ATIP Avenir Program 2018 Young group leader

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ATIP Avenir Program 2018 Young group leader Important dates - October 17th (4 pm) 2017 : opening of the registrations online - November 23 th 2017: deadline for the online submission, the mailing of the hard copy of the scientific project, and the letters of recommendation - Mid-April 2018: publication of the short list of candidates to be interviewed - Mid-June 2018: interviews of the selected applicants - July 2018: publication of the final list of laureates - From January 2019: Start of the contract Summary A- Eligibility and evaluation criteria B- Elements for the application C- Scientific file D- ATIP-Avenir evaluation panels and fields of research covered by the respective panels Contacts Catherine Cavard: atip-avenir@cnrs-dir.fr Christiane Durieux: atip-avenir@inserm.fr 1

A- Eligibility and evaluation criteria: Eligibility ATIP-Avenir grants are open to researchers of any nationality who may reside in any country in the world at the time of application. Projects must be developed within an Inserm and/or CNRS host laboratory in France. An identified host lab is not a pre-requisite for applying for the program. Applicants must have defended their PhD (or equivalent doctoral degree) for over 2 years and under 10 years (PhD between 15 September 2007 and 15 September 2015). The projects have to be developed within a Unit in which the applicant: - has not been working for more than 18 months - will not find any previous mentors (of PhD and/or post doctorate). Laureates of a grant for the young researchers similar to the ATIP-Avenir program are not eligible (e.g. ANR programs to start an independent research group or ERC grants). However laureates with an ANR program are eligible to an ATIP-Avenir grant if their ANR contract is finished and if they develop their project in another lab. ATIP-Avenir laureates can candidate to similar programs, but cannot cumulate fundings for programs similar to ATIP-Avenir. Applicants cannot apply for more than two different calls. Exemptions Medical doctors For medical doctors, an MD will not be accepted by itself as equivalent to a PhD award. To be considered eligible medical doctors (MDs) need to provide the certificates of both basic studies (MD) and a PhD or proof of an appointment that requires doctoral equivalency (e.g. post-doctoral fellowship, professorship appointment). Additionally, candidates must also provide information on their research experience (including peer reviewed publications) in order to substantiate the equivalence of their overall training to a PhD. The MD completion should be within the last 12 years instead of 10 years. Teachers (MCU, MCU-PH, PU, PU-PH) For teachers, the rule that the project has to be developed within a structure in which the scientist has not been working for more than 18 months does not apply. Leaves For maternity, the effective elapsed time since the award of the PhD will be reduced by 1 year for each child before or after the PhD award. For paternity, the effective elapsed time since the award of the PhD will be reduced by the amount of paternity leave actually taken for each child born before or after the PhD award. For national service, the effective elapsed time since the award of the PhD will be reduced by the amount of leave actually taken after the PhD award. Evaluation Scientific excellence is the sole criterion on the basis of which ATIP-Avenir grants are awarded. However, candidates should be able to show their early achievements attested by significant publications (as main author) in major international peer-reviewed multidisciplinary scientific journals, or in the leading international peer-reviewed journals of their respective field. 2

Evaluation criteria: - Quality of the applicant (background and publications) - Scientific quality of the research proposal (originality of the project and suitability of the proposed methodology) - Quality of the management (ability of the applicant to manage the project and a team) B- Elements for the application: 1- CV 2- Form to be filled in online 3- Scientific file containing the description of your research project 4- Two letters of recommendation (written in English, stating the ability of the candidate to conduct his/her own research project should be sent directly by their authors by e-mail to: Christiane Durieux: atip-avenir@inserm.fr 5- Host laboratory and host university document (if identified, not mandatory) 6- PhD diploma Registration through the Submission Website is mandatory. : https://www.eva3.inserm.fr/login All the documents and forms must be written in English C- Scientific file - Summary of the research project - Research project Your document (no more than 10 pages, Arial 10, figures included and references not included) should adhere to the following format: - Start of the art and proposed work (must be backed up by references that include the major relevant publications) - Experimental approaches to be used - Originality and feasibility of the project - Expected results - Expected applications in the medical, social, economic and technological domains - Expected collaborations - Work plan for a period of 3 first years Formatting references: please use the reference style outlined by the International Committee of Medical Journal Editors (ICMJE), also referred as the Vancouver style (title and list of all authors). - Your publications limited to accepted publications / invited conferences/ For each reference, give the full name and initials of each author in the exact order, full title, name of journal, year of publication, volume number, first and last pages. 3

