Laboratory Analyzers buyers guide

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1 Laboratory Analyzers buyers guide 2010 Laboratory Analyzers buyers guide Editor s note: This annual resource represents a collaborative effort between ADVANCE editorial consultants/advisors, industry manufacturers and editorial staff. A more detailed guide is offered on our Website, ADVANCE relies on its readership for feedback. If you have suggestions that would make the Buyers Guide more useful, please lnace@advanceweb.com. Listings do not represent endorsement by ADVANCE. AUTOMATION PG Bio-Rad Laboratories 74 Roche Diagnostics 78 Siemens Healthcare Diagnostics CHEMISTRY Alfa Wassermann Diagnostic Technologies LLC 79 PG 72 The Binding Site 73 Mindray Medical International Ltd. 76 va Biomedical 77 Roche Diagnostics 78 Siemens Healthcare Diagnostics COAGULATION 80 PG Beckman Coulter 73 Siemens Healthcare Diagnostics HEMATOLOGY Mindray Medical International Ltd. Siemens Healthcare Diagnostics 81 PG IMMUNOASSAY PG The Binding Site 73 DiaSorin Inc. 74 Inverness Medical 75 Phadia US Inc. 78 Roche Diagnostics 78 Siemens Healthcare Diagnostics INTEGRATED SYSTEMS Siemens Healthcare Diagnostics LC/MS/MS 83 PG 85 PG AB SCIEX 72 URINALYSIS Siemens Healthcare Diagnostics PG 89 AB SCIEX LC/MS/MS Lisa Sapp (508) lisa.sapp@absciex.com AB SCIEX QTRAP 5500 LC/MS/MS System Multiple reaction monitoring (MRM) for quantitation using high-sensitivity triple quadrupole system t cleared or approved by the FDA or any other agency, or under the European IVD Directive, for diagnostic or other clinical use. Application dependent 3 to 6 months for validation 5 µl/min to 3 ml/min Weekly Superior sensitivity, low detection limits, high specificity, faster results, reduced sample preparation time, increased throughput, easy to use, easy analyte updates, maximum instrument uptime, cost savings. Includes open reagent system, primary tube sampling and positive sample ID. 72 JULY 2010 advance /Laboratory All chromatography and MRM Any Depends on the type of autosampler used Cooling rack 15 minutes Alfa Wassermann Diagnostic Technologies LLC CHEMISTRY Lauren DiPrima (800) info@alfawassermannus.com ACE Alera Clinical Chemistry System Photometry, potentiometry (Ion Selective Electrode), turbidemetric/homgeneous EIA Alanine Aminotransferase, Albumin, Alkaline Phosphatase, Amylase, Apolipoprotein A1, Apolipoprotein B, Aspartate Aminotransferase, Bilirubin, Direct, Bilirubin, Total, Blood Urea Nitrogen, Calcium Arsenazo, Carbon Dioxide, Cedia T-Uptake, Chloride, Cholesterol, Creatine Kinase, Creatinine, Ferritin, Gamma-Glutamyl Transferase, Glucose, Hemoglobin A1c, High Density Lipoprotein, Cholesterol, Inorganic Phosphorous, Iron, Lactate Dehydrogenase, Lipase, Lipoprotein-a, Low Density Lipoprotein, Cholesterol, Magnesium, Microalbumin, Potassium, Sodium, TIBC, Direct, Total Protein, Total Thyroxine, Transferrin, Triglycerides, Uric Acid 165 photometric, 120 ISE

2 Beckman Coulter COAGULATION 2-10 minutes, assay dependent 3-50 µl, assay dependent Assay dependent Closed tube sampling, integrated data management, positive sample ID, primary tube sampling, open reagent system, onboard dilution Primary tube, sample tube or cup Centrifugation 40 positions 2-4 hour walkaway time <15 minutes ACL TOP in the U.S.: Venita Shirley (714) Clot detection, LED optical, chromogenic, immunologic PT, APTT, Fibrinogen, TT, Factors, SCT, drvvt, APCR-V, Protein C/S, Heparin, AT Plasminogen, Plasmin Inhibitor, D-Dimer, D-Dimer HS, vwf, Factor XIII, Homocysteine Up to 360 PTs/hour PT<3 minutes PT & PTT - 50 µl; FVIII - 25 µl PT & PTT - 50 µl; FVIII - 25 µl Features clot signature curve analysis; continuous operation without interruption to workflow; minimized operator intervention using Windows XP software; 2D bar code for reagent, calibration and control assay value import; HemosIL INR plasma sets for INR test system validation and calibration; HemosIL liquid heparin with universal cal curve for UFH and LMWH. Includes integrated data management, primary tube sampling and onboard dilution. 120 samples on board (10 samples per rack); 800 cuvettes on board; 30 tests per sample 44 Daily maintenance <10 minutes ACL TOP 500 CTS Clot detection, LED optical, chromogenic, immunologic (turbidimetric) PT, APTT, Fibrinogen, TT, Factor Assays, SCT, drvvt, APCR-V, Protein C/S, Heparin, AT Plasminogen, Plasmin Inhibitor, D-Dimer, D-Dimer HS, vwf, Factor XIII, Homocysteine Up to 240 PTs/hour <3 minutes PT & PTT - 50 µl; FVIII - 25 µl Varies by assay Complete assay menu, including D-dimer and D-dimer HS with VTE exclusion; 671 nm LED detection minimizes interference from lipemia, hemoglobin and bilirubin; HemosIL plasma sets for validation of INR test system; HemosIL liquid heparin with universal cal curve for UFH and LMWH. Includes integrated data management, primary tube sampling and onboard dilution. 120 samples on board (10 samples per rack); 800 cuvettes on board; 30 tests per sample 44 Daily maintenance <10 minutes ACL ELITE Series Clot detection, LED optical, chromogenic, immunologic PT, APTT, Fibrinogen, TT, Factor Assays, SCT, drvvt, APCR-V, Protein C/S, Heparin, AT Plasminogen, Plasmin Inhibitor, D-Dimer, vwf, Factor XIII, Homocysteine 175 PTs/hour 4 minutes PT 60 µl The Binding Site CHEMISTRY/IMMUNOASSAY in the U.S.: Test menu features D-Dimer; barcode reagent management; ACL Family harmonization; HemosIL INR plasma sets for INR test system validation and calibration; HemosIL liquid heparin with universal cal curve for UFH and LMWH. Includes integrated data management, primary tube sampling and onboard dilution. Up to 40 samples onboard Daily maintenance <5 minutes Faranak Atrzadeh (800) faranak.atrzadeh@thebindingsite.com SPA PLUS Special Protein Analyzer Turbidimetry Freelite Kapp (Free Kappa Light Chain), Freelite Lambda (Free Lambda Light Chain), Beta-2- Microglobulin, IgG, IgA, IgM, IgD, IgG1, IgG2, IgG3, IgG4, Cystatin C, T. Tox Plasma Screen (RUO) 240 tests per hour (up to 120 tests per hour with sample dilution) 15 minutes, and each consecutive sample every 30 seconds

3 Laboratory Analyzers buyers guide 3-30 µl Bio-Rad Laboratories AUTOMATION Type of Analyzer: Prozone detection, Auto-dilution Dual Compartment reaction cuvettes, air pressure mixing system and extensive washing processes ideal especially for latex assays, low maintenance, integrated data management, primary tube sampling, positive sample ID, onboard dilution Batch, random access Homogenous 24 reagent positions; 100 tests per container; onboard reagent cooling; 30-day onboard reagent stability 45 specimens, 6 assays ~15 minutes Maria Rosa Spedaletti (510) maria-rosa_spedaletti@bio-rad.com TANGO optimo Automated blood bank instrument Hemagglutination is used for the Erytype assays. Dried monoclonal antisera coats the microwells. The placement and identity of the antisera is predetermined. Patient sample is added and reactions are graded and interpreted by the instrument. For the Solidscreen II assays, a solid phase method is employed. Uses microwells coated with Protein A that has a high affinity for the Fc portion of the antihuman globulin which attaches also to patient antibody. Solid phase offers advantages such as long shelf-life, long on-board stability and outstanding specificity and sensitivity. ABO Forward and Reverse Grouping with D Typing, ABO and Rh Donor Confirmation, Antibody Screen Testing, Compatibility Testing, Direct Antiglobulin Testing, Antibody Identification, Weak D Testing, Phenotype Testing 24 blood typing / 60 minutes 96 2-cell screens 17 minutes for typing, 32 minutes for screen 500 microliters Long onboard reagent shelf lives (up to 7 days), unique solid phase and erytype technology, stat capability, quick and simple daily and weekly maintenance, easy to operate, processes strips individually for minimal waste, reagents have up to a 2 year shelf life. Offers integrated data management, open reagent system, primary tube sampling, positive sample ID and onboard dilution. DiaSorin Inc. IMMUNOASSAY Onboard reagent storage: 10 microplates with positive plate and strip identification 12 cooled liquid reagent positions (reagent red cells) 6 RT liquid reagent positions (bromelin, LISS and anti- IgG) 48 2-cell screens / plate (96 wells) 12 blood typing / plate (96 wells) 48 ABO or Rh confirmation typing / plate (96 wells) 550 tests / reagent red cell bottle & anti-igg bottle 1400 tests / LISS bottle, up to 7 days Both LIAISON Hands-on 5 minutes, total 5 minutes Greta Schwichtenberg (800) greta.schwichtenberg@diasorin.com Fully-automated random access chemiluminescent 25 OH Vitamin D, N-Tact PTH, EBV IgM, VCA IgG, EBNA IgG, EA(D) IgG, CMV IgG, CMV IgM, Toxo IgG, Toxo IgM, VZV IgG, Treponema (IgG/ IgM), Borrelia burgdorferi, Rubella IgG, HSV-1 Type Specific IgG, HSV-2 Type Specific IgG, HAV Total Antibodies, HAV IgM, hgh, insulin Max 180 tests per hour, assay dependent minutes, assay dependent As low as 5 µl, assay dependent 1-4 weeks, assay dependent A fully-automated, random access chemiluminescent analyzer available for 25OH Vitamin D, Treponema IgG/IgM, HSV-1 and HSV-2 Type Specific IgG, VZV IgG, CMV IgM and Borrelia burgdorferi assays. Offers integrated data management, primary tube sampling, positive sample ID and onboard dilution. Random access, batch mode setting also available Paramagnetic microparticle Capacity for 15 reagent integrals/up to 3,000 tests onboard/ tests per reagent integral 144 samples/1,500 tests/15 assays 20 minutes Lance Schlenker (800) lance.schlenker@diasorin.com ETI-MAX 3000

