CHEMICAL MIXING COMPATIBILITY TABLE AND CHART College of Charleston Charleston, SC October 2012
Chemical Mixing Compatibility Substances in the left column (Column A) should be stored and handled so that they cannot come in contact with corresponding substances in the right column (Column B). Liquid reagents must be in secondary containment large enough to hold the total volume of all substances in the containment. Do not storer this Acetic acid Acetic anhydride Acetone Acetylene Alkali metals Ammonia (anhydrous) Ammonium nitrate Aniline Arsenates Azides Bromine Carbon, activated Chlorates Chromic acid; chromium trioxide Chlorine Chlorine dioxide Copper Cyanides Flammable liquids Fluorine Hydrazine Hydrocarbons, flammable Hydrofluoric acid Hydrogen peroxide Chromic acid, nitric acid, sulfuric acid; peroxides, perchloric acid, permanganates; hydroxyl compounds Oxidizers, as above;alcohols, glycols, water Oxidizers, as above;hydrogen peroxide;halogens Halogens;metals or metal ions, such as copper, silver, mercury Carbon dioxide;chlorinated compounds like carbon tetrachloride;water Mercury;halogens;oxidizing agents, as above;hydrofluoric acid Acids;metal powders;reducing agents;flammable liquids;combustible materials;sulfur;alkalis;urea Nitric acid, hydrogen peroxide Any reducing agents Acids Ammonia, acetylene;alkenes and polyenes;powdered metals;methane All oxidizing agents;calcium hypochlorite Acids;metal powders;ammonium salts;finely divided organic or combustible materials;sulfur All reducing agents, including flammable liquids and combustibles; organic solvents See Bromine Ammonia;all reducing agents, including flammables and combustibles Acetylene;hydrogen peroxide, other peroxides Acids All strong oxidizing agents; halogens Storage not permitted All strong oxidizers, especially hydrogen peroxide All strong oxidizers;halogens;bases Ammonia;silica;sodium (anhydrous) Metals and metal salts;flammables and combustibles;aromatic amines;organic materials;oxidizing gases
Hydrogen sulfide Hypochlorites Iodine Mercury Nitrates Nitric acid (concentrated) Nitrites Nitroparaffins Oxalic acid Oxygen Perchloric acid Peroxides (organic) Phosphorus (white) All strong oxidizers;ammonia Acids, activated carbon;strong reducing agents Acetylene;ammonia (anhydrous or aqueous) Acetylene;nitric acid;ammonia Acids;all reducing agents and flammables All organics;all flammables;chromic acid;hydrohalic acids;hydrogen sulfide Acids;strong oxidizers;strong reducing agents Inorganic bases;amines Silver and silver salts;mercury and mercury salts;strong oxidizing agents All flammable and combustible organics, including oil and grease All organics;all metals except stainless steel Acids;heat;friction and shock Air;oxygen;alkalis;reducing agents Potassium Organic halides;water;alcohols of three carbons or fewer;co 2 Potassium perchlorate Sulfuric/other acids;alcohols;combustible materials;reducing agents Potassium permanganate Glycerol, other polyols;low molecular weight aldehydes;sulfuric acid Selenides Reducing agents (produce H 2 Se) Silver, silver salts Acetylene;dicarboxylic acids;ammonium salts;oxidizers Sodium Acids;metals;oxidizers;hydrazine;water Sodium peroxide All oxidizable organics;water Sulfuric acid Easily oxidizable organics;hydrohalic acids;chlorates and perchlorates; permanganates