D- ATIP-Avenir Evaluation panels and fields of research covered by the respective panels LS1 Molecular and Structural Biology and Biochemistry: Physico-chemical and biochemical studies of the interactions between macromolecules Study of in vivo assembly of macromolecules in biological processes DNA biosynthesis, modification, repair and degradation RNA synthesis, processing, modification and degradation Protein synthesis, modification and turnover Biochemistry of signal transduction Biochemistry and physiology of microorganisms Biophysics Structural biology (crystallography, NMR, EM) of single molecules or interacting partners Computer modelling of 3D structures, reactivity predictions and molecular dynamics LS2 Genetics, Genomics, Bioinformatics and Systems Biology: Genomics, comparative genomics, functional genomics Transcriptomics Proteomics Metabolomics Glycomics Molecular genetics, reverse genetics and RNAi Quantitative genetics Epigenetics and gene regulation Genetic epidemiology Bioinformatics Computational biology Biostatistics Systems biology Biological systems analysis, modelling and simulation Study of genome dynamics, gene transfer between unrelated species Systems microbiology and modeling Synthetic biology and new bio-engineering concepts Systems Evolution, biological adaptation, phylogenetic, systematics Biodiversity, comparative biology LS3 Cell Biology, Development and Evolution: Morphology and functional imaging of cells Cell biology and molecular transport mechanisms Cell cycle and division Apoptosis Cell differentiation, physiology and dynamics Organelle biology Cell signalling and cellular interactions Signal transduction Development, developmental genetics, pattern formation and embryology in animals or plants Stem cell biology Evolution of developmental mechanisms LS4 Physiology, Pathophysiology and Translational Research: Organ physiology Comparative physiology Endocrinology Ageing 4

Metabolism, biological basis of metabolism related disorders Cancer and its biological basis Cardiovascular diseases Non-communicable diseases (except for neural/psychiatric and immunity-related disorders) LS5 Neurosciences and Disorders of the nervous system: Molecular and cellular neurobiology Neuroanatomy and neurosurgery Neurophysiology Neurochemistry and neuropharmacology Sensory systems Mechanisms of pain Developmental neurobiology Cognition (e.g. learning, memory, emotions, speech) Behavioural neuroscience (e.g. sleep, consciousness, handedness) Systems neuroscience Neuroimaging and computational neuroscience Neurological and psychiatric disorders LS6 Immunity, Infection and Microbiology: Innate immunity Adaptive immunity Phagocytosis and cellular immunity Immunosignalling Immunological memory and tolerance Immunogenetics Mycology, Virology, Bacteriology, Parasitology: Interaction of microorganisms with their environment Prevention and treatment of infection by pathogens (e.g. vaccination, antibiotics, fungicide) Biological basis of immunity-related disorders Allergy New targets for drug development, resistance to drugs LS7 Diagnostic tools, Therapies, Biotechnology and Public Health: Medical engineering and technology Diagnostic tools (e.g. genetic, imaging) Pharmacology, pharmacogenomics, drug discovery and design, drug therapy Analgesia Toxicology Gene therapy, stem cell therapy, regenerative medicine Surgery Radiation therapy Genetic engineering, transgenic organisms, recombinant proteins, biosensors Biotechnology, bioreactors, applied microbiology Health care research epidemiological, bio-statistical, human, economic and social sciences research about social determinants of health Public health and epidemiology Environment and health risks including radiation Occupational medicine Medical ethics Health services research 5