4 Microplate analyzer Infectious disease and autoimmune ELISA; contact manufacturer for detailed assay information Assay dependent hours, assay dependent >10 µl, assay dependent Complete infectious disease and autoimmune menu; offers integrated data management, open reagent system, primary tube sampling, positive sample ID and onboard dilution. Batch ELISA microplate Capacity: reagents for up to 384 tests onboard Inverness Medical IMMUNOASSAY 160 samples/384 tests/8 assays 20 minutes Michelle Fradette (877) AtheNA Multi-Lyte The AtheNA is a multiplexed, fluorescent, beadbased system using patented xmap technology. ANA test system (ANA screen, dsdna, Sm, RNP, SSA, SSB, Jo-1, Scl-70, centromere b, histones), EBV-G test system (VCA, EBNA, EA), EBV-M test system (VCA), Autoimmune Vasculitis (MPO, PR-3, GBM), TPO/Tg, RF, MMV IgG test system (measles, mumps, varicella), MMRV IgG test system (measles, mumps, rubella, varicella), HSV (type specific HSV-1, HSV-2). Later in 2010, pending FDA approval, the menu will include the AtheNA Multi- Lyte Torch IgG Plus Test System (Toxoplasma gondii, rubella, cytomegalovirus, and HSV-1/2, Type-specific), and the AtheNA Multi-Lyte Borrelia VIsE-1/pepC10 Plus Test System (detects IgG and IgM antibodies to VIsE-1 and pepc10, Lyme) well plate in approximately 2 hours 2 hours for 96-well plate for all analytes in a specific test system 10 μl human sera Every well undergoes a unique calibration curve generated at the time of testing, Intra-Well calibration Broadest FDA-cleared multiplex diagnostic menu; each AtheNA Multi-Lyte Test System utilizes Intra-Well Calibration, offers integrated data management, open reagent system and positive sample ID Batch Heterogeneous, vacuum wash Manual minutes 30 minutes AIMS System Multiplex and ELISA methodologies ANA (ANA, dsdna, Sm, RNP, SSA, SSB, Jo-1, Sci-70, Centromere B, Histones); Autoimmune Vasculitis (MPO, PR-3, GBM); TPO/Tg (Thyroid Peroxidase, Thyroglobulin); RF IgM (Rheumatoid Factor); EBV-IgG (VCA, EBNA-1, EA); EBV-IgM (VCA); MMRV IgG (Measles, Mumps, Rubella, Varicella Zoster); MMV IgG (Measles, Mumps, Varicella Zoster); HSV 1&2 IgG (Herpes Simplex Virus, Type 1 & Type 2); Wampole II ELISAs; Pending FDA approval: Torch IgG Plus Test System (Toxoplasma gondii, rubella, cytomegalovirus, and HSV-1/2, Type-specific), and the Borrelia VIsE-1/ pepc10 Plus Test System (detects IgG and IgM antibodies to VIsE-1 and pepc10, Lyme). Two 96-well plates at one time with up to 4 assays 3 hours for one 96-well plate for AtheNA Multi- Lyte assays; 1.5 hours for one 96-well plate for ELISA assays 12 sample racks, 20 sample tube positions for 240 samples Onboard? Every 6 months The Automated Immunoassay Multiplexing System or AIMS is the first fully automated, integrated, open, multi-methodology platform for performing both multiplex assays (AtheNA Multi-Lyte ) and ELISAs. Laboratories can now consolidate workstations and maximize their versatility for autoimmune and infectious disease testing. Includes integrated data management, open reagent system, primary tube sampling, positive sample ID and onboard dilution. Batch AtheNA Multi-Lyte: Bead; ELISA: Microwell-plate AtheNA Multi-Lyte: 4 Reagent s holding up to 7 reagent bottles and 6 control vials; ELISA: 4 Reagent s holding up to 6 reagent bottles and 6 control vials 192 samples 15 minutes DSX

5 Laboratory Analyzers buyers guide your product from others on the market? Reagents Refridgerated Onboard? Tests Assays: ELISA 4-plate processing system Chlamydia, CMV, EBV-EA, EBNA, EBV-VCA, H. pylori, HSV, Legionella, Lyme, Measles, Mumps, Myco, Parvovirus B-19, Rubella, Syphillis, Toxo, VZV. AI-ANCA, ANA, CCP, ASCA, Beta 2, Cardiolipins, dsdna, ENA, Gliadin, Histone, Jo-1, Mitochondria, MPO, PR-3, RF, Ribosomal P, Scl- 70, SM, SM/RNP, SS-A, SS-B, TPO, TG, TTG. Osteo- NTx, Bladder Cancer NMP22, Enterics Tox AB, GDH, Crypto, Giardia, E Histo, ASCA, IBD, Leuko Up to 12 different assays per plate simultaneously in up to four 96-well microplates Approximately 2 hours for a full 96-well plate μl sample tube positions for 96 samples Lot specific Completely open system allows lab to run virtually any ELISA-based assay. Modular design allows the lab to customize the system by adding extra incubators, including a bar code scanner, or even choosing certain types of sample racks. Offers integrated data management, primary tube sampling, positive sample ID and onboard dilution. Batch Coated microwell 24 reagent plus 33 control containers Perform entire complement of analytical steps required for ELISA immunoassays; adding samples and reagents, washing, incubation and absorbance detection 5 minutes DS2 ELISA 2- plate processing system Chlamydia, CMV, EBV-EA, EBNA, EBV-VCA, H. pylori, HSV, Legionella, Lyme, Measles, Mumps, Myco, Rubella, Syphillis, Toxo, VZV. AI-ANCA, ANA, CCP, ASCA, Beta 2, Cardios, dsdna, ENA, Gliadin, Histone, Jo-1, Mitochondria, MPO, PR-3, RF, Ribosomal P, Scl-70, SM, SM/RNP, SS-A, SS-B, TPO, TG, TTG. Osteo- NTx, Bladder Cancer NMP22, Enterics Tox AB, GDH, Crpto, Giardia, E Histo, ASCA, IBD, Leuko Up to 12 different assays per plate simultaneously in up to two 96-well microplates μl sample tube positions for 100 samples Small automated option for manual customers looking to automate. It s completely open system allows a customer to run virtually any ELISAbased assay; offers integrated data management, primary tube sampling, positive sample ID and onboard dilution. Batch Coated well Reagents Refridgerated Onboard? 18 reagent plus 24 control containers Performs entire complement of analytical steps required for ELISA immunoassays; adding samples and reagents, washing, incubation and absorbance detection 5 minutes Mindray Medical International Ltd. CHEMISTRY/HEMATOLOGY Caroline Li (416) c.li@mindray.com BS-200 Chemistry Analyzer Photometric, Turbidimetry, and ISE General Chemistry: Albumin, Alkaline Phosphatase, ALT, Amylase, AST, Direct Bilirubin, Total Bilirubin, BUN, Calcium, Carbon Dioxide, Cholesterol, CK, Creatinine, CRP hs, Fructosamine, Gamma GT, Glucose, HbA1c, autohdl, Iron, LD, autoldl, Lipase-Color, Magnesium, Phosphorus, Total Protein, Triglycerides, Uric Acid Drug of Abuse: Amphetamines, Barbiturates, Benzodiazepines, Buprenophine, Cocaine, Dronabinol (THC), Ethanol (Alcohol), Ethchlorvynol, Fentanyl, Methadone, Methampheta, Opiates, Oxycodone, Phencyclidine, Propoxphine, TCA, XTC, 6-Acetylmorphine 200 tests/hour for photometric tests, 330 tests/hour with ISE 3-10 minutes 3-45 µl Open system allowing mixes and matches of quality reagents at low cost. Equipped with features that only come with high-volume instrument. Zero daily maintenance. Asian design with great reliability and accuracy. Includes integrated data management, positive sample ID, primary tube sampling and onboard dilution. Random access Ring 38 onboard chemistries and 40 samples 38 5 minutes daily startup; no daily maintenance BS-380 Turbidimetry, colorimetry AST, ALT, ALP,Na, K, CL, CA, TP, Albumin, Cholesterol, HDL, Iron, Phos, D.Bili, T.Bili, TG, CRP, BUN, Uric Acid, CK, CKMB, Creat, Gluc, GGT, LDH, LDL

