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1 / P r o d u c t C a t a l o g E N Z Y M E S diagnostic reagents blood culture plates immunochemistry applications biosensors urinalysis p oi n t-of-ca re

2 ENZYMES PRODUCT CATALOG Sekisui Diagnostics has been a leader in the manufacturing of high quality enzymes and specialist biochemicals to the global healthcare market for over 40 years. We have worked with many global partners to supply high quality materials for a variety of applications, including enzymes for biotherapeutic manufacture, pharmaceutical production, clinical chemistry and biosensors. From enzyme discovery through to commercialization, we commit to excellence in quality, attention to detail and customer service. Our flexibility of scale, from small R&D quantities to full scale manufacturing, allows us to support you every step of the way from concept to product launch. Key elements for success lie within the way we work and the systems that are in place. Working closely with our partners and disciplined project management ensures a focused and timely delivery of your product. Our accreditation to ISO 9001, plus manufacturing systems that exceed this benchmark, guarantees high standards, consistency, and reliability of product supply. Our accreditations to ISO (Environmental Management System), OHSAS (Safety Management System) and knowledge of CTPAT (security), provide assurance of responsible manufacturing and supply. By utilizing our fully integrated, multi-functional teams and accredited quality management systems we are able to offer the complete solution, tailored to your requirements. 1-5-Anhydroglucitol-6-Phosphate Dehydrogenase Escherichia coli T-95 Acyl-CoA Oxidase Arthrobacter sp. T-17 Acyl-CoA Synthetase Pseudomonas fragi T-16 Alcohol Oxidase Candida sp. T-38 Alkaline Phosphatase Escherichia coli T-08 Ascorbate Oxidase Zucchini Ascorbate Oxidase Acremonium sp. T-53 Ascorbate Oxidase Acremonium sp. (R) T-187 Bilirubin Oxidase Myrothecium sp. BIOX Bilirubin Oxidase Bacillus subtilis T-188 Catalase Aspergillus sp. (L) CATA Cholesterol Dehydrogenase Nocardia sp. CHDE Cholesterol Esterase NEW Microbial (R) CHES Cholesterol Esterase Candida rugosa Cholesterol Esterase Pseudomonas sp. CHES Cholesterol Esterase Pseudomonas sp. T-18 Cholesterol Esterase Microorganism T-98 Cholesterol Esterase Candida rugosa Cholesterol Oxidase Nocardia sp. CHOX Cholesterol Oxidase Microorganism T-101 Cholesterol Oxidase Microorganism (L) T-84 Cholesterol Oxidase Microbial (R) RECO Cholesterol Oxidase Streptomyces lividans (R) RECO Choline Oxidase Arthrobacter globiformis T-05 Colipase Porcine pancreas (L) Diacentinase Bacillus subtilis (L) Diaphorase (NADH) Bacillus megaterium T-06 Diaphorase (NADPH) Bacillus megaterium T-10 DNASE B Escherichia coli (L) (R) Glucoamylase Rhizopus sp. GLUC Glucose Dehydrogenase NAD Dependent Bacillus sp. GLDE Glucose Dehydrogenase FAD Dependent Aspergillus sp. GLDE Glucose Oxidase HPS150 Aspergillus niger (R) GLOX Glucose Oxidase HPS300 Aspergillus niger (R) GLOX Glucose Oxidase Aspergillus niger (L) Glucose Oxidase L150 Aspergillus niger (R) (L) GLOX ENZ 1

