MagCore Automated Nucleic Acid Extractor Overview

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1 MagCore Automated Nucleic Acid Extractor Overview Cost -Effective Cost-Effective MagCore HF16 New Generation MagCore HF16 Plus New! Spectrophotometer Built-in MagCore Super New! Economical and Space Saving MagCore Compact High Capacity Module MagCore HF48 MagCore Automated Nucleic Acid Extractor MagCore Nucleic Acid Extraction Kits 1-8 Samples 1-16 Samples 1-48 Samples Built-in Spectrophotometer MagCore HF48 MagCore e Super MagCore Core HF1 HF16 UI Touch Screen UV Decontamination MagCore gcore C Compact Barcode Scanner optional optional Thermo Printer optional MagCore HF16Plus Programs Bulit-in (Upgradeable via RS232 ports) MagCore Nucleic Acid Extraction ti Kits 96 Tests MagCore oe N Nucleic Acid Extraction Kits 36 Tests Programs Bulit-in (Upgradeable via USB ports, Plug&Play)

2 MagCore Nucleic Acid Extraction Kits MagCore Nucleic Acid Extraction Kits Selection Guide Genomic DNA Viral Nucleic Acids Total RNA MagCore Nucleic Acid Extraction Kits: MagCore Genomic DNA Whole Blood Kit (Speedy installation) MagCore Genomic DNA Whole Blood Kit MagCore Genomic DNA Large Volume Whole Blood Kit (1.2 ml) MagCore Plasma DNA Extraction Kit (1.2 ml) MagCore Cultured Cells DNA Kit MagCore Genomic DNA Plant Kit MagCore Genomic DNA Tissue Kit MagCore Genomic DNA FFPE One-Step Kit MagCore Genomic DNA Bacterial Kit MagCore Viral Nucleic Acid Extraction Kit MagCore Viral Nucleic Acid Extraction Kit (Low PCR Inhibition) MagCore Viral Nucleic Acid Large Volume Extraction Kit (2.4 ml) MagCore Viral Nucleic Acid Large Volume Extraction Kit (1.2 ml) MagCore Total RNA Whole Blood Kit MagCore Total RNA Cultured Cells Kit Cat No. Cat No. Cat No. 36 preps 72 preps 96 preps MGB MGB MCC-01 MGP-01 MGT-01 MGF-01 MGF-02 MBB-01 MVN MVN MRN-01 MRC-01 MGB MGB MGB1200 MPD1200 MCC-02 MGP-02 MGT-02 MBB-02 MVN MVN MVN2400 MVN1200 MRN-02 MRC-02 * * * For isolation of total RNA from animal tissues and FFPE samples, the MagCore total RNA Cultured Cells Kit is a relatively suitable choice and functions with a special protocol. In the near future, a more unique and convenient reagent will be developed for the extraction of RNA from animal tissue and FFPE samples.

3 MagCore Automated Nucleic Acid Extractor MagCore Super MagCore Super is RBC Bioscience's most advanced and efficient robotic workstation for nucleice acid extraction. It is the first platform combining EXTRACTOR and SPECTOPHOTOMETER. Users are benefited with automatic purification, OD values retrieval and final eluate concentration measurement. It is equipped with a colored touch screen, thermo printer, barcode scanner, USB flash p&p. Worldwide Patented Magnetic Beads With RBC patented magnetic bead technology, cellulose coating particles give high binding capacity and the best purity of nucleic acid. Ideal for DNA/RNA Extraction Built-in protocols are created for various sample types including whole blood, viral nucleic acid, tissue, plant, cultured cells, etc. Automatic Optical Scanning and Retrieval of OD Values The optical module provides O.D. A260 and A280 of individual samples. UV Decontamination The equipped UV lamp prevents the risk of cross-contamination, improving user safety and product quality. Barcode Scanner It enables a complete tracking of samples throughout the entire purification process and helps systematically organize test results. Test Report Test results can be saved inside of internal memory and/or printed out by a built-in printer. Built-in USB Output (USB flash drive not provided) It is convenient for users to save test reports in excel format by a USB flash drive. Thermo Printer Test reports are available in hard copy by printing out.