6 2-45 µl 450 tests/hour with ISE Weekly or bi-weekly Automated chemistry analyzer, 450 T/H with ISE, 75 sample position, 58 reagent position, refrigerated reagent compartment, carryover minimizing program, automatic on board predilution, automatic probe clean, level sense detection, vertical and horizontal collision protection, 8 steps cuvette wash, 12 wavelength: nm, LIS connectivity. Includes integrated data management, primary tube sampling, positive sample ID, onboard dilution and an open reagent system. Random access and batch Sample disk 60 reagent container position minute startup time; <5 minutes daily maintenance BC µl Flow cell, laser scatter, chemical dye, DC impedence CBC with 5-part differential 60 tests/hour As needed 5-part diff hematology analyzer, 27 parameters, 3 histogram, 1 scattergram, load up to 30 samples with autoloader, closed tube compartment for stats, whole blood and predilution mode, data storage: up to 40,000 samples, Semi-conductor laser scatter, Flow Cytometry, chemical dye method, compact, powerful and affordable for any laboratory. Includes integrated data management, primary tube sampling, positive sample ID and an open reagent system. Autoloader, stat, random access Autoloader rack 60 samples/hour <10 minutes start-up time; <5 minutes daily maintenance BC-3200 Impedance and cyanide-free photometry method va Biomedical CHEMISTRY your product from other products on the market? CBC, 3-part differential 60 tests/hour 1 minute 13 µl for whole blood, 20 µl for pre-diluted blood As required by local inspecting agency Flagging of abnormal QC results; large en suite database storage: 558 (up to 6-month) QC files and 35,0000 test results with histograms. Automatic start-up, close-down cleaning and programmable cleaning cycles. Includes integrated data management, primary tube sampling, positive sample ID and onboard dilution. Single sample 4-position tube holders for different types of tubes Homogenous, no separation 3 reagents 5 minutes Richard Rollins (781) marketing@novabiomed.com Stat Profile phox Depending on test: direct ISE; enzyme/ amperometric ph, pco2, po2, SO2%, Hct, Hb, Na+, K+, Cl-, Ca++, Mg++, Glucose, BUN, Creatinine, Lactate, tbil, HHb, O2Hb, MetHb, COHb Up to 50 samples per hour 50 to 123 seconds microliters (depending upon menu selected) Fully automatic 2-point calibration every 2 hours; user-selectable Color touch screen; integrated co-oximeter; calculates egfr with creatinine measurement; snap-in reagent cartridges with sealed waste system; automated, onboard quality control; tankless gas calibration; SmartCheck automated maintenance; integrated data management; primary tube sampling; positive sample ID; ionized Mg assay. Includes integrated data management, primary tube sampling, positive sample ID and onboard dilution. Single sample Whole blood Up to 5 snap-in reagent cartridges with sealed waste system One

7 Laboratory Analyzers buyers guide Phadia US Inc. IMMUNOASSAY Cold startup time: 5 minutes. daily maintenance required Nicole Vosters (800) nicole.vosters@phadia.com ImmunoCAP Specific IgE Blood Test, EliA Autoimmune Assays FEIA SIgE, TIgE, TG, TPO, EliA CCP, dsdna, Symphony(ENA Screen), individual ENA's, Celikey IgA/IgG (ttg), Gliadin IgA/IgG. 48 tests Roche Diagnostics AUTOMATION Ed Duning (317) Ed.duning@roche.com Modular Pre-Analytics Text Maximum of 400 samples per hour with 2 centrifuges CHEMISTRY Varies by number of tests requested Modular design allows for customization and increased efficiency and productivity. Connections to analytics can be made in any direction. Industry leading system reliability and service. Provides integrated data management, primary tube sampling and positive patient ID. 5-position rack 300 samples Daily maintenance: <5 minutes per day Scott Erekson (317) scott.erekson@roche.com cobas p 501/cobas p Post Analytical Unit Post analytical units for specimen storage and retrieval 400 tubes/hour Provides automated storage and retrieval for many different sample and tube types in a small footprint. It provides a quick retrieval time for add-on testing and allows a customized disposal process. Includes integrated data management. 5-position rack Adam Sterle (317) Adam.sterle@roche.com cobas c 311 analyzer Photometric, ISE, immunoturbidimetric Substrates, enzymes, ISE, drugs of abuse, therapeutic drugs, specific proteins, whole blood HbA1c Up to 300 results per hour 5 minutes Typically 2-10 µl Other Utility Requirements: Daily Startup Time and Daily Maintenance: Typically once per lot Deionized water Standardized chemistry solution incorporates common reagents and user interface (similar to other cobas modular series analyzers). Combines ease of use and proven Hitachi reliability. Offers integrated data management, open reagent system, primary tube sampling, positive sample ID and onboard dilution. Homogenous 108 position sample disk 42 reagent positions ( tests per c pack) CHEMISTRY/IMMUNOASSAY Up to 100 samples Startup: 5 minutes; daily maintenance: <30 minutes Sheila Brewer (317) Sheila.brewer@roche.com cobas 6000 analyzer series Photometry, ISE, homogeneous immunoassay, immunoturbidimetric, electrochemiluminescence Substrates, enzymes, ISE's, drugs of abuse, therapeutic drugs, specific proteins, whole blood HbA1c, cardiac, thyroid, bone, fertility Up to 1,000 tests per hour for chemistry and 170 tests per hour for immunoassay Assay dependent, 5-27 minutes Typically 2-50 µl your product from others on the market? Typically once per lot Second generation integrated analyzer combining chemistry and immunoassay. Modular design (seven different configurations) for customization. Chemistry or immunoassay modules can be added at a later date. Offers integrated data management, primary tube sampling, open reagent system, positive sample ID and onboard dilution.

8 Tests Assays: Homogeneous immunoassay (chemistry), heterogeneous immunoassay (IA) 5 position rack Up to 60 reagent c-packs ( tests each) and 3 ISE's for chemistry, up to 25 different assays for immunoassay Up to 150 samples Startup: <5 minutes; daily maintenance: <30 minutes Nathan Patton (317) Modular Analytics Photometry, ISE, immunoturbidometry, electrochemiluminescence Substrates, enzymes, ISE, drugs of abuse, therapeutic drugs, specific proteins, cardiac, thyroid, bone, fertility D module: up to 2,400 results per hour; P module: up to 800 results per hour; E module: up to 170 results per hour; ISE up to 1,800 results per hour <5 minutes Typically 2-50 µl IMMUNOASSAY Typically once per lot Integrated modular system consisting of D module for high volume chemistries, P module for all chemistries including esoterics, E module for immunoassay. Modular design for customization and upgrading. Ability to seamlessly connect to automation. Offers integrated data management, primary tube sampling, positive sample ID, onboard dilution and open reagent system. Homogeneous and heterogeneous immunoassay 5-position rack D module: 16 reagent positions (500-4,000 tests); P module: 44 reagent positions (100-1,000 tests); E module: 25 reagent positions ( tests) Up to 300 samples <25 minutes Adam Sterle (317) Adam.sterle@roche.com cobas e 411 analyzer Electrochemiluminescence Cardiac, thyroid, bone, tumor, fertility, infectious disease Up to 88 results per hour 9-18 minutes µl Typically once per lot Fully automated system for low end sensitivity and broad assay ranges. Utilizes common IA reagent packaging and user interface, allowing for minimized training. 9 minute assays available for critical tests including TnT, CK-MB, Myoglobin, HCG and PTH. Offers integrated data management, primary tube sampling, positive sample ID and onboard dilution. Heterogeneous immunoassay (electrochemiluminescence) 5 position rack or 30 position disk Up to 18 reagent positions, tests per kit 75 or 30 samples Siemens Healthcare Diagnostics AUTOMATION Startup: <10 minutes; daily maintenance: <10 minutes Eric LaFleche (914) eric.lafleche@siemens.com ADVIA LabCell /WorkCell Solutions Configuration dependent Configuration dependent Configuration dependent Configuration dependent Configuration dependent Configuration dependent Customizable approach to total laboratory automation. Unique design allows automation to be implemented in stages. Multiple configuration options allow for chemistry, immunoassay, hematology, urinalysis and coagulation instrument connectivity on one platform. Single workstation to review results and monitor instruments. Large onboard menu minimizes need for aliquotting. Each analyzer can function independently. Offers integrated data management, open reagent system, primary tube sampling, positive sample ID and onboard dilution. Samples may be stored in automation racks for archiving and easy retrieval for add on testing. Configuration dependent

