Target and Non-target Pesticide Residue Analysis Using GC/QQQ and GC/Q-TOF with a Discussion on Ways to Use Sandwich Injections
|
|
- Brandon McGee
- 5 years ago
- Views:
Transcription
1 Target and Non-target Pesticide Residue Analysis Using GC/QQQ and GC/Q-TOF with a Discussion on Ways to Use Sandwich Injections Philip L. Wylie Agilent Technologies Wilmington, DE 1
2 Topics Target vs. Non-target vs Comprehensive Pesticide Analysis 10X more sensitive GC/QQQ Agilent 7010 GC/Q-TOF as a screening tool for >740 pesticides Sandwich injections make life easier & chromatography better 2
3 Target and Non-target Pesticide Analysis Target Compounds are known Have mass spectra or MRMs Have a defined list of compounds You know what you are looking for You will only find what you are looking for Typically look for pesticides True Non-target It could be anything May not be in any library May need multiple tools to identify it Sort of Non-target or Comprehensive Screening It could be any pesticide It is in a library or PCDL You cast a much wider net May find pesticides you didn t expect to see Screen for virtually all GC-able pesticides (>740) 3
4 GC/MS tools for target and non-target pesticide residue analysis Target Non-target 7010 GC/QQQ (or GC/MS SIM) 7200 GC/Q-TOF (or GC/MS Scan) 4
5 GC/QQQ Electron Ionization has gotten much more sensitive with introduction of the 7010! 500 attograms of OFN 5
6 Dioxins 2,3,7,8-TCDD at 5 fg Level 2,3,7,8-TCDD 10 fg on column 5 fg/µl; 2 ul injected Courtesy of Jessica Westland, Agilent Technologies 6
7 Taking advantage of 10X increase in GC/QQQ sensitivity Reduce sample amount for extraction - Use less solvent and QuEChERS reagents Save $ Reduce injection volume - Liners last longer Save time and $ - Column stays cleaner Better chromatography - Source stays cleaner More up time Shorter dwell times & still more sensitive - More analytes in the method More comprehensive - More MRMs per compound More confidence in hits 7
8 Recoveries for 126 Difficult Pesticides Spiked into Carrot, Tomato & Celery at 1, 5, 10 & 50 ng/g Reduced QuEChERS extraction from 15 g to 2 g Reduced injection volume from 2 µl to 0.5 µl Melissa Churley and Joan Stevens, ASMS 2015 Poster WP 060 8
9 64 Injections of a QuEChERS Extract of an Apple Comparing 2 µl to 0.5 µl Injections 2 µl 0.5 µl 9
10 Build a Pesticide MRM Method in Minutes from the Pesticides & Environmental Pollutants Database >1000 compounds Average of 8 MRMs/compound $70,000 of standards purchased 10
11 But, why do we also need to screen? About 300 pesticides listed with names beginning with C
12 Comprehensive Pesticide Screening is Needed along with Target Analysis Screen for >740 GC-able pesticides by GC/Q-TOF in TOF Mode Add any hits to the GC/QQQ target method 12
13 Enhanced Selectivity using Accurate Mass 5 ppb in Ginseng Extract Extracted Ions = and /- 10 ppm Full Scale 200,000, , /- 10 ppm /- 10 ppm 13
14 PCDL : Personal Compound Database & Library with ~740 Pesticides Name Mol. Formula Mono-isotopic exact mass Locked RT CAS # Exact mass spectrum
15 All Ions data processing - Method setup Specify PCDL Lock your acquisition method to the RTs in the PCDL Choose mass extraction window size Choose the number of significant ions to extract Choose the minimum number of Qualified ions for a hit Pesticide screening GC-Q/TOF
16 Vinclozolin: 10 ppb in Catfish Extract
17 Vinclozolin: 10 ppb in Catfish Extract Target Compound List And Results Compound Identification Results Extracted Ion Chromatograms Molecular Ion / Isotope Ratio Results Coelution Plot Spectrum & Extracted Ion Plots
18 Analysis of spiked fruits and vegetables Use organically grown produce EN QuEChERS extraction 2 spiking levels 10 ppb and 100 ppb Compare two different GC methods 20 min vs 40 min Optimize All Ions setpoints See how many pesticides can be found Measure TOF mass accuracy 18
19 Backflush, RTL GC Methods Employed 40.5 Minute Constant Flow Method 20 Minute Constant Flow Method Columns 2 x 15m 5m + 15m Back flush type Mid-point Mid -point # Spiked Pesticides in PCDL Inlet Mid-point Back flush Aux Inlet Mid -point Back flush Aux Column #1 15m Column #2 15m Column #1 5m Column #2 15m PCT MS PCT MS
