Webinar July 9, Noon. The Essentials of Diagnostics: Introduction to Molecular Diagnostics
|
|
- Alexis Cross
- 6 years ago
- Views:
Transcription
1 Webinar July 9, Noon The Essentials of Diagnostics: Introduction to Molecular Diagnostics 1
2 DxInsights mission is to educate healthcare stakeholders on the power and value of diagnostics and their impact on improving patient outcomes and reducing costs 2
3 DxInsights is an industry-wide educational organization connecting stakeholders to the best diagnostic resources and to each other. Web-based Resource Center Educational Events Medical School Curriculum Original Research and Collaboration 3
4 AdvaMedDx is a diagnostics association within an association at AdvaMed, representing about 70 global diagnostics manufacturers. Vision Government Affairs Technology & Regulation Global AdvaMedDx will be a world leader in advocating for the power of medical diagnostics to promote wellness, improve patient outcomes and advance public health. Goals Medical Technology Learning Institute Payment Create an understanding of the value of medical diagnostic tests. Be a valued contributor to diagnostics and health care policy. Legal Public Affairs Ensure timely patient access to safe and effective diagnostic tests. Modernize payment systems for diagnostic tests.
5 Advocacy & Public Affairs Form and strengthen stakeholder alliances. Develop policy and educational content; establish communications channels. Create a core group of policy makers who understand diagnostics and key policy needs. Expand global collaboration. AdvaMedDx.org
6 DxInsights and AdvaMedDx Present: The Essentials of Diagnostics: Introduction to Molecular Diagnostics 6
7 Introduction Diagnostic tests are the foundation of a successful health care system, providing critical information that healthcare providers and patients need to make the right medical decisions. Molecular diagnostics is a dynamic and transformative area of diagnostics, leading to insights in research and treatment in many disease states that are revolutionizing health care. This report provides: An overview of the current landscape for molecular diagnostics Explains the key technologies that are driving the molecular revolution Illustrates the power of molecular diagnostics with some specific examples Notes some challenges that have the potential to influence progress in the future. 7
8 Molecular In The News Continued clinical breakthroughs using molecular technologies Long-Term Reduction in Peripheral Blood HIV Type 1 Reservoirs Following Reduced-Intensity Conditioning Allogeneic Stem Cell Transplantation Long awaited legal decisions announced Supreme Court Rule Isolated Human Genes Cannot Be Patented Deals in molecular continue Thermo Fisher Scientific Acquires Life Technologies in $13.6B Deal Companion dx gets more interesting Pfizer, Collaborators Developing NanoString ALK Test as Lower- Cost Alternative to FISH, IHC Celebrities Weigh In My Medical Choice: A New York Times Op-Ed by Angelina Jolie 8
9 What Is Molecular Diagnostics? Molecular diagnostics examine the molecules in the cell, i.e. the proteins, the RNA and DNA and how they are operating within the system that we call human biology. Cancer Cells DNA Tissue RNA Pathogen Protein Source: DxInsights/AdvaMedDx 9
10 Molecular and the Global IVD Market Molecular is a portion of the total global in vitro diagnostics market. Global In Vitro Diagnostics Market Molecular The global IVD market was $45.6B in Total IVD market expected to grow at about 7% Molecular market expected to grow at about 12% Growth fueled by infectious disease and oncology testing, and markets in new geographies Rest of IVD Source: Frost and Sullivan. 10
11 Molecular Technology Evolution With its start as a classic life science tool, polymerase chain reaction (PCR) licenses and products topped a billion dollars in the 2000s, and the transition to the core lab is just beginning. PCR Climb To Adoption 1985 Kary Mullis invents PCR 1991 Roche acquires PCR from Cetus $0 clinical revenue 1998 First PCR-based tests for HIV viral loads available in labs <$1B clinical revenue from licenses and products High-volume infectious disease tests on automated PCR-based platforms begin to enter core lab 1980s 1990s 2000s 2010s Note: Adapted from Health Advances AACC presentation 2011 Source: Washington G2 reports, Health Advances analysis, Roche company data. Source: DxInsights/AdvaMedDx 11
