Quality In Vitro Research Services

Transcription

1 Quality In Vitro Research Services

2 About Vivacell GmbH Vivacell Biotechnology GmbH is a privately owned contract-based research organisation (CRO) that provides specialised in vitro and in vivo models for testing and developing pharmaceutical and phytopharmaceutical compounds. Additional services for clinical trials and marketing studies are offered. VivaCell s preclinical services include standard protocols and protocols adapted to the needs of the customers using a variety of in vitro and in vivo systems. Why Vivacell GmbH? Because VivaCell is combining highly qualified cellular and molecular biology knowledge and expertise in various fields with a focus on natural products. At VivaCell we offer you complete research projects from basic R&D up to pre-clinical research in one hand. Our clients do not have to gather the research data form various CROs. Application In Vitro Test VivaCell s services include standard protocols and protocols adapted to the needs of the customers using a variety of in vitro assays for cosmetic research. Vivacell, the expert in efficacy testing, offers services for a large variety of indications. 1. ANTI - AGING 2. BEAUTY / ESTHETIC 6. SKIN COMFORT 7. PHYTOCHEMISTRY 3. REGENERATION 4. IMMUNOCOSMETIC 5. SKIN PROTECTION 1

3 1. Claim: Anti-Aging Cell Proliferation Cellular Oxidative Stress ORAC (Total Antioxidant activity) Glucose uptake Oxygen uptake Hypoxia Telomerase activity and length of telomeres Tissue Remodeling (ECM proteins) Autophagy Sensory Receptors (anti-wrinkle) /Dermal Fibroblasts Cell-free assay /Fibroblasts /Immune cells Fibroblasts TRPV-1 assays (inhibition) 2. Claim: Beauty/Esthetic Hair Growth Hair Growth (hair loss) Whitening Cell Volume Vasular tone (NO release) Vascular tone (HIF-1 pathway) Human dermal papilla cells In Vitro enzymatic activity Melanocytes Adipocytes Human Dermal Microvascular Cells /Fibroblasts 2

4 3. Claim: Regeneration Cell Proliferation Tissue Remodeling Real-time wound healing Apoptosis Differentiation (Cornification) Cell Metabolism Immunomodulation I Expression of skin differentiation genes Endocannabinoid system /Dermal Fibroblasts Fibroblasts/Adipocytes, Fibroblasts, Fibroblasts, Fibroblast/Adipocytes T Cells, Fibroblasts/Adipocytes 4. Claim: Immunocosmetic Inflammation Immunosenescence Histamine Release Immunomodulation I Immunomodulation II Immunomodulation III Macrophages/Fibroblasts/ Human primary T Cells Mastocytes T Cells Dendritic Cells Dendritic-to-keratinocytes communication 3

5 5. Claim: Skin Protection Cytotoxicity Inflammation I (cytokines and PGs) Inflammation II (NF-kB and STATs) Cellular Oxidative Stress Detoxification (Nrf2 activators) Transepithelial electrical resistance (TEER) Expression of tight junction proteins /Dermal Fibroblasts Dermal cells and Immune cells, Fibroblasts and 3D cultures *Proliferation Low Saturation 4

6 6. Claim: Skin Comfort Inflammation Itching (histamin release inhibition) Sensory receptors (cooling, analgesia...) Macrophages/Fibroblasts/ Mastocytes TRPV-1/TRPA-1/TRPM-8/CB1 7. Claim: Phytochemistry Natural products from medicinal plants, either as pure compounds or as standardized extracts, provide unlimited opportunities for new dermocosmetics because of the unmatched availability of chemical diversity. Therefore, we also provide phytochemistry services to identify the chemical profile of your extracts and to isolate the major bioactive products. We have experience in analytical methodologies, which include the extraction, isolation and characterization of active ingredients in botanicals and herbal preparations. 5

7 In Collaboration with SimCosmetic Biotech SimCosmetic Biotech is a company focused on the development of novel dermocosmetics based on natural products. SimCosmetic Biotech has developed technological platforms for screening and studying the biological activity of potential cosmetics and dermatological products in order to respond to the increasing demand of new dermatological agents with tested mechanism and proven efficacy. In addition we can generate novel products with synergistic activities saving costs and time. Intelligent Solutions for Novel Cosmetic Developments Vivacell s Contact Vivacell Biotechnology GmbH Ferdinand-Porsche-Str. 5 D Denzlingen Germany Dr. Bernd Fiebich (CEO) fiebich@vivacell.de