Formulation Boosting R&D Services

Transcription

1 Formulation Boosting R&D Services

2 Contents Van Loon Chemical Innovations Core Technologies HT Capacities Our USP s

3 Van Loon Chemical Innovations

4 About Us Founded in November 2008 by Sander van Loon, CEO. Provides innovative R&D Services and practical solutions to the formulation industry. Number 1 formulation centre in Europe; combines applied state-ofthe-art formulation science with High Throughput screening. Offers knowledge and faster R&D (3-8) Cost savings up to 20-30%.

5 Founder Sander van Loon, 7 years working experience at SigmaKalon/PPG: from literature research up to industrial production. Enormous creativity and ability to transfer science into products, proven by 2 patents at SigmaKalon/PPG.

6 Structure CEO Sander van Loon CFO Kees Peelen Innovation Manager Alejandro Gutierrez BD Manager Pauline Equy van Gelder Formulation Chemist Sam Peel Formulation Chemist Gwenola Le Mouée Formulation Engineer Nacho Martinez Formulation & Synthesis High Throughput

7 Two locations in Europe Science Park Amsterdam: Headquarters High Throughput Capabilities Amsterdam Science Park Barcelona: Barcelona Technology Distribution Centre

8 Our Approach Independent lab serving RM suppliers, universities, institutes and end user market. Core technologies: HT, HLD-NAC, HSP, EIS Coatings, cosmetics, personal care, household

9 Our Approach Generating new insights and products based on broad applied formulation knowledge. Boosting R&D process via High Throughput. Formulation Science Boosting your development! High Throughput

10 Core Technologies

11 Core Technologies (Micro-)emulsions via HLD-NAC Hansen Solubility Parameters Electrochemical Impedance Determination of Cc (Characteristic curvature) and EACN (Equivalent Alkane Carbon Number) parameters. Effective surfactant selection for emulsions and resin dispersions. Effective solvent selection and raw material matching. Improvement of solubility, stability and efficacy. Accelerated testing for corrosion inhibition and barrier performance. Analysis of emulsion Transitions and to generate phase diagrams.

12 (Micro-)emulsions via HLD-NAC Hydrophilic Lipophilic Difference Net Average Curvature Effective surfactant selection for the formulation of (micro-) emulsions and resin dispersions. Based on the HLD-NAC Equation: HLD = F(S) k.eacn -. T + Cc + f(a) EACN: Equivalent Alkane Carbon Number of the oil Cc: Characteristic Curvature of the surfactant k, : constants depending on the surfactant F(S): salinity function (depends on the surfactant) f(a): co-surfactant/co-solvent function Allows profound predictions (o/w, w/o, ME)

13 (Micro-)emulsions via HLD-NAC HLD = F(S) k.eacn -. T + Cc + f(a) HLD < 0 HLD = 0 HLD > 0 Oil Type Winsor I, o/w Type Winsor III or IV Type Winsor II, w/o

14 Hansen Solubility Parameters (HSP) Certified and worldwide centre for the determination of HSP parameters. Strong collaborations with Dr. Charles Hansen and Prof. Steven Abbott. Hansen Solubility Parameters: - δd for Dispersion (van der Waals) - δp for Polarity (Dipole Moment) - δh for Hydrogen Bonding Based on like seeks like principle: likeness is measured by the HSP distance metric.

15 Hansen Solubility Parameters (HSP) Polymers (Bio-based) Solvents Oils Surfactants API s Pigments & Fillers Replace toxic solvents by non-hazardous solvent blends Match ingredients e.g. optimum dispersant for stable solid suspensions Improve efficacy e.g. solubility of actives / film formation of high- MFFT resin dispersions

16 Electrochemical Impedance Spectroscopy (EIS) Well-established quantitative method for testing corrosion inhibition and barrier performance. Provides reliable predictions on long-term behaviour in a short amount of time. Result: Impedance of electrochemical system as function of frequency, described with an equivalent electrical circuit. 2 methods: - Standard EIS (ISO 16773): 3 weeks - Accelerated EIS (ISO 17463): 24 hours

17 Core Technologies - References Our Customers EU Subsidy Projects Chemspeed HT Prof. Edgar Acosta Emulsions University of Jena HT and polymer testing Our Collaborations Prof. Steven Abbott Emulsions and HSP implementations Dr. Charles Hansen HSP

18 High Throughput (HT)

19 High Throughput (HT) Capabilities Used as an extension of the lab / not meant to reduce staff. Speeds up R&D (3-8 times). Saves costs: 20-30%. Free your mind to increase knowledge! HT expertise within VLCI.

20 High Throughput (HT) Capabilities Aim: Smart and fast screening to identify most promising formulations. The entire product development process can be translated to HT: polymer synthesis, preparation of various formulated products via mixing/dispersing, and testing.

21 High Throughput Formax

22 Automated Dispensing Units

23 Automated Preparation

24 High Throughput (HT) Capabilities High accuracy Independent control of: - Stirring - Dispersing - Feeding - Heating/cooling Formulations: paints, inks, personal care, cosmetics, styling products, cleaners, dispersions, polymers, samples for phase diagrams and solubility samples.

25 High Throughput (HT) Capabilities HT platform customizable up to needs and requirements Further expansion in formulation testing, e.g. rheology

26 High Throughput (HT) Capabilities 1. Save on time to market: - Reformulation with HT to solve problems in the market - Speeding up R&D innovation process - Screening and characterization of raw materials 2. Save on costs 3. Increase knowledge / Build up a library 4. Processing research

27 High Throughput (HT) Capabilities Man vs. HT Man VLCI / HT Formulations/day 4 12 Hours/100 formulations Costs/100 formulations Savings - : 33% Hours: 66%

28 High Throughput VLCI Knowledge Competitive Advantage KNOW-WHAT - Calibration parameters for different RM - Database of workflows for downscaling lab processes - Applied formulation science with HT screening KNOW-WHY - Moving the formulation industry to a higher level - Reliable R&D partner to improve development process VLCI KNOW-HOW - Multidisciplinary team of formulation experts - Long experience operating and improving HT systems & methods - Flexible HT platform with a wide range of tools and vessels KNOW-WHO Chemspeed Flamac University of Jena

29 Unique Selling Points RM Suppliers Connects VLCI Formulation science Extensive RM knowledge DoE & HT New insights/ products Formulators

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31 Science Park XH Amsterdam The Netherlands Formulation Boosting R&D Services I: E: T: 0031(0) Parc Científic Barcelona Baldiri Reixac, Barcelona Spain

32 Formulation Boosting R&D Services I: E: T: 0031(0) Science Park XH Amsterdam The Netherlands Parc Científic Barcelona Baldiri Reixac, Barcelona Spain