3 ENZYMES PRODUCT CATALOG Glucose-6-Phosphate Dehydrogenase Leuconostoc mesenteroides GLPD Glucose-6-Phosphate Dehydrogenase Bacillus sp. T-51 Glycerol Kinase Flavobacterium meningosepticum T-64 Glycerol Kinase Cellulomonas sp. GLKI Glycerol Kinase Escherichia coli Glycerol Phosphate Oxidase Pediococcus sp L-α-Glycerophosphate Oxidase Streptococcus sp. (R) T-107 L-α-Glycerophosphate Oxidase Streptococcus sp. (R) L-α-Glycerophosphate Oxidase Aerococcus viridians T-15 Glycerophosphorylcholine Phosphodiesterase Gliocladium roseum T-33 Hexokinase Yeast HEXO Hexokinase Bacillus sp. T-50 Hexokinase Rhodothermus obamensis T-141 Hexokinase ADP Dependent Pyrococcus furiosus T-92 Hexokinase ADP Dependent Thermococcus litoralis T-93 3 α-hydroxysteroid Dehydrogenase Pseudomonas sp. T α-Hydroxysteroid Dehydrogenase Bacillus spaericus T Hydroxybutyrate Dehydrogenase Alcaligenes faecalis T-68 Lactate Dehydrogenase Microbial LADE Lactate Oxidase Aerococcus viridians (R) RELO Lipase Chromobacterium viscosum LIPA Lipase Chromobacterium viscosum and Bacillus sp. T-116 Lipase Microorganism T-63 Monoglyceride Lipase Bacillus sp. T-117 Lysophospholipase Vibrio sp. T-32 Malate Dehydrogenase Microbial MADE Maltase (α-glucosidase) Yeast MALT NAD Synthetase Bacillus stearothermophilus T-67 Oxaloacetate Decarboxylase Pseudomonas sp. T-14 Peroxidase RZ 2.0 Horseradish PERO Phosphofructokinase Bacillus stearothermophilus T-142 Phosphoglucose Isomerase Bacillus stearothermophilus T-120 Phospholipase A 2 Streptomyces violaceoruber (L) T-194 Phospholipase C Bacillus cereus T-11 Phospholipase D Streptomyces chromofuscus T-07 Phospholipase D Streptomyces sp. T-39 Purine Nucleoside Phosphorylase Bacillus sp. (L) T-69 Pyruvate Oxidase Aerococcus viridans T-45 Streptolysin O Escherichia coli (R) (L) Sarcosine Oxidase Bacillus sp. T-46 Tyramine Oxidase Arthrobacter sp. T-25 Urease Jack bean UREA Urease Jack bean (L) Uricase Bacillus fastidiosus URIC Uricase Escherichia coli (R) URIC Uricase Arthrobacter globiformis (R) URIC Xanthine Dehydrogenase Microorganism (L) T-134 ANTIBIOTIC INACTIVATING ENZYMES Sekisui Diagnostics is a prime manufacturer of both β-lactamase and Penicillinase from Bacillus cereus, for inactivation of all classes of β-lactam antibiotics; cephalosporins up to 5th generation, carbapenems and penicillins. PRODUCT FORMAT USAGE PART NO. β-lactamase ES Bulk powder Specially developed for use when inactivation of BELA more resistant cephalosporins such as Cefepime, Cefoxitin,Cefradine and Ceftazidime is required. β-lactamase ES Sterile vials (pack of 10) Convenient format of β-lactamase ES (BELA ) BELA β-lactamase Bulk powder A freeze-dried product containing buffer salts and BELA zinc that has a range of activity against both penicillins (βi activity) and cephalosporins (βii activity). β-lactamase Sterile vials (pack of 10) Convenient format of β-lactamase (BELA ) BELA Penicillinase Bulk powder Penicillinase is a freeze-dried product containing PENI buffer salts that is active against penicillins only. Penicillinase Sterile vials (pack of 10) Convenient format of Penicillinase (PENI ) PENI SPECIALITY PRODUCTS PRODUCT USAGE PART NO. Streptavidin Streptavidin is sourced from Streptomyces avidinii. Suitable for techniques such as STRE ELISA, RIA, DNA probes, immunocytochemistry and protein blotting. Valinomycin Valinomycin is sourced from Streptomyces sp. Suitable as a potassium VALI ionophore in electrodes or other devices for the measurement of potassium. CNPG 3 2-Chloro-4-nitrophenyl maltotrioside (CNPG 3 ) is a proprietary substrate for CHNM the determination of pancreatic α-amylase. No requirement for auxillary enzymes as colour is directly released by α-amylase cleavage. BpNPG 7 Blocked p-nitrophenyl-α-d-maltoheptaoside (BpNPG 7 ) is a substrate BLNM for the determination of pancreatic α-amylase. Auxillary enzymes, Glucoamylase and Maltaseare required to release the chromogen. 2 ENZ ENZ 3

4 NOTES SEKISUI DIAGNOSTICS YOUR GLOBAL PARTNER FOR OVER 30 YEARS Sekisui Diagnostics was created in 2011 when Sekisui Medical acquired Genzyme Diagnostics. The new company brings together extensive products development capabilities and a broad global sales/distribution network for our comprehensive product lines: Clinical chemistry systems and reagents Coagulation systems and reagents Infectious disease rapid tests, line immunoassays, and ELISA Kits Enzymes and specialty biochemicals Sekisui Diagnostics is a diverse company with extensive product development capabilities, state of the art manufacturing facilities, and deep diagnostics expertise. We are Sekisui Diagnostics and we are dedicated to improving the lives of patients all around the world. 4 ENZ

5 Locations Worldwide HQ Lexington, MA, USA San Diego, CA, USA Exton, PA, USA Stamford, CT, USA Sekisui Diagnostics P.E.I. Inc. Charlottetown, PEI, Canada Sekisui Diagnostics (UK) Ltd. Kings Hill, West Malling Kent, UK Sekisui Virotech GmbH Rüsselsheim, Germany American Diagnostica GmbH Pfungstadt, Germany Sekisui Medical Co., Ltd. Tokyo, Japan Sekisui Medical Technology (China) Ltd. Shunyi District, Beijing, China Sekisui Medical Technology (China) Ltd. Chaoyang District, Beijing, China /14

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