12 Molecular Technology Example The Polymerase Chain Reaction (PCR) is one of many techniques used to isolate and amplify a specific segment of DNA. Amplification Cycles Purified DNA Source: DxInsights/AdvaMedDx Primers choose DNA segment of interest, PCR amplifies sample in cycles 12
13 Classic Molecular Diagnostics A person with cystic fibrosis has a deletion of three nucleotides in their genetic sequence, which results in the deletion of an amino acid. This manifests in the classic CF symptoms. Genetic Comparison in Cystic Fibrosis Normal Person CFTR Sequence Nucleotide: Amino acid: ATC ATC TTT GGT GTT Ile Ile Phe Gly Val Deleted in ΔF508 Person with Cystic Fibrosis ΔF508 CFTR Sequence Nucleotide: Amino acid: ATC ATT GGT GTT Ile Ile Gly Val 506 Source: DxInsights/AdvaMedDx 13
14 Comprehensive Role of Diagnostics Diagnostics can help clinicians optimally manage patients through the continuum of care. Risk Assessment Screening Diagnosis Staging and Prognosis Therapy Selection Monitoring Description Diagnostic tests to complement traditional risk factors Applied to high-risk patients to identify disease early Used for definitive diagnosis and general typing Assess severity and/or risk of recurrence Inform adjuvant therapy decision Used to predict efficacy or safety response to specific treatments Recurrence monitoring Monitoring for treatment efficacy Clinical Implications Implement wellness programs proactively Nip disease in the bud with early treatment Refer to the appropriate specialist Determine whether treatment is necessary Do not waste unproductive therapy Control disease progression with changes in treatment Source: DxInsights/AdvaMedDx 14
15 Molecular Diagnostic Examples There are hundreds of examples of molecular diagnostics across this continuum. Risk Assessment Screening Diagnosis Staging and Prognosis Therapy Selection Monitoring Description Diagnostic tests to complement traditional risk factors Applied to high-risk patients to identify disease early Used for definitive diagnosis and general typing Assess severity and/or risk of recurrence Inform adjuvant treatment decision Used to predict efficacy or safety response to specific treatments Recurrence monitoring Monitoring for treatment efficacy Molecular Diagnostic Example CF carrier testing BRCA1 testing MRSA HPV TB CT/NG OncoType Dx MammaPrint BRAF KRAS Her2 BCR-ABL HIV viral load Source: DxInsights/AdvaMedDx 15
16 Example Companies in Molecular Diagnostics Companies playing in the molecular diagnostics space are varied; and collaboration and M&A is vibrant. Note: Example companies only Source: DxInsights/AdvaMedDx 16
17 The Future Of Molecular Diagnostics Excitement about the future of this field must be tempered by recognition of the challenges of continuing innovation and timely patient access. Clinical Evidence What is the minimal clinical evidence needed for adoption and what investment is required? Regulatory How do regulatory bodies stay current and develop rules that makes sense for all stakeholders? IP What can we patent and what can we not? IT How do we capture, store and analyze the tremendous amount of diagnostic data? Reimbursement When will our evolving reimbursement system stop evolving? Ethical Considerations How do we address the ethical and privacy issues around some of this diagnostic data? Source: DxInsights/AdvaMedDx 17
18 Read The Report The Essentials of Diagnostics: Introduction to Molecular Diagnostics 18
19 Q&A and For More Information Kristin Pothier Partner, Health Advances; Founder, DxInsights Andrew Fish Executive Director, AdvaMedDx 19
Future of Molecular Diagnostics: Innovative Technologies Driving Market Opportunities
Future of Molecular Diagnostics: Innovative Technologies Driving Market Opportunities Introduction The report analyzes current and potential world molecular diagnostics markets and advances in the field.
More informationRoche, Roche Molecular Diagnostics and more
, Molecular and more [Monte Wetzel, PhD] Patients have questions. We provide answers. Group Clear focus on Healthcare Innovation with two strong pillars Pharma Pharma Genentech Chugai Molecular Professional
More informationNOTES - CH 15 (and 14.3): DNA Technology ( Biotech )
NOTES - CH 15 (and 14.3): DNA Technology ( Biotech ) Vocabulary Genetic Engineering Gene Recombinant DNA Transgenic Restriction Enzymes Vectors Plasmids Cloning Key Concepts What is genetic engineering?
