Overview of PhytoCellTec Products

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1 Overview of Products

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3 Stem Cell Cosmetic Stem Cell Cosmetic, the New Trend Stem cells are one of the most fascinating areas of modern biology and medicine. This is due to their remarkable characteristics and the fact that they play a key role in skin regeneration. With the launch of Malus Domestica in 2008, Mibelle Biochemistry was the first company in the world to promote a cosmetic active based on plant stem cells for the protection of human skin. This pioneering cosmetic ingredient proved to trigger a global success story and is still considered to be a truly international innovation thanks to its outstanding study documentations and high product quality. What are Stem Cells? The concepts of renewal and repair are on-going processes in the human body. As regards adult stem cells, these supply the necessary cells for the replacement of damaged or dead cells and these have been identified in over 20 organs or tissues. Two key features set them apart from ordinary cells: firstly, they can differentiate into a diverse range of specialized cells of the same tissue, while secondly they have the remarkable ability to renew and regenerate themselves by cell division throughout a person s life. This makes particularly valuable and a key target area for regenerative skin care research. Stem Cells in the Skin Epidermal : Adult of the epidermis are found at the innermost layer of the epidermis (basal layer) and 1 % 2 % of the cells in this layer are stem cells. Epidermal have the unique function of constantly rejuvenating and repairing the epidermis by forming new keratinocytes. Whilst in young skin the epidermis is renewed approximately every four weeks by this process, as we age it continuously slows down. The number of epidermal is reduced and their vitality diminishes. And as epidermal are responsible for ensuring a strong skin barrier and a radiant and healthy skin complexion, it is absolutely critical to maintain the vitality of these valuable cells. Dermal : The function of the dermis is to provide mechanical support and elasticity to the skin and in order to maintain these important functions the dermis undergoes a similar cell turnover. Adult dermal are responsible for this regenerative process in the dermis and they reside in the dermal papilla of the hair follicle. These cells have been found to self-renew, have involvement in wound-healing but also differentiate into fibroblasts, which is the predominant cell type of the dermis. They are responsible for the production of the extracellular matrix proteins elastin and collagen. Therefore, it is crucial to both protect and vitalize these dermal to achieve a deep-seated rejuvenation of the skin. With Argan, Mibelle Biochemistry launched the very first cosmetic active specifically targeting these dermal. April 2015

4 Malus Domestica Solar Vitis Symphytum Alp Rose Argan nunatak Swiss apple variety Uttwiler Spätlauber Very rare Swiss apple variety known for its longevity without shrivelling Longevity, regeneration, vitalization French grape variety, Burgundy Gamay teinturier Fréaux Rare red-fleshed grape cultivar with high antioxidant content, tolerant to strong UV exposure UV-protection, photo-aging Comfrey Symphytum officinale Old medicinal plant with powerful healing properties Recharges youthfulness of skin stem cells, boosts cell turnover Alpine Rose Rhododendron ferrugineum Swiss alpine plant that is able to resist harsh and aggressive weather conditions Resistance, improved barrier function and moisture Argan tree, Morocco Argania spinosa One of the oldest tree species in the world, which is perfectly adapted to intense droughts and extremely high temperatures Vitalization of dermal, rejuvenation, improved skin density and firmness Dwarf soapwort Central European Alps Saponaria pumila Plant that survived the last Ice Age in the Alps on rare ice-free mountain peaks (nunataks), with effective repair mechanisms and protecting components Protects dermal stem cells, re-densifies the skin, improves the skin s self defense Epidermis Epidermal Dermis Dermal Mibelle Biochemistry offers different products that focus on rejuvenation of the epidermis and the dermis Epigenetic factors of plant are used to stimulate the vitality of human in the skin. In vivo and in vitro studies have demonstrated the efficacy of products on human epidermal and dermal. Moreover, each of the products contains plant-specific metabolites that have a positive effect on different tissue layers of the skin.