9 Laboratory Analyzers buyers guide Tests Assays: your product from other products on the market? CHEMISTRY Puck based Dependent on configuration Configuration dependent Dependent on configuration Tim Keating (302) VersaCell System Multiple instrument configurations with small footprint and flexible layouts. Processes multiple tube sizes simultaneously. Tube centric sample management prioritizes testing by tube rather than by rack. track is required for sample delivery. scheduled maintenance. Connected analyzers are functionally independent allowing. StreamLAB Automation Solution Simplifies sample management with an easy-touse, single operator interface for all sample input, output and status monitoring. Routes individual stat and routine samples to the appropriate analyzer, optimizing throughput and turnaround time. Completed tubes can be sorted and mapped into output racks to enable easy storage, subsequent testing or retrieval. The Workcell is capable of running a wide range of sample tube sizes and types simultaneously without pre-sorting. Multi-tube carrier with RFID 2 chip for continuous, reliable sample tracking. Refrigerated storage and retrieval is also available. Eric LaFleche (914) eric.lafleche@siemens.com ADVIA 1800 Chemistry System End-point, rate reaction, 2-point rate in the U.S. (cont.): your product from others on the market? Barbiturates (Urine) Barbiturates (Serum) Benzodiazepines (Urine) Benzodiazepines (Serum) Cannabinoids (THC) Cocaine Metabolite Ethanol Methadone Methadone Metabolites Opiates Phencyclidine Propoxyphene Salicylate Tricyclic Antidepressants Ammonia Cholinesterase Manual Pretreatment Hemoglobin A1c (HbA1c) Automated Pretreatment Hemoglobin A1c (A1c) Microalbumin Pancreatic Amylase Prealbumin Total Iron Binding Capacity Carbamazepine Digoxin Gentamicin Lithium Phenobarbital Phenytoin Theophylline Tobramycin Valproic Acid Vancomycin Up to 1,800 tests per hour 10 minutes 2-30 µl per test; assay dependent Up to 60 days 200 Basic Metabolic Panels per hour. Automatic Sample Retain technology provides ability to perform repeats, diluitions, and reflex testing without retrieving the primary tube. Comprehensive menu. Consistent cycle times. Point-in-space aspiration offers connectivity to automation track or rack handler without robotics or special hardware. Stat sample prioritization. Direct sampling from track prevents detaining tubes at analyzer and reduces aliquoting. Robust hardware and simplified software design, with automatic calibration validation and tracking. Unique no-maintenance oil bath. Sample integrity checking, including serum indices, short sample and clot detection, reduces manual intervention. Offers integrated data management, open reagent system, primary tube sampling, positive sample ID and onboard dilution. Concentrated reagents provide as many as 3,060 tests in a compact 40 or 70 ml container for maximum productivity. Latex agglutination/centrifugation Onboard 84 position sample wheel, Universal Handler option with universal 5-position rack, 425 total onboard capacity, continuous feed capability, automation track connectivity with unlimited samples 55 tests onboard (including ISEs); test per kit varies by assay Acid Phosphatase Alanine Aminotransferase Alanine Aminotransferase (P5P) Albumin Alkaline Phosphatase (AMP) Alkaline Phosphatase (DEA) Amylase Aspartate Aminotransferase Aspartate Aminotransferase (P5P) Bilirubin, Direct Bilirubin, Total Calcium (Arsenazo) Calcium (CPC) Carbon Dioxide Chloride (ISE) Cholesterol Creatine Kinase Creatinine (Jaffe) Creatinine (Enzymatic) Direct HDL Cholesterol Direct LDL Cholesterol Gamma- Glutamyltransferase (GGT) Glucose Hexokinase Glucose Oxidase Inorganic Phosphorous Iron Lactate Lactate Dehydrogenase (L-P) Lactate Dehydrogenase (P-L) Lipase Magnesium Potassium (ISE) Sodium (ISE) Total Protein Total Protein - Urine/CSF Triglycerides Urea Nitrogen Uric Acid Alpha-1 Antitrypsin Anti-Streptolysin O Apolipoprotein A1 Apolipoprotein B Complement 3 (C3) Complement 4 (C4) C-Reactive Protein (CRP) Wide Range C-Reactive Protein (wr-crp) Cardiophase hscrp Cystatin C Haptoglobin Immunoglobulin A (IgA) Immunoglobulin G (IgG) Immunoglobulin M (IgM) Rheumatoid Factor (RF) Transferrin Acetaminophen Amphetamines Automatic sample retain technology, auto-dilution, auto-reflex testing, auto-repeat testing 5 minutes ADVIA 2400 Chemistry System Endpoint, rate reaction, 2-point rate, multi-point homogeneous immunoassay Acid Phosphatase Alanine Aminotransferase Alanine Aminotransferase (P5P) Albumin Alkaline Phosphatase (AMP) Alkaline Phosphatase (DEA) Amylase Aspartate Aminotransferase Aspartate Aminotransferase (P5P) Bilirubin, Direct Bilirubin, Total Calcium (Arsenazo) Calcium (CPC) Carbon Dioxide Chloride (ISE) Cholesterol Creatine Kinase Creatinine (Jaffe) Creatinine (Enzymatic) Direct HDL Cholesterol Direct LDL Cholesterol Gamma-

10 in the U.S. (cont.): Glutamyltransferase (GGT) Glucose Hexokinase Glucose Oxidase Inorganic Phosphorous Iron Lactate Lactate Dehydrogenase (L-P) Lactate Dehydrogenase (P-L) Lipase Magnesium Potassium (ISE) Sodium (ISE) Total Protein Total Protein - Urine/CSF Triglycerides Urea Nitrogen Uric Acid Alpha-1 Antitrypsin Anti-Streptolysin O Apolipoprotein A1 Apolipoprotein B Complement 3 (C3) Complement 4 (C4) C-Reactive Protein (CRP) Wide Range C-Reactive Protein (wr-crp) Cardiophase hscrp Cystatin C Haptoglobin Immunoglobulin A (IgA) Immunoglobulin G (IgG) Immunoglobulin M (IgM) Rheumatoid Factor (RF) Transferrin Acetaminophen Amphetamines Barbiturates (Urine) Barbiturates (Serum) Benzodiazepines (Urine) Benzodiazepines (Serum) Cannabinoids (THC) Cocaine Metabolite Ethanol Methadone Methadone Metabolites Opiates Phencyclidine Propoxyphene Salicylate Tricyclic Antidepressants Ammonia Cholinesterase Manual Pretreatment Hemoglobin A1c (HbA1c) Automated Pretreatment Hemoglobin A1c (A1c) Microalbumin Pancreatic Amylase Prealbumin Total Iron Binding Capacity Carbamazepine Digoxin Gentamicin Lithium Phenobarbital Phenytoin Theophylline Tobramycin Valproic Acid Vancomycin Up to 2,400 tests per hour COAGULATION in the U.S.: your product from others on the market? Jackie Hauser (847) jacqueline.k.hauser@siemens.com BFT II Coagulation Analyzer Turbido-densitometric system for clotting assays PT, APTT, Fibrinogen N/A, manual system Assay dependent 50 μl Assay dependent. CLIA guidelines recommend calibration at least once every six months. More frequent calibration may be required if QC is outside of the acceptable range or as dictated by local regulations. Unique turbo-densitometric detector tests lipemic and icterica samples accurately, built-in printer and INR printouts for ease of use. Open reagent system. Manual Manual 10 minutes 2-30 µl; assay dependent Up to 60 days A rapid 2-second probe cycle time maximizes tube speed and test throughput. Automatic Sample Retain technology, auto-repeat, autodilution and auto-reflex testing. Point-in-space aspiration offers connectivity to track or rack handler without robotics or special hardware. STAT sample prioritization. Direct sampling from track prevents detaining tubes at analyzer and reduces aliquoting. Sample integrity check for icterus, hemolysis and lipemia. Sample probe with automatic clot/clog detection, liquid level sensing, short sample detection and crash protection. Advances in reagent onboard stability, calibration frequency, interference reduction and linearity expansion. Offers integrated data management, open reagent system, primary tube sampling, positive sample ID and onboard dilution. Concentrated reagents provide as many as 3,060 tests in a compact 40 or 70 ml container. Latex agglutination/centrifugation Onboard 84 position sample wheel, Universal Handler option with universal 5-position rack, 425 total onboard capacity, continuous feed capability, automation track connectivity with unlimited samples. 49 tests onboard (including ISEs); tests per kit varies by assay in the U.S.: your product from others on the market? 4 containers/tests vary Daily maintenance 1 minute Sysmex CA-530 Coagulation Analyzer Optical based system. Clotting and chromogenic methodologies used. PT, APTT, Fibrinogen, TT, Factor Assays, Reptilase time, Protein C clot, AT III, Protein C chromo, Heparin 54 PT tests/hour, 43 PT/APTT tests/hour 7 minutes 50 μl PT Assay dependent. CLIA guidelines recommend calibration at least once every six months. More frequent calibration may be required if QC is outside of the acceptable range or as dictated by local regulations. Smallest footprint in class, low operating expense, 5-parameter true random access with clotting/chomogenic capabilities; integrated data management, open reagent system, primary tube sampling, onboard dilution. Automatic sample retain technology, auto-dilution, auto-reflex testing, auto-repeat testing 11 containers/tests vary 5 minutes Tests Assays: 10 specimens/assays vary