20 Chromatograms of QuEChERS Extracts
21 MassHunter Qual Showing Compound Details View: Results for Quinoxyfen at 10 ng/ml in Green Bean Extract a) b) c) e) d) f) 21
22 Quinoxyfen at 10 ng/ml in Green Bean Extract Extracted ion chromatograms Coelution plot Compound identification results 22
23 Quinoxyfen at 10 ng/ml in Green Bean Extract: Molecular ion isotope pattern Red rectangles show theoretical abundance and spacing Extracted exact mass ions of M *+ TIC in M *+ range 23
24 Pesticides Identified at 10 ng/ml Spiking Level Matrix Ave. % Identified (5X15) Of 93 Pest. % Identified (15X15) of 86 Pest % %
25 Pesticides Identified at 100 ng/ml Spiking Level Matrix Ave. % Identified (5X15) Of 93 Pest. % Identified (15X15) of 86 Pest % %
26 Sandwich Injections 2-layer or 3-layer 26
27 Analyte Protectants in a Sandwich Injection ethylglycerol *sorbitol *gulonolactone shikimic acid Examples of Analyte Protectants *APs used in the following experiments
28 Ratio of peak heights for 17 pesticides when APs are on bottom compared to APs on top layer 2.00 Ratio Bottom:Top Ratio Bottom:Top
29 Ratio of APs on bottom to APs on Top (blue) Ratio of APs on bottom to no APs injected (yellow) Ratio Bottom:Top Ratio Bottom:No APs
30 Atrazine APs on bottom APs on top No APs
31 Conclusions Target and comprehensive screening methods are needed for pesticide residue analysis Target analysis is usually done by GC/QQQ New GC/QQQ is 10X more sensitive Attogram level detection (for some compounds) New Screening approach uses GC/Q-TOF with exact mass PCDL with >740 GC-able pesticides >97% of spiked pesticides were found at 10 ppb level in spiked produce (>99% at 100 ppb) Sandwich injections: an easy way to add analyte protectants (and/or matrix and/or internal standards) 31
32 Acknowledgements Agilent Colleagues Joni Stevens Sophia Nieto Kai Chen Melissa Churley Jessica Westland 32
33 Portrait with Vegetables (The Greengrocer) Artist: Giuseppe Arcimboldo b d. 1593, Milan, Italy Thank You
Summary results using G7000A GC-QQQ for OCPs, Pesticides and PCBs in Marine Sediment and Biota
Summary results using G7000A GC-QQQ for OCPs, Pesticides and PCBs in Marine Sediment and Biota Paul Zavitsanos Agilent Technologies PITTCON 2009 Chicago G7000A GC-QQQ OCPs and PCBs in Marine Sediment and
More informationAccurately Identify and Quantify One Hundred Pesticides in a Single GC Run
Accurately Identify and Quantify One Hundred Pesticides in a Single GC Run Application Note Author Jessica Westland Agilent Technologies, Inc. Abstract A selected target compound list of 195 various pesticides
More informationPesticide & Environmental Pollutant (P&EP) GC/MS/MS Analyzer 2.0
Pesticide & Environmental Pollutant (P&EP) GC/MS/MS Analyzer 2.0 Get on the Analyzer FAST TRACK Identify Analytes in Complex Matrices Obtain Analytical Results on DAY ONE! -- based on the most comprehensive
More informationWith the globalization of trade, food production
November 2008 Comprehensive Screening, Confirmation, and Quantification of Organic Pesticides in Foods by GC MS and LC MS The global focus on keeping food safe has intensified, resulting in major changes
More informationExpand Your Research with Metabolomics and Proteomics. Christine Miller Omics Market Manager ASMS 2017
Expand Your Research with Metabolomics and Proteomics Christine Miller Omics Market Manager ASMS 2017 New Additions to Agilent Omics Workflows Acquisition Ion Mobility Q-TOF IM All Ions MS/MS Find Features
More informationANALYSIS OF PESTICIDE RESIDUES IN DRINKING WATER AS PER BUREAU OF INDIAN STANDARDS USING THE AGILENT 7000 GC/MS/MS WITH PESTICIDES ANALYZER
ENVIRONMENTAL ANALYSIS ANALYSIS OF PESTICIDE RESIDUES IN DRINKING WATER AS PER BUREAU OF INDIAN STANDARDS USING THE AGILENT 7000 GC/MS/MS WITH PESTICIDES ANALYZER Solutions for Your Analytical Business
More informationResolve Your Search for More Ions: The 5977B, 7000D, and 7010B GC/MS Instruments. Stephan Baumann ASTS Talk November, 2016
Resolve Your Search for More Ions: The 5977B, 7000D, and 7010B GC/MS Instruments Stephan Baumann ASTS Talk November, 2016 1 The Most Powerful EI GC/MS Source Ever Made. More intense electron beam NEW!
