9:15-9:30 WELCOME Paula Alves (Conference Chair) & Lino Ferreira (SPCE-TC President)

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Scientific Programme DAY 1 - Thursday, 15 th October, 2015 8:30-13:00 REGISTRATION Set up of posters and exhibition area 9:15-9:30 WELCOME Paula Alves (Conference Chair) & Lino Ferreira (SPCE-TC

1 Scientific Programme DAY 1 - Thursday, 15 th October, :30-13:00 REGISTRATION Set up of posters and exhibition area 9:15-9:30 WELCOME Paula Alves (Conference Chair) & Lino Ferreira (SPCE-TC President) 9:30-10:30 OPENING KEYNOTE LECTURE Chair: Joana Paredes (IPATIMUP, Portugal) Delta One T cells for leukemia immunotherapy: clinical-grade expansion, differentiation and in vivo proof-of-concept Bruno Silva-Santos (IMM, FMUL & Lymphact, Portugal) 10:30-10:45 COFFEE BREAK SESSION 1: NICHES AND SIGNALING IN DEVELOPMENT AND DISEASE Sponsored by Grupo Tecnimede Chairs: Perpétua Pinto-do-Ó (i3s & INEB, Portugal) Catarina Brito (ibet & ITQB-NOVA, Portugal) 10:45-11:10 INVITED LECTURE I Programming Definitive Hematopoiesis Filipe Pereira (CNC-UC, Portugal) 11:10-11:25 O1 Cell surface map of the developing mouse heart Tatiana Resende (I3S & INEB, Portugal) 11:25-11:40 O2 Fine-tuning neurogenesis: apoptosis-related microrna regulatory networks Ana L. Morgado (imed.ul, Portugal) 11:40-11:55 O3 Global & targeted DNA demethylation during ipsc reprogramming Inês Milagre (The Babraham Institute, Cambridge, UK) 11:55-12:10 O4 The neurotrophic factor receptor RET drives HSC survival & function Sílvia Arroz-Madeira (IMM, FMUL, Portugal) 12:10-12:35 INVITED LECTURE II Signaling pathways and players in cardiogenesis: from embryonic heart fields to cardiac cells and secreted molecules José Belo (CEDOC-NOVA Medical School, Portugal) 12:35-13:30 LUNCH 13:30-15:00 POSTER SESSION & EXHIBITION

2 13:30-14:15 POSTER SESSION ODD NUMBERS 14:15-15:00 POSTER SESSION EVEN NUMBERS SESSION 2: STEM CELL METABOLISM Sponsored by MERCK Chairs: Luís Almeida (CNC-UC, Portugal) Ana Teixeira (ibet & ITQB-NOVA, Portugal) 15:00-15:25 INVITED LECTURE III Metabolic remodeling during oligodendrocyte precursor cell differentiation Ana Amaral (Welcome Trust - MRC Cambridge Stem Cell Institute, University of Cambridge, UK) 15:25-15:40 O5 Carbon monoxide improves neuronal differentiation in NT2 cell line by reinforcement of oxidative phosphorilation Ana S. Almeida (CEDOC-NOVA Medical School, Portugal) 15:40-15:55 O6 P-cadherin expression: its role in the regulation of metabolic properties of breast cancer stem cells Bárbara Sousa (IPATIMUP and ICBAS, Portugal) 15:55-16:10 O7 MFA of neuronal stem cells and astrocytes derived from ESCs João V. Sá (ibet & ITQB-NOVA, Portugal) 16:10-16:25 O8 StemCellNet: an interactive platform for network-oriented investigations in stem cell biology Matthias E. Futschik (UAlg, Portugal) 16:25-16:50 COFFEE BREAK & EXHIBITION SESSION 3: TARGETING UNMET MEDICAL NEEDS WITH ADVANCED CELL THERAPIES Sponsored by Bial Chairs: Cláudia Lobato da Silva (IBB & IST-UL, Portugal) Vítor E. Santo (ibet & ITQB-NOVA, Portugal) 16:50-17:15 INVITED LECTURE IV Self-assembled liver organoids recapitulate hepato-biliary organogenesis in vitro Pedro Baptista (Aragon Health Sciences Institute & Aragon Biomedical Research Institute, Zaragoza, Spain) 17:15-17:30 O9 Modulating cell activity by opto-nanomedicine Miguel M. Lino (CNC-UC and Biocant, Portugal) 17:30-17:45 O10 Transplantation of cerebellar neural stem cells alleviates neuropathology and motor impairments in Machado Joseph Disease mice Luís Pereira de Almeida (CNC-UC, Portugal)

3 17:45-18:00 O 11 A small molecule approach to engineering vascularized tissue Hugo Fernandes (CNC-UC, Portugal) 18:00-18:15 O12 MicroRNA-loaded nanoparticles induce subventricular zone neurogenesis in a mouse model for Parkinson's disease Cláudia M. Saraiva (CICS, Portugal) 18:15-18:30 O13 Neural Stem Cell Culture in Electrospun nanofibers: morphology and cell organization Miriam C. A. Sousa (IBB & IST-UL, Portugal) 18:30-18:55 INVITED LECTURE V Exploring functional genomics for the development of novel approaches for cardiac regeneration Miguel Mano (ICGEB, Italy & UC-Biotech, CNC, Portugal) 20:00 CONFERENCE DINNER

