For research use only. Not for use in diagnostic procedures. CHEMTREC: (INTERNATIONAL) (NORTH AMERICA)

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1 SAFETY DATA SHEET Issuing date 19-Apr-2007 MSDS P/N: REV. C 1. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Product Code Product Name N-Methylpiperidine/Water/Methanol Trade Name(s) NMPIP/H2O/MEOH (N-METHYLPIPERIDINE/WATER/METHANOL); R2, PROTEIN SEQUENCING REAGENT; NMPIP/H2O/MEOH Recommended Use For research use only. Not for use in diagnostic procedures. Contact Manufacturer APPLIED BIOSYSTEMS 7 KINGSLAND GRANGE, WOOLSTON WARRINGTON, CHESHIRE WA1 4SR Telephone: (UK) Fax: Emergency Telephone Number CHEMTREC: (INTERNATIONAL) (NORTH AMERICA) 2. COMPOSITION/INFORMATION ON INGREDIENTS Chemical nature of the preparation Aqueous solution of alcohol and amine. Haz/Non-haz Chemical Name EINECS-No. CAS-No Weight % Classification F;R11 T;R23/24/25-39/23/24/25 1-Methylpiperidine EEC No F;R11 C;R34 R52/53 For the full text of the R phrases mentioned in this Section, see Section HAZARDS IDENTIFICATION The preparation is classified as dangerous in accordance with Directive 1999/45/EC. Classification F;R11 C;R34 T;R23/24/25-39/23/24/25 F - Highly flammable. T - Toxic. Most Important Hazards Highly flammable. Causes burns. Toxic by inhalation, in contact with skin and if swallowed. 4. FIRST AID MEASURES Page 1 / 7

2 4. FIRST AID MEASURES General advice Immediate medical attention is required. Show this safety data sheet to the doctor in attendance. In case of injury caused by fire:. Flush with plenty of water immediately. Continue flushing during transport to hospital or medical center. Eye contact contact Ingestion Inhalation Notes to physician Protection of first-aiders Immediate medical attention is required. Immediately flush with plenty of water. After initial flushing, remove any contact lenses and continue flushing for at least 15 minutes. Keep eye wide open while rinsing. Do not rub affected area. Wash off immediately with soap and plenty of water removing all contaminated clothes and shoes. Call a physician immediately. Clean mouth with water and afterwards drink plenty of water. Do NOT induce vomiting. Drink plenty of water. Never give anything by mouth to an unconscious person. Call a physician or Poison Control Centre immediately. Move to fresh air. If not breathing, give artificial respiration. Call a physician or Poison Control Centre immediately. Product is a corrosive material. Use of gastric lavage or emesis is contraindicated. Possible perforation of stomach or esophagus should be investigated. Do not give chemical antidotes. Asphyxia from glottal edema may occur. Marked decrease in blood pressure may occur with moist rales, frothy sputum, and high pulse pressure. Ethanol may inhibit methanol metabolism. Remove all sources of ignition. Avoid direct contact with skin. Use barrier to give mouth-tomouth resuscitation. 5. FIRE-FIGHTING MEASURES Suitable extinguishing media Dry chemical, CO2 water spray or alcohol-resistant foam. Move containers from fire area if you can do it without risk. Extinguishing media which must not be used for safety reasons Do not use a solid water stream as it may scatter and spread fire. Specific hazards The product causes burns of eyes, skin and mucous membranes. In the event of fire and/or explosion do not breathe fumes. Special protective equipment for firefighters Corrosive hazard. Wear protective gloves/clothing and eye/face protection. Vapors from liquefied gas are initially heavier than air and spread along ground. Wear self contained breathing apparatus for fire fighting if necessary. 6. ACCIDENTAL RELEASE MEASURES Environmental precautions Personal precautions Methods for cleaning up Methods for Containment Prevent further leakage or spillage if safe to do so. Prevent entry into waterways, sewers, basements or confined areas. Local authorities should be advised if significant spillages cannot be contained. Look out! Corrosive material. Use personal protective equipment. Remove all sources of ignition. Ensure adequate ventilation. Evacuate personnel to safe areas. Keep people away from and upwind of spill/leak. Soak up with inert absorbent material (e.g. sand, silica gel, acid binder, universal binder, sawdust). Keep in suitable, closed containers for disposal. Prevent further leakage or spillage if safe to do so. Absorb with earth, sand or other noncombustible material and transfer to containers for later disposal. Other information Refer to protective measures listed in Sections 7 and 8. Page 2 / 7