More informationIntroducing a Rugged Core Method for GC/MS/MS Pesticide Residue Analysis
Introducing a Rugged Core Method for GC/MS/MS Pesticide Residue Analysis Offering New Reference Guide for Pesticide GC/MS/MS Analysis Katerina Mastovska Excellcon International LLC Developed by: Katerina
More informationInstrumental Solutions for Metabolomics
Instrumental Solutions for Metabolomics Dr. Desislav Donchev US14702384-16012196010132-S01-A01.tif 300 400 500 600 700 800 3100 3200 3300 3400 3500 3600 3700 3800 Color Scale R = [52 1484] G = [26 514]
More informationThe Use of High Resolution Accurate Mass GC/Q-TOF and Chemometrics in the Identification of Environmental Pollutants in Wastewater Effluents
The Use of High Resolution Accurate Mass GC/Q-TOF and Chemometrics in the Identification of Environmental Pollutants in Wastewater s Application Note Environmental Authors Anthony Gravell and Praveen Kutty
More informationApplication Note. Abstract. Authors. Environmental
Maintaining Compound Retention Times with the Backflush Enabled Pressure Controlled Tee Configuration for Agilent 7890A GCs with Agilent 5975 Series MSD and Agilent 7000 Series Triple Quadrupole MS Systems
More informationMetabolic Changes in Lung Tissue of Tuberculosis-Infected Mice Using GC/Q-TOF with Low Energy EI
Metabolic Changes in Lung Tissue of Tuberculosis-Infected Mice Using GC/Q-TOF with Low Energy EI Application Brief Authors Mª Fernanda Rey-Stolle 1, Vineel P. Reddy 2, Santiago Angulo 1, Adrie J.C. Steyn
More informationPesticide Analysis in a Complex Matrix using a 2D GC/MS System
Welcome to our E-Seminar: Pesticide Analysis in a Complex Matrix using a 2D GC/MS System Slide 1 Multidimensional (2-D) GC Very old (>25 yrs) but powerful separation technique Based on cutting peak(s)
More informationMassHunter Profinder: Batch Processing Software for High Quality Feature Extraction of Mass Spectrometry Data
MassHunter Profinder: Batch Processing Software for High Quality Feature Extraction of Mass Spectrometry Data Technical Overview Introduction LC/MS metabolomics workflows typically involve the following
More informationAnalysis of 16 Pesticide Residues in Broccoli Using CarbonX dspe QuEChERS AOAC Kits Using GC/MS
Analysis of 16 Pesticide Residues in Broccoli Using CarbonX dspe QuEChERS AOAC Kits Using GC/MS Authors: Conor Smith, Doug Fryer United Science Corp. 15911 Furuby Rd. Center City, MN 55012 USA Abstract
More informationImproving GC-MS Method Robustness and Cycle Times Using Capillary Flow Technology and Backflushing
Improving GC-MS Method Robustness and Cycle Times Using Capillary Flow Technology and Backflushing Application Note Environmental Author Chris Sandy Agilent Technologies, Inc. UK and Ireland Sales Headquarters
More informationConfident Pesticides Analysis with the Agilent LC/Triple Quadrupole and TOF/QTOF Solutions
Confident Pesticides Analysis with the Agilent LC/Triple Quadrupole and TOF/QTOF Solutions Screening and Confirmation Chemical Analysis Solution Unit November, 2009 Page 1 Agilent s New 6540 Ultra High
More informationMethods for Increased Sample Throughput with Dirty Samples
Methods for Increased Sample Throughput with Dirty Samples Alan D Broske, Limian Zhao, and William H. Wilson Agilent Technologies, Inc. 1 Introduction GC inlet liner impacts sample transfer to the GC column
More informationEvolution3 Triple Quadrupole GC-MS/ Transforming the best GC-MS system into something even better.