4 Specification Model : Super Processing Capacity : Max. 16 samples per batch System Components: 1. Pipetting Unit: dispensing, transferring, X -Y two axis movements 2. Electric Control: PLC module and Arm-based main board embedded in 3. UV Light: power 8w, life duration11,000hrs 4. Heating Block: RT~80 C 5. OD Detection Range: ABS Detection Source: D2 lamp 7. Detection Wavelength: 260nm, 280nm 8. Display Screen: 3-inch color touch panel 9. Accessories: T-racks, cartridge racks, cuvette racks, barcode scanner, thermal printer System Feature : 1. Special design of cartridge racks for an easy installation; auto-cartridge locking. 2. An optical module built-in for auto-od value retrieval and derived concentrations of eluates. (OD<2.5) 3. Visual and audio alarms appear along with the emergency stop. 4. Test results can be saved by a USB drive and printed out by a built-in printer. Power Supply : Voltage: AC 100V ~240V; Frequency: 50/60Hz Dimension : W760 x D700 x H770 (mm) / W29.92 x D27.55 x H30.31 (inches) Net Weight : 78kg / lbs MagCore Super Overview Operating Parameters Processing Capacity: 1~16 samples per batch Sample Volume: 200/400/1200ul Elution Volume: 60/100/150/200 μl Purity: DNA : O.D A260/280 ratio 1.8 ± 0.1 RNA : O.D A260/280 ratio 2.0 ± 0.2 Operating Environment Storage Temperature: 15 C~35 C Operation Temperature: 18 C~30 C Pollution Degree: Indoor

5 MagCore Automated Nucleic Acid Extractor MagCore HF16 Plus MagCore HF16 Plus is the 2nd generation of HF 16 with improvements at mechanical design and program efficiency. With a user friendly design and built-in programs, up to 16 samples can be isolated at your fingertip. CE-IVDD certificated reagent kits available for various samples of whole blood, serum, plasma, body fluids, bacteria, plant, cultured cells, tissues, etc. Barcode scanner and thermo printer are available on request. Worldwide Patented Magnetic Beads With RBC patented magnetic bead technology, cellulose coating particles give high binding capacity and the best purity of nucleic acid. Ideal for DNA/RNA Extraction Built-in protocols are created for various sample types including whole blood, viral nucleic acid, tissue, plant, cultured cells, etc. UV Decontamination The equipped UV lamp prevents the risk of cross-contamination, improving user safety and product quality. Barcode Scanner (optional) It enables a complete tracking of samples throughout the entire purification process and helps systematically organize test results. Built-in USB Output (USB flash drive not provided) It is convenient for users to save test reports in excel format by a USB flash drive. Thermo Printer (optional) Test reports are available in hard copy by printing out.

6 Specification Model : HF16 Plus Processing Capacity : Max. 16 samples per batch System Components: 1. Pipetting Unit: dispensing, transferring, X -Y two axis movements 2. Electric Control: PLC module and Arm-based main board embedded in 3. UV Light: power 8w, life duration11,000hrs 4. Heating Block: RT~80 C 5. Display Screen: 3-inch color touch panel 6. Accessories: T-racks, cartridge racks, barcode scanner (optional), thermal printer (optional) System Feature : 1. Special design of cartridge racks for an easy installation; auto-cartridge locking. 2. Visual and audio alarms appear along with the emergency stop. Power Supply : Voltage: AC 100V~ 240V; Frequency: 50/60Hz Dimension : W760 x D700 x H770 (mm) / W29.92 x D27.55 x H30.31 (inches) Net Weight : 70kg / lbs MagCore HF16 Plus Overview Operating Parameters Processing Capacity: 1~16 samples per batch Sample Volume: 200/400/1200 μl Elution Volume: 60/100/150/200 μl Purity: DNA : O.D A260/280 ratio 1.8 ± 0.1 RNA : O.D A260/280 ratio 2.0 ± 0.2 Operating Environment Storage Temperature: 15 C~35 C Operation Temperature: 18 C~30 C Pollution Degree: Indoor