3 7. HANDLING AND STORAGE Handling Storage Ensure adequate ventilation. Keep away from open flames, hot surfaces and sources of ignition. Avoid contact with skin, eyes and clothing. To avoid ignition of vapours by static electricity discharge, all metal parts of the equipment must be grounded. In case of insufficient ventilation, wear suitable respiratory equipment. Do not eat, drink or smoke when using this product. Keep containers tightly closed in a dry, cool and well-ventilated place. Keep away from heat and sources of ignition. Keep in properly labelled containers. 8. EXPOSURE CONTROLS / PERSONAL PROTECTION Exposure Limits Chemical Name EU The United Kingdom France Spain Germany TWA: 260 mg/m 3 TWA: 266 mg/m³ STEL: 333 mg/m³ VME: 200 ppm VME: 260 mg/m 3 VLCT: 1000 ppm VLCT: 1300 mg/m 3 VLA-ED: 200 ppm VLA- ED; 266 mg/m 3 VLA-ED MAK: 200 ppm MAK: 270 mg/m 3 Ceiling / Peak: 1080 mg/m 3 Ceiling / Peak: 800 ppm TWA: 270 mg/m 3 Chemical Name Italy Portugal The Netherlands Finland Denmark STEL: 400 ppm STEL; 520 mg/m 3 STEL MAC: 200 ppm MAC; 260 mg/m 3 MAC TWA: 270 mg/m 3 STEL: 330 mg/m 3 TWA: 260 mg/m 3 Chemical Name Austria Switzerland Poland Norway Ireland TWA: 100 ppm Occupational Exposure Controls STEL: 800 ppm STEL; 1040 mg/m 3 STEL MAK: 200 ppm MAK; 260 mg/m 3 MAK STEL: 800 ppm STEL; 1040 mg/m 3 STEL MAK: 200 ppm MAK; 260 mg/m 3 MAK NDSCh: 300 mg/m 3 NDS: 100 mg/m 3 TWA: 260 mg/m 3 STEL: 310 mg/m 3 Engineering measures Personal protective equipment Respiratory protection Eye protection and body protection Hand protection Hygiene measures Environmental exposure controls Showers, eyewash stations, and ventilation systems. In case of insufficient ventilation wear suitable respiratory equipment. Tightly fitting safety goggles. Wear fire/flame resistant/retardant clothing. Impervious clothing. Chemical resistant apron. Butyl rubber. When using, do not eat, drink or smoke. Keep away from food, drink and animal feeding stuffs. Remove and wash contaminated clothing before re-use. Wash hands before breaks and immediately after handling the product. 9. PHYSICAL AND CHEMICAL PROPERTIES Page 3 / 7

4 9. PHYSICAL AND CHEMICAL PROPERTIES Appearance No information available Odour Physical state Liquid. ph Flash point 3 C / 37 F Autoignition temperature Boiling point/range Melting point/range Flammability Limits in Air Specific Gravity Solubility Evaporation rate Vapour pressure Vapour density VOC content Viscosity 10. STABILITY AND REACTIVITY Stability Conditions to avoid Materials to avoid Stable under recommended storage conditions. Heat, flames and sparks. Exposure to air or moisture over prolonged periods. Halogens. Common metals. Combustible materials. Strong oxidizing agents. Peroxides. Acids. Bases. Metal carbide. Halo carbons. Hazardous decomposition products Thermal decomposition can lead to release of irritating gases and vapours. Carbon oxides. Hazardous polymerisation Hazardous polymerisation does not occur. 11. TOXICOLOGICAL INFORMATION Acute Toxicity Product Information. Chronic Toxicity Corrosivity Reproductive Toxicity Developmental Toxicity Target Organ Effects Causes burns. Central nervous system (CNS). Eyes. Gastrointestinal tract (GI). Respiratory system.. Ecotoxicity Ecotoxicity effects of component substances. 12. ECOLOGICAL INFORMATION Chemical Name Toxicity to algae Toxicity to fish Microtox Data Daphnia magna (Water flea) Page 4 / 7