More informationTHE PATH TO PRECISION MEDICINE IN MULTIPLE MYELOMA. themmrf.org
THE PATH TO PRECISION MEDICINE IN MULTIPLE MYELOMA themmrf.org ABOUT THE MULTIPLE MYELOMA RESEARCH FOUNDATION The Multiple Myeloma Research Foundation (MMRF) was established in 1998 by identical twin sisters
More informationPersonalised Healthcare Solutions (PHCS) Excellence for your Biomarker-driven Strategies
Personalised Healthcare Solutions (PHCS) Excellence for your Biomarker-driven Strategies The value of In Vitro Diagnostics The value of diagnostics as an integral part in the healthcare value chain Diagnostics
More informationBIOLOGY Dr.Locke Lecture# 27 An Introduction to Polymerase Chain Reaction (PCR)
BIOLOGY 207 - Dr.Locke Lecture# 27 An Introduction to Polymerase Chain Reaction (PCR) Required readings and problems: Reading: Open Genetics, Chapter 8.1 Problems: Chapter 8 Optional Griffiths (2008) 9
More informationLeveraging an Academic-Industry Partnership for Commercial Success
Leveraging an Academic-Industry Partnership for Commercial Success For 115 Years, the Nation s Leading Respiratory Hospital Respiratory Heritage: 115 Years of Respiratory Research and Care Allergy, Asthma,
More informationPolymerase Chain Reaction (PCR) May 23, 2017
Polymerase Chain Reaction (PCR) May 23, 2017 Outline History of PCR Uses of PCR How PCR works How to set up and run PCR The structure of DNA PCR Polymerase chain reaction Selective amplification of target
More informationDeveloping an Accurate and Precise Companion Diagnostic Assay for Targeted Therapies in DLBCL
Developing an Accurate and Precise Companion Diagnostic Assay for Targeted Therapies in DLBCL James Storhoff, Ph.D. Senior Manager, Diagnostic Test Development World Cdx, Boston, Sep. 10th Molecules That
More informationThe Polymerase Chain Reaction. Chapter 6: Background
The Polymerase Chain Reaction Chapter 6: Background PCR Amplify= Polymerase Chain Reaction (PCR) Invented in 1984 Applications Invention of PCR Kary Mullis Mile marker 46.58 in April of 1983 Pulled off
More informationCENTRAL NERVOUS SYSTEM (CNS) BIOMARKERS: TECHNOLOGIES AND GLOBAL MARKETS
CENTRAL NERVOUS SYSTEM (CNS) : TECHNOLOGIES AND GLOBAL MARKETS BIO074C March 2016 Jackson Highsmith Project Analyst ISBN: 1-62296-246-X BCC Research 49 Walnut Park, Building 2 Wellesley, MA 02481 USA 866-285-7215
More informationLecture 3 (FW) January 28, 2009 Cloning of DNA; PCR amplification Reading assignment: Cloning, ; ; 330 PCR, ; 329.
Lecture 3 (FW) January 28, 2009 Cloning of DNA; PCR amplification Reading assignment: Cloning, 240-245; 286-87; 330 PCR, 270-274; 329. Take Home Lesson(s) from Lecture 2: 1. DNA is a double helix of complementary
More informationQIAGEN Sample & Assay Technologies From Discovery to Patient
QIAGEN From Discovery to Patient New York, February 14 QIAGEN 2008 Analyst & Investor Day Peer Schatz, CEO -7- Forward Looking Statements Safe Harbor Statement: Certain of the statements contained in this
More informationPresented by: Tess L. Crisostomo Laboratory Quality Assurance/Compliance Officer Naval Medical Center San Diego
Presented by: Tess L. Crisostomo Laboratory Quality Assurance/Compliance Officer Naval Medical Center San Diego Discuss the difference between DNA Genotyping and Genome Sequencing What makes you who you
More information35th Annual J.P. Morgan Healthcare Conference
35th Annual J.P. Morgan Healthcare Conference Investor Presentation Nachum Homi Shamir President and Chief Executive Officer January, 2017 Safe Harbor Statement Certain statements made during the course
More informationFirst Annual Biomarker Symposium Quest Diagnostics Clinical Trials
First Annual Biomarker Symposium Quest Diagnostics Clinical Trials Terry Robins, Ph.D. Director Biomarker R&D and Scientific Affairs Quest Diagnostics Clinical Trials Key Considerations: Biomarker Development
More informationLATE-PCR. Linear-After-The-Exponential
LATE-PCR Linear-After-The-Exponential A Patented Invention of the Laboratory of Human Genetics and Reproductive Biology Lab. Director: Lawrence J. Wangh, Ph.D. Department of Biology, Brandeis University,
More informationStem Cell Services. Driving Innovation for Stem Cell Researchers
Driving Innovation for Stem Cell Researchers Stem Cell Services Partner with us and have access to the most advanced and comprehensive stem cell services available today. 675 W. Kendall St. Cambridge,
More informationREIMAGINING DRUG DEVELOPMENT:
Biology Reconstructed REIMAGINING DRUG DEVELOPMENT: Accurate Disease Modeling To Drive Successful Therapies Julia Kirshner, CEO julia@zpredicta.com 1 SUCCESS RATES OF DRUG DEVELOPMENT ARE LOW, " PARTICULARLY
More informationPage 2. Explain how the structure of DNA is related to its functions (Extra space)
