The worldwide leader in the automation of Immunohistochemistry (IHC), in situ Hybridization (ISH), Fluorescent in situ Hybridization (FISH),

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1 2006

2 The worldwide leader in the automation of Immunohistochemistry (IHC), in situ Hybridization (ISH), Fluorescent in situ Hybridization (FISH), Immunofluorescence (FITC) and Special Stains testing.

3 Elisabeth FALK Account Executive Sweden Sweden and Norway Morten Sten JHANSEN Regional Manager Nordic Countries The Nordic organization and support Jeff MITREVSKI Application spec Norway and Finland Mekkeri ANNER Account Executive Finland Finland Sweden Michael WIESE Account Executive Denmark Customer Marianne LUNDING Application spec Sweden and Denmark Therese JENSEN Account Executive Sweden Pål Jacob GUNDERSEN Account Executive Norway VENTANA Strasbourg Customer care, Logistics, TCC, Training, Marketing, etc. Perrin WINKELMAN Field Service Engineer

4 Workflow Solutions - Primary Staining - Advanced Staining - Image Analysis - LIS Connectivity - Workflow Consultation

5 Primary Staining Exceptional breakthrough technology Safety Productivity Reproducibility Automation Modular design Individual slide staining Integral coverslipping

6 Advanced Staining State-of-the-art IHC and ISH staining automation - Flexibility - Automation - Throughput - Integrated Diagnostics

7 Image Analysis Integrated Patient Reports

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9 In addition NLY Ventana provides Modularity, Scalability and Flexibility Modularity For IHC, ISH, FISH, FITC and/or Special Stains testing Scalability Up to 8 staining modules per system control center Process 30 to 240 slides per run (XT) Flexiblility To meet the changing needs of your laboratory

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11 #$ Up to 500 slides Up to 25 trays Continuous and random access Walk away time up to 2.5 hours

12 Easy to load Easy to label and read Stackable Clean and dry 20 slide capacity

13 %&%' Bag in a box Concentrates

14 %' ' Easy to use Minimize exposure Add reagents anytime Automated reagent recognition and tracking

15 # ( ' Symphony is NT a bath stainer Fresh reagent every slide No deterioration of reagents No cross contamination

16 #' Glass Slides never move Proprietary coverslip No liquid mounting media

17 )(*+), Integrated computer (no external PC) Touch screen user interface Pre-set protocols Programmable for custom user protocols

18 # ' - Barcode reading - Consumable Tracking - QA/QC Report Printing - LIS connectivity

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20 !" #'- VIAS

21 #'- Image Analysis State-of-the-art integrated image analysis automation Easy to use Standardized Integrated into workflow Integrated into information systems Integrated patient report

22 Rabbit Monoclonals Estrogen (SP1) Progesterone (1E2) Ki-67 (30.9) Her-2/neu (4B5)

23 Ease of Use Fits with current workflow pathologist is in control Use like a normal microscope Real time image capture and analysis Previously imaged areas at a click High end microscope from Carl Zeiss Superior Imaging Software

24 Standardized Standardized image capture Standardized image analysis Reproducibility of result Previously imaged areas at a click

25 Integrated into workflow Fits with current pathologist workflow Integrates seamlessly into the way the lab works today Barcode recognition

26 Integrated into information flow Recognition & generation of all Imaging and reporting data via the Ventana Barcode & Ventana s VLM technology No double labeling No additional data entry Elimination of manual data entry procedures and workflow interruption due to LIS connectivity No data entry

27 Integrated Patient Report Shows the patients'diagnostic results Shows the captured images Shows the results of the analysis Can be customized VIAS provides the Pathologist with the capability and data to create an Integrated Patient Report which can be used as a valuable communication and reporting tool

28 #'- Image Analysis Aid for the pathologist in routine diagnostic Real time capture & analysis of selected areas detection, classification and counting of cells of interest based on marker intensity, size and shape Integrated patient report LIS connectivity

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30 # AP specificities Connection types Ventana Solutions Ventana Vision Workcells: Each step is done in specific rooms by different technical teams Sample flow: Sample have to be carried between the workcells Information Flow: Sample identification and work orders have to reach workcells

31 & AP specificities Connection types Ventana Solutions Ventana Vision 1. T e s t re q u e s t e n te re d in to L IS. 2. T e s t in fo rm a tio n s e n t fr o m L IS to V e n ta n a p rin te r. 3. S lid e la b e ls g e n e ra te d a u to m a tic a lly. 4. T e s t ru n b e g in s!

32 / AP specificities Connection types Ventana Solutions Ventana Concept 1. Ventana sends status updates to the LIS. L I S 2. Management monitors staining progress in LIS. Label has printed. Test has begun. Test completed.

33 # - AP specificities Connection types Ventana Solutions Ventana Concept Single Point of LIS Interface Centralized Management Ventana Interface Point Ventana Lab Manager V. I. P. 2.0 NexES 10.0 Host Computer Host Computer Host Computer

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35 ultra,& 0-/ 0 1

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37 ' HS SH SH + N N H N N H NH 2 HRP HN 1 eq. 3 eq. HN NH 2 N N 16 hr., r.t. N N H N N H NH 2 HRP HN HN NH 2 Multimer, 90% yield by FPLC N N S S S N N N N H N N H H N N H NH 2 HRP HN NH 2 HRP HN HN HN NH 2 N NH 2 N N N

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39 02i 3ultra iview ultraview

40 !%i#!3ultra iview ultraview

41 ultra,& %!0 0 1

42 0456/7*89:;<578<8=> ultraview Red ultraview DAB EnhV Red Protocol : Pretreatment : Mild CC1 Antibody Incubation Time : 20 min FR INTERNAL USE NLY Célia Fragoso Applications Laboratory Specialist- Europe MEA

43 0 60!7%7229:;=578?24> ultraview Red Ultra View DAB EnhV Red Protocol : Pretreatment : Protease 1 for 12 min Antibody Incubation Time : 32 min FR INTERNAL USE NLY Célia Fragoso Applications Laboratory Specialist- Europe MEA

44 0 ' ultraview Universal DAB Detection Kit ultraview Universal RED Detection Kit

45 0 7#! 0-/ #! %!0 Protocol duration: 3 hrs 40 min!!! FR INTERNAL USE NLY Célia Fragoso Applications Laboratory Specialist- Europe MEA

46 i#!,#!%0 1 #**!%78. Get out of the dark - step into the light

47 #* SISH CHRMGEN REAGENTS A, B, & C Goat antirabbit / HRP Molecule Primary antibody: Rabbit anti-biotin *%(A A *%( *%( Biotin Labeled probe hybridized to target

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49 #* 100X Highly Amplified HER-2/neu Gene copy number (40X) Normal HER-2/neu Gene copy number

50 0 ' iview SILVER Detection Kit SISH HER-2/neu ultraview Universal RED Detection Kit Her-2 (4B5)

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