NIHR Invention for Innovation Workshop. Leeds Clinical Research Facility Adding Value Debbie Beirne NIHR Leeds CRF Manager
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1 NIHR Invention for Innovation Workshop Leeds Clinical Research Facility Adding Value Debbie Beirne NIHR Leeds CRF Manager
2 Integrated R&I Model Surgical MedTech (MIC) CRF R&I In Vitro Diagnostics (MIC) BRC
3 Integrated R&I Model Research and Innovation Centre on St James Campus Central point for access for industry, SME s, research charities, CRN, AHSN Central conduit for collaboration across all our NIHR entities, linking academics, industry, nhs, pharma, 3 rd sector to deliver innovation and improve outcomes
4 NIHR CRF purpose Experimental Medicine (EM) focus (proof of principal but also applied health facilitating translational pipeline) Patient access to new treatments, diagnostics, technology, enhanced care Translate scientific advances into healthcare adopted practices and improved care/management of disease Economic growth agenda
5 Leeds model Facilities, varied and map onto service delivery : DentTCRU One CRF One team Hub Delivery spokes LGI Jubilee Central Bexley CRF CAH MSK/BRC Multiple sites and specialties LGI Paeds
6 Scope of activities History of investigation drug based studies, including immunomodulatory, cellular, GM and small molecule CTIMP investigational agents Increase in device and diagnostics studies, strong imaging components in MSK, CV, oncology,dental specialties Growing medical physics/radiotherapy ( +imaging) and novel combination approaches
7 Scope of activities Areas of strength: Musculoskeletal, Cardiovascular, Cancer Growth in dental and perioral health, paediatrics New areas of EM research emerging Gastroenterology, Infection Prevention, immunology
8 Adding Value We can offer researchers: Physical, purpose built estate facilities to deliver EM and complex later phase trial research Trained research delivery workforce with specialist expertise in many clinical specialties Quality Assurance systems to underpin governance and accountability Academic laboratory services for complex sample processing within studies
9 Adding Value Advice on practical and logistical aspects of feasibility including study design and protocol development Input into grant applications, financial cost of support Delivery of pilot studies, leading to early phase trials, evaluation of later phase studies leading to adoption/ IP ( translational) where specialist facilities needed Novel methodology studies - personalised medicine, genomic approaches
10 Successful CRF support
11 Promoting our unique selling points to enhance external and internal identity as an NIHR CRF and research led organisation Informatics Imaging and digital technology Experimental Clinical trials Precision medicine Biomarkers and diagnostics Of 19 CRF s Leeds ranked 6 th for number of SME s working with (2016/17)
12 LTHT CRF Contributing to economic growth Bid Proposal for development of a new Life Science Clinical Research Facility (CRF) where Leeds City Region (LCR) SMEs work with clinical experts to create new products which can be commercialised, generate IP
13 Strategy for CRF Life Sciences Industrial Strategy emphasis on clinical trial delivery, novel design CRF role Our goals: Collaborate with AHSN/ Leeds Enterprise Partnership/Regional consortia Northern Powerhouse Increase number of Industry partnerships and grow Charity partnerships NHS arm of academic research delivery underpinning safe participant care, and high quality research outputs Sustainable financial model investment vs revenue
14 St James CRF development
15 Early Phase, interventional Experimental Research Concentrated expertise at one site (SJUH) 18 patient, flexible 24 hour, secure facility Enhanced patient experience of participation Equipped for broad spectrum of interventional studies Close to all critical care services Central governance and oversight Internal audit programme
16 Some examples: Robotic systems/diagnostics
17 Magnetic telemanipulation of a soft-tethered endoscopic capsule for painless colonoscopy PI: Pietro Valdastri, Chair in Robotics and Autonomous Systems, University of Leeds Clinical Lead: Venkat Subramanian, Clinical Associate Professor of Gastroenterology, University of Leeds Tethered endoscopic capsule (white) compared to a pediatric scope (black) P. Slawinski, A. Taddese, K. Musto, K. Obstein, P. Valdastri, Autonomous Retroflexion of a Magnetic Flexible Endoscope, IEEE Robotics and Automation Letters, 2017, Vol. 2, No. 3, pp Sinusoidal trajectory with heading along the tangent of the curve and varying pitch angle A. Taddese, P. Slawinski, K. Obstein, P. Valdastri, Closed loop Control of a Tethered Magnetic Capsule Endoscope, RSS 2016, available at
18 Some Examples: Digital platforms R&I/In vitro Diagnostic MIC/CRF Exploratory work re potential collaboration Artificial Intelligence - Digital diagnostic platform Melanoma setting Big data UoL LIDA Health Economics NHS clinicians/academics
19 PPIE 4 PPI panels with special interests alongside general support for researchers, grants, study design, co-production Patient Research Ambassadors championing research, raising public profile Cohesive approach and strategy for PPIE across BRC/CRF Dedicated CRF website and communications to promote research and innovation locally and nationally
20 Patients and Public supporting research Involvement and Engagement
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