Q1.(a) Explain how the structure of DNA is related to its functions. (Extra space)... (6) Scientists investigated three genes, C, D and E, involved in controlling cell division. Page 2 They studied the
More informationPolymerase Chain Reaction (PCR) and Its Applications
Polymerase Chain Reaction (PCR) and Its Applications What is PCR? PCR is an exponentially progressing synthesis of the defined target DNA sequences in vitro. It was invented in 1983 by Dr. Kary Mullis,
More informationInstrument specifications Technology Software Host interfaces Printer interfaces Data Station Physical dimensions Weight Certifications
The evolution of PCR Introducing the COBAS TaqMan 48 Analyzer At the forefront of PCR evolution Since Roche acquired the rights to PCR in 1991, its mission has been to fully realize the potential of this
More informationTargeted Sequencing of Leukemia-Associated Genes Using 454 Sequencing Systems
Sequencing Application Note March 2012 Targeted Sequencing of Leukemia-Associated Genes Using 454 Sequencing Systems GS GType TET2/CBL/KRAS and RUNX1 Primer Sets for the GS Junior and GS FLX Systems. Introduction
More informationHow to Build a Molecular Testing Laboratory: Key Strategic & Operational Considerations. The complete guide to developing or expanding your lab
How to Build a Molecular Testing Laboratory: Key Strategic & Operational Considerations The complete guide to developing or expanding your lab Includes step-by-step plans for basic and full-service MDx
More informationBIOMARKERS: TECHNOLOGIES AND GLOBAL MARKETS
: TECHNOLOGIES AND GLOBAL MARKETS BIO061C April 2014 Jackson Highsmith Project Analyst ISBN: 1-56965-801-3 BCC Research 49 Walnut Park, Building 2 Wellesley, MA 02481 USA 866-285-7215 (toll-free within
More informationQuantStudio Dx Real-Time PCR Instrument
QuantStudio Dx Real-Time PCR Instrument Behind every diagnosis, there is a promise You believe in molecular medicine. So do we. We are committed to providing you with comprehensive solutions that help
More informationGenetics Lecture 21 Recombinant DNA
Genetics Lecture 21 Recombinant DNA Recombinant DNA In 1971, a paper published by Kathleen Danna and Daniel Nathans marked the beginning of the recombinant DNA era. The paper described the isolation of
More informationBacteria in Semen. Sponsored by Bedford Research Foundation
Bacteria in Semen Background: The concept of detecting and identifying bacteria by ribosomal RNA gene sequences is about 15 years old. Although limited, the application of this approach to clinical specimens
More informationAccessible answers. Targeted sequencing: accelerating and amplifying answers for oncology research
Accessible answers Targeted sequencing: accelerating and amplifying answers for oncology research Help advance precision medicine Accelerate results with Ion Torrent NGS Life without cancer. This is our
More informationNext Generation Sequencing (NGS) Market Size, Growth and Trends ( )
Next Generation Sequencing (NGS) Market Size, Growth and Trends (2014-2020) July, 2017 4 th edition Information contained in this market report is believed to be reliable at the time of publication. DeciBio
More informationRoche in Australia Innovation Leader
Roche in Australia Innovation Leader About Roche Innovation: it s in our DNA 7,000,874 hours of work 6,587 experiments 423 researchers 1 drug For nearly 120 years, Roche has been committed to improving
More informationAGRO/ANSC/BIO/GENE/HORT 305 Fall, 2016 Overview of Genetics Lecture outline (Chpt 1, Genetics by Brooker) #1
AGRO/ANSC/BIO/GENE/HORT 305 Fall, 2016 Overview of Genetics Lecture outline (Chpt 1, Genetics by Brooker) #1 - Genetics: Progress from Mendel to DNA: Gregor Mendel, in the mid 19 th century provided the
More informationMolecular Diagnostics OEM and Commercial Supply Services. Your partners for success
Molecular Diagnostics OEM and Commercial Supply Services Your partners for success We enable the success of our molecular diagnostics partners in the development and commercialization of integrated solutions
More informationCHARTING THE COURSE FOR PRECISION MEDICINE
A Friends of Cancer Research White Paper CHARTING THE COURSE FOR PRECISION MEDICINE ADOPTING CONSENSUS ANALYTICAL STANDARDS AND STREAMLINING APPROVAL PATHWAYS FOR POST-MARKET MODIFICATIONS FOR NGS TESTS
More informationnot to be republished NCERT BIOTECHNOLOGY AND ITS APPLICATIONS CHAPTER BIOLOGY, EXEMPLAR PROBLEMS MULTIPLE-CHOICE QUESTIONS
82 BIOLOGY, EXEMPLAR PROBLEMS CHAPTER 12 BIOTECHNOLOGY AND ITS APPLICATIONS 1. Bt cotton is not: a. A GM plant b. Insect resistant MULTIPLE-CHOICE QUESTIONS c. A bacterial gene expressing system d. Resistant