4 DAY 2-16 th October 8:30-9:30 SPCE-TC GENERAL ASSEMBLY (MEMBERS ONLY) SESSION 4: STEM CELL MANUFACTURING Sponsored by Medinfar Chairs: Pedro Cruz (ECBio) Francisco dos Santos (Cell2B, Portugal) Margarida Serra (ibet & ITQB-NOVA, Portugal) 9:30-9:55 INVITED LECTURE VI Cell-based gene delivery leverages conventional immunotherapy for cancer: Treatment of Advanced Gastrointestinal Cancer in a Phase I/II trial with modified autologous MSC_apceth_101 Volker Scherhammer (apceth GmbH & Co. KG, Germany) 9:55-10:10 O14 Scalable production of mesenchymal stem/stromal cells from different human sources in microcarrier-based stirred culture systems Ana Fernandes-Platzgummer (IBB & IST-UL, Portugal) 10:10-10:25 O15 Exploring integrated strategies for downstream processing of hmsc Bárbara Cunha (ibet & ITQB-NOVA, Portugal) 10:25-10:40 O16 Spatial and temporal control of cell aggregation efficiently directs hpsc towards neural commitment Cláudia C. Miranda (IBB & IST-UL, Portugal) 10:40-10:55 O17 Integrated strategies for the production, maturation and storage of functional cardiomyocytes derived from human pluripotent stem cells Cláudia Correia (ibet & ITQB-NOVA, Portugal) 10:55-11:20 COFFEE BREAK & EXHIBITION SESSION 5: CELLS AS PRODUCTS: VALIDATION AND QUALIFICATION Sponsored by Laboratórios Azevedos Chairs: Lino Ferreira (CNC UC, Portugal) Patrícia Gomes-Alves (ibet & ITQB-NOVA, Portugal) 11:20-11:45 INVITED LECTURE VII Cell therapy: moving to clinics a regulatory perspective Ivana Haunerova (State Institute for Drug Control, Czech Republic) 11:45-12:00 O18 The vulnerability of smooth muscle cells derived from Hutchinson- Gilford Progeria Syndrome (HGPS) ipscs to arterial flow shear stress is mediated by metalloproteases Patricia Pitrez (CNC-UC, Portugal) 12:00-12:15 O19 Enabling diffusion and adoption of Cell Therapies innovation under Medicines Adaptive Pathways: risk-based judgment and evidence generation under imperfection in the era of personalized medicine Miguel Amador (IN+, IST, Portugal)

5 12:15-12:30 O20 ClinUCX project: research and development of a cell product (UCX) for clinical use on advanced therapy of cardiovascular diseases Helder Cruz (ECBio S.A., Portugal) 12:30-13:00 POSTER SNAPSHOT PRESENTATIONS Poster session organizers: Bárbara Cunha (ibet & ITQB-NOVA, Portugal) Cláudia Correia (ibet & ITQB-NOVA, Portugal) Daniel Simão (ibet & ITQB-NOVA, Portugal) 13:00-13:45 LUNCH 13:45-14:45 POSTER SESSION & EXHIBITION WORKSHOP: MOVING CELL THERAPIES TO THE CLINIC CLINICAL CHALLENGES & INDUSTRY HIGHLIGHTS Sponsored by ibet Workshop organizers: Manuel Carrondo (ibet & FCT-NOVA, Portugal) Joaquim Sampaio Cabral (IBB & IST-UL, Portugal) 14:45-15:00 Manuel Abecasis (IPOLFG, E.P.E., Portugal) 15:00-15:15 João Forjaz Lacerda (Instituto de Medicina Molecular, FMUL, Portugal) 15:15-15:30 António Fiarresga (Hospital Santa Marta, Lisboa, Portugal) 15:30-15:45 David Malta (Cell2B, Portugal) 15:45-16:00 Hélder Cruz (ECBio S.A., Portugal) 16:00-16:25 Wilfried Dalemans (Tigenix, Leuven, Belgium) 16:25-16:45 Discussion 16:45-17:10 COFFEE BREAK & EXHIBITION 17:10-18:10 CLOSING KEYNOTE LECTURE Chair: Paula Alves (ibet & ITQB-NOVA) Cell Therapy Setbacks, Hopes, and Challenges Greg Russotti (Celgene Cellular Therapeutics, USA) 18:10-18:30 CLOSING SESSION Paula Alves (Conference Chair) Best Poster Award: Sponsored by Grupo Tecnimede Best Oral Presentation Award: Sponsored by ECBio

Organizing committee at imed.ulisboa/ffulisboa Joao Goncalves (Coordinator) and Paula Brito.

Organizing committee at imed.ulisboa/ffulisboa Joao Goncalves (Coordinator) and Paula Brito. PhD Programme in Medicines and Pharmaceutical Innovation Course BioPharmaceuticals and Advanced Therapies Lisbon, 18, 19, 20 and 25, 26 September 2017 Faculty of Pharmacy Amphitheatre B Universidade de