about wearing personal protective equipment and the warranty given by the manufacturer for the safe function. General protective measures 9. Physical and Chemical Properties : Handle in accordance with good industrial hygiene and safety practice. Avoid contact with skin, eyes and clothing. Form : liquid Colour : No data available. Odour : No data available. Odour threshold : No data available. ph value : No data available. Melting point/ -range : No data available. Boiling point/boiling range : No data available. Flash point : not applicable Ignition temperature : not applicable Evaporation rate : No data available Page 3 from 6
4 Flammability : does not ignite Lower explosion limit : not applicable Upper explosion limit : not applicable Vapour pressure : No data available. Relative vapour density : No data available. Relative density : No data available. Solubility in water : No data available. Miscibility with water : miscible in all proportions Partitioning coefficient n- octanol/water (log Pow) : No data available. Thermal decomposition : No data available. Viscosity, dynamic : No data available. Explosiveness : No data available. Peroxides : No data available. Further information Density : No data available. 10. Stability and Reactivity Hazardous reactions : Conditions to avoid : No data available. Substances to avoid : No data available. 11. Toxicological Information Acute oral toxicity : No data available. Acute inhalation toxicity : No data available. Acute dermal toxicity : No data available. Skin irritation : No data available. Eye irritation : No data available. Sensitization : No data available. Genetic toxicity in vitro : No data available. Genetic toxicity in vivo : No data available. Carcinogenicity : No data available Page 4 from 6
5 Reproductive toxicity : No data available. Teratogenicity : No data available. Aspiration hazard : No data available. 12. Ecological information Ecotoxicity Toxicity to fish : No data available. Toxicity to daphnia : No data available. Toxicity to algae : No data available. Toxicity to bacteria : No data available. Chronic toxicity to fish : No data available. Chronic toxicity to aquatic invertebrates : No data available. Persistence and degradability Biological degradation : No data available. Transport between environmental compartments : No data available. Bioaccumulation : No data available. PBT and vpvb assessment : No data available. 13. Disposal Considerations Product : Dispose of in accordance with local regulations. Contaminated packaging : Packs that cannot be cleaned should be disposed of in the same manner as the contents. Uncontaminated packaging can be recycled. 14. Transport Information Page 5 from 6
6 Further information : Not classified as dangerous in the meaning of transport regulations. For the internal transport: Use only released containers. Use only tightly closed containers. Protect container against fall down. The container must be correctly labelled. 15. Regulatory information National legislation/regulations Water hazard class : VWVWS WGK 1 slightly water endangering Annex 4 VwVwS (Germany) dated Mai, 17 th Other particulars The information provided in this Safety Data Sheet is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other materials or in any process, unless specified in the text Page 6 from 6
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