ADAPTIVE BIOTECHNOLOGIES DIAGNOSTIC PORTAL: ACCOUNT LOGIN

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ADAPTIVE BIOTECHNOLOGIES DIAGNOSTIC PORTAL: ACCOUNT LOGIN 1. Create an account. To set up your account for our online order entry and reporting system, please go to: https://diagnostics.adaptivebiotech.com/account/login. After signing up, please see your email for a link to set up your password. After completing this step, if you have not filled out a Physician Registration Form contact Clinical Services. 2. After logging in, you will be prompted to create a new order. Welcome Get started by creating a new order. NEW ORDER Multiple Ways to Create a New Order

3. Select an ordering physician and verify relevant physician information. Our Test Requisition Form (TRF) is filled out entirely online within the Diagnostic Portal. Select an ordering physician from the drop down menu. Once selected, confirm the address for the physician is correct. Input the study code, if applicable. Clinical Services P: 888 552 8988 F: 866 623 4408 E: clinicalservices@adaptivebiotech.com Copyright 2017 Adaptive Biotechnologies Corp. All rights reserved. MRK-20001-4 clonoseq.com

ADAPTIVE BIOTECHNOLOGIES DIAGNOSTIC PORTAL: PATIENT SET-UP 1. Select a patient and diagnosis. Select Pick a Patient on the main screen. Search for an existing patient. OR Click to create a new patient and then input the required patient information. 2. Select the correct Diagnosis / ICD code by searching in the text box. Clinical Services P: 888 552 8988 F: 866 623 4408 E: clinicalservices@adaptivebiotech.com Copyright 2017 Adaptive Biotechnologies Corp. All rights reserved. MRK-20001-4 clonoseq.com

ADAPTIVE BIOTECHNOLOGIES DIAGNOSTIC PORTAL: ORDERING 1. Select the test you wish to order. You may order either a Clonality Test, which identifies the dominant clone(s) in a diagnostic sample, or a Tracking Test to monitor the presence and level of MRD. For a new (not previously tested) patient, the Clonality Test should be ordered first. If you select Tracking Test for a patient who doesn't already have a Clonality Test result, you will be notified that a Clonality Test is required. Select which clonoseq Assay test you would like to order. For the Clonality Test, select B-cell Test, T-cell Test, or both. If ordering a Tracking Test, click the checkbox here. 2. Provide relevant billing information. Select the correct billing instructions from the drop down menu and then fill out the required information. Verify the insurance information prior to each test order.

3. OPTION A Provide specimen information and shipping instructions. Select Shipping to Adaptive under the first drop down menu. Select the type of sample that will be sent under the second drop down menu. Once selected, please fill out the information that is requested. Option A: Ordering physician sends sample OPTION B Provide specimen information and shipping instructions. Please submit the following to Clinical Services to request assistance with sample collection: 1) Signed clonoseq Test Requisition form (to be printed upon completion of this order) 2) Complete Pathology Report Select Adaptive Assists with specimen retrieval under the first drop down menu. Option B: Adaptive Biotechnologies assists with specimen retrieval

4. Submitting your Order. To submit the order, click Save on the top left side of your screen. After saving, you will be prompted to print and sign the Test Requisition Form. You can easily download a PDF of the TRF by clicking Download TRF in the bottom right corner. After printing, please ensure that the specimen type, collection date, and unique identifier are all filled in. Include the signed TRF with your shipment. If Adaptive Biotechnologies is assisting with specimen retrieval, please email or fax the TRF to Clinical Services. NOTE: REQUIRED SECTIONS MISSING INFORMATION ON THE PRINTED TRF WILL BE HIGHLIGHTED YELLOW. MISSING INFORMATION WILL RESULT IN TEST PROCESSING DELAYS.. Clinical Services P: 888 552 8988 F: 866 623 4408 E: clinicalservices@adaptivebiotech.com Copyright 2017 Adaptive Biotechnologies Corp. All rights reserved. MRK-20001-4 clonoseq.com