Aminotriazole. 3-Amino-1,2,4-triazole. Triazole herbicide. Use Class: Comments NORMAN Use pattern

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1 1 CHEMICAL IDENTITY Common name Chemical name (IUPAC) Synonym(s) Aminotriazole 3-Amino-1,2,4-triazole 1,2,4-Triazol-3-amine, Amitrole, Amitolamitril CAS number EU number Chemical class Triazole herbicide Molecular formula C 2 H 4 N 4 Molecular structure Molecular weight (g.mol -1 ) NORMAN Category 1 : 2 NORMAN Final score 1 : 1.23 Known metabolites Major metabolites observed in the environment 1,2,4-triazole (soil) 2 MAJOR USES Use Class: Comments NORMAN Use pattern Main: Pesticide Sub: Herbicide Amitrole is a nonselective systemic triazole herbicide. It is used on non-cropland for control of annual grasses and perennial and annual broadleaf weeds, for poison ivy control, and for control of aquatic weeds in marshes and drainage ditches. Amitrole is a Restricted Use Pesticide (RUP) and may be purchased and used only by certified applicators. Used in the environment EXTOXNET 1993

2 3 EXISTING EVALUATIONS and REGULATORY INFORMATION Legislation/Evaluation Score 1 Existing evaluations EFSA conclusion (2014) n.a. Pesticides (91/414/EEC) Approved PPP n.a Biocides (98/8/EC) No information found n.a. PBT/vPvB Other relevant chemical regulations (veterinary products, medicament,...) CMR P: very persistent (DT 50 water = 71 days) B: not bioaccumulative (BCF = 2.4) T: Toxic (NOEC = mg/l) OSPAR candidate Reprotoxic Category 3: Suspected human reproductive toxicant, based on evidence from humans or experimental animals, but not sufficiently convincing to place the substance in Category n.a Endocrine disrupter Endocrine disruptor ENVIRONMENTAL OCCURENCE 4.1 Occurrence data (NORMAN all data 1 ) Surface water (relevant matrix) Countries Stations Stations with Analysis > LOQ Analysis Frequency of quantification Value % Score n.a. 0.5 n.a Occurrence data from According to the NORMAN Prioritisation Methodology (Dulio & von der Ohe ) 4.2 LOQ min, Median, Max and MEC 95 (NORMAN all data 1 ) Matrix LOQ min Median concentration Max concentration MEC Surface water Occurrence data from MEC95 is the 95th percentile of the measured Maximum Environmental Concentrations at each site 2

3 5 HAZARDOUS PROPERTIES AND EFFECTS 5.1 Aquatic toxicity data Trophic level Test Endpoint Value Algae and higher plants Invertebrates Fish 120h EC50 120h NOEL Daphnia magna 48h EC 50 (static) Daphnia magna 21d NOEC (semi-static) Oncorhynchus mykiss 96h LC50 Oncorhynchus mykiss 96h NOEL , ,000 95,000 Tscheu-Schluter & Skibba (1986) 5.2 Existing Quality Criteria (PNEC or QS proposals) PNEC or QS Endpoint AF Value (Lowest in bold) 1 EQS water (AA-EQS) 72h EC INERIS Lowest PNEC for a substance refers to the lowest available PNEC value that might be derived on the basis of, or non-standard tests (see below) and is intended as a non-legally binding threshold value for the protection of the receptors at risk in, or via, the aquatic environment. 6 POTENTIAL RISK OF EXCEEDANCE OF LOWEST PNEC 6.1 Summary: Risk of Exceedance of the Lowest PNEC Value Score 1 Frequency of Exceedance 38% 0.38 Extent of Exceedance

4 7 CONCLUSIONS AND RECOMMENDATIONS 7.1 Conclusions Rational for inclusion in the Watch List Frequency of quantification (relevant matrix) Value Score 1 10% 0.10 Exposure N of countries with concentration >LOQ NORMAN data N of sites with concentration >LoQ Exposure score (0-1) Hazardous properties very P: DT50 water = 71 days 1.00 PPDB PBT/vPvB not B: BCF = PPDB T: NOEC = mg/l 1.00 INERIS 2011 ED Endocrine Disruptor 1.00 BKH 2000 CMR Reprotoxic Category IARC, 2001 Hazardous score (0-1) Risk Frequency of Exceedance 38% 0.38 NORMAN Extent of Exceedance data Risk score (0-1) Final score (0-3) BIBLIOGRAPHY, SOURCES AND SUPPORTIVE INFORMATION EXTOXNET (1993): Access: Dulio V and Von der Ohe P () NORMAN Prioritisation framework for emerging substances. NORMAN Association, N W , Verneuil en Halatte, France, 70 pages. INERIS (2011) Proposition de norme de qualité environnementale: Aminotriazole ( ), Contact: Sandrine Andres, INERIS, Verneuil en Halatte, France, 15 pages. PPDB Management Team () PPDB pesticide property database. The Pesticide Properties Data Base (PPDB) developed by the Agriculture & Environment Research Unit (AERU), University of Hertfordshire, Accessed: () Pesticide Ecotoxicity Database (Formerly: Environmental Effects Database (EEDB)), Environmental Fate and Effects Division, U.S.EPA, Washington, D.C. 4

5 Tscheu-Schluter, M. and W.D. Skibba (1986) Comparative Water-Toxicological Results with Selected Groups of Aquatic Pollutants and Aquatic Organisms, Acta Hydrochim. Hydrobiol.14(6): EFSA (2014) Conclusion on the peer review of the pesticide risk assessment of the active substance amitrole, European Food Safety Authority (EFSA), Parma, Italy, 84 pages. EU Commission. (2007). Comm. Staff Work. Doc. on the implement. of the "Community Strat. for Endocrine Disrupters" - a range of subst. suspected of interfering with the hormone systems of humans and wildlife (COM (1999) 706), (COM (2001) 262) and (SEC (2004) 1372) SEC IARC (2001). Monographs on the Evaluation of Carcinogenic Risks to Humans, Volume 79. 5