Kloster Seeon Meeting on BACE Proteases in Health and Disease. October 6-8, 2013 in Kloster Seeon, Bavaria, Germany

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1 Kloster Seeon Meeting on BACE Proteases in Health and Disease October 6-8, 2013 in Kloster Seeon, Bavaria, Germany Invited Speakers: Bruce Albala, Eisai Mark Albers, Harvard Medical School Michael Boulton, University of Florida Bastian Dislich, DZNE & TUM Bart De Strooper, University of Leuven & VIB Christian Haass, DZNE & LMU Jochen Herms, DZNE & LMU Matthew Kennedy, Merck Peer-Hendrik Kuhn, DZNE & TUM Patrick May, Eli Lilly Guillaume van Niel, Institute Curie, Paris Lawrence Rajendran, University of Zurich Markus Stoffel, ETH Zurich Giuseppina Tesco, Tufts University Taisuke Tomita, University of Tokio Philip Wong, Johns Hopkins University Riqiang Yan, Lerner Research Institute Robert Vassar, Northwestern University Ryan Watts, Genentec organized by: Stefan Lichtenthaler DZNE & Technical University Munich

2 Meeting on BACE Proteases in Health and Disease October 6-8, 2013 in Kloster Seeon Klosterweg Seeon-Seebruck Germany Phone: +49 (0) Information and registration information: organized by: Stefan Lichtenthaler DZNE, German Center for Neurodegenerative Diseases Munich &Technical University Munich Max-Lebsche-Platz 30, Munich Phone: +49 (0) Fax: +49 (0) Mail: stefan.lichtenthaler@dzne.de Administration: Carolin Nierwetberg Phone: +49 (0) Mail: carolin.nierwetberg@dzne.de We gratefully thank the following companies and institutions for financial support:

3 Program Sunday, October 6, Welcome (Stefan Lichtenthaler, DZNE & Technical University Munich) Session 1: Key Note Lecture Robert Vassar, Northwestern University, USA The beta-secretase BACE1 in health and Alzheimer's disease Coffee break Session 2: BACE2 substrates and function Chair: N.N Markus Stoffel, ETH Zurich, Switzerland BACE2: A regulator of the pancreatic beta cell sheddome and beta cell function Guillaume van Niel, Institut Curie, France Role of BACE2 in the processing of functional amyloids Dinner Poster session Monday, October 7, 2013 Session 1: BACE1 phenotypes and substrates 1 Chair: Erik Portelius Mark Albers, Harvard Medical School, USA Physiological functions of the BACE1 protease in the context of a neural circuit in vivo Mike Boulton, University of Florida, USA BACE and retinal pathophysiology 3

4 Jochen Herms, DZNE & LMU Munich, Germany BACE inhibition affects spine formation Philip Wong, Johns Hopkins University, USA Evaluating a novel substrate of BACE1 and BACE2 and therapeutic potential of BACE Coffee break / Poster session Session 2: BACE1 phenotypes and substrates 2 Chair: Michael Willem Christian Haass, DZNE & University of Munich, Germany Function and dysfunction of the two BACE proteases Carmen Birchmeier, Max-Delbrück-Centrum, Berlin, Germany BACE1 and Nrg1 cooperate to induce muscle spindles Riqiang Yan, Lerner Research Institute, Cleveland, USA BACE1 in the control of hippocampal astrogenesis and neurogenesis Lunch Session 3: BACE1 Substrates and Therapeutic potential Chair: Dirk Montag Bart De Strooper, University of Leuven & VIB, Belgium The role of BACE1 in neuronal differentiation and wiring Peer-Hendrik Kuhn, DZNE & Technical University Munich, Germany BACE1 substrates and implications for BACE1 physiological function in the CNS Ryan Watts, Genentech, USA Enhancing antibody uptake in brain with TfR/BACE1 bispecific antibodies to reduce amyloid Coffee Break Session 4: Therapeutics Chair: Martin Citron Matthew Kennedy, Merck, USA Discovery of a novel class of beta-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease 4

5 Patrick May, Eli Lilly, USA Discovery and development of a small molecule BACE1 inhibitor Bruce Albala, Eisai Inc, USA Experiences with a novel BACE inhibitor: from test tube to man Dinner Tuesday, October 8, 2013 Session 1: Modulation and function 1 Chair: Lawrence Rajendran Gopal Thinakaran, University of Chicago, USA Illuminating BACE1 trafficking in neurons Giuseppina Tesco, Tufts University, USA Regulation of BACE1 degradation in health and disease Mikko Hiltunen, University of Eastern Finland, Finland Global expression analysis of Alzheimer s disease brain samples to identify novel targets affecting APP and BACE Coffee break Session 2: Modulation and function 2 Chair: Massimo Tabaton Taisuke Tomita, The University of Tokio, Japan Modulation of expression and activity of BACE1 by membrane environment" to "Modulation of BACE1 activity by membrane environment Lawrence Rajendran, University of Zurich, Swizzerland A neuregulin-sparing BACE1 inhibitor for Alzheimer's disease therapy Bastian Dislich, DZNE & Technical University Munich, Germany Global proteomic profiling of BACE1 knock-out mouse brain Lunch Departure 5