5 Plant Stem Cells to Protect Skin Stem Cells. How does it Work? Every stem cell contains specific epigenetic factors, which have the task of preserving the multi-potency and unique ability to self-renew of the. Plant stem cells also contain such epigenetic factors. Several in vitro and in vivo studies have demonstrated the positive effect of products on the vitality of human skin and their regenerative capacity. Mibelle Biochemistry currently has a patent pending relating to the application of plant to protect skin stem cells. What is? is the name of a new biotechnology that researchers from Mibelle Biochemistry have successfully used to both generate and cultivate plant. The technology relies on the wound healing mechanism of a plant whereupon following injury the healing of the cut surface begins with the formation of callus cells. This healing tissue consists of dedifferentiated cells which are and for this purpose a small part of the respective plant (germ, leaf, fruit) was selected and injured to induce callus formation. The callus cells were then cultivated in an appropriate medium and large-scale production was achieved in a specially developed WAVE bioreactor system. Benefits of the Technology Possibility of using endangered and rare plant species for the production of cosmetic ingredients without the risk of over harvesting threatened species (sustainability) Production is not restricted by seasonal harvesting Defined controlled process conditions prevent variations in product yield and quality (high product quality and a guaranteed standard)

6 Noteworthy Benefits of Mibelle Biochemistry s Stem Cell Ingredients stem cell actives are formulated in a vector system (liposomes) that bring the active right to the basal layer where the epidermal are located. To reach the dermal, liposomes can even penetrate to the hair papilla via the follicular pathway Several in vitro tests with human epidermal / dermal stem cell cultures for all products Specific clinical in vivo studies that prove the efficacy in the skin Pending patent of Mibelle Biochemistry on the application of plant to protect skin (see below) INNOVATION PRIZE 2008 Innovation Prize In 2008, Mibelle Biochemistry launched its first product based on plant, Malus Domestica, which contains from the now almost legendary Uttwiler Spätlauber apple. It was considered revolutionary as for the first time it was proven that the use of plant improves the vitality and efficiency of the skin s most important cells the skin. Mibelle Biochemistry was awarded with the European Cosmetics Innovation Prize at the in-cosmetics 2008 event for this highly innovative new product. International Press The November 2009 issue of the US magazine Vogue featured the headline Skin care s miracle anti-aging apple. The article on Malus Domestica generated an enormous global response across a diverse range of media (print, TV, online etc.). According to the Vogue article, style icon and First Lady Michelle Obama buys a serum that uses the apple stem cell extract. And in a letter she has written to the company, she has explained that she is a fan of the serum. According to various journals, cosmetic products with Malus Domestica are used by a number of other figures in the public eye, including Helen Mirren and Jennifer Lopez. Logo Companies / Brands using Mibelle Biochemistry s products in the proposed concentration are welcome to use the exclusively developed logo on their product packaging. The logo is available upon request from your local distributor. Customer benefits relating to the quality logo include: free added quality value information platform on USP, POD refers to Swiss origin Patent of Mibelle Biochemistry Mibelle Biochemistry has a patent pending on the application of plant to protect skin. (EP A3, US 12 / 148, 241).

7 Sustainability Thanks to the innovative technology, it is possible to even use endangered and rare plant species as a source for cosmetic ingredients. Only a very small amount of plant material is needed to produce large quantities of high-quality active ingredients, which makes a highly sustainable technology. Full Product Documentation Full documentation regarding all products, including product brochures, technical sheets, publications and study results, are available from your local distributor. Malus Domestica Plant for skin stem cell protection Solar Vitis Protects epidermal against UV damage Symphytum Speed up your skin renewal through stem cell activation Malus Domestica Solar Vitis Symphytum In 2012, Mibelle Biochemistry was invited to present the technology as an example for a green economy at the Rio+20 congress the United Nations Conference on Sustainable Development (UNCSD), which was staged in Rio de Janeiro. Rio+20 was the largest UN conference ever held and it resulted in a broad participation from leaders across governments, businesses and society in general. The technology was presented as an eco-breakthrough in natural cosmetics ingredients as it allows the production of active raw materials for the beauty industry without harming the environment: only very little of the plant material (e.g. one fruit or one leaf) is used to establish the plant culture. Therefore, this biotechnology protects and helps to preserve rare and endangered plants no agricultural land is required to produce biomass significant reduction of water consumption compared to conventional biomass production no need for fertilizer, pesticides and other chemicals Alp Rose Charges skin stem cell resistance Alp Rose Argan Vitalizing dermal to improve skin density Argan nunatak Secrets of beauty from the ice age nunatak Websites This provides an overview of the entire Mibelle Biochemistry product range. This offers detailed information on all products with a short presentation of study results and features a FAQ section.

8 Mibelle AG Biochemistry, 5033 Buchs / Switzerland, Phone +41 (0) , info@mibellebiochemistry.com, The information contained in this publication is provided in good faith and is based on our current knowledge. No legally binding promise or warranty regarding the suitability of our products for any specific use is made. Claim ideas are offered solely for your consideration, investigation and verification. Mibelle Biochemistry will not assume any expressed or implied liability in connection with any use of this information.