CELLULAR AND MOLECULAR IMMUNOLOGY IN HEALTH AND DISEASE

Size: px

Start display at page:

Download "CELLULAR AND MOLECULAR IMMUNOLOGY IN HEALTH AND DISEASE"

Milton Mills
5 years ago
Views:

A Symposium to Celebrate the 60th Birthda

, Chief, L aboratory of Molecular and Cell Biology and Immunology, National Institute on

rick Alt, h.d. Harvard Medical S chool, USA Dipanjan Chowdhury, h.d. Harvard Medical S chool, USA Date: January 30, 2016 Time: 8:30a.

David Schatz, h.d. Yale S chool of Medicine, USA Stephen Desiderio, M.D., h.d. John Hopkins Medicine, USA Sankar Ghosh, h.

d. University of California Los Angeles, USA Joel omerantz, h.d. Johns Hopkins University S chool of Medicine, USA Rudolf Grosschedl, h.

d. University of California S an Diego S chool of Medicine, USA Yehudit Bergman, h.d. The

1 A Symposium to Celebrate the 60th Birthday of Dr. Ranjan Sen Ranjan Sen, h.d., Chief, L aboratory of Molecular and Cell Biology and Immunology, National Institute on Aging CELLULAR AND MOLECULAR IMMUNOLOGY IN HEALTH AND DISEASE Frederick Alt, h.d. Harvard Medical S chool, USA Dipanjan Chowdhury, h.d. Harvard Medical S chool, USA Date: January 30, 2016 Time: 8:30a.m. 6:00p.m. lace: Gerstenzang 121 Brandeis University 415 South Street Waltham, MA David Schatz, h.d. Yale S chool of Medicine, USA Stephen Desiderio, M.D., h.d. John Hopkins Medicine, USA Sankar Ghosh, h.d. Columbia University, USA Barbara Nikolajczyk, h.d. Boston University, USA Stephen Smale, h.d. University of California Los Angeles, USA Joel omerantz, h.d. Johns Hopkins University S chool of Medicine, USA Rudolf Grosschedl, h.d. Max lanck Institute, G ermany Batu Erman, h.d. Sabanci University, Turkey Christina Jamieson, h.d. University of California S an Diego S chool of Medicine, USA Yehudit Bergman, h.d. The Hebrew University of Jerusalem, Israel Columbia University Whitehead, MIT Brandeis University National Institute of Health

Ranjan Sen, h.d. Dr. Ranjan Sen, received his h.d. in chemistry from Columbia University in 1982.

The NF- κb transcription factor family plays critical roles in many normal physiological processes and pathological conditions such as cancers, inflammation and autoimmune diseases. In 1987, Dr.

2 Ranjan Sen, h.d. Dr. Ranjan Sen, received his h.d. in chemistry from Columbia University in He made the transition to molecular biology as a postdoctoral fellow in David Baltimore's laboratory at M.I.T. and the Whitehead Institute, where he identified the transcription factor NF- κb. The NF- κb transcription factor family plays critical roles in many normal physiological processes and pathological conditions such as cancers, inflammation and autoimmune diseases. In 1987, Dr. Sen was appointed Assistant rofessor in the Department of Biology and Rosenstiel Research Center at Brandeis University. He earned tenure in 1991 and was promoted to rofessor of Biology in He moved to his present position as Chief, Laboratory of Cellular and Molecular Biology and Immunology at the National Institute on Aging in In 2014, Dr. Sen was elected as an American Association for the Advancement of Science (AAAS) fellow for his distinguished contributions to the fields of transcription factor biology and molecular immunology, specifically related to immune system development.

3 Celebrating the 60 th Birthday of Ranjan Sen, h.d. Symposium: Cellular and Molecular Immunology in Health and Disease lace: Gerstenzang 121, Brandeis University 8:30 9:30 a.m. Continental Breakfast (Carl J. Shapiro Science Center Atrium) 9:30 9:45 a.m. Introductory Remarks Joan ress, h.d. Session I: DNA Recombination/Repair Chair: Weihong Wang, h.d.* 9:45 10:15 a.m. Frederick Alt, h.d. Recurrent DSB cluster genes in neural stem & progenitor cells may contribute to brain diversity & disease 10:15 10:35 a.m. Dipanjan Chowdhury, h.d.* Modulating the DNA DSB repair machinery is critical for genomic stability 10:35 10:45 a.m. Coffee Break 10:45 11:15 a.m. David Schatz, h.d. Evolution & regulation of the V(D)J recombinase 11:15 11:45 a.m. Stephen Desiderio, M.D., h.d. Allosteric control of V(D)J recombination: How RAG reads epigenetic marks 11:45 12:45 p.m. Lunch (Carl J. Shapiro Science Center Atrium) Session II: Inflammation/NF- κb Chair: Irvith Carvajal, h.d.* 12:45 1:15 p.m. Sankar Ghosh, h.d. Regulation of Immune homeostasis by NF- κb 1:15 1:35 p.m. Barbara Nikolajczyk, h.d.* T cell inflammatory signatures link human obesity to type 2 diabetes 1:35 2:05 p.m. Stephen Smale, h.d. Gene- specific regulatory strategies for NF- κb 2:05 2:25 p.m. Joel omerantz, h.d.* Mechanisms of normal & oncogenic signaling to NF- κb 2:25 2:40 p.m. Coffee Break Session III: Immunity/Gene Expression Chair: Winnie Tam, h.d.* 2:40 3:10 p.m. Rudolf Grosschedl, h.d. Transcriptional networks in B lymphopoiesis 3:10 3:30 p.m. Batu Erman, h.d.* Regulation of p53 by DNA damage 3:30 3:50 p.m. Christina Jamieson, h.d.* Inducible transcription: from T cells to bone metastatic prostate cancer and back again? 3:50 4:20 p.m. Yehudit Bergman, h.d. rogramming asynchronous replication in development Conclusion: 4:20 4:35 p.m. Barbara Nelsen, h.d.* 4:35 4:45 p.m. Video resentation Winnie Tam, h.d.* & Jaimy Joy 4:45 4:50 p.m. Aditi riyadarshini Sen, h.d. 4:50 5:00 p.m. Closing Remarks Ranjan Sen, h.d. 5:00 6:00 p.m. Social Hour (Carl J. Shapiro Science Center Atrium) * Sen lab alumni

Maps / Directions: http://www.brandeis.edu/about/visiting/directions.

Science Main Entrance Athletics Lot Contacts: Winnie Tam ( 781)504-9816 Weihong Wong (

4 Maps / Directions: Upper S cience Lot Gerstenzang Lower S cience Lot Rosenstiel B asic Medical Science Main Entrance Athletics Lot Contacts: Winnie Tam ( 781) Weihong Wong ( 617) Irvith Carvajal (857) Dipanjan Chowdhury (781) B arbara Nikolajczyk (617)

5 Special Thanks to Our Sponsors: Biology Department, Brandeis University RA N J A N

EPIGENETIC CONTROL AND CELLULAR PLASTICITY

International Symposium EPIGENETIC CONTROL AND CELLULAR PLASTICITY At the Beckman Center of the National Academy of Sciences 100 Academy, Irvine, CA 92617 October 4 5, 2018 School of Medicine University