More informationMolecular Diagnostics
Molecular Diagnostics Positioning the Laboratory for the Future Through Scalable Lab Developed Test Workflows, Clinical-level Quality, & Operational Efficiency Path to the heart of healthcare Change It
More informationKonica Minolta to Acquire Invicro (US)
Konica Minolta to Acquire Invicro (US) Acceleration of expansion of precision medicine business Offering new value for drug discovery and development in immuno-oncology and neurodegenerative disease September
More informationHistory has Demonstrated that Sub-optimal CDx Strategies can Impact Drug Success
DOES YOUR COMPANION DIAGNOSTIC STRATEGY BEST P OSITION YOU FOR SUCCESS? History has Demonstrated that Sub-optimal CDx Strategies can Impact Drug Success Real-World Examples 1 st Year Sales Increased complexity
More informationOwn the future As molecular testing evolves, so can you
Own the future As molecular testing evolves, so can you Not for distribution in the US; not available in all markets. cobas 8800 System Introducing the cobas 6800 and 8800 Systems Redefining molecular
More informationThe Polymerase Chain Reaction. Chapter 6: Background
The Polymerase Chain Reaction Chapter 6: Background Invention of PCR Kary Mullis Mile marker 46.58 in April of 1983 Pulled off the road and outlined a way to conduct DNA replication in a tube Worked for
More informationNeue Technologien für die patientennahe personalisierte Diagnostik
Neue Technologien für die patientennahe personalisierte Diagnostik 2014 Dr. Soeren Schumacher, M.B.A. 27th of June 2014 1 A heterogeneous pool 27th of June 2014 2 A heterogeneous pool Personalized Medicine
More informationIntroduction to BioMEMS & Medical Microdevices DNA Microarrays and Lab-on-a-Chip Methods
Introduction to BioMEMS & Medical Microdevices DNA Microarrays and Lab-on-a-Chip Methods Companion lecture to the textbook: Fundamentals of BioMEMS and Medical Microdevices, by Prof., http://saliterman.umn.edu/
More informationINTRODUCTION TO REVERSE TRANSCRIPTION PCR (RT-PCR) ABCF 2016 BecA-ILRI Hub, Nairobi 21 st September 2016 Roger Pelle Principal Scientist
INTRODUCTION TO REVERSE TRANSCRIPTION PCR (RT-PCR) ABCF 2016 BecA-ILRI Hub, Nairobi 21 st September 2016 Roger Pelle Principal Scientist Objective of PCR To provide a solution to one of the most pressing
More informationInnovations in Molecular Lab Operation. Joseph M. Campos, PhD, D(ABMM), F(AAM)
Innovations in Molecular Lab Operation Lessons in the Best Ways to Blend Automation, Lean Workflow, and Paperless Processes Joseph M. Campos, PhD, D(ABMM), F(AAM) Interim Chief, Division of Laboratory
More informationMr. Lou Panaccio Executive Chairman
Mr. Lou Panaccio Executive Chairman 1 Overview Objective Develop compelling multiplexed test solutions for the $4BN global molecular diagnostic testing industry using our silica bead based AmpaSand technology
More informationBy Dr. Zainab khalid
By Dr. Zainab khalid Introduction to PCR PCR was invented in 1984 by ( Kary mullis ) & he received the Nobel Prize in chemistry in 1993, for his invention What is PCR? PCR is an exponentially progressing
More informationMolecular Diagnostics for Global Heath Problems. Proactive Investors Forum 5 October 2017
Molecular Diagnostics for Global Heath Problems Proactive Investors Forum 5 October 2017 2 Document Information The information contained in this document and made verbally to you (together the Presentation
More informationPositioning of TB Diagnostics within a Tiered System Integrated Approach from Reference to District Laboratory. Giorgio Roscigno CEO FIND
Positioning of TB Diagnostics within a Tiered System Integrated Approach from Reference to District Laboratory Giorgio Roscigno CEO FIND Integrated Laboratory Network Definition An integrated laboratory
More informationPHYSICIAN RESOURCES MAPPED TO GENOMICS COMPETENCIES AND GAPS IDENTIFIED WITH CURRENT EDUCATIONAL RESOURCES AVAILABLE 06/04/14
PHYSICIAN RESOURCES MAPPED TO GENOMICS COMPETENCIES AND GAPS IDENTIFIED WITH CURRENT EDUCATIONAL RESOURCES AVAILABLE 06/04/14 Submitted resources from physician organization representatives were mapped
More informationPLTW Biomedical Science Medical Interventions Course Outline
Follow the fictitious Smith family as you learn about the prevention, diagnosis, and treatment of disease. Play the role of biomedical professionals to analyze case information and diagnose and treat your
More informationBiocartis: pushing boundaries in healthcare. Hilde Windels Dag van de Tips 10 October 2015
Biocartis: pushing boundaries in healthcare Hilde Windels Dag van de Tips 10 October 2015 2 NOTICES AND WARNINGS This presentation has been prepared by the management of Biocartis Group NV (the "Company").
