capsugel.com Innovative Solutions Portfolio for Your Dosage Form Needs

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1 capsugel.com Innovative Solutions Portfolio for Your Dosage Form Needs

2 Services that Work for You With over 100 years of experience in capsule technology, Capsugel can work with you from early stage development through final production. Our goal is to develop long-lasting relationships with our customers based on trust, reliability and security. lipid-based formulations Our team of highly-knowledgeable scientists offers specialized expertise in lipid-based formulations to both speed formulation and improve drug absorption. Supported by our proprietary Lipidex system with over 12 years of laboratory data, Capsugel can quickly define the most suitable microemulsion region for a given compound. product differentiation & line extensions Extend your reach and build your brand by leveraging Capsugel s consumer preferred dosage forms and marketing insights. We can help you select fill options (liquids, pellets or powder), colors, branding and printing to help your product win in the marketplace. pre-clinical & clinical support From formulation and analytics to small-scale manufacturing for animal and stability studies, Capsugel is a trusted partner to help you prepare for your pre-clinical and clinical trials. powder formulations Capsugel s expertise extends to powder formulations giving you the ability to leverage our Powder Formulations Expert System. A proprietary database of information such as drug properties, compatibility with excipients, capsule sizes and company practices can help recommend a winning formula and corresponding tests to be performed. manufacturing & technical services Capsugel s staff of Technical Service Engineers provide customers with hands-on manufacturing support including troubleshooting, training and consultation, helping you maximize productivity and minimize waste. quality management expertise From raw material selection to rigorous manufacturing quality assurance and quality control, Capsugel leads the industry with our quality standards, sharing our expertise to help you maintain excellence in your capsule filling operations. health & nutrition products Capsugel offers a full range of turnkey services for fast-to-market delivery of innovative, quality supplements. regulatory assistance Capsugel has country-by-country regulatory and compliance expertise to help you comply with the latest regulations and do business successfully around the globe. Capsugel Quality Guarantee Get the peace of mind you deserve knowing every Capsugel order is backed by our vast worldwide production network that follows global quality standards aligned with international regulations. ISO certified and cgmp compliant, our certified global quality assurance system ensures consistent batch-to-batch performance for all of our capsule products around the globe.

3 Capsugel Leading the World in Innovative Dosage Form Solutions Capsugel s diverse portfolio of dosage-delivery products, equipment, and technical services remain at the forefront of healthcare industry quality and innovation. Our understanding of the global healthcare market can help you deliver value for all types of active ingredients and throughout the full product lifecycle. Flexibility = Faster Time to Market The flexibility of capsules often translates into faster time to market, giving manufacturers a significant competitive advantage. Formulation Flexibility The most versatile container for both liquids and powders Requires fewer processing steps and excipients Choose from a large array of polymer options to meet your active delivery needs Helps improve the stability of sensitive drug compounds and addresses the issue of poorly-water-soluble compounds Potential for immediate, modified, sustained or dual release Dosing Flexibility Combine active ingredients in a single capsule for patient and consumer convenience Develop innovative product concepts without compromising on production Capsules are better suited for cytotoxic and high-potency drugs than tablets Cannot be split for more consistent dosing, enhancing patient compliance and preventing possible revenue loss Marketing Flexibility Convenient to use and preferred by patients and consumers, capsules mask ingredient tastes and odors, and are easy to swallow Available in a myriad of colors, capsules have an attractive appearance and can be printed with text and graphics Market research confirms that consumers consider liquid dosage forms to be faster acting and more effective Prolong patent protection or extend your product line through innovative reformulation concepts supported by our Product Development Centers Manufacturing Flexibility Capsules are cost-effective for emerging markets, product innovations and alternative applications Use the same blend and filling process for different capsule sizes Leverage Capsugel s industry leading know-how in powder and liquid filling to optimize your production lines Capsugel offers the widest range of sizes, colors and polymers available with the shortest lead-times in the industry to speed your operations

4 Quality Products that Deliver Results Capsules for Powder-fills coni-snap hard gelatin capsules Global standard for healthcare products The best selling capsule in the world Proven performance from small to large production scale Pharmaceutical-grade gelatin meeting Pharmacopeia standards Preservative-free, starch-free and gluten-free Fully customizable vcaps and vcaps plus capsules High performance HPMC (hypromellose) capsules Can solve formulation challenges with widespread acceptance for pharmaceutical and nutritional product registrations Excellent with low moisture or hygroscopic ingredients Vcaps Plus capsules offer fast release performance Satisfies a wide variety of lifestyle, cultural and dietary requirements, Kosher and Halal certified, Vegetarian Society approved Organic ingredient carrier in Europe plantcaps tm capsules Pullulan capsules, the more natural choice All the benefits of gelatin in a vegetarian capsule with the best oxygen barrier properties The more natural alternative, starch-free, gluten-free, preservative-free, and non-gmo Beautiful, crystal-clear transparency, with high luster no spotting Organic labeling allowed in the U.S. when filled with organic ingredients Meets dietary needs, certifications include GRAS status, Halal and Kosher Capsules for Liquid-fills licaps capsules Innovative and proven concept with unique visual appeal Unique filling technology patented by Capsugel Innovative solution for lipid-based delivery Employs Capsugel s proprietary Fusion Technology to form a leak-proof, perfectly airtight capsule Offers unique multi-phase options for a variety of release profiles Ideal for product differentiation Consistently preferred by consumers globally Available in gelatin and HPMC sgcaps softgels Add quality to a flexible dosage form Proven and convenient technology for both oral and topical applications Sizes, shapes and colors can be customized according to product requirements Manufactured at the highest quality and safety standards Ideal for both the health & nutrition and pharmaceutical markets Application Specific Capsules press-fit and xpress-fit gelcaps Extend the lifecycle of your existing tablet formulations Distinct dosage form (high gloss gelatin over caplet core) Extensive color choices for market differentiation, brand awareness dbcaps capsules The unique solution for double-blind clinical trials Unique locking mechanism Highly efficient over-encapsulation Smaller size improves compliance Available in gelatin and HPMC pccaps capsules Designed for humane pre-clinical trials Ease administrations and prevent regurgitation & upper GI tract irritation Single dosing kit or multi-dosing filler available pearlcaps tm capsules Shiny, iridescent capsules for standout sophisticated products drcaps tm capsules The vegetarian capsule designed to release when you need it Protects sensitive dietary supplement ingredients from stomach acidity to ensure maximum benefits Acid-resistance without the cost and complexity of coatings Maximum taste masking dry powder inhaler (dpi) capsules Custom engineered to allow more consistent bronchial delivery Inner surface properties that minimize powder adhesion to inside wall of the capsule for consistent dose delivery Low moisture level shell with optimized puncture properties Strict microbial limits that comply with all global DPI regulatory guidelines Available in both DPI-specific gelatin or hypromellose capsules oceancaps tm capsules Made of highest quality fish gelatin for all marine concepts

