«Tit» «Name» «Fam_Nam» «Organization» «Address1» «Address_2» «PO_Box» «City». «Country» Sevilla, November, 2011

Transcription

1 «Tit» «Name» «Fam_Nam» «Organization» «Address» «Address_» «PO_Box» «City». «Country» Proficiency Test - Laboratory Code: «Lab_code» Sevilla, November, Dear participants, Enclosed you will find the report of the Proficiency Test - on Drugs of Abuse in Hair, organized by the Society of Hair Testing. Each of the participating laboratories received an identifying code. Your particular code is «Lab_code». Sets of three samples were sent to thirty eight participating laboratories. Thirty two of them sent the report forms back. Sample contents were as follows: Sample A was a drug-free hair sample. Sample B was a drug-addict hair sample positive for opiates (6-MAM, morphine and codeine), cocainics (cocaine and BE), which also contained methadone, dihydrocodeine, tramadol, diazepam, nordiazepam and traces of cannabis and amphetamine compounds. Sample C was a drug-addict hair sample positive for opiates (6-MAM, morphine and codeine), cocainics (cocaine and BE), cocainics (cocaine and BE), amphetamines (amphetamine, methamphetamine, MDMA and traces of MDA) and cannabis (THC, CBD, CBN and THC-COOH), which also contained methadone and tramadol. This year a more comprehensive statistical study has been performed to evaluate quantitative results. has been calculated based on robust estimators (median instead of mean and interquartile instead of standard deviation).

2 has been calculated as follows: = (x - χ) / IQR Where: x: Concentration reported by the participant χ: Median concentration obtained from the participating laboratories IQR: Interquartile range: It is calculated as: Q-Q (the upper quartile minus the lower quartile) Q: Third quartile (percentile 75) Q: First quartile (percentile 5) Decision criteria The following criteria have been adopted: Satisfactory results: ± Questionable results: < Unsatisfactory results: Certificate A certificate has been mailed to all the participants. Yours faithfully, Carmen Jurado

3 Proficiency Test - on Drugs of Abuse in hair QUALITATIVE RESULTS Laboratory Code: Sample A Sample B Sample C Substances A T F Substances A T F Substances A T F Drugs N MAM P MAM P Morphine P Morphine P Codeine P Codeine P Cocaine P Cocaine P BE P BE P Amphetamine Metamphetamine MDMA MDA THC P P P P P A: Your answer T: True answer F: False answer P: Positive N: Negative NR: Not reported NA: Not analyzed FN: False Negative FP: False Positive Comments: Sample B contains methadone, dihydrocodeine, tramadol, diazepam, nordiazepam and traces of cannabis and amphetamine compounds (amphetamine, methamphetamine, MDMA). The median concentration of THC reported by the participating laboratories is.. All of the median concentrations reported for amphetamine compounds are below. ng/mg, which is the cut-off proposed by SoHT for these compounds. Sample C contains THC-COOH, methadone and tramadol. The concentrations of codeine and MDA in Sample C are very low. The median concentrations reported by the participating laboratories are.8 and.6 ng/mg for codeine and MDA, respectively. Both of them are lower than the cut-off s proposed by SoHT (. ng/mg for both compounds)

4 Proficiency Test - on Drugs of Abuse in hair Lab. No. MAM Result 9,5 -,6 Satisfactory,7 -,7 Satisfactory,8 -,6 Satisfactory, -, Satisfactory 5,5 -,8 Satisfactory 5,5 -,8 Satisfactory 6 5,57 -,8 Satisfactory 5,8 -,75 Satisfactory 8 6,8 -,6 Satisfactory 6,6 -,55 Satisfactory 6 6,66 -,5 Satisfactory 9 7, -,7 Satisfactory 8 7,7 -,7 Satisfactory 7 7,9 -, Satisfactory 5 8, -,7 Satisfactory 8,6 -, Satisfactory 5 8,9, Satisfactory 8,95,5 Satisfactory 9,,9 Satisfactory 9,5, Satisfactory 7 9,,7 Satisfactory 9,5,9 Satisfactory 9,65, Satisfactory, Satisfactory 5,6,7 Satisfactory,57 Satisfactory 6,57 Satisfactory,57 Satisfactory 8,5,6 Satisfactory 7,8 Satisfactory 5,,6 Satisfactory 9 6,85 Satisfactory MAM conc. (ng/mg) ,5,5 -,5 - -,5 - Sample B - MAM Average 8, SD, CV% 6,85 Median 8,75 Minimum,5 Quartile 5 6, Quartile 75,5 Maximum 6