More informationThis Webcast Will Begin Shortly
This Webcast Will Begin Shortly If you have any technical problems with the Webcast or the streaming audio, please contact us via email at: webcast@acc.com Thank You! Personalized Medicine Promise and
More informationDISEASE DISEASE FUNCTION MAP FUNCTION MAP GENE GENE. Figure 9.15 TD Gelehrter, FS Collins, D Ginsburg. Principles of Medical Genetics
DISEASE DISEASE MAP FUNCTION MAP FUNCTION GENE GENE FUNCTIONAL CLONING POSITIONAL CLONING Figure 9.15 TD Gelehrter, FS Collins, D Ginsburg. Principles of Medical Genetics. 1997. 1 Figure 9.31 TD Gelehrter,
More informationChapter 20: Biotechnology
Name Period The AP Biology exam has reached into this chapter for essay questions on a regular basis over the past 15 years. Student responses show that biotechnology is a difficult topic. This chapter
More informationBio Rad PCR Song Lyrics
Bio Rad PCR Song Lyrics There was a time when to amplify DNA, You had to grow tons and tons of tiny cells. (Oooh) Then along came a guy named Dr. Kary Mullis, Said you can amplify in vitro just as well.
More informationIndustry Academic Collaboration: A Key to Successful Involvement of Patients Early in Clinical Development
Industry Academic Collaboration: A Key to Successful Involvement of Patients Early in Clinical Development Aernout van Haarst PhD Director, European Corporate Development Feb 2016 Industry Academic Collaboration
More informationClassification under the IVD Regulation
Classification under the IVD Regulation Nick Baker Head of IVD Notified Body LRQA Ltd Improving performance, reducing risk IVD regulation shift in regulatory scrutiny Under the current IVD directive 10-15%
More informationEUROPEAN TECHNOLOGY PLATFORM NANOMEDICINE. Work plan for GA, 16th January 2008
Work plan for 2008 1 Vision In 10 years nanomedicinebased products will lead to breakthroughs in the treatment of diseases such as cardiovascular disease, cancer, CNS diseases and diabetes. 2 The ETP is
More informationCOPE. FAQs CORPORATE ONCOLOGY PROGRAM FOR EMPLOYEES
COPE CORPORATE ONCOLOGY PROGRAM FOR EMPLOYEES FAQs This brochure addresses FAQ and is prepared solely for the German market. Local adjustments may be necessary. Please contact us if you require additional
More informationChapter 15 Gene Technologies and Human Applications
Chapter Outline Chapter 15 Gene Technologies and Human Applications Section 1: The Human Genome KEY IDEAS > Why is the Human Genome Project so important? > How do genomics and gene technologies affect
More informationWhat are clones? Genetically identical copies
Cloning What are clones? Genetically identical copies The possibility of human cloning was raised when Scottish scientists at Roslin Institute created the much-celebrated sheep "Dolly" Cloning Cloning
More informationHealth Care Logistics: an Enabler of Change BioLogistics in a Changing Healthcare World Northwestern University Transportation Center
Health Care Logistics: an Enabler of Change BioLogistics in a Changing Healthcare World Northwestern University Transportation Center Dave Bode VP, Health Care Solutions DSC Logistics April 20, 2016 Health
More informationFusion Gene Analysis. ncounter Elements. Molecules That Count WHITE PAPER. v1.0 OCTOBER 2014 NanoString Technologies, Inc.