5 State-of-the-art Precision Filling Equipment xcelodose and xcelolab precision powder micro-dosing systems Shorten drug development time and speedup time to first-in-human clinical trials with these highly consistent cgmp compliant systems that precisely fill capsules and other small receptacles with powders at weights as low as 100µg with an accuracy of 1-2% RSD, eliminating the need for excipients or bulking agents and lowering costs by reducing the need for stability studies. cfs liquid filling and sealing machines Exploit the potential of lipid-based formulations with these systems designed for liquid and semi-solid filling and sealing of capsules for clinical batch trials. The CFS 1200 bench-top machine is perfect for R&D, filling and sealing up to 1,200 capsules per hour, and the CFS 1500 floor-standing machine has a throughput of 1,500 capsules per hour and allows for easy integration into a suitable containment system. manual capsule machines Perfect for R&D labs, small scale runs and compounding pharmacies, our manual capsule machines are available in 100 or 300 hole options and can fill up to 3,000 or 9,000 capsules per hour respectively, while our manual over encapsulator machines facilitate the filling of small batches of DBcaps capsules allowing you to double blind up to 1,500 doses of caplets, tablets or capsules per hour. commercial scale capsule machines Designed for high-speed semi-automatic filling applications, the Ultra 8 II machine can process up to 33,000 capsules per hour and offers numerous operational safety features that streamline the production process. Also available is the CAP 8 machine, a reliable and affordably priced semi-automatic capsule filling machine with unique safety features and throughput rates of up to 29,000 capsules per hour. Customizable Options for Your Product s Unique Needs Colors Color is what the consumer remembers most and so the right color can help you make your mark in the marketplace. Capsugel s unique Colorlab and Colormatch service guarantees you optimal satisfaction by ensuring you get the exact capsule color you ordered. And in addition to the hundreds of standard and custom colors Capsugel can provide, we also offer our unique Pearlcaps, pearlescent colored capsules as well as a full palette of natural colorants as color options. Printing Capsule printing opens up a variety of possibilities for uniquely identifying your product by adding information such as: Your company or brand logo Your brand or product name Patient dosage details Axial, rectified axial and rectified radial printing is all available and can be done with pharmaceutical grade, food grade or even natural inks. Fillings Capsugel offers a number of innovative filling options, including granules, powders, liquids, semi-solids, and mini tablets. All can easily be filled alone or in combination for a one-of-a-kind product that will attract consumers and patients while meeting your unique formulation and delivery needs. Sizes Capsugel capsules are available in a wide range of sizes. Size 00 elongated Size 00 Size 0 Size 1 elongated Size 1 Size 2 elongated Size 2 Size 3 Size 4 Size 5 Size 000 Size 0 elongated

6 Capsugel s Global Footprint Ensures Certainty of Supply Capsugel operates 24x7 in manufacturing locations, state-of-the-art Product Development Centers and multiple business offices around the world. Morristown Boston Massachusetts New Jersey To work together or learn more, contact us at capsugel.com Bornem Sagamihara Belgium Japan Suzhou Delhi China India Hong Kong China Rio de Janerio Strasbourg Brazil France Greenwood Colmar South Carolina France Puebla Mexico Ploërmel France Bangkok Thailand Jakarta Indonesia West Ryde Australia Our global presence, industry-leading capsule products, and innovative drug delivery technologies translate into shorter go-to-market time for Capsugel customers. Current Capsugel customers have access to personalized technical and ordering information at mycapsugel.com. Contact your sales representative for more details. Capsugel will use reasonable efforts to include accurate and up-to-date information on this brochure but makes no warranties or representations of any kind as to its accuracy or completeness. The entire contents of this brochure are subject to copyright protection. Copyright 2012 Capsugel Belgium NV. All rights reserved. GMCN Our customers span the world, and so does Capsugel. Each year we produce close to 200 billion capsules for more than 4,000 customers in over 100 countries. Our vast production capacity helps us effectively respond to changing marketplace demands no matter where our customers are located providing you with the peace of mind that your dosage-form requirements will be met rapidly and with world-class quality.