5 Proficiency Test - on Drugs of Abuse in hair Lab. No. Morphine Result 9,6 -,9 Satisfactory,8 -,8 Satisfactory,9 -,78 Satisfactory,9 -,77 Satisfactory,96 -,75 Satisfactory 5,6 -,59 Satisfactory 7,6 -, Satisfactory,6 -, Satisfactory,8 -, Satisfactory 7,8 -,8 Satisfactory 6,9 -,5 Satisfactory,6 -,7 Satisfactory 8, -, Satisfactory 8, -, Satisfactory 9, -, Satisfactory 8,6 -, Satisfactory,, Satisfactory,5,8 Satisfactory,8, Satisfactory,9,8 Satisfactory 5, Satisfactory 9, Satisfactory 6,9,7 Satisfactory,59,6 Satisfactory,8,75 Satisfactory 7,,7 Satisfactory,56,5 Satisfactory 5,9 Satisfactory 5 5,87,85 Satisfactory 6 6,,9 Satisfactory 7, Questionable 7,6,5 Questionable Average,89 SD,7 CV% 6,9 Median,8 Minimum,6 Quartile 5,75 Quartile 75,6 Maximum 7,6 Morphine conc. (ng/mg) ,5,5,5 -,5 - -,5 - Sample B - Morphine

6 Proficiency Test - on Drugs of Abuse in hair Lab. No. Codeine Result 9, -,8 Satisfactory, -,8 Satisfactory,6 -,66 Satisfactory,9 -,58 Satisfactory, -,9 Satisfactory 5,7 -,9 Satisfactory 9,7 -,9 Satisfactory 6,8 -,6 Satisfactory, -, Satisfactory 7,5 -,9 Satisfactory 8,5 -,9 Satisfactory 5,9 -,9 Satisfactory,5 -,7 Satisfactory,5 Satisfactory,5 Satisfactory 6,5 Satisfactory,6,7 Satisfactory 9,6,7 Satisfactory 8,6, Satisfactory 8,66, Satisfactory 7,69,9 Satisfactory,79,6 Satisfactory 5,8,7 Satisfactory 6,8,7 Satisfactory,9,95 Satisfactory,96,5 Satisfactory 7,5 Satisfactory,6,9 Satisfactory,6,6 Questionable NA NA NA Average,6 SD, CV% 5, Median,5 Minimum, Quartile 5,8 Quartile 75,79 Maximum,6 Codeine conc. (ng/mg),8,6,,,8,6,,,5,5,5 -,5 - -,5 - Sample B - Codeine

7 Proficiency Test - on Drugs of Abuse in hair Lab. No. Cocaine Result 9, -,8 Satisfactory, -,6 Satisfactory, -,7 Satisfactory,6 -,5 Satisfactory 7,8 -,98 Satisfactory,5 -,8 Satisfactory 8,5 -,8 Satisfactory 6,6 -,56 Satisfactory 7,6 -,56 Satisfactory 9,6 -,56 Satisfactory 6,6 -,6 Satisfactory 5,69 -, Satisfactory 5,7 -, Satisfactory,7 -, Satisfactory,75 -, Satisfactory 9,77, Satisfactory,77, Satisfactory,8, Satisfactory,8, Satisfactory,85, Satisfactory,86,5 Satisfactory 5,87,8 Satisfactory,89,6 Satisfactory,9,9 Satisfactory 8,9,5 Satisfactory 8,96,7 Satisfactory,7, Satisfactory,,5 Satisfactory,,89 Satisfactory 5,6 7, Unsatisfactory 6 N -- 7 NA Average,89 SD,9 CV%,56 Median,76 Minimum, Quartile 5,6 Quartile 75,88 Maximum 5,6 Cocaine conc. (ng/mg) Sample B - Cocaine

