Pasteur course HUMAN POPULATION GENOMICS AND GENETIC EPIDEMIOLOGY
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1 Pasteur course HUMAN POPULATION GENOMICS AND GENETIC EPIDEMIOLOGY PROGRAM
2 PASTEUR COURSE HUMAN POPULATION GENOMICS AND GENETIC EPIDEMIOLOGY October 9-20, 2017 This two-week course presents theoretical lectures, research examples and hands-on computer training on concepts and tools used in the study of human population genomics and genetic epidemiology. The first week consists in three days of both theoretical lectures and research examples, and two days of hands-on-computer training and discussions presenting the concepts and the technical tools used in both human population genomics and genetic epidemiology. The second week consists in detailed theoretical bases in population genomics and genetic epidemiology analyses and practical computer-based training in the most recent concepts and analyses used in both disciplines. The practical training (computer laboratory work and discussion of the results) is based on real-data examples, using as a paradigm infectious diseases. Candidates must have basic knowledge in molecular genetics, statistics and informatics Co-directors Lluis QUINTANA-MURCI Unit of Human Evolutionary Genetics CNRS URA 3012 Institut Pasteur, Paris Alexandre ALCAIS Human Genetics of Infectious Diseases INSERM /Univ. Paris Descartes Unité 1163 Institut Imagine, Paris
3 HUMAN POPULATION GENOMICS AND GENETIC EPIDEMIOLOGY FIRST WEEK Monday, October 9 HUMAN GENOME DIVERSITY 9:00-10:30 Welcome Register office General Introduction Alexandre ALCAIS and Lluis QUINTANA-MURCI (Institut Pasteur, Paris) 10:45-12:15 Human genome diversity and public databases Lluis QUINTANA-MURCI 13:30-15:15 A survival kit to Genetic Epidemiology Alexandre ALCAIS 15:30-17:00 A survival kit to bioinformatics Guillaume LAVAL Tuesday, October 10 GENOTYPE-BASED ANALYSES: LINKAGE ANALYSIS 9:00-10:30 Research in Genetic Epidemiology: Alexandre ALCAIS Why, When, Who, How 10:45-12:15 Research in genetic epidemiology: Alexandre ALCAIS WWWHOW part II 13:30-15:00 Linkage analyses: principles and methods Sophie GARNIER (Univ. Pierre et Marie Curie, Paris) 15:30-17:00 Linkage analyses: hands-on computer Gaspar KERNER (Univ. Paris-Descartes, Paris) Wednesday, October 11 GENOTYPE-BASED ANALYSES: ASSOCIATION STUDIES 9:00-10:30 Linkage disequilibrium: principles and methods Etienne PATIN 10:45-12:15 Linkage disequilibrium: hands-on computer Jeremy MANRY 13:30-15:00 Association studies: principles and methods Alexandre ALCAIS 15:30-17:00 Association studies: hands-on computer Aurélie COBAT
4 Thursday, October 12 GENOTYPE-BASED ANALYSES: ASSOCIATION STUDIES II 9:00-10:30 Genome-wide association studies: principles and methods Etienne PATIN 10:45-12:15 A survival kit to Whole exomes/genomes sequencing Aurélie COBAT 13:30-15:00 Genome-wide association studies: hands-on computer Alexandre ALCAIS and Jeremy MANRY 15:30-17:00 Genome-wide association studies: hands-on computer II Alexandre ALCAIS and Jeremy MANRY Friday, October 13 SEQUENCE-BASED ANALYSIS: WHOLE EXOME/GENOME STUDIES 9:00-10:30 Whole-exomes studies: hands-on computer Aurélie COBAT and Gaspar KERNER 10:45-12:15 Whole-exomes studies: hands-on computer II Aurelie COBAT and Gaspar KERNER 13:30-15:00 Research example I Antonio RAUSELL 15:30-17:00 Research example II Anavaj SAKUNTABHAI
5 HUMAN POPULATION GENOMICS AND GENETIC EPIDEMIOLOGY SECOND WEEK Monday, October 16 POPULATION GENETICS, EVOLUTION AND HUMAN DEMOGRAPHY 9:00-9:30 Population genetics, evolution and demography: an overview Lluis QUINTANA-MURCI 9:45-12:15 Principles in population genetics Laurent EXCOFFIER (University of Bern, Germany,) 13:30-15:00 Population structure and human demography I Guillaume LAVAL 15:30-17:00 Population structure and human demography II Guillaume LAVAL Tuesday, October 17 NATURAL SELECTION AND GENETIC ADAPTATION 9:00-9:45 Research examples of natural selection: why and how Lluis QUINTANA-MURCI 10:00-12:15 Natural selection: principles and methods Luis BARREIRO (Univ.Montreal, Montreal) 13:30-15:45 Natural selection: hands-on computer Hélène QUACH and Luis BARREIRO (Univ.Montreal, Montreal) 16:00-17:00 Genetics of social networks in non-human primates: research example Luis BARREIRO (Univ.Montreal, Montreal) Wednesday, October 18 GENOME-WIDE SCANS FOR SELECTION (GSS) 9:00-10:30 Basics in genome-wide statistics for selection detection Guillaume LAVAL 10:45-12:15 Genome-wide scans for selection: principles and Guillaume LAVAL hands-on computer I and Etienne PATIN 13:30-15:45 Genome-wide scans for selection: principles and Guillaume LAVAL hands-on computer I and Etienne PATIN 16:00-17:00 A genome-wide view of demography and selection in Etienne PATIN African populations: research example
6 Thursday, October 19 THE GENETICS OF GENE EXPRESSION AND BEYOND 9:00-10:30 Genetics of gene expression: principles, methods and eqtls Maxime ROTIVAL 10:45-12:15 Genetics of gene expression: hand-on computer I Maxime ROTIVAL and Lucas HUSQUIN 13:30-15:00 Genetics of gene expression: hand-on computer II Maxime ROTIVAL and Lucas HUSQUIN 15:15-16:00 Gene expression, immune response and adaptation in Hélène QUACH humans: research example 16:00-17:00 Purifying selection and burden of deleterious mutations Marie LOPEZ Friday, October 20 KEYNOTE LECTURES Both lectures will take place at Room Jules Bordet Metchnikoff, on the ground floor 10:00-11:00 Human genetics of tuberculosis Laurent ABEL (Inserm/Université Paris Descartes/Institut Imagine, Paris) 11:00-12:00 The genetic basis of human adaptation to environments: Matteo FUMAGALLI novel insights from NGS data 14:30-17:30 Written examination (Room 4 of the Teaching Centre) Duration 3 hours - Grade out of 20 (Imperial College London United Kingdom)
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