CAPITAL COST ESTIMATING. 23 rd Jan 2017

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CAPITAL COST ESTIMATING 23 rd Jan 2017

ESTIMATING PLANT CAPITAL COST (Projects Financial Viability) SO FAR (?):- Project has a defined technical solution Flow Sheeting NOW (?):- What is the cost of the project

ESTIMATING PLANT CAPITAL COST Final Cost Plan Summary Report This is a + 30% / - 5% estimate. REF. Direct Costs PROJECT SECTION TOTAL PLANT CAPITAL COST TIC = NEW BUILDING SUBSTRUCTURE SUPERSTRUCTURE 66,928 490,820 DIRECT BUILDING COST + INTERNAL FINISHES 193,541 FIITINGS & FURNISHINGS SERVICES 100,000 956,759 REFURBISHMENT DEMOLITIONS & ALTERATIONS SUPERSTRUCTURE INTERNAL FINISHES FIITINGS & FURNISHINGS SERVICES WORKS TO EXISTING PREMISES (M&E Strip out) EXTERNAL WORKS BUILDING CONTRACTOR PRELIMINARIES SUB TOTAL BUILDING 66,800 139,485 182,512 100,000 551,932 125,000 28,000 750,444 3,752,221

ESTIMATING PLANT CAPITAL COST 709.2-2SC-003-2 709.2-2SC-003-2 HIPPO New MTO PROCESS EQUIPMENT @ 50% Scale Platform UTILITIES @ 50% Scale Platform PROCESS PIPEWORK ( 4.5% of equipment cost) FEMS - Pharmagraph 3,314,660 4,100,000 335,712 30,000 TOTAL PLANT CAPITAL COST TIC = Delete Chart Recorders Process Control System (8.9% of equipment cost) Process Instruments (3.4% of equipment cost) 660,000 250,000 Equipment & Materials Costs + Process MCC (1.8% of equipment cost) 130,000 SUB TOTAL PROCESS 8,820,372 SUB DIRECT COSTS (DCC) 12,572,593 Direct Cost Value

ESTIMATING PLANT CAPITAL COST ENGINEERING, PROCUREMENT, CONSTRUCTION MANAGEMENT (@20% COMMISSIONING & VALIDATION (@ 8%) RISK/DEVELOPMENT ALLOWANCE (@12.55%) INFLATION (1%) TOTAL PLANT CAPITAL COST TIC = Engineering Design Costs + 705,630 Commissioning & Qualification Costs + 2,514,519 TOTAL CONSTRUCTION COSTS (TCC) 15,792,741 1,981,989 177,747 TOTAL INDICATED COST (TIC) 17,952,478 Risk & Inflation + OWNERS COSTS TOTAL INSTALLED COST (TIC) EXCLUDED 17,950,000 TIC TOTAL INSTALLED COST LOW (-5%) 17,052,500 TOTAL INSTALLED COST HIGH (+30%) 23,335,000 Accuracy Allowance

ESTIMATING PLANT CAPITAL COST Final Cost Plan Summary Report This is a + 30% / - 5% estimate. REF. Direct Costs PROJECT SECTION TOTAL PLANT CAPITAL COST = NEW BUILDING SUBSTRUCTURE SUPERSTRUCTURE 66,928 490,820 DIRECT BUILDING COST + INTERNAL FINISHES 193,541 FIITINGS & FURNISHINGS SERVICES 100,000 956,759 REFURBISHMENT DEMOLITIONS & ALTERATIONS SUPERSTRUCTURE INTERNAL FINISHES FIITINGS & FURNISHINGS SERVICES WORKS TO EXISTING PREMISES (M&E Strip out) EXTERNAL WORKS BUILDING CONTRACTOR PRELIMINARIES SUB TOTAL BUILDING 66,800 139,485 182,512 100,000 551,932 125,000 28,000 750,444 3,752,221

ESTIMATING PLANT CAPITAL COST ENGINEERING DESIGN COST = DESIGN PROJECT MANAGEMENT PURCHASE CONSTRUCTION SUPERVISION COMMISSIONING VALIDATION FOR BIOPHARM PROJECTS = 15 to 30% of total project cost TIC

ESTIMATING PLANT CAPITAL COSTS EQUIPMENT COST = MAIN PLANT ITEMS (MPI s) + PROCESS UTILITY SERVICES MATERIAL COST = PIPING, INSTRUMENT, CONTROLS, ELECTRICS etc UTILITY SERVICES COST = CONSTRUCTION & INSTALLATION COSTS = BUILDING SERVICES,HVAC, COOLING WATER, HOT WATER, COMPRESSED AIR etc. CIVILS, BUILDING, BUILDING FIT OUT/CLEANROOMS INSTALLATION OF EQUIPMENT, MATERIALS & SERVICES

ESTIMATING PLANT CAPITAL COSTS CONTINGENCY = A VALUE FOR UNKNOWN SCOPE/DESIGN DEVELOPMENT ACCURACY = OOM ESTIMATE = ± 50% STUDY ESTIMATE = ± 30% BASIC ESTIMATE = ± 20% DETAILED ESTIMATE = ± 10% (Cap Authorisation) Very the often the minus part is dropped or modified e.g) + 30% - 5%.