8 Proficiency Test - on Drugs of Abuse in hair Lab. No. BE Result 9, -,9 Satisfactory,7 -,9 Satisfactory,5 -,85 Satisfactory,5 -,85 Satisfactory,56 -,67 Satisfactory 5,6 -,5 Satisfactory,6 -,8 Satisfactory 7,6 -,5 Satisfactory,6 -, Satisfactory,65 -,9 Satisfactory,67 -, Satisfactory 8,68 -, Satisfactory,69 -,7 Satisfactory,76 -,6 Satisfactory 9,78 Satisfactory 7,8,6 Satisfactory,8,8 Satisfactory,8,8 Satisfactory 6,88, Satisfactory 5,9,5 Satisfactory,9,8 Satisfactory 6,96,5 Satisfactory 8,66 Satisfactory 5,66 Satisfactory 8,5,8 Satisfactory,,97 Satisfactory,5, Satisfactory,,88 Satisfactory,5, Questionable 6 N 7 NA 9 NA Average,8 SD,6 CV%, Median,78 Minimum, Quartile 5,6 Quartile 75,96 Maximum,5 BE conc. (ng/mg),6,,,8,6,,,5,5,5 -,5 - -,5 - Sample B - BE

9 Proficiency Test - on Drugs of Abuse in hair Lab. No. MAM Result,5 -,8 Satisfactory 9,5 -,8 Satisfactory,6 -,7 Satisfactory,7 -,56 Satisfactory,7 -,55 Satisfactory,78 -,5 Satisfactory,79 -, Satisfactory 7,8 -, Satisfactory 8,85 -, Satisfactory,86 -, Satisfactory 6,88 -, Satisfactory 6,9 -,7 Satisfactory,9 -,6 Satisfactory 6,9 -, Satisfactory 8,9 -, Satisfactory 5,9 Satisfactory,, Satisfactory,, Satisfactory,, Satisfactory,,5 Satisfactory 5,,5 Satisfactory 9,5,59 Satisfactory,5,6 Satisfactory 9,5,6 Satisfactory 7,59,7 Satisfactory,7,88 Satisfactory,89,5 Satisfactory 7,,59 Satisfactory 5,7,69 Satisfactory 8,79,5 Questionable 9,,8 Unsatisfactory NR -- Average,6 SD,5 CV%, Median,9 Minimum,5 Quartile 5,8 Quartile 75,55 Maximum 9, MAM conc. (ng/mg) Sample C- MAM Lab. Number

10 Proficiency Test - on Drugs of Abuse in hair Lab. No. Morphine Result, -,9 Satisfactory, -,85 Satisfactory,5 -,7 Satisfactory 5,6 -,7 Satisfactory,6 -,7 Satisfactory 7, -,55 Satisfactory 8, -, Satisfactory 8,5 -,7 Satisfactory 8,5 -,7 Satisfactory,5 -,7 Satisfactory 7,6 -, Satisfactory,7 -,9 Satisfactory,9 -, Satisfactory 9, -,8 Satisfactory,5 Satisfactory 6,6, Satisfactory,,8 Satisfactory,,8 Satisfactory 5,,8 Satisfactory 9,6, Satisfactory,7, Satisfactory,8,8 Satisfactory,6,7 Satisfactory,8,7 Satisfactory 6,9,5 Questionable 5,96,6 Questionable,,78 Questionable 7,,78 Questionable,89 5,7 Unsatisfactory 6 N -- 9 N -- Traze -- Average,7 SD,9 CV% 8, Median,5 Minimum, Quartile 5,5 Quartile 75,5 Maximum,89 Morphine conc. (ng/mg),8,6,,,8,6,, Sample C- Morphine