11 Laboratory Analyzers buyers guide Daily maintenance <5 minutes Sysmex CA-560 Coagulation Analyzer Optical based system. Clotting, chromogenic and immunologic methodologies used. PT, APTT, Fibrinogen, TT, Factor Assays, Reptilase time, Protein C clot, AT III, Protein C chromo, Heparin, D-Dimer 54 PT tests/hour, 43 PT/APTT tests/hour 7 minutes 50 μl Assay dependent. CLIA guidelines recommend calibration at least once every six months. More frequent calibration may be required if QC is outside of the acceptable range or as dictated by local regulations. Smallest footprint in its class; onboard quality control package; primary tube sampling; integrated data management; positive sample ID; onboard dilution, specialty assay capability 39 containers/tests vary 50 specimens/assays vary Daily maintenance <5 minutes Sysmex CA-7000 Coagulation Analyzer Optical based system. Clotting, chromogenic and immunologic methodologies used. PT, APTT, Fibrinogen, TT, Reptilase time, Factor Assays, drvvt screen and confirm, Factor V Leiden, Protein C clot, Protein S activity, AT III, Plasminogen, Factor VIII chromo, Alpha-2 Antiplasmin, Protein C chromo, Heparin, D-dimer 280 PT tests/hour, 480 PT/APTT tests/hour 7 minutes 11 containers/tests vary 10 specimens/assays vary Daily maintenance <5 minutes Sysmex CA-1500 Coagulation Analyzer Optical based system. Clotting, chromogenic and immunologic methodologies used. PT, APTT, Fibrinogen, TT, Reptilase time, Factor Assays, drvvt screen and confirm, Factor V Leiden, Protein C clot, Protein S activity, AT III, Plasminogen, Factor VIII chromo, Alpha-2 Antiplasmin, Protein C chromo, Heparin, D-dimer 120 PT tests/hour, 80 PT/APTT tests/hour 7 minutes 50 μl In Specimen/ 50 μl Assay dependent. CLIA guidelines recommend calibration at least once every six months. More frequent calibration may be required if QC is outside of the acceptable range or as dictated by local regulations. Fastest throughput available for routine testing; robust 2nd generation cap-piecing; PT, APTT results every 7 seconds; continuous loading of reagents, consumables and patient samples without interruption; integrated data management; primary tube sampling with cap piercing standard; positive sample ID; onboard dilution. 58 containers/tests vary 100 specimens/assays vary Daily maintenance <5 minutes Assay dependent. CLIA guidelines recommend calibration at least once every six months. More frequent calibration may be required if QC is outside of the acceptable range or as dictated by local regulations. Simultaneous curve calibration and patient testing; robust 2nd generation cap-piecing; ability to load multiple bottles or multiple lots of reagent; integrated data management; primary tube sampling with cap piercing optional; positive sample ID; onboard dilution BCS XP System Optical based system. Clotting, chromogenic and immunologic methodologies used. PT, APTT, Fibrinogen, TT, Reptilase time, Factor Assays, drvvt screen and confirm, Factor V Leiden, Protein C clot, Protein S activity, AT III, Plasminogen, Factor VIII chromo, Alpha-2 Antiplasmin, Protein C chromo, Heparin, D-dimer, BC von Willebrand-risto. Cofactor assay. 380 PT tests/hour, 325 PT/APTT tests/hour <5 minutes 50 μl

12 Assay dependent. CLIA guidelines recommend calibration at least once every six months. More frequent calibration may be required if QC is outside of the acceptable range or as dictated by local regulations. User-definable calibration curve expiration and pre-warning alerts; user-definable barcode utility enables customizable reagent protocols; userfriendly Windows XP software; integrated data management; primary tube sampling; positive sample ID; onboard dilution In Specimen/ Bead/centrifugation 12 reagents onboard; tests per container varies with assay ; cooled area. Up to 100 tests 90 containers/tests vary 5 minutes startup, daily maintenance ~15 minutes IMMUNOASSAY 100 specimens/assays vary Daily maintenance <5 minutes Martu Richards (914) martu.richards@siemens.com IMMULITE 1000 Immunoassay System Enzyme enhanced chemiluminescence ACTH, AFP, Androstenedione, Anti-HBc IgM, Anti-HBc Total, Anti-HBs, Anti-TG Ab, Anti-TPO Ab, Beta-2 Microglobulin, BR-MA (CA 15-3), Calcitonin, Canine TLI, Canine Total T4, Canine TSH, Carbamazepine, CEA, CKMB, Cortisol, C-Peptide, DHEA-SO4, Digoxin, EPO, Estradiol, Ferritin, Folic Acid, Free PSA, Free T3, Free T4, FSH, Gastrin, Growth Hormone (hgh), H. pylori IgG, HBs Ag, HBs Ag confirmatory, HCG, Herpes I & II IgG, High Sensitivity CRP, Homocysteine, IGFBP-3, IGF-I, Insulin, Intact PTH, LH, Microalbumin (urine) (ALB), Myoglobin, OM-MA (CA 125), PAP, Phenobarbital, Phenytoin, Progesterone, Prolactin, PSA, PYRILINKS-D, Rapid TSH, RBC Folate, Rubella IgM, Rubella Quantitative IgG, SHBG, TBG, Theophylline, Third Generation PSA, Third Generation TSH, Thyroglobulin, Thyroid Uptake, Total IgE, Total T3, Total T4, Total Testosterone, Toxoplasma Quant. IgG, Troponin I, Turbo CKMB, Turbo HCG, Turbo Intact PTH, Turbo Myoglobin, Turbo Troponin I, Unconjugated Estriol, Valproic Acid, Vitamin B12 *Under Development, not available for sale: Canine FT4*, CMV IgM*, D-Dimer*,EBV NA IgG*, EBV VCA IgG*, EBV VCA IgM*,aToxoplasma IgM* Up to 120 tests/hour 15 (Turbo assays); minutes (assay dependent) Assay dependent Assay dependent, mostly 2-4 weeks Routine, esoteric and allergy testing. Samples can be continuously processed for improved turnaround times. Stat samples easily added. Remote Diagnostics provides customers with enhanced support and troubleshooting assistance that can reduce downtime. Offers integrated data management and onboard dilution. IMMULITE 2000 Immunoassay System Enzyme-enhanced chemiluminescence 3gAllergy Specific IgE, ACTH, AFP, Androstenedione, Anti-HBc IgM, Anti-HBc Total, Anti-HBs, Anti-TG Ab, Anti-TPO Ab, Beta-2 Microglobulin, BR-MA (CA 15-3), Calcitonin, Canine TLI, Canine Total T4, Canine TSH, Carbamazepine, CEA, CKMB, Cortisol, C-Peptide, DHEA-SO4, Digitoxin, Digoxin, EPO, Estradiol, Ferritin, Folic Acid, Free PSA, Free T3, Free T4, FSH, Gastrin, Growth Hormone (hgh), H. pylori IgG, HBsAg, HBsAg confirmatory, HCG, Herpes I & II IgG, High Sensitivity CRP, Homocysteine, IGFBP-3, IGF-I, Insulin, Intact PTH, LH, Microalbumin (urine) (ALB), Myoglobin, OM-MA (CA 125), PAP, Phenobarbital, Phenytoin, Progesterone, Prolactin, PSA, PYRILINKS-D, Rapid TSH, RBC Folate, Rubella IgM, Rubella, Quantitative IgG, SHBG, TBG, Syphilis, Theophylline, Third Generation PSA, Third Generation TSH, Thyroglobulin, Thyroid Uptake, Total IgE, Total T3, Total T4, Total Testosterone, Toxoplasma IgM, Toxoplasma Quant. IgG, Troponin I, Unconjugated Estriol, Valproic Acid, Vitamin B12 *Under Development, not available for sale: Canine FT4*, CMV IgM*, D-Dimer*, EBV NA IgG*, EBV VCA IgG*, EBV VCA IgM*, HBsAbQuant*, Toxoplasma IgM* Up to 200 tests/hour 35 minutes (assay dependent) Assay dependent 1-4 weeks, assay dependent Routine, esoteric and allergy testing; proprietary wash technique for high sensitivity third-generation assays; no detectable carryover; proactive technical support through RealTime Solutions; integrated data management, primary tube sampling, positive sample ID, proprietary onboard dilution and up to 5 hours of usable walkaway time. Bead/centrifugation 24 reagents onboard; 200 tests per kit