SIMPLE TECHNIQUES - Use of process engineering cost index for equipment or complete industry specific types of plant. - Factory cost 260 m in 1980. What is the current price x process index factor = 586 - Industry Price Books. SPONS (Architects & building & building mechanical & electrical services and civil engineering). Standard and small jobs. - [Lang] Factorial Methods IchemE Blue Book Method - Cost estimate is factored on the costs of the main equipment items (MPI s) - For the facilities consider total installed cost based on floor area.

MAIN EQUIPMENT ITEMS (MPI S) - Prepare a detailed specification and ask a vendor of equipment for a fixed price = ultimate accuracy. - Ask vendor for a budget price - In-house data banks (estimating departments collect from previous quotations - Estimating charts based on equipment size. - Estimating charts based on materials of construction Material Factors CS x 1.0 SS X 2.0 - Use of general size factoring exponents 2/3 or six tenths rule.

6/10 RULE & MATERIAL FACTORS 6/10 Rule 10 cubic metre vessel = A 20 cubic metre vessel = (20/10) 0.6 = 1.5 X A Material Factors 10 cubic metre carbon steel heat exchanger = A 20 cubic metre stainless steel heat exchanger = 2 x A

FACTORIAL METHOD 1 Total Plant Cost = Total Equipment Cost x Lang Factor. Pharmaceutical & Fine Chem. Petrochemical Refinery Lang Factor = 6 8 4 5 3-4 For Biotech facilities is normally in the range 3-6

FACTORIAL METHOD 2 Estimate cost of the main plant items (MPIs) Add estimated costs for following, factored against the equipment list: - Erection & Construction: [0.1 to 0.4] - Piping, insulation & painting: [ 0.15 to 0.7] - Electrical: [ 0.1 to 0.15] - Instrumentation: [ 0.1 to 0.35] - Utilities: [0.3 to 0.75] xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx - Process Buildings & Struct: [0.30] - Ancillary buildings: [0.15] - Tech space: [0.15] - Warehouse: [0.15] - Environmental: [0.1 to 0.30]

FLOOR AREA COSTS Biofacility Cost Comparison AK pharma PROJECT client 1 2 3 4 5 /m2 of Production Area 18,129 8,246 25,816 19,876 32,483 /m2 of FA 6,258 6,264 7,633 5,206 5,988 Prod. Area over FA 35% 76% 30% 26% 18% (FA - Floor Area)

FLOOR AREA COSTS Cost/m 2 Footprint Cost/m 2 GIFA Cost/m 2 Area A Grade A/B B Grade C C Grade D D Tech/office. 33000 22000 30000 n/a 10000 12500 8500 10000 29500 42000 32500 13500 A B C D A B C D GIFA: Gross Internal Floor Area All figures in A B C D

OPERATIONAL COSTS Fixed Costs Salaries of permanent staff Maintenance Variable Costs Raw materials Direct labour Plant upgrades Semi-Fixed Costs Utilities Contract Production Activity Activity Activity

SUMMARY - Estimates can be very complex & expensive task - Cost estimation methods are approximate and the more distant the data on which the estimate is based the less accurate it will be. - Sometimes it is better/faster/cheaper to ask a supplier for a quotation + add a margin. - As you move into detailed design phase. Specify plant & generate material take off prices for equipment plant and materials-fixed pricing from all suppliers to increase the accuracy of the estimate.

GROUP /INDIVIDUAL EXERCISE Prepare and OOM estimate for your proposed project flowsheet and layout developed in last exercise. This process is currently in R&D and operated at 20 Litre scale with a bioreactor yield of 7 g/l. The equipment costs for the current process are supplied. The forecast capacity for the full scale commercial process is 1,000,000 vials containing 1 mg of protein product. Establish scale up factor. Think about yield losses across the process stages?

GROUP /INDIVIDUAL EXERCISE COST DATA FOR DESIGN Equipment Supplier Year of Purchase Cost when Purchased Cell Bank Freezer ICS 40,000 450 L Fermenter Pierre Guerin 350,000 75 L Fermenter Pierre Guerin 90,000 20 L Fermenter Pierre Guerin 50,000 7 L Fermenter Pierre Guerin 35,000 CSA Centrifuge GEA Centrifuge 150,000 Cell Disruptor GEA Soavi 120,000 25 cm Column GE Health care 90,000 Column Liquid Handling 1/2" GE Health care 250,000 200 Litre Stainless steel vessel Suncombe 30,000 Virus Filtration Skid Pall 150,000 UF TFF Skid Pall 70,000 Kill Tanks Suncombe 50,000 Autocalves Steritech 120,000 Glycol Plant Johnson Controls 50,000 HVAC Plant Woods 20,000 WFI Still Steritech 300,000 Vial Filling Line IMA 1,000,000 Clean Steam Generator Steritech 170,000 Compressed Air Generation Motivair 35,000 Plant Steam Clayton 500,000 CIP Skid Suncombe 150,000