11 Proficiency Test - on Drugs of Abuse in hair Lab. No. COD Result, -,8 Satisfactory, -, Satisfactory, -, Satisfactory,5 Sample C- Codeine, -, Satisfactory,7 -,6 Satisfactory,7 -,58 Satisfactory,8 -, Satisfactory 9, Satisfactory 7,, Satisfactory 5,5, Satisfactory 5,5, Satisfactory,6, Satisfactory Codeine conc. (ng/mg),,5,,5, 8,7, Satisfactory,, Questionable,5,, Unsatisfactory 9 <,5 -- <, -- 6 N N -- 9 N -- N -- 5 N -- 6 N -- 7 N --,5 6 N -- 7 N -- 8 N -- N -- NA -- NA -- NA -- P -- Average, SD,7 CV% 68, Median, Minimum, Quartile 5,5 Quartile 75,5 Maximum,,5,5 -,5 - -,

12 Proficiency Test - on Drugs of Abuse in hair Lab. No. Cocaine Result 9,5 -,5 Satisfactory,6 -, Satisfactory 7,86 -,9 Satisfactory,9 -, Satisfactory,7 -,8 Satisfactory,5 -,7 Satisfactory 8,9 -,68 Satisfactory 6, -,67 Satisfactory, -,67 Satisfactory 6, -,5 Satisfactory 9, -,5 Satisfactory,5 -,8 Satisfactory,69 -,5 Satisfactory,7 -, Satisfactory,7 -, Satisfactory,77, Satisfactory 6,8,8 Satisfactory,8, Satisfactory,85, Satisfactory,9, Satisfactory 7,9, Satisfactory 5,97,9 Satisfactory, Satisfactory 8,,5 Satisfactory 9,8,55 Satisfactory 5,9,57 Satisfactory,9,57 Satisfactory,58 Satisfactory 8,,7 Satisfactory,,5 Questionable 7 NA 5 NR Average, SD,7 CV% 7, Median,75 Minimum,5 Quartile 5, Quartile 75 Maximum, Cocaine conc. (ng/mg) Sample C- Cocaine

13 Proficiency Test - on Drugs of Abuse in hair Lab. No. BE Result 9,69 -, Satisfactory,89 -,8 Satisfactory, -,9 Satisfactory, -,8 Satisfactory,6 -,78 Satisfactory 7,5 -,7 Satisfactory,9 -,6 Satisfactory,67 -,5 Satisfactory,8 -,5 Satisfactory,8 -,5 Satisfactory,9 -, Satisfactory BE conc. (ng/mg),5,5,5 Sample C- Benzoylecgonine, -, Satisfactory 5, -,7 Satisfactory,5 -,6 Satisfactory 9, Satisfactory,,5 Satisfactory, ,,5 Satisfactory 6,,5 Satisfactory 6,,9 Satisfactory 8,,9 Satisfactory,, Satisfactory 8,9,5 Satisfactory,9,56 Satisfactory 5,6,67 Satisfactory 7,,78 Satisfactory 8,5,8 Satisfactory,5, Satisfactory,77,5 Satisfactory 6,8,7 Satisfactory 7 NA 9 NA 5 NR,5,5 -,5 - -, Average, SD,8 CV% 7,8 Median, Minimum,69 Quartile 5,67 Quartile 75,9 Maximum,8

14 Proficiency Test - on Drugs of Abuse in hair Lab. No. Amphetamine Result 9 <,5 --, -, Satisfactory, -,7 Satisfactory 7, -,9 Satisfactory,7 -,8 Satisfactory 5,9 -,75 Satisfactory 7,5 -,7 Satisfactory,5 -,68 Satisfactory,5 -,6 Satisfactory 6,5 -,6 Satisfactory 5,6 -,8 Satisfactory,6 -,8 Satisfactory,6 -,5 Satisfactory,67 -, Satisfactory,68 -,7 Satisfactory,7 Satisfactory Amphetamine conc. (ng/mg),8,6,,,8,6,, Sample C- Amphetamine ,7,7 Satisfactory,7, Satisfactory,77,5 Satisfactory 9,78,8 Satisfactory 8,78,8 Satisfactory,8,6 Satisfactory 8,8,9 Satisfactory 6,9,86 Satisfactory 7,7 Satisfactory 6,,8 Satisfactory,,57 Satisfactory 5,,78 Satisfactory 8,, Questionable 8,75,75 Unsatisfactory NA 9 NA Average,75 SD, CV%, Median,7 Minimum, Quartile 5,5 Quartile 75,8 Maximum,