Evolution3 Triple Quadrupole GC-MS/ Transforming the best GC-MS system into something even better. CHROMTECH EVOLUTION3 TRIPLE QUADRUPOLE GC-MS/MS Transforming the best GC-MS system into something even
More information[3-5] GC/MS LC/MS. Agilent 7890A/5975C GC/MS (DRS) GC/MS DRS
: GC/MS Philip L. Wylie Agilent Technologies, Inc. 2850 Centerville Rd. Wilmington, DE 19808-1610 USA 2006 GC/MS LC/MS (DRS) 430 GC GC/MS 2 2005 11 29 (MHLW) [1,2] 758 65 15 [3-5] 0.01 ppm2006 5 29 GC
More informationImproving Productivity in Your Environmental and Food Testing Labs with Agilent 7890A/5975C GC/MS System
Improving Productivity in Your Environmental and Food Testing Labs with Agilent 789A/5975C GC/MS System Mike Szelewski Senior Applications Chemist Page 1 Overview Capillary Flow Devices A family of tools
More informationRobustness of the Agilent Ultivo Triple Quadrupole LC/MS for Routine Analysis in Food Safety
Technical Overview Robustness of the Agilent Ultivo Triple Quadrupole LC/MS for Routine Analysis in Food Safety Authors Mark Sartain, Theresa Sosienski, and Dan Hui Dorothy Yang Agilent Technologies, Inc.
More informationA Highly Accurate Mass Profiling Approach to Protein Biomarker Discovery Using HPLC-Chip/ MS-Enabled ESI-TOF MS
Application Note PROTEOMICS METABOLOMICS GENOMICS INFORMATICS GLYILEVALCYSGLUGLNALASERLEUASPARG CYSVALLYSPROLYSPHETYRTHRLEUHISLYS A Highly Accurate Mass Profiling Approach to Protein Biomarker Discovery
More informationIntroduction. Benefits of the SWATH Acquisition Workflow for Metabolomics Applications
SWATH Acquisition Improves Metabolite Coverage over Traditional Data Dependent Techniques for Untargeted Metabolomics A Data Independent Acquisition Technique Employed on the TripleTOF 6600 System Zuzana
More informationMulti-Residue Pesticide Methodologies. Frans Schoutsen
Multi-Residue Pesticide Methodologies Frans Schoutsen Why Pesticide Analysis? Extensively used in agriculture to control pests & improve yields More than 1000 different active substances used Thoroughly
More informationThe Importance of High Speed Data Acquisition in the Design and Implementation of GC/MS Applications
TECHNICAL BRIEF Gas Chromatography/ Mass Spectrometry The Importance of High Speed Data Acquisition in the Design and Implementation of GC/MS Applications C 14 scans Introduction As gas chromatography
More informationDrinking Water Semivolatiles Analysis using the 6890N/5975B inert GC/MSD. Application. Author. Abstract. Instrument Operating Parameters.
Drinking Water Semivolatiles Analysis using the 6890N/5975B inert GC/MSD Application Author Mike Szelewski Agilent Technologies, Inc. 2850 Centerville Road Wilmington, DE 19808 USA Abstract The analysis
More informationMultiresidue Pesticide Analysis with the Agilent Intuvo 9000 GC and Agilent 7000 Series Mass Spectrometer
Multiresidue Pesticide Analysis with the Agilent Intuvo GC and Agilent 7 Series Mass Spectrometer Application Note Author Rebecca Veeneman, PhD and Joan Stevens, PhD Agilent Technologies, Inc. Abstract
More informationAgilent 6000 Series LC/MS Solutions. Confidence in Quantitative and Qualitative Analysis
Agilent 6000 Series LC/MS Solutions Confidence in Quantitative and Qualitative Analysis Agilent 6000 Series LC/MS Solutions SOLUTIONS THAT SET THE STANDARD Your work with Agilent instruments benefits from
More informationThe Use Of Automated Backflush on the 7890A/5975A GC-MS System. Application. Setup Example Using Biomarkers. Authors. Abstract.
The Use Of Automated Backflush on the 7890A/5975A GC-MS System Setup Example Using Biomarkers Application Hydrocarbon Processing Authors Courtney Milner and Russell Kinghorn BST International 41 Greenaway
More informationEvolution Triple Quadrupole GC-MS/MS. Transforming the best GC-MS system into something even better.