Fusion Gene Analysis NanoString Technologies, Inc. Fusion Gene Analysis ncounter Elements v1.0 OCTOBER 2014 NanoString Technologies, Inc., Seattle WA 98109 FOR RESEARCH USE ONLY. Not for use in diagnostic
More informationRoche Molecular Biochemicals Technical Note No. LC 10/2000
Roche Molecular Biochemicals Technical Note No. LC 10/2000 LightCycler Overview of LightCycler Quantification Methods 1. General Introduction Introduction Content Definitions This Technical Note will introduce
More information2054, Chap. 14, page 1
2054, Chap. 14, page 1 I. Recombinant DNA technology (Chapter 14) A. recombinant DNA technology = collection of methods used to perform genetic engineering 1. genetic engineering = deliberate modification
More informationMutation entries in SMA databases Guidelines for national curators
1 Mutation entries in SMA databases Guidelines for national curators GENERAL CONSIDERATIONS Role of the curator(s) of a national database Molecular data can be collected by many different ways. There are
More informationLearning Objectives. Introduction
Tools for Teaching Genetics in Primary Care Charles J. Macri, MD Leon Moore, Ph.D. NEGEA Baltimore, Maryland 3 March 2001 Learning Objectives Why is genetics an important topic for discussion now? Identify
More informationBiology (BIOL) Biology BIOL 1620
(BIOL) BIOL 1010 General Biology, Summer Introduces major themes and concepts of biology including cell and molecular biology, genetics, diversity, evolution, and ecology. Provides students with necessary
More informationMy PCR Frequently Asked Questions
My PCR Frequently Asked Questions Dear friend, This Frequently Asked Questions (FAQ) booklet has been created for you as part of the My PCR. The booklet contains FAQs prepared by chronic myeloid leukemia
More informationGenetic Engineering & Recombinant DNA
Genetic Engineering & Recombinant DNA Chapter 10 Copyright The McGraw-Hill Companies, Inc) Permission required for reproduction or display. Applications of Genetic Engineering Basic science vs. Applied
More informationSupreme Court Decision on Gene Patents
Supreme Court Holds Naturally Occurring, Isolated DNA Is Not Patentable, While Synthetic DNA Is Patentable SUMMARY In a decision having implications for the healthcare, biotechnology, and pharmaceutical
More informationGENE EXPRESSION REAGENTS MARKETS (SAMPLE COPY, NOT FOR RESALE)
TriMark Publications April 2007 Volume: TMRGER07-0401 GENE EXPRESSION REAGENTS MARKETS (SAMPLE COPY, NOT FOR RESALE) Trends, Industry Participants, Product Overviews and Market Drivers TABLE OF CONTENTS
More informationCRO partner in Rx/CDx Co-Development
CRO partner in Rx/CDx Co-Development DEDICATED DIALOGUE A sponsored roundtable discussion published in Pharmaceutical Executive Two Covance executives discuss a CRO s role in supporting Companion Diagnostics
More informationTRANSFORMING GLOBAL GENETIC DATA INTO MEDICAL DECISIONS
TRANSFORMING GLOBAL GENETIC DATA INTO MEDICAL DECISIONS THE DOORS ARE OPEN: FEEL FREE TO COME IN CENTOGENE UNLOCKS THE POWER OF GENETIC INSIGHTS TO IMPROVE THE QUALITY OF LIFE OF PATIENTS WITH GENETIC
More informationGlobal In-Vitro Diagnostic Market Report
Global In-Vitro Diagnostic Market Report ----------------------------------------------------- 2013 Executive Summary The process of performing a diagnostic test outside of a living organism in an artificial
More informationAmerican Society of Cytopathology Core Curriculum in Molecular Biology
American Society of Cytopathology Core Curriculum in Molecular Biology American Society of Cytopathology Core Curriculum in Molecular Biology Chapter 4 Stephanie A. Hamilton, EdD, SCT, MB(ASCP) CM MD Anderson
More informationREGISTRATION DOCUMENT FOR RECOMBINANT DNA RESEARCH
EHRS Date Received: Reg. Doc. No.: REGISTRATION DOCUMENT FOR RECOMBINANT DNA RESEARCH Principal Investigator: Penn ID#: Position Title: School: Department: Mailing Address: Mail Code: Telephone: FAX: E-mail:
More informationGen Bio 1 Lab #10: PCR & Transcription/Translation Lab
Name: Date: Gen Bio 1 Lab #10: PCR & Transcription/Translation Lab Pre-Lab extends from page 1-4 Pre-Lab Reading: Pre-lab activities on pages 1-4 & video below; Pages 414-416, 432-433, 336-339 in the 10
More informationChapter 8: DNA and RNA
Chapter 8: DNA and RNA Lecture Outline Enger, E. D., Ross, F. C., & Bailey, D. B. (2012). Concepts in biology (14th ed.). New York: McGraw- Hill. 1 8-1 DNA and the Importance of Proteins Proteins play
More information"Stratification biomarkers in personalised medicine"
1/12 2/12 SUMMARY REPORT "Stratification biomarkers in personalised medicine" Workshop to clarify the scope for stratification biomarkers and to identify bottlenecks in the discovery and the use of such
More informationCHAPTER 20 DNA TECHNOLOGY AND GENOMICS. Section A: DNA Cloning
Section A: DNA Cloning 1. DNA technology makes it possible to clone genes for basic research and commercial applications: an overview 2. Restriction enzymes are used to make recombinant DNA 3. Genes can
More informationGREAT STRIDES IN SCIENCE WHAT ABOUT ACCESS? Marlene E. Haffner, MD, MPH 2nd IRDiRC Conference Shenzhen, China November 8, 2014
GREAT STRIDES IN SCIENCE WHAT ABOUT ACCESS? Marlene E. Haffner, MD, MPH 2nd IRDiRC Conference Shenzhen, China November 8, 2014 1982 WHAT HAS HAPPENED SINCE IN TECHNOLOGY ASSESSMENT AND. US Orphan Drug
More informationProtein Synthesis. Lab Exercise 12. Introduction. Contents. Objectives
Lab Exercise Protein Synthesis Contents Objectives 1 Introduction 1 Activity.1 Overview of Process 2 Activity.2 Transcription 2 Activity.3 Translation 3 Resutls Section 4 Introduction Having information
More informationUNDERSTANDING GENETIC RESEARCH AND ALTERNATING HEMIPLEGIA OF CHILDHOOD. IT ALL BEGINS WITH THE AHC PATIENT And The Scientific Process
IT ALL BEGINS WITH THE AHC PATIENT And The Scientific Process Genetic discovery AHC Patients Need Help! Researchers collect data on AHC patients (observation) Researchers interpret and evaluate data AHC
More informationCreate a model to simulate the process by which a protein is produced, and how a mutation can impact a protein s function.