13 Laboratory Analyzers buyers guide 1,000 tests 4 minutes startup; daily maintenance 15 minutes IMMULITE 2500 Immunoassay System Enzyme-enhanced chemiluminescence 3gAllergy Specific IgE, ACTH, AFP, Androstenedione, Anti-TG Ab, Anti-TPO Ab, Beta- 2 Microglobulin, BR-MA (CA15-3), Calcitonin, Carbamazepine, CEA, CKMB, CMV IgG, Cortisol, C-Peptide, DHEA-SO4, Digoxin, EPO, Estradiol, Ferritin, Folic Acid, Free T3, Free T4, FSH, Gastrin, Growth Hormone (hgh), H. pylori IgG, HCG, Herpes I & II IgG, High Sensitivity CRP, Homocysteine, IGFBP-3, IGF-I, Insulin, Intact PTH, LH, Microalbumin (urine) (ALB), Myoglobin, OM-MA (CA125), Phenobarbital, Phenytoin, Progesterone, Prolactin, PSA, PYRILINKS-D, Rapid TSH, RBC Folate, Rubella IgM, Rubella Quantitative IgG, SHBG, TBG, Theophylline, Third Generation PSA, Third Generation TSH, Thyroglobulin, Thyroid Uptake, Total IgE, Total T3, Total T4, Total Testosterone, Toxoplasma IgM, Toxoplasma Quant. IgG, Troponin I, Turbo CKMB, Turbo Intact PTH, Turbo Myoglobin, Turbo Troponin I, Unconjugated Estriol, Valproic Acid, Vitamin B12. Direct Chemiluminescence Cortisol (Urine, Serum), Cortisol (Urine) Cortisol (Serum), Total IgE, Ferritin, RBC Folate, Folic Acid/ Folate, VB12, Homocysteine, Myoglobin, TnI- Ultra, BNP, CK-MB, Insulin, C-Peptide (Serum), C-Peptide (Urine), HAV-IgM, Carbamazepine, Digoxin, Gentamicin, Theophylline, Tobramycin, Valproic Acid, Vancomycin, AFP, CA 15-3, CEA, PSA, Complexed PSA, BR 27-29, CA125II, CA19-9, free T4, free T3, ipth, T3, T4, TSH, TSH-3, T-Uptake, Estradiol-6 III, FSH, HCG (Total HCG), LH, Progesterone, Prolactin, Total Testosterone Up to 180 tests per hour in random access or batch 15 minutes Varies by test Assay dependent, 3-28 days Optimal productivity, speed and efficiency and the power to process up to 180 tests per hour; 15 refrigerated onboard reagents, 84 sample onboard capacity, and no pause loading/unloading of samples, reagents and consumables. Offers integrated data management, primary tube sampling, positive sample ID and onboard dilution. Random access Magnetic particle 5 µl *Under Development, not available for sale: none Up to 200 tests/hour 15 minutes (stat assays); minutes (routine, assay dependent) 1-4 weeks, assay dependent Routine, esoteric and allergy testing; proprietary wash technique for high sensitivity thirdgeneration assays; no detectable carryover; technical support through RealTime Solutions; stat testing; integrated data management; primary tube sampling; positive sample ID; proprietary onboard dilution; up to 5 hours of usable walkaway time. 15 reagents with tests per container (assay dependent) Refrigerated reagents with barcode identification, automatic inventory tracking and flagging, calibration validity tracked and flagged, reagent on board residency tracked and flagged, reagent expired/low flags. 400 tests daily startup; 15 minutes daily maintenance Tests Assays: Bead/centrifugation 24 reagents onboard; 200 tests per kit 1,000 test walkaway capacity; 5 hours of usable walkaway time 4 minutes daily startup; daily maintenance ~15 minutes Louise Chang (310) x7035 louise.chang@siemens.com ADVIA Centaur XP Immunoassay System Direct chemiluminescence Total IgE, Ferritin, RBC Folate, Folic Acid/Folate, Vitamin B12, BNP, CK-MB, Homocysteine, Myoglobin, TnI- Ultra, C-Peptide (Serum), C-Peptide (Urine), Insulin, HAV Total, HAV IgM, HBc Total, HBc IgM, Anti-HBs, HBsAg, HBsAg Confirmatory, HCV, HIV Enhanced (1/O/2), Rubella IgG, Rubella IgM, Toxoplasma IgG, Toxoplasma IgM, Cortisol (Urine), Cortisol (Serum), AFP, Estradiol-6, Estradiol-6 III, FSH, HCG (Total HCG), LH, Progesterone, Prolactin,, Total Testosterone, Carbamazepine, Digitoxin, Digoxin, Gentamicin, Phenobarbital, Phenytoin, Theophylline, Tobramycin, Valproic Acid, Vancomycin, Free T3, Total T3, Free T4, Total T4, Intact PTH, Anti-TG, Anti-TPO, Thyroid Uptake, TSH, Third Generation TSH, BR27-29, CEA, CA15-3, CA125II, CA19-9, Her-2/neu, PSA, Complexed PSA Up to 240 tests/hour 18 minutes, then every 15 seconds thereafter ADVIA Centaur CP Immunoassay System 10 µl to 200 µl; assay dependent

14 Other Utility Requirement: INTEGRATED SYSTEMS Assay dependent, 7-42 days; most assays are 28 days Deionized water Comprehensive disease state menu including HIV; disposable pipette tips that eliminate sampleto-sample carryover, automatic dilution, repeat and reflex testing; Smart Algorithm Software automatically repeats and confirms reactive infectious disease tests. Offers integrated data management, primary tube sampling, positive sample ID and onboard dilution. Magnetic particle 5 position universal rack 30 refrigerated onboard reagents; tests/kit (assay dependent) 840 test walkaway capacity, ready to use daily start-up; automated daily maintenance is 40 minutes with 5 minutes of hands-on time Christina Tassone christina.tassone@siemens.com Dimension EXL with LOCI Module Integrated Chemistry Analyzer LOCI, ACMIA, EMIT, PETINIA, photometry, potentiometry Acid Phosphatase, Albumin, Alcohol, Alkaline Phosphatase, Ammonia, Amphetamines DAT, Automated LDL, Acetaminophen, Amylase, Automated HDL, Barbiturate DAT, Benzodiazepine DAT, Blood Urea Nitrogen, C-Reactive Protein, C3, C4, Calcium, Carbamazepine, CardioPhase hscrp Flex, CRP, Cholesterol, Cocaine DAT, Creatine Kinase MB, Creatine Kinase Revised, Creatinine, Cyclosporine, Cyclosporine A Extended Range, Digotoxin, Digoxin, Direct Bilirubin, Ecstasy, Enzymatic Carbonate, Ferritin, Free PSA, Glucose,GGT, GOT/ AST, GPT/ALT, Gentamicin, HCG, Hemoglobin A1C Kit, IBCT (-pre-treat), IgA, IgG, IgM, Iron, LOCI FT4, LOCI NT-proBNP, LOCI TSH, LOCI Troponin I, Lactate Dehydrogenase, Lactic Acid, Lidocaine, Lipase, Lithium, Microalbumin, MMB, Magnesium, Methadone DAT, Myoglobin, NAPA, Opiate DAT, Phencyclidine DAT, Phenobarbital, Phenytoin, Phosphorus, Prealbumin, Procainamide, Propoxyphene DAT, Pseudocholinesterase, Salicylate, Serum Barbiturates, Serum Benzodiazepines, Serum Tricyclic Antidepressants, Sirolimus, THC DAT, TPSA, Tacrolimus, Theophylline, Thyronine Uptake, Thyroxine, Tobramycin, Total Bilirubin, Total Iron Binding Capacity, Total Protein, Transferrin, Triglycerides, Uric Acid, Urine CFP, Valproic Acid, Vancomycin 624 tests/hour <60 seconds 5, 7 and 10 ml primary tubes days Other utility requirement: Analyzer integrates homogeneous LOCI and heterogeneous immunoassays onboard with other chemistries; allows a single platform for over 95 percent of most requested tests; eliminates sample splitting between general chemistry tests and immunoassays; integration of Lean design concepts with no specimen pretreatment or reagent preparation by the operator; fully automated onboard ISD assays. Offers integrated data management, open reagent system, primary tube sampling, positive sample ID and onboard dilution Deionized water NCCLS Type 2 Batch, random access, continuous random access Magnetic particle; all LOCI and EMIT methods are homogenous Segmented sample wheel 91/ specimens / 6,000 tests System startup not required. Daily maintenance is <5 minutes. Dimension RxL Max w/hm Integrated Chemistry Analyzer Photometry, potentiometry, ACMIA, EMIT, PETINIA Acid Phosphatase, Albumin, Alcohol, Alkaline Phosphatase, Ammonia, Amphetamines DAT, Automated LDL, Acetaminophen, Amylase, Automated HDL, Barbiturate DAT, Benzodiazepine DAT, Blood Urea Nitrogen, C-Reactive Protein, C3, C4, Calcium, Carbamazepine, CardioPhase hscrp Flex, CRP, Cholesterol, Cocaine DAT, Creatine Kinase MB, Creatine Kinase Revised, Creatinine, Cyclosporine, Cyclosporine A Extended Range, Digotoxin, Digoxin, Direct Bilirubin, Ecstasy, Enzymatic Carbonate, Ferritin, Free PSA, Free T4, Glucose,GGT, GOT/AST, GPT/ALT, Gentamicin, HCG, Hemoglobin A1C Kit, IBCT (-pre-treat), IgA, IgG, IgM, Iron, NT-proBNP, Lactate Dehydrogenase, Lactic Acid, Lidocaine, Lipase, Lithium, Microalbumin, MMB, Magnesium, Methadone DAT, Myeloperoxidase, Myoglobin, NAPA, Opiate DAT, Phencyclidine DAT, Phenobarbital, Phenytoin, Phosphorus, Prealbumin, Procainamide, Propoxyphene DAT, Pseudocholinesterase, Salicylate, Serum Barbiturates, Serum Benzodiazepines, Serum Tricyclic Antidepressants, Sirolimus, THC DAT, TPSA, TSH, Tacrolimus, Theophylline, Thyronine Uptake, Thyroxine, Tobramycin, Total Bilirubin, Total Iron Binding Capacity, Total Protein, Total T3, Transferrin, Triglycerides, Troponin I, Uric Acid, Urine CFP, Valproic Acid, Vancomycin 800 tests/hour photometric and potentiometric, 167 heterogeneous immunoassay tests/hour 36 seconds 21 minutes 5, 7 and 10 ml primary tubes, small sample cups days

