Single Cell Biology 6-8 March Wellcome Genome Campus, Hinxton, Cambridge, UK

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Single Cell Biology 6-8 March 2018 Wellcome Genome Campus, Hinxton, Cambridge, UK Conference Programme Tuesday, 6 March 2018 12:30-13:50 Registration with Lunch 13:50-14:00 Welcome and Introductions

1 Single Cell Biology 6-8 March 2018 Wellcome Genome Campus, Hinxton, Cambridge, UK Conference Programme Tuesday, 6 March :30-13:50 Registration with Lunch 13:50-14:00 Welcome and Introductions Bertie Göttgens, University of Cambridge, UK 14:00-15:00 Keynote Lecture: Chair: Bertie Göttgens, University of Cambridge, UK In situ imaging of the organizations of transcriptome and genome in single cells Xiaowei Zhuang Harvard University/HHMI, USA 15:00-16:00 Session 1: Technology Development Chair: Timm Schroeder, ETH Zurich, Switzerland 16:00-16:30 Afternoon Tea 15:00 Understanding cellular heterogeneity Sarah Teichmann 15:30 Finding and interpreting genetic interactions using Perturb-seq single cell RNA-seq CRISPR screens Jonathan Weissman UCSF/HHMI, USA 16:30-17:45 Session 1 continued: Technology Development Chair: Timm Schroeder, ETH Zurich, Switzerland 16:30 Exploring the dynamic benefits of intracellular noise Mustafa Khammash ETH Zurich, Switzerland 17:00 Single cell transcriptional dynamics underlying gene family expansion Jonathan Chubb MRC LMCB, UK

2 17:15 Tracking hematopoietic stem cell kinship during in vitro clonal expansion provides insight at the most detailed level of cell fate and differentiation Marijn van Loenhout Hubrecht Institute, The Netherlands 17:30 Microfluidics for live cell imaging and cellular context Mark D. Lynch Fluidigm Corporation 17:45 Discussion 17:45-19:30 Poster Session 1 (odd numbers) with drinks reception 19:30 Dinner Wednesday, 7 March :00-10:30 Session 2: Development Chair: Andrea Münsterberg, University of East Anglia, UK 10: Morning Coffee 09:00 Self-organization and symmetry breaking during intestinal organoids Prisca Liberali FMI, Switzerland 09:30 Charting the diversification of mammalian cells at whole organism scale Bertie Göttgens University of Cambridge, UK 10:00 Systematic mapping of cell state trajectories, cell lineage, and perturbations in the zebrafish embryo using single cell transcriptomics Daniel Wagner Harvard Medical School, USA 10:15 Identification of a neural crest stem cell niche by Spatial Genomic analysis Antti Lignell, University of Helsinki, Finland 11:00-12:30 Session 3: Computational Tools Chair: Fabian Theis, Helmholtz Center Munich, Germany 11:00 Multimodal and multiplex molecular imaging tools for single cell analysis Scott Fraser University of Southern California, USA 11:30 Cell states in the tumor ecosystem and the transitions between them Dana Pe er Columbia University, USA 2

3 12:30-14:00 Lunch 12:00 Decomposing spatially dependent and cell type specific contributions to cellular heterogeneity Guocheng Yuan Harvard University, USA 12:15 Concerted computational approaches to interpret transcriptional heterogeneity in pluripotent stem cells Kirsten McEwen Imperial College London, UK 14:00-15:30 Session 4: Cancer Chair: Michael Rieger, Goethe University Frankfurt, Germany 15:30-16:00 Afternoon Tea 14:00 Tracking the fate of single mutant stem cells in oesophageal pre-cancer Philip Jones 14:30 Deciphering intra-tumoral heterogeneity by single cell RNA-seq Itay Tirosh Weizmann Institute of Science, Israel 15:00 Intracellular (phospho-) protein and mrna quantification from single human epidermal stem cells Klaas Mulder Radboud University, The Netherlands 15:15 TARGET-seq: a novel method for single-cell mutational analysis and parallel RNA-sequencing Alba Rodriguez-Meira University of Oxford, UK 16:00-17:30 Session 5: Neurobiology Chair: Scott Fraser, University of Southern California, USA 16:00 Molecular organization of the mammalian nervous system at the single-cell level Sten Linnarsson Karolinska Institute, Sweden 16:30 Gene delivery across the blood-brain-barrier, whole-body tissue clearing, and optogenetics to understand and influence physiology and behavior Viviana Gradinaru Caltech, USA 17:00 Single-cell transcriptome profiling of Drosophila optic lobe neurons Chaimaa Fadil New York University Abu Dhabi, UAE 17:15 Spatiotemporal trajectories in the developing human cortex Aparna Bhaduri UCSF, USA 3

4 17:30-19:00 Poster Session 2 (even numbers) with drinks reception 19:00 Conference Dinner Thursday, 8 March :00-10:00 Keynote Lecture Chair: Ellen Rothenberg, Caltech, USA Organizing principles of gene regulatory programs in somatic evolution Itai Yanai NYU Langone, USA 10:00-11:15 Session 6: Stem Cells Chair: Ellen Rothenberg, Caltech, USA 11:15-11:45 Morning Coffee 10:00 Characterising cell state transitions in mammalian epidermis Fiona Watt King s College London, UK 10:30 Exploring the mechanisms of haematopoietic lineage progression at the single-cell level Ana Cvejic University of Cambridge and 11:00 Restriction of lineage potential within the human haematopoietic stem cell pool Serena Belluschi Stem Cell Institute, UK 11:45-13:00 Session 7: Immunology Chair: Sarah Teichmann, 11:45 Multi-parameter analyses of single primitive human cord blood cells reveals a complex topology of early hematopoietic differentiation events Connie Eaves BC Cancer Agency, Canada 12:15 Deciphering the regulatory control of γδt cell development by single cell transcriptome analysis Dominic Grün Max Planck Institute of Immunobiology and Epigenetics, Germany 12:30 Simultaneous lineage tracing and cell type identification using CRISPR/Cas9 induced genetic scars Jan Philipp Junker Max Delbrück Center, Germany 4

5 13:10-14:00 Lunch & depart 13:00 Closing remarks Sarah Teichmann 14:00 Coaches depart to Cambridge City Centre and Train Station, Heathrow Airport and Stansted Airport 5

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