HASPI Medical Biology Lab 0 Purpose Create a model to simulate the process by which a protein is produced, and how a mutation can impact a protein s function. Background http://mssdbio.weebly.com/uploads/1//7/6/17618/970_orig.jpg
More informationUpdate on the IVDR. Sue Spencer
Update on the IVDR Sue Spencer Caution The new regulations are draft the principles have now been agreed but the Annexes are subject to minor changes Further details will be added later pre and post application
More informationGene Regulation & Mutation 8.6,8.7
Gene Regulation & Mutation 8.6,8.7 Eukaryotic Gene Regulation Transcription factors: ensure proteins are made at right time and in right amounts. One type forms complexes that guide & stabilize binding
More informationIQ4I Research. and Consultancy. Research and Consultancy v4023/ Publisher Sample
IQ4I Research and Consultancy http://www.marketresearch.com/iq4i Research and Consultancy v4023/ Publisher Sample Phone: 800.298.5699 (US) or +1.240.747.3093 or +1.240.747.3093 (Int'l) Hours: Monday -
More informationDEMONSTRATING YOUR MEDICINE S VALUE TO ALL STAKEHOLDERS TRUSTED COMMERCIALIZATION AND MARKET ACCESS EXPERTISE
CATALYSTS DRIVING SUCCESSFUL DECISIONS IN LIFE SCIENCES DEMONSTRATING YOUR MEDICINE S VALUE TO ALL STAKEHOLDERS TRUSTED COMMERCIALIZATION AND MARKET ACCESS EXPERTISE WHEN COMMERCIALIZING A MEDICINE, IT
More informationIndividualised medicine: regulatory challenges
www.pei.de Individualised medicine: regulatory challenges Outline Revision IVD Directive Opportunities and challenges Possibilities for interaction http://upload.wikimedia.org/wikipedia/commons/thumb/6/66/gummy_bears.jpg
More informationFundamentals of Next-Generation Sequencing: Technologies and Applications
Fundamentals of Next-Generation Sequencing: Technologies and Applications Society for Hematopathology European Association for Haematopathology 2017 Workshop Eric Duncavage, MD Washington University in
More informationMolecular Diagnostics: Local vs. Central Lab
Molecular Diagnostics: Local vs. Central Lab Robert B. Colvin, M.D. Massachusetts General Hospital Harvard Medical School Boston MA Banff Consensus Conference Barcelona March 30, 2017 Innovative Research
More informationProduct selection guide Ion S5 and Ion S5 XL Systems
Product selection guide Ion S5 and s Cancer genomics research Molecular profiling Ion AmpliSeq Ready-to-Use Panels Ion AmpliSeq Comprehensive Cancer Panel Cat. No. 4477685 Ion AmpliSeq Made-to-Order Panels
More informationChapter 7 DNA Fingerprinting By the end of this chapter you will be able to:
Chapter 7 DNA Fingerprinting By the end of this chapter you will be able to: explain how crime scene evidence is collected and processed to obtain DNA describe how radioactive probes are used in DNA fingerprinting
More informationSection I: Pharmaceuticals and Medical Devices
SUPPLEMENT on HEALTHCARE INNOVATION Visionary Goals and Recommendations 51th Japan-U.S. Business Conference Japan-U.S. Business Council / U.S.-Japan Business Council November 14, 2014 The R&D-based pharmaceutical
More informationNHS ENGLAND BOARD PAPER
NHS ENGLAND BOARD PAPER Paper: PB.30.03.2017/06 Title: Creating a genomic medicine service to lay the foundations to deliver personalised interventions and treatments Lead Director: Professor Sir Bruce
More information