7 MagCore Automated Nucleic Acid Extractor Sample MagCore HF48 MagCore HF48 is a powerful system with consistent and simultaneous processing of 1st~24th or 24th~48th samples of DNA/RNA at A/B operation zones. It provides fast, cost-effective, and automated extraction purification of nucleic acids from diverse sample types including whole blood, bacteria cells, plant cells, cultured cells, virus particles and tissues. With a sterilization system built-in, optimized protocols pre-programmed and magnetic bead-based reagent cartridges supplied, MagCore HF48 provides users a fast, efficient and cross-contamination-free isolation of various DNA/RNA samples. Its superb processing capacity makes itself a perfect solution for high-capacity nucleic acid purification. Worldwide Patented Magnetic Beads With RBC patented magnetic bead technology, cellulose coating particles give high binding capacity and the best purity of nucleic acid. Ideal for DNA/RNA Extraction Built-in protocols are created for various sample types including whole blood, viral nucleic acid, tissue, plant, cultured cells, etc. UV Decontamination The equipped UV lamp prevents the risk of cross-contamination, improving user safety and product quality. High Capacity of 48 Samples Two modules of 24 sample rack provide flexibility and convenience during processing. Touch Screen with User Friendly Interface An integrated 8-inch full-color touch screen with intuitive interface simplifies protocol selection. Only one touch is required to run your daily works. 48 test 24 test 105 Sample Volume Elution Buffer Elution Volume Optical Detection True Walk Away System Each of programs is controlled by a specific 3-digit protocol code. Simply key-in the code number and let the machine do the rest for you. The MagCore automated system makes it realized that the nucleic acid purification is without user intervention since from the input of starting materials to the final output of ready-to-use DNA/RNA.

8 Specification Model : HF48 Processing Capacity : Max. 48 samples per batch System Feature : 1. Special designs of the cartridge rack, T-rack, and tube rack for an easy installation. 2. Auto-cartridge locking inch full-color touch screen Power Supply : Voltage: AC 200V~220V; Frequency: 50/60Hz Dimension : W1000 x D800 x H1600 (mm) ; W39.37 x D31.49 x H62.99(inches) Net Weight : 250kg / lbs Operating Parameters Processing Capacity: 1~48 samples per batch Sample Volume: 200/400/1200 μl Elution Volume: 60/100/150/200 μl Purity: DNA : O.D A260/280 ratio 1.8 ± 0.1 RNA : O.D A260/280 ratio 2.0 ± 0.1 Operating Environment Storage Temperature: 15 C~35 C Operation Temperature: 18 C~30 C Pollution Degree: Indoor MagCore HF48 Overview Status LED Light Pipetting Module Operation Zone oneb Operation nzone ne A Elution Area

9 MagCore Automated NucleicAcid Extractor MagCore HF16 MagCore HF16 is a simple, fast and cost-effective technique to automatically purify nucleic acids from a wide range of sample types for applications like gene expression analysis, clinical molecular diagnosis, human identity testing, forensics, and biomedical research. The MagCore HF16 System enables the parallel processing of up to 16 samples per run. With the pre-programmed protocols and magnetic bead based reagent cartridges, the system provides consistent and stable nucleic acid purification for every busy laboratory. Features 1. Flexible design:1-16 samples can be run without waste of resources 2. Simple procedure guaranteed by touch button operation 3. Rapid and reliable results in minimum 30 minutes (DNA purification) 4. Contamination free achieved with the use of prefilled reagents, disposables and integrated UV sterilization. Cartridge Design and Extraction Principle MagCore reagent cartridges are pre-sealed incorporating all reagents needed for the purification process. No additional reagents are required and no handling is necessary. Pre-filled and sealed buffer cartridge and automated piercing step eliminate possible contamination or buffer spout. Patented Heating Well and Separation Well in the cartridge provide strong circulate force for Binding/Washing steps and give high purity in final eluate. The MagCore beads are pre-allocated into each cartridge in Well 4. Mixing of the beads, reagents and sample is achieved by the liquid handling action of the instrument. Separation is achieved by magnetic attraction and liquid handling. MagCore Nucleic Acid Extraction Kits contain all reagents and consumables needed for 36, 72 and 96 nucleic acid isolation reactions. The consumables consist of reagent cartridges, individually packaged tip sets, sample tubes and elution tubes. add Lysis buffer add beads Sample Homogenate Cell Lysis add wash buffer add elution buffer N N N S S S