5 Chemical Name Toxicity to algae Toxicity to fish Microtox Data Daphnia magna (Water flea) LC50= mg/l Oncorhynchus mykiss 96 h LC50= mg/l Pimephales promelas 96 h EC50 = mg/l 25 min EC50 = mg/l 15 min EC50 = mg/l 5 min Persistence and degradability Bioaccumulative potential Mobility No product level data available. The product is water soluble, and may spread in water systems. Chemical Name log Pow DISPOSAL CONSIDERATIONS Waste from residues / unused products Contaminated packaging Dispose of as hazardous waste in compliance with local and national regulations. Do not re-use empty containers. Dispose of in accordance with local regulations. EWC waste disposal No Other information According to the European Waste Catalogue, Waste Codes are not product specific, but application specific. Waste codes should be assigned by the user based on the application for which the product was used. 14. TRANSPORT INFORMATION IMDG/IMO Proper shipping name Flammable liquid, n.o.s. EmS F-E, _S-E_, Flammable liquid, n.o.s. (Methanol, 1-Methylpiperidine solution), 3, PG RID ADR Proper shipping name Flammable liquid, n.o.s. Classification Code F1 Flammable liquid, n.o.s. (Methanol, 1-Methylpiperidine solution), 3,, RID ADR/RID-Labels 3 Proper shipping name Flammable liquid, n.o.s. Classification Code F1 Flammable liquid, n.o.s.(,1-methylpiperidine),3,,adr ADR/RID-Labels 3 ICAO Page 5 / 7

6 14. TRANSPORT INFORMATION Proper shipping name Flammable liquid, n.o.s.* Flammable liquid, n.o.s.* (Methanol, 1-Methylpiperidine solution), 3,, PG ICAO/IATA Proper shipping name Flammable liquid, n.o.s.* ERG Code 3H, Flammable liquid, n.o.s.* (Methanol, 1-Methylpiperidine solution), 3, PG 15. REGULATORY INFORMATION The preparation is classified as dangerous in accordance with Directive 1999/45/EC. Labelling Contains Symbol(s), 1-Methylpiperidine. F - Highly flammable. T - Toxic. R-phrase(s) R11 - Highly flammable. R34 - Causes burns. R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R39/23/24/25 - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. S-phrase(s) S 7 - Keep container tightly closed. S 9 - Keep container in a well-ventilated place. S16 - Keep away from sources of ignition - No smoking. S33 - Take precautionary measures against static discharges. S35 - This material and its container must be disposed of in a safe way. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible). S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. Take note of Dir 94/33/EC on the protection of young people at work Not to be used by professional users below 18 years of age, see the National Working Environment Authorities Executive Order on young peoples dangerous work. International Inventories Chemical Name EINECS ELINCS TSCA DSL NDSL PICCS ENCS China AICS KECL Present X - X X X X KE Methylpiperidine Present - X X X X X OTHER INFORMATION Page 6 / 7

7 16. OTHER INFORMATION Text of R phrases mentioned in Section 2 R11 - Highly flammable. R34 - Causes burns. R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R39/23/24/25 - Toxic: danger of very serious irreversible effects through inhalation, in contact with skin and if swallowed. Issuing date Revision Date Revision Note 19-Apr Jun-2007 No information available Disclaimer The information provided on this SDS is correct to the best of our knowledge, information and belief at the date of its publication. The information given is designed only as a guide for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered as a warranty or quality specification. The information relates only to the specific material designated and may not be valid for such material used in combination with any other material or in any process, unless specified in the text. End of Safety Data Sheet Page 7 / 7