Reactivity Group No. Reactivity Group Name 1 Acids, Mineral, Non-Oxidizing 1 2 Acids, Mineral, Oxidizing 2 3 Acids, Organic G, H 3 4 Alcohols and Glycols H H, F H, P 4 5 Aldehydes H, P H, F H, P 5 6 Amides H H, GT 6 7 Amines, Aliphatic and Aromatic H H, GT H H 7 8 Azo Compounds, Diazo Compounds and Hydrazines H, G H, GT H, G H, G H 8 9 Carbamates H, G H, GT G, H 9 10 Caustics H H H H H, G 10 11 Cyanides GT, GF GT, GF GT, GF G 11 12 Dithiocarbamates H, GF, F H, GF, F H, GF, GT GF, GT U H, G 12 13 Esters H H, F H, G H 13 14 Ethers H H, F 14 15 Fluorides, Inorganic GT GT GT 15 16 Hydrocarbons, Aromatic H, F 16 17 Halogenated Organics H, GT H, GT, F H, GT H, G H, GF H 17 18 Isocyanates H,G H, GT, F H, G H, P H, P H, G H, P, G H, G U 18 19 Ketones H H, F H, G H H 19 20 Mercaptans and Other Organic Sulfides 21 Metals, Alkali and Alkaline Earth, Elemental 22 Metals, Other Elemental Alloys as Powders, Vapors, or Sponges 23 Metals, Other Elemental Alloys as Sheets, Rods, Moldings, Etc. GF, GT H, GT, F H, G H H H 20 GF, H, F GF, H, F GF, H, F GF, H, F GF, H, F GF, H GF, H GF, H GF, H GF, H GF, H GF, GT, H GF, H H, E GF, H GF, H GF, H 21 GF, H, F GF, H, F G, F GT, H, F U GF, H H, E GF, H GF, H, F 22 GF, H, F GF, H, F H, F, G H, F 23 24 Metals and Metal Compounds, Toxic S S S S S S 24 25 Nitrides GF, H, F H, F, E GF, H GF, H, GF, H U H, G U GF, H GF, H GF, H GF, H U GF, H GF, H E 25 E 26 Nitriles H, GT, GF GT, H, F H U H, P S GF, H 26 27 Nitro Compounds, Organic GT, H, F H H, E GF, H, E GF, H, E 27 28 Hydrocarbons, Aliphatic, Unsaturated H H, F H H, E 28 29 Hydrocarbons, Aliphatic, Saturated H, F 29 30 Peroxides and Hydroperoxides, H, G H, E H, F H, G GT, H H, F, E GT, H, F GT, H, GT, H, F H, E H E H, F H, E H, G H, G GF, H, GT, H, H, P 30 Organic E GT E P 31 Phenols and Cresols H H, F H, G H, P GF, H GF, H H 31 32 Organophosphates,Phosphothioates, GT, H GT, H U H, E H U 32 Phosphodithioates 33 Sulfides, Inorganic GT, GF HF, GF GT H E H GT, H 33 34 Epoxides H, P H, P H, P H, P U H. P H, P H, P H, P U H, P H, P H, P H, P H, P H, P H, P U H, P 34 101 Combustible and Flammable Materials, Miscellaneous H, G GT, H, F H, G, F GF, H, F 102 Explosives H, E H, E H, E H, E H, E H, E H, E H, E H, E E E H, E H, E H, E H, E H, E 102 103 Polymerizable Compounds P, H P, H P, H P, H P, H P, H U P, H P, H P, H P, H P, H P, H P, H P, H H, E 103 104 Oxidizing Agents, Strong GT, H GT, H H, F H, F GT, H, F 105 Reducing Agents, Strong GF, H GT, H, F GF, H GF, H, F GT, H, F H, E GT, H, F H,E,GT H,F, GT H, F H, F H, F GT, H GT, H, F GF, H, F GF, H G, H GT, H H, F H, F E GT, H, F H, F GT, H, H, F, E H, F, E H, F H, F, E GT, H, H, E H, F H, F H, G H, F GT, H, GT, H, H, G, F H, G, F H, E GT, H, F F F F F H, E GF, H GF, H GF, H GF, H H, E H, E GF, H GF,H GT 101 104 H GF, H H, E GF, H, H, F, E 105 P 106 Water and Mixtures Containing Water H H G H, G GF, H GF, H S GF, H GF, GT GF, GT 107 Water Reactive Substances E X T R E M E L Y R E A C T I V E! D O N O T M I X!!! 106 107 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 101 102 103 104 105 107
Chemical Mixing Compatibility Table Based on the Above Chart Click on the hypertext listing of numbers to get the names of reactivity groups with which the chosen reactivity group is incompatible. RGN Reactivity Group Name Incompatible With: 1 Acids, Mineral, Non-Oxidizing 4-15,17-26,28,30-34,101-107 2 Acids, Mineral, Oxidizing 3-34,101-103,105-107 3 Acids, Organic 2,4,5,7,8,10-12,15,18,21,22,24-26,33,34, 102-105,107 4 Alcohols and Glycols 1-3,8,18,21,25,30,34,104,105,107 5 Aldehydes 1-3,7,8,10,12,21,25,27,28,30,33,34,104,105,107 6 Amides 1,2,21,24,104,105,107 7 Amines, Aliphatic and Aromatic 1-3,5,12,17,18,21,24,30,34,104,105,107 8 Azo Compounds, Diazo Compounds and Hydrazines 1-5,9,11-13,17-23,25,30-34,102-104,106-107 9 