10 MagCore HF16 Overview Specification Model : HF16 System Method : Cellulose coated magnetic beads System Components : 1. Pipetting Unit: dispensing, transferring, X-Y two axis movements 2. Electric Control: internal microprocessor 3. UV Light: power 5w, life duration >6,000hrs 4. Heating Block: RT~100 C 5. Display Screen: 3-inch LCM screen with a membrane keypad 6. Accessories: T-racks, cartridge racks, empty cartridges, tips/holders, sample tubes, microcentrifuge tubes, syringe O-rings and grease Power Supply : Voltage: AC V; Frequency: 50/60Hz; Power Consumption >1.0KVA Dimension : W550 X D660 X H680 (mm); W21.65 x D25.98 x H26.77 (inches) Net Weight : 70kg / 155lbs Operating Parameters Processing Capacity: 1~16 samples per batch Processing Time: minutes (depends on sample type and method) Sample Volume: 200μl /400μl /1,200μl (2.4 ml available on request) Elution Volume: 60 μl /100 μl /150 μl /200 μl Yield: Average 6 μg Genomic DNA from 200 μl human whole blood Average 1 μg total RNA from 400 μl human whole blood Purity: DNA : O.D A260/280 ratio 1.8 ± 0.1 RNA : O.D A260/280 ratio 2.0 ± 0.2 UV Lamp LCD Window Operating Environment Storage Temperature: 15 C~35 C Operation Temperature: 18 C~30 C Pollution Degree: Indoor Operation Area Power Switch

11 MagCore Automated NucleicAcid Extractor MagCore Compact MagCore Compact is RBC Bioscience's mini automated workstation for fast and economical purification of nucleic acids from a diverse range of sample sources. In terms of its literal meaning of Compact, all basic and necessary functions are crammed and equipped to meet the requirements of customers who take care of the small number of samples during a day. Features 1. Flexible design:1-8 samples can be run without waste of resources. 2. Simple procedure guaranteed by touch button operation. 3. Built-in protocols created for various sample types. 4. Contamination free achieved with the use of prefilled reagents, disposables and integrated UV sterilization. Cartridge Design and Extraction Principle MagCore reagent cartridges are pre-sealed incorporating all reagents needed for the purification process. No additional reagents are required and no handling is necessary. Pre-filled and sealed buffer cartridge and automated piercing step eliminate possible contamination or buffer spout. Patented Heating Well and Separation Well in the cartridge provide strong circulate force for Binding/Washing steps and give high purity in final eluate. The MagCore beads are pre-allocated into each cartridge in Well 4. Mixing of the beads, reagents and sample is achieved by the liquid handling action of the instrument. Separation is achieved by magnetic attraction and liquid handling. MagCore Nucleic Acid Extraction Kits contain all reagents and consumables needed for 36, 72 and 96 nucleic acid isolation reactions. The consumables consist of reagent cartridges, individually packaged tip sets, sample tubes and elution tubes. add Lysis buffer add beads Sample Homogenate Cell Lysis add wash buffer add elution buffer N N N S S S

12 MagCore Compact Overview Specification Model : Compact System Method : Cellulose coated magnetic beads System Components : 1. Pipetting Unit: dispensing, transferring, X-Y two axis movements 2.Electric Control: internal microprocessor 3.UV Light: power 5w, life duration >6,000hrs 4. Heating Block: RT~100 C 5.Display Screen: 3-inch LCM screen with key press panel 6. Accessories: T-racks, cartridge racks, empty cartridges, tips/holders, sample tubes, microcentrifuge tubes, syringe O-rings and grease Power Supply : Voltage: AC V; Frequency: 50/60Hz; Power Consumption >1.0KVA Dimension : W350 x D660 x H680 (mm) ; W13.79 x D25.98 x H26.77 (inches) Net Weight : 50 kg / 110 lbs Operating Parameters Processing Capacity: 1~8 samples per batch Processing Time: minutes (depends on sample type and method) Sample Volume: 200 μl /400 μl /1,200 μl (2.4 ml available on request) Elution Volume: 60 μl /100 μl /150 μl /200 μl Yield: Average 6 μg Genomic DNA from 200 μl human whole blood Average 1 μg total RNA from 400 μl human whole blood Purity: DNA : O.D A260/280 ratio 1.8 ± 0.1 RNA : O.D A260/280 ratio 2.0 ± 0.2 UV Lamp LCD Window Operating Environment Storage Temperature: 15 C~35 C Operation Temperature: 18 C~30 C Pollution Degree: Indoor Operation Area Power Switch

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