15 Laboratory Analyzers buyers guide Integrates heterogeneous immunoassays onboard with other chemistries; allows single platform for over 95 percent of most requested tests; eliminates sample splitting between general tests and immunoassays; fully automated onboard ISD assays. Offers integrated data management, open reagent system, primary tube sampling, positive sample ID and onboard dilution; integration of Lean design concepts with no specimen pre-treatment or reagent preparation by the operator. EIA, latex particle turbidimetric, direct turbidimetric/ heterogeneous-magnetic particle, homogenous (none) Segmented sample wheel with rack system 47 reagents, 91 reagents with optional reagent management system/ specimens / 6,000 tests System startup not required. Daily maintenance is <5 minutes. in the U.S. (con.): (MPA), Tacrolimus (no manual pretreatment), Sirolimus, 1-Acid Glycoprotein (Orosomucoid), Antistreptolysin, C3 Complement, C4 Complement, C-Reactive Protein, C-Reactive Protein Extended Range, Haptoglobin, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Rheumatoid Factor, Transferrin, Ammonia, Urine/Cerebrospinal Fluid, Protein, Lactic Acid, Prealbumin, Human Chorionic Gonadotropin Hormone, Ferritin, Total PSA, Free PSA 437 photometric and potentiometric tests per hour, 167 heterogeneous IA tests per hour 60 seconds 21 minutes 5, 7 and 10 ml primary tubes and small sample cups days Low-volume workstation that integrates immunoassays onboard with other chemistries, utilizes a single reagent format to meet over 95 percent of testing needs. Offers integrated data management, open reagent system, primary tube sampling, positive sample ID and onboard dilution. Low volume reagent configuration option available for Troponin I, NT-proBNP and HCG assays. Integration of Lean design concepts with no specimen pre-treatment or reagent preparation by the operator, no sample splitting or aliquotting, automated calibration and control processes, and fully automated ISD assays onboard. Jason F. Ong (847) jason.f.ong@siemens.com Dimension Xpand Plus Integrated Chemistry Analyzer Photometry, potentiometry, ACMIA, EMIT, PETINIA Albumin, Calcium, Creatinine, Creatinine Enzymatic, Direct Bilirubin, Iron, Magnesium, Phosphorus, Total Bilirubin,, Total Iron-Binding Capacity (no manual pretreatment), Total Protein, Urea Nitrogen, Uric Acid, Enzymatic Carbon Dioxide (CO2), Chloride, Potassium, Sodium, Acid Phosphatase, Alanine Aminotransferase, Aldolase1,3, Alkaline Phosphatase, Amylase, Aspartate Aminotransferase, Creatine Kinase, Creatine Kinase MB Isoenzyme, Dibucaine Number, Glutamyl Transferase, Lactic Dehydrogenase, Lipase, Pancreatic Amylase, Pseudocholinesterase, Hemoglobin A1c (no manual pretreatment), Glucose, Glucose from Hemolysate, Microalbumin, Cardiac Troponin I, Mass CK-MB, Myoglobin, NT-proBNP, Apolipoprotein A1 1, Apolipoprotein B 1, CardioPhase hscrp, Cholesterol, High Density Lipoprotein, Cholesterol, Low Density Lipoprotein, Cholesterol, Lp(a)1,3, Myeloperoxidase, Triglycerides, Thyroid Stimulating Hormone, Thyronine Uptake, Total T3, Total T4, Free T4, Urine Amphetamine Screen, Urine Barbiturates Screen, Urine Benzodiazepines Screen, Urine Cannabinoids Screen, Urine Cocaine, Metabolite Screen, Urine Ecstasy, Urine Methadone Screen, Urine Methaqualone Screen, Urine Opiates Screen, Urine Phencyclidine, Urine Propoxyphene Screen, Acetaminophen, Ethyl Alcohol, Salicylate, Serum Barbiturates, Serum Benzodiazepines, Serum Tricyclic, Antidepressants, Gentamicin, Tobramycin, Vancomycin, Digoxin, Digitoxin, N-Acetylprocainamide (NAPA), Lidocaine, Procainamide, Carbamazepine, Lithium, Phenobarbital, Phenytoin, Theophylline, Valproic Acid, Cyclosporine (CsA C0) (no manual pretreatment), Cyclosporine Extended Range, (CsA C2) (no manual pretreatment), Mycophenolic Acid Other utility requirement: Deionized water NCCLS Type 2 Heterogeneous-magnetic particle Segmented sample wheel with rack system 47/ / 6,000 routine startup, 10 minutes daily maintenance with 5 minutes hands-on time Colleen Grier (302) colleen.m.grier@siemens.com Dimension Vista 1500 and 3000T Intelligent Lab System LOCI Advanced Chemiluminescence, photometry, nephelometry, EMIT technology, heterogeneous immunoassay (ACMIA, PETINIA, PETIA), turbidimetric, V-LYTE multisensor - potentiometry a1acid Glycoprotein (Orosomucoid), a1antitrypsin, a1microglobulin, Acetaminophen, Alanine Transaminase, Albumin, Alkaline Phosphatase, Ammonia, Amylase, Antistreptolysin O, Apolipoprotein A1, Apolipoprotein B, Aspartate Transaminase, ß2Microglobulin, Blood Urea Nitrogen, C Reactive Protein, C3 Complement, C4 Complement, Calcium, Carbamazepine, Carbon Dioxide, Ceruloplasmin, Chloride, Cholesterol, Creatine Kinase, Creatine Kinase MB Isoenzyme,