Carbamates 1,2,8,10,21,22,25,30,104,107 10 Caustics 1-3,5,9,13,17-19,21,22,24-27,32,34,102,103,107 11 Cyanides 1-3,8,17-19,21,25,30,34,102,104,107 12 Dithiocarbamates 1-3,5,7,8,18,21,25,30,34,103-105,107 13 Esters 1,2,8,10,21,25,102,104-105,107 14 Ethers 1,2,104,107 15 Fluorides, Inorganic 1-3,107 16 Hydrocarbons, Aromatic 2,104,105,107 17 Halogenated Organics 1,2,7,8,10,11,20-23,25,30,104,105,107 18 Isocyanates 1-4,7,8,10-12,20-22,25,30,31,33,104-107 19 Ketones 1,2,8,10,11,20,21,25,30,104,105,107 20 Mercaptans and Other Organic Sulfides 1,2,8,17-19,21,22,25,30,34,104,105,107 21 Metals, Alkali and Alkaline Earth Elemental 1-13,17-20,25-27,30-32,34,101-104,106,107 22 Metals, Other Elemental and Alloys as 1-3,8-10,17,18,20,28,30,34,102-104,106,107 Powders, Vapors or Sponges 23 Metals, Other Elemental and Alloys as 1,2,8,17,102-104,107 Sheets, Rods, Drops, Moldings 24 Metal and Metal Compounds, Toxic 1-3,6,7,10,26,30,34,102,103,106,107 25 Nitrides 1-5,8-13,17-21,26-27,30,31,34,101-104,106,107 26 Nitriles 1-3,10,21,24,25,30,104,105,107 27 Nitro Compounds, Organic 2,5,10,21,25,104,105,107 28 Hydrocarcons, Aliphatic, Unsaturated 1,2,5,22,30,104,107 29 Hydrocarbons, Aliphatic, Saturated 2,104,107 30 Peroxides and Hydroperoxides, Organic 1,2,4,5,7-9,11,12,17-22,24-26,28,31-34,101-105,107 31 Phenols and Cresols 1,2,8,18,21,25,30,34,102-105,107
32 Organophosphates, Phosphothioates, Phosphodithioates 1,2,8,10,21,30,34,104,105,107 33 Sulfides, Inorganic 1-3,5,8,18,30,34,102-104,106,107 34 Epoxides 1-5,7,8,10-12,20-22,24,25,30-33,102,104,105,107 Combustible and Flammable 101 Materials, Misc. 1,2,21,25,30,102,104,105,107 102 Explosives 1-3,8,10,13,21-25,30,31,33,34,101,103-105,107 103 Polymerizable Compounds 1-3,8,10-12,21-25,30,31,33,102,104,105,107 104 Oxidizing Agents, Strong 1,3-9,11-14,16-23,25-34,101-103,105,107 105 Reducing Agents, Strong 1-7,11,12,16-20,26,27,30-34,101-104, 106-107 106 Water and Mixtures Containing Water 1,2,8,18,21,22,24,25,33,105,107 107 Water Reactive Substances ALL! Acids, Mineral, Non-Oxidizing (top) 6. Amides 9. Carbamates 13. Esters 14. Ethers 15. Fluorides, Inorganic 17. Halogentated 20. Mercaptons and Other Organic Sulfides 23. Metals, Other Elemental and Alloys as Sheets, Rods, Drops, Moldings 26. Nitriles 28. Hydrocarbons, Aliphatic, Unsaturated 32. Organophosphates, Phosphothioates, Phosphodithioates 101. Combustible and Flammable Materials, Misc. 106. Water and Mixtures Containing Water
Acids, Mineral, Oxidizing (top) s 6. Amides 9. Carbamates 13. Esters 14. Ethers 15. Fluorides, Inorganic 16. Hydrocarbons, Aromatic 17. Halogentated 20. Mercaptons and Other Organic Sulfides 23. Metals, Other Elemental and Alloys as Sheets, Rods, Drops, Moldings 26. Nitriles 27. Nitro Compounds, Organic 28. Hydrocarbons, Aliphatic, Unsaturated 29. Hydrocarbons, Aliphatic, Saturated 32. Organophosphates, Phosphothioates, Phosphodithioates 101. Combustible and Flammable Materials, Misc. 106. Water and Mixtures Containing Water Acids, Organic (top) 15. Fluorides, Inorganic
26. Nitriles Alcohols and Glycols (top) s Aldehydes (top) s 27. Nitro Compounds, Organic 28. Hydrocarbons, Aliphatic, Unsaturated
Amides (top) Amines, Aliphatic and Aromatic (top) s 17. Halogentated Azo Compounds, Diazo Compounds, and Hydrazines (top) s 9. Carbamates 13. Esters 17. Halogentated 23. Metals, Other Elemental and Alloys as Sheets, Rods, Drops, Moldings 25. Nitriles 32. Organophosphates, Phosphothioates, Phosphodithioates
