Review of medical 3D printing technology and its possible endovascular applications

Transcription

1 Review of medical 3D printing technology and its possible endovascular applications Peter Mercelis, Phd Dir. Applied Technologies Healthcare 3DSystems

2 3D printing technology basics Basic principle: 3D object is manufactured as a stack of 2D layers that are interconnected Various technologies depending on type of material and mechanism of consolidation; polymers, metals, ceramics, composites, etc.

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5 3D printing technology basics Inherent advantages of 3D printing: Shape freedom: Ideal for anatomical shapes and patient-specific geometries Facilitates production of porous cell-growth scaffolds Direct digital manufacturing: Ideal to accept medical imaging input Short lead times Distributed design and manufacturing setups Multiple materials including biocompatible metals and polymers and sterilizable plastics

6 Patient specific medical devices Patient specific medical devices Hearing aids Dental prostheses Main drivers for adoption of 3DP: Replacement of labor-intensive design and manufacturing Improved precision Improved functionality

7 Patient specific medical devices Acetabular Implant Surgical templates for mandible reconstruction The World s First Total Mandible Replacement

8 Volume manufacturing of medical implants Volume manufacturing of standard medical devices Orthodontic implants Orthopedic implants Spinal implants Components of implanted medical devices Main drivers for adoption of 3DP: Integration of osseoconductive bone scaffolds Allows fully anatomical designs; no manufacturing limitations Lower manufacturing costs Short lead times Spinal fusion implant Acetabular cup

9 Complimentary to simulation didactic materials 1:1 scale 3D printed model Real 3D view of specific anatomy or real procedure scene Remarkably detailed anatomical models Valuable haptic tool for surgical training Quick customization of models to fit different training needs Great improvement of model accuracy over the years Anatomical models

10 Anatomical models CJP Gypsum based, full color Removed from powder bed, cleaned, infiltrated for strength Not sterilizable SLA Acrylic-like, semi-translucent, photo-reactive dye for selective color of structures in magenta Support structures removed, washed, UV-cured Sterilizable (steam) MJP Multiple materials and material properties in one print In development

11 DICOM segmentation and 3D conversion is first step 3D model adjustment Expert review Adjust models for printability Anatomical models

12 3D printed models Flexible materials possible with variable rigidity

13 MR: Slices =1.2mm, pixels = 0.586mm Fontan

14 MR: Slices = 1.4mm, pixels = 1.40mm Senning

15 Vascular Ring MR, Slices = 4mm, pixels = Combined low resolution volumetric data with measurements to create model design

16 CT: Slices = 0.7mm, pixels = 0.346mm DORV

17 Procedural planning: aiming for highest precision Case illustration by Dr. Katzen, Baptist Health South Florida

18 Future outlook Near to mid term applications: Use of anatomical models for preoperative planning and communication Biodegradable polymer devices Cell and tissue printing models for pre-clinical drug screening Cell therapy based on 3D printed cell growth structures; Inert or bio-degradable 3D printed scaffolds as cell culturing surface Target domains: cartilage repair, neurology, cancer treatment, orthopedic, ophthalmology, cardiovascular, etc. Long term applications: Patient specific stents Biodegradable metal 3D printed implants 3D printing of fully functional organs or organ tissue Challenges; cell biology/behavior rather than 3D printing challenge

19 Thank you for your attention Contact information: Peter Mercelis