16 in the U.S. (con.): Creatinine, Cyclosporine, Cyclosporine extended, Cystatin C, Digitoxin, Digoxin, Direct Bilirubin, Ethyl Alcohol, Gamma Glutamyl Transaminase, Gentamicin, Glucose, Haptoglobin, Hemoglobin A1C, High Density Lipoprotein Cholesterol, High Sensitivity CRP (CardioPhase hscrp), Homocysteine, Immunoglobulin E, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Iron, Lactate Dehydrogenase, Lactic Acid, Lidocaine, Lipase, Lithium, LOCI Beta Human Chorionic Gondatropin, LOCI Alpha feto-protein, LOCI Carcinoembryonic Antigen, LOCI Cardiac Troponin I, LOCI Ferritin, LOCI Free Thyroxine, LOCI Free Triiodothyronine, LOCI Mass Creatine Kinase MB Isoenzyme, LOCI Myoglobin, LOCI N-terminal probrain natriuretic peptide, LOCI Thyroid Stimulating Hormone, Low Density Lipoprotein Cholesterol, Magnesium, Microalbumin, N-acetyl Procainamide, Phenobarbital, Phenytoin, Phosphorus, Potassium, Prealbumin (Transthyretin), Procainamide, Pseudocholinesterase, Total Kappa Light Chains,Total Lambda Light Chains, Specialty albumin, Rheumatoid Factor, Serum Barbiturates*, Serum Benzodiazepines*, Serum Salicylate, Serum Tricyclic Antidepressants*, Sodium, Soluble Transferrin Receptor, Theophylline, Thyronine Uptake, Thyroxine, Tobramycin, Total Bilirubin, Total Iron Binding Capacity, Total Protein, Transferrin, Triglyceride, Triiodothyronine, Uric Acid, Urinary/ Cerebrospinal Fluid Protein, Urine Amphetamine, Urine Barbiturates, Urine Benzodiazepines, Urine Cocaine, Urine Ecstasy, Urine Methadone, Urine Methaqualone*, Urine Opiate, Urine Phencyclidine, Urine Propoxyphene* (*Syva Emit applications) Up to 1,500 tests per hour for the Vista 1500 and up to 3,000 test per hour for the Vista 3000T System Varies by method: 22 seconds-21 minutes Method dependent (< 1-20 µl) days method dependent. Automatic calibration for hands-off operation with method specific user-selected criteria with calibration materials stored onboard the system. Automatic monitoring of calibration frequency. Ultra-integrated system with 4 detectors (including nephelometry and LOCI Advanced chemiluminescence) for concurrent processing of over 100 assays; continuous sample loading of routine and stat specimens without interruption. Onboard aliquot system for quick return of primary specimen and automatic onboard sample dilution/rerun capability. Samples require no manual pretreatment and reagents require no manual preparation. Automatic Calibration & QC processing with onboard calibrators and QC in vials. Windows-based fully multitasking software with online reference for training, maintenance and troubleshooting; real-time system monitoring for predictive, proactive service. EasyLink middleware system for result and QC management, including autoverification of patient results. Ability to twin systems (3000T) to optimize workflow and turnaround time. Ability to connect to StreamLAB automation system for pre-analytical sample processing. Homogeneous (none), magnetic particle. Six position sample rack allows for intermix of various tube types and cups. Onboard sample aliquot used to automate specimen dilutions and reruns. Priority loading for stat and whole blood samples with dual clot check and level sense. Vista 1500 has 166 slots for reagents, calibrators and/or QC materials. Vista 3000T has double the capacity/ 20 1,200 tests per Reagent Flex cartridge. 200 sample tubes per hour with continuous loading/over 100 test methods/over 20,000 tests. Reagents can be loaded during operation. Daily minutes, no weekly, monthly minutes. Intelligent device management monitoring through RealTime SolutionsSM for remote, proactive predictions of maintenance needs. Pamela Curtin pamela.curtin@siemens.com Dimension Vista 500 and 1000T Intelligent Lab System LOCI Advanced Chemiluminescence, photometry, nephelometry, EMIT technology, heterogeneous immunoassay (ACMIA, PETINIA, PETIA), turbidimetric, V-LYTE multisensor - potentiometry a1acid Glycoprotein (Orosomucoid), a1antitrypsin, a1microglobulin, Acetaminophen, Alanine Transaminase, Albumin, Alkaline Phosphatase, Ammonia, Amylase, Antistreptolysin O, Apolipoprotein A1, Apolipoprotein B, Aspartate Transaminase, ß2Microglobulin, Blood Urea Nitrogen, C Reactive Protein, C3 Complement, C4 Complement, Calcium, Carbamazepine, Carbon Dioxide, Ceruloplasmin, Chloride, Cholesterol, Creatine Kinase, Creatine Kinase MB Isoenzyme, Creatinine, Cyclosporine, Cyclosporine extended, Cystatin C, Digitoxin, Digoxin, Direct Bilirubin, Ethyl Alcohol, Gamma Glutamyl Transaminase, Gentamicin, Glucose, Haptoglobin, Hemoglobin A1C, High Density Lipoprotein Cholesterol, High Sensitivity CRP (CardioPhase hscrp), Homocysteine, Immunoglobulin E, Immunoglobulin A, Immunoglobulin G, Immunoglobulin M, Iron, Lactate Dehydrogenase, Lactic Acid, Lidocaine, Lipase, Lithium, LOCI Beta Human Chorionic Gondatropin, LOCI Alpha feto-protein, LOCI Carcinoembryonic Antigen, LOCI Cardiac Troponin I, LOCI Ferritin, LOCI Free Thyroxine, LOCI Free Triiodothyronine, LOCI Mass Creatine Kinase MB Isoenzyme, LOCI Myoglobin, LOCI N-terminal probrain natriuretic peptide, LOCI Thyroid Stimulating Hormone, Low Density Lipoprotein Cholesterol, Magnesium, Microalbumin, N-acetyl Procainamide, Phenobarbital, Phenytoin, Phosphorus, Potassium, Prealbumin (Transthyretin), Procainamide, Pseudocholinesterase, Total Kappa Light Chains,Total Lambda Light Chains, Specialty albumin, Rheumatoid Factor, Serum Barbiturates*, Serum Benzodiazepines*, Serum Salicylate, Serum Tricyclic Antidepressants*, Sodium, Soluble Transferrin Receptor, Theophylline, Thyronine Uptake, Thyroxine, Tobramycin, Total Bilirubin, Total Iron Binding Capacity, Total Protein, Transferrin, Triglyceride, Triiodothyronine, Uric Acid, Urinary/ Cerebrospinal Fluid Protein, Urine Amphetamine, Urine Barbiturates, Urine Benzodiazepines, Urine Cocaine, Urine Ecstasy, Urine Methadone, Urine Methaqualone*, Urine Opiate, Urine Phencyclidine, Urine Propoxyphene* (*Syva Emit applications)

17 Laboratory Analyzers buyers guide Up to 1,000 tests per hour for the Vista 500 and up to 2,000 test per hour for the Vista 1000T System Varies by method: 22 seconds-21 minutes Method dependent (<1-20 µl) days method dependent. Automatic calibration for hands-off operation with method specific user-selected criteria with calibration materials stored onboard the system. Automatic monitoring of calibration frequency. Ultra-integrated system with 4 detectors (including nephelometry and LOCI Advanced chemiluminescence) for concurrent processing of over 100 assays; continuous sample loading of routine and stat specimens without interruption. Onboard aliquot system for quick return of primary specimen and automatic onboard sample dilution/rerun capability. Samples require no manual pretreatment and reagents require no manual preparation. Automatic Calibration & QC processing with onboard calibrators and QC in vials. Windows-based fully multitasking software with online reference for training, maintenance and troubleshooting; and real-time system monitoring for predictive, proactive service. EasyLink middleware system for result and QC management, including autoverification of patient results. Ability to twin systems (1000T) to optimize workflow and turnaround time. 120 CBC samples per hour/74 retics per hour 2.5 minutes 157 whole blood, 300 CSF Minimum of every 6 months Manual open-tube and closed-tube sampling; small reagent consumption; flexible rack- based autosampler; dual WBC methodology, dual Hgb methodology, optional MultiSpecies test selectivity software supports 23 species and strains plus 30 user-definable species; CSF assay performs automated RBC and WBC differential; system integrates with ADVIA Autoslide (sold separately). Dependent on configuration 150 specimens/1,800 CBC/Automated Diffs Homogeneous (none), magnetic particle Startup <2 minutes; daily wash cycles 6.5 minutes each HEMATOLOGY Six position sample rack allows for intermix of various tube types and cups. Onboard sample aliquot used to automate specimen dilutions and reruns. Priority loading for stat and whole blood samples with dual clot check and level sense. Vista 500 has 144 slots for reagents, calibrators and/or QC materials. Vista 1000T has double the capacity. 20-1,200 tests per Reagent Flex cartridge. 200 sample tubes per hour with continuous loading/over 100 test methods/over 20,000 tests. Reagents can be loaded during operation. Daily minutes; monthly minutes. Intelligent device management monitoring through RealTime SolutionsSM for remote, proactive predictions of maintenance needs. Rita White (302) rita.f.white@siemens.com ADVIA 2120i Hematology System with Autoslide Cytochemistry, flow cytometry, laser light scatter WBC, RBC, Hgb, Hct, MCV, MCH, MCHC, Plt, CHCM, RDW, HDW, CH, CHDW, N#, N%, L#, L%, M#, M%, E#, E%, B#, B%, LUC#, LUC%, Retic#, Retic%, MCVr, CHCMr, CHr, RBC morphology (NRBC, ANISO, MICRO, MACRO, HC VAR, HYPO, HYPER, RBC Fragments, RBC Ghosts, Platelet Clumps, Large Platelets) and WBC morphology (Left Shift, Atypical Lymph, Blasts, Immature Granulocytes, Myeloperoxidase Deficiency), CSF WBC, CSF RBC, CSF PMN, CSF MN, CSF N# and N%, CSF L# and L%, CSF M# and M% ADVIA 120 Hematology System Cytochemistry, flow cytometry, laser light scatter WBC, RBC, Hgb, Hct, MCV, MCH, MCHC, Plt, CHCM, RDW, HDW, CH, CHDW, N#, N%, L#, L%, M#, M%, E#, E%, B#, B%, LUC#, LUC%, Retic#, Retic%, MCVr, CHCMr, CHr, RBC morphology (NRBC, ANISO, MICRO, MACRO, HC VAR, HYPO, HYPER, RBC Fragments, RBC Ghosts, Platelet Clumps, Large Platelets) and WBC morphology (Left Shift, Atypical Lymph, Blasts, Immature Granulocytes, Myeloperoxidase Deficiency), CSF WBC, CSF RBC, CSF PMN, CSF MN, CSF N# and N%, CSF L# and L%, CSF M# and M% 120 CBC samples per hour/74 retics per hour 2.5 minutes 157 whole blood, 300 CSF Minimum of every 6 months Manual open-tube and closed-tube sampling; small reagent consumption; flexible rack-based autosampler; dual WBC methodology, dual Hgb methodology, optional MultiSpecies test selectivity software supports 23 species and strains plus 30 user-definable species; CSF assay performs automated RBC and WBC differential; system integrates with ADVIA Autoslide (sold separately). Dependent on configuration

18 150 specimens/1,800 CBC/automated diffs Startup <2 minutes; daily wash cycles 6.5 minutes each URINALYSIS in the U.S. (cont.): John Ebbs (352) CLINITEK AUWi Automated Urinalysis System*, CLINITEK Atlas Automated Urine Chemistry Analyzer *Only available in the U.S., Canada and Puerto Rico. Dry pad test measure, refractive index, fluorescent flow cytometry, laser light scatter Leukocyte Esterase, Nitrite, Occult Blood, Protein, Glucose, Ketones, Urobilinogen, Bilirubin, ph, Specific Gravity, Color, Clarity, WBC, RBC, Epithelial Cells, Hyaline Casts, Bacteria, Pathological casts, Crystals, Small Round Cells, Sperm, Yeast 80 samples an hour on the AUWi, up to 225 an hour on the stand alone Atlas 4 minutes on the AUWi, <1 minute on a standalone Atlas 4 ml on the AUWi, 2 ml on a standalone Atlas Minimum of every 6 months Streamlines workflow, unattended operation, enhanced clinical results Dependent on configuration 100 specimens on the AUWi, 200 on the Atlas Startup: <2 minutes; daily wash cycle: 10 minutes each