106. Water and Mixtures Containing Water Carbamates (top) Caustics (top) s 9. Carbamates 13. Esters 17. Halogentated 26. Nitriles 27. Nitro Compounds, Organic 32. Organophosphates, Phosphothioates, Phosphodithioates Cyanides (top) s 17. Halogentated
Dithiocarbamates (top) s Esters (top) Ethers (top)
Fluorides, Inorganic (top) s Hydrocarbons, Aromatic (top) Halogenated Organics (top) 23. Metals, Other Elemental and Alloys as Sheets, Rods, Drops, Moldings Isocyanates (top) s
106. Water and Mixtures Containing Water Ketones (top) Mercaptons and Other Organic Sulfides (top) 8. Azo Compounds, Diazo Compounds, and Hydrazines 17. Halogentated Metals, Alkali and Alkaline Earth Elemental (top) s 6. Amides 9. Carbamates 13. Esters
17. Halogentated 26. Nitriles 27. Nitro Compounds, Organic 32. Organophosphates, Phosphothioates, Phosphodithioates 101. Combustible and Flammable Materials, Misc. 106. Water and Mixtures Containing Water Metals, Other Elemental and Alloys as Powders, Vapors or Sponges (top) 9. Carbamates 17. Halogenated Organics 28. Hydrocarcons, Aliphatic, Unsaturated 106. Water and Mixtures Containing Water Metals, Other Elemental and Alloys as Sheets, Rods, Drops, Moldings (top) 17. Halogenated Organics
Metals, and Metal Compounds, Toxic (top) 6. Amides 26. Nitriles 106. Water and Mixtures Containing Water Nitrides (top) 9. Carbamates 13. Esters 17. Halogenated Organics 26. Nitrites 27. Nitro Compounds, Organic 101. Combustible and Flammable Materials, Misc. 106. Water and Mixtures Containing Water Nitrites (top)
Nitro Compounds, Organic (top) Hydrocarcons, Aliphatic, Unsaturated (top) Hydrocarcons, Aliphatic, Saturated (top) Peroxides and Hydroperoxides, Organic (top) 9. Carbamates 17. Halogenated Organics
26. Nitriles 28. Hydrocarcons, Aliphatic, Unsaturated 32. Organophosphates, Phosphothioates, Phosphodithioates 101. Combustible and Flammable Materials, Misc. Phenols and Cresols (top) Organophosphates, Phosphothioates, Phosphodithioates (top)
Sulfides, Inorganic (top) 106. Water and Mixtures Containing Water Epoxides (top) 32. Organophosphates, Phosphothioates, Phosphodithioates Combustible and Flammable Materials, Misc. (top)
Explosives (top) 13. Esters 23. Metals, Other Elemental and Alloys as Sheets, Rods, Drops, Moldings 101. Combustible and Flammable Materials, Misc. Polymerizable Compounds (top) 23. Metals, Other Elemental and Alloys as Sheets, Rods, Drops, Moldings Oxidizing Agents, Strong (top)
6. Amides 9. Carbamates 13. Esters 14. Ethers 16. Hydrocarbons, Aromatic 17. Halogenated Organics 23. Metals, Other Elemental and Alloys as Sheets, Rods, Drops, Moldings 26. Nitriles 27. Nitro Compounds, Organic 28. Hydrocarcons, Aliphatic, Unsaturated 29. Hydrocarbons, Aliphatic, Saturated 32. Organophosphates, Phosphothioates, Phosphodithioates 101. Combustible and Flammable Materials, Misc. Reducing Agents, Strong (top) 6. Amides 16. Hydrocarbons, Aromatic 17. Halogenated Organics 26. Nitriles 27. Nitro Compounds, Organic 32. Organophosphates, Phosphothioates, Phosphodithioates 101. Combustible and Flammable Materials, Misc.
106. Water and Mixtures Containing Water Water and Mixtures Containing Water (top) Water Reactive Substances (top) 6. Amides 9. Carbamates 13. Esters 14. Ethers 15. Fluorides, Inorganic 16. Hydrocarbons, Aromatic 17. Halogenated Organics 23. Metals, Other Elemental and Alloys as Sheets, Rods, Drops, Moldings 26. Nitriles 27. Nitro Compounds, Organic 28. Hydrocarcons, Aliphatic, Unsaturated 29. Hydrocarbons, Aliphatic, Saturated
32. Organophosphates, Phosphothioates, Phosphodithioates 101. Combustible and Flammable Materials, Misc. 106. Water and Mixtures Containing Water