15 Proficiency Test - on Drugs of Abuse in hair Lab. No. MethAP Result,5 -, Satisfactory,6 -,9 Satisfactory,5 -, Satisfactory 9,5 -,5 Satisfactory,6 -, Satisfactory,7 -,8 Satisfactory,77 -,78 Satisfactory 5,8 -,66 Satisfactory,9 -,5 Satisfactory 7,9 -,5 Satisfactory,99 -,5 Satisfactory 8 -, Satisfactory,5 -, Satisfactory 7,6 -, Satisfactory,8, Satisfactory,9, Satisfactory Methamphetamine conc. (ng/mg),5,5,5,5 Sample C- Methamphetamine ,,6 Satisfactory,, Satisfactory 6,, Satisfactory,,5 Satisfactory 5,,5 Satisfactory 8,,9 Satisfactory 9,6,7 Satisfactory 5,,9 Satisfactory,,9 Satisfactory 5 8 6,59,8 Satisfactory 7,8, Satisfactory 8,7, Unsatisfactory N NA NA 9 NA Average,6 SD,5 CV% 6,6 Median,7 Minimum,6 Quartile 5,86 Quartile 75, Maximum,

16 Proficiency Test - on Drugs of Abuse in hair Lab. No. MDMA Result 8,6 -,95 Satisfactory,8 -,7 Satisfactory 5,6 -,9 Satisfactory, -, Satisfactory, - Satisfactory,5 -,87 Satisfactory,55 -,8 Satisfactory,66 -,68 Satisfactory 7,67 -,67 Satisfactory 9,7 -,6 Satisfactory,7 -,6 Satisfactory 9,9 -,6 Satisfactory,6 -, Satisfactory 9, -,6 Satisfactory,8 -,6 Satisfactory,8,6 Satisfactory,,8 Satisfactory,,8 Satisfactory 6,,8 Satisfactory 8,,8 Satisfactory,,8 Satisfactory 5,7,9 Satisfactory 5,5, Satisfactory 7,5,6 Satisfactory 8,55,8 Satisfactory,7,58 Satisfactory,7,59 Satisfactory 6,9,8 Satisfactory 6,8,8 Satisfactory 7, Questionable N NA Average, SD,66 CV%,7 Median, Minimum,8 Quartile 5,67 Quartile 75,5 Maximum MDMA conc. (ng/mg),5,5,5,5,5,5,5,5 -,5 - -,5 - -,5 Sample C- MDMA

17 Proficiency Test - on Drugs of Abuse in hair Lab. No. THC Result,8 -,77 Satisfactory 6,9 -,6 Satisfactory, -,5 Satisfactory, -,5 Satisfactory 8, -,5 Satisfactory, -,9 Satisfactory, -,9 Satisfactory, -,9 Satisfactory, -, Satisfactory, -, Satisfactory 5, -, Satisfactory 7, Satisfactory 8, Satisfactory 9, Satisfactory,5, Satisfactory 5,7,9 Satisfactory,8,5 Satisfactory,9,6 Satisfactory 5,9,6 Satisfactory,,9 Satisfactory 9,6,55 Satisfactory 9,,5 Unsatisfactory,,5 Unsatisfactory NA 6 NA 7 NA NA 7 NA 8 NA NR 6 NR POS THC conc. (ng/mg),5,,5,,5,,5,,5 - Sample C- THC Average,6 SD,8 CV% 5,8 Median, Minimum,9 Quartile 5, Quartile 75,8 Maximum, -