L Intérêt du Projet CTI Prof. Yogeshvar N. Kalia Molecular Therapeutics Delivery Group Section des sciences pharmaceutiques CMU, 1 Rue Michel Servet, Genève Email: yogi.kalia@unige.ch REUSSIR VOS PROJETS CTI Université de Genève / Faculté des sciences Mercredi 8 février 2017
My group s research interests and expertise NEW ACTIVITIES CREATED THROUGH CTI PROJECTS DRUG DELIVERY ACROSS BIOLOGICAL BARRIERS Transdermal, Ocular, Buccal & Intestinal absorption PRODRUG DESIGN Synthesis & Characterisation THERAPEUTICS Small Molecules, Peptides, Proteins and Antibodies DRUG VISUALISATION UNIGE Bioimaging Platform QUANTIFICATION AND DETERMINATION OF DRUG BIODISTRIBUTION HPLC + UHPLC with UV, Fluorescence & MS/MS, ELISA, Activity Assays DRUG FORMULATION Micelles, Microparticles, Nanoparticles, Semi-solids, Films & Patches DRUG DELIVERY TECHNOLOGIES Polymer Systems, Iontophoresis, Fractional Laser Ablation 2
Industrial collaborations and CTI projects FUNDING? DIRECT CTI YN Kalia UNIGE, 2017 PERSONNEL 3
Different projects different activities and goals Project Title #9307.1 2008-10 #14416.1 2012-14 #14334.1 2012-14 Novel approaches for minimally invasive intraepidermal drug delivery (PI) Development of a new alcohol-free gel product for the controlled transdermal delivery of testosterone to treat sexual dysfunction (PI) Peptides based on animal venom constituents as new active ingredients for cosmetic products (Co-I) #13933.2 2013-15 #14931.1 2013-15 #19086.1 2016-18 Development of novel hydrocolloid patches for use with P.L.E.A.S.E. fractional laser ablation system for the intraepidermal needle-less delivery of biotechnology therapeutics (PI) Development of a physiological model for drug permeation in the gastrointestinal tract using porcine intestinal mucosa: A new efficient method for drug screening and identification of lead candidates (PI) Spironolactone-ApidSOL formulation for delayed healing of minor wounds in glucocorticoid treated patients (PI) 4
Device projects (Pantec Biosolutions) Novel approaches for minimally invasive intraepidermal drug delivery (PI) Development of novel hydrocolloid patches for use with P.L.E.A.S.E. fractional laser ablation system for the intraepidermal needle-less delivery of biotechnology therapeutics (PI) PLEASE PROFESSIONAL Launched BioPharm America Sep 2011 AIMS Development and evaluation of new transdermal systems for minimally invasive drug delivery to provide a safe, efficient alternative to parenteral administration ACHIEVEMENTS & REWARDS Acquired new skills and know-how wrt molecules, created new drug delivery technology; first report of needle-free local antibody delivery Clinical trials initiated 5
Sometimes possible to publish
Making better formulations: PharmaCo X, Activen, Apidel Development of a new alcohol-free gel product for the controlled transdermal delivery of testosterone to treat sexual dysfunction (PI) Peptides based on animal venom constituents as new active ingredients for cosmetic products (Co-I) Spironolactone-ApidSOL formulation for delayed healing of minor wounds in glucocorticoid treated patients (PI) YN Kalia UNIGE, 2017 AIMS Develop new, more efficient formulations for topical or transdermal delivery ACHIEVEMENTS & REWARDS Successful development of new formulations with possibility of entering clinical trials New research opportunities and activities created Possibilities for future collaboration Experience of industrial product development and requirements/rigour 7
Developing a new preclinical model: Debiopharm International Development of a physiological model for drug permeation in the gastrointestinal tract using porcine intestinal mucosa: A new efficient method for drug screening and identification of lead candidates (PI) AIMS Develop new, preclinical model ACHIEVEMENTS & REWARDS Successful development of model New research axis Collaboration opportunities created 8
Conclusions: Take home message SCIENTIFIC OPPORTUNITIES Create new research activities innovation. Acquire new skills and capabilities. Learn new applications of routine techniques. NETWORKING / COLLABORATION OPPORTUNITIES Mechanism to create collaborations and expand network. Build awareness, credibility this leads to further collaborations. Improve employment opportunities for group members (postdocs). DIFFERENT APPROACH Must understand the needs and requirements of the industrial partner. Precise, clear objectives required goal-oriented. Results must be delivered within the required timeframe. SOCIAL RESPONSABILITY Public-Private Partnerships - build closer links to companies in the Lemanic region and Switzerland. 9