Evolution Triple Quadrupole GC-MS/MS Transforming the best GC-MS system into something even better. CHROMTECH EVOLUTION TRIPLE QUADRUPOLE GC-MS/MS Transforming the best GC-MS system into something even
More informationAtmospheric Pressure Gas Chromatography: Background & Applications. Jody Dunstan MS Systems Evaluation, Manchester 2011 Waters Corporation 1
Atmospheric Pressure Gas Chromatography: Background & Applications Jody Dunstan MS Systems Evaluation, Manchester 2011 Waters Corporation 1 What is APGC? 2011 Waters Corporation 2 What is APGC Waters APGC
More informationOlefin Analyzer Solutions for Polymer Grade Ethylene and Propylene
Olefin Analyzer Solutions for Polymer Grade Ethylene and Propylene Angela Smith Henry Kelly Beard George Gonzalez 1 Impurity Monitoring in Olefin Production Analysis of contaminants in ethylene and propylene
More informationPesticide Residues in Produce Analyzed by Targeted MRM HR Full- Scan Acquisition and Processing
Pesticide Residues in Produce Analyzed by Targeted MRM HR Full- Scan Acquisition and Processing MRM HR for Concurrent Quantitation, Library Searching, and High-Confidence ID Confirmation KC Hyland SCIEX,
More informationAgilent s NEW MassHunter Profinder
Agilent s NEW MassHunter Profinder The Most Advanced Batch Feature Extraction Software for Metabolomics Theodore Sana, Ph.D. Metabolomics Marketing Manager 1 MassHunter Profinder A Batch Feature Extraction
More informationQuantification of genotoxic "Impurity D" in Atenolol by LC/ESI/MS/MS with Agilent 1200 Series RRLC and 6410B Triple Quadrupole LC/MS
Quantification of genotoxic "Impurity D" in Atenolol by LC/ESI/MS/MS with Agilent 12 Series RRLC and 641B Triple Quadrupole LC/MS Application Note Manufacturing Process Development Author Siji Joseph Agilent
More informationThe Agilent Metabolomics Dynamic MRM Database and Method
The Agilent Metabolomics Dynamic MRM Database and Method White Paper Author Mark Sartain Agilent Technologies, Inc. Santa Clara, California, USA Introduction A major challenge in metabolomics is achieving
More informationChanging the Game in LC-MS/MS. New Tools for Unprecedented Performance in Residue Analysis. Dr. Thomas Glauner
Changing the Game in LC-MS/MS New Tools for Unprecedented Performance in Residue Analysis Dr. Thomas Glauner EMEA LC/MS Food Segment Scientist Agilent Technologies Waldbronn The New 6490 Triple Quadrupole
More informationAgilent New 6470 Triple Quadrupole LC/MS System
Agilent New 6470 Triple Quadrupole LC/MS System ROCK SOLID Performance For Confident Quantitation Na Pi Parra, Ph.D Product Manager for Triple Quadrupole LC/MS 1 Overview of Topics The New 6470 QQQ LC/MS
More informationAgilent Triple Quadrupole LC/MS Quantitation of Pesticides. Workflow Guide
Agilent Triple Quadrupole LC/MS Quantitation of Pesticides Workflow Guide Notices Agilent Technologies, Inc. 2011 No part of this manual may be reproduced in any form or by any means (including electronic
More informationSample Matrix Influence on GC/MS/MS Multiresidue Pesticide Analysis
Application Note Food Testing & Agriculture Sample Matrix Influence on GC/MS/MS Multiresidue Pesticide Analysis Author Jessica Westland Agilent Technologies, Inc. Abstract The complexity of pesticide analysis
More informationMetabolomics of Carbon-Fixing Mutants of Cyanobacteria by GC/Q-TOF
Metabolomics of Carbon-Fixing Mutants of Cyanobacteria by GC/Q-TOF Application Note Biofuel Authors Dong Hee Chung, Christine Rabinovitch-Deere, and Shota Atsumi Department of Chemistry University of California-Davis,
More informationAnalysis of Suspected Flavor and Fragrance Allergens in Cosmetics Using the 7890A GC and Capillary Column Backflush Application
Analysis of Suspected Flavor and Fragrance Allergens in Cosmetics Using the 7890A GC and Capillary Column Backflush Application Food Authors Frank David Research Institute for Chromatography Pres. Kennedypark
More informationOptimizing Productivity and Reliability for Monocyclic Aromatic Hydrocarbon Purity Analysis According to ASTM D7504 on the Agilent 8890 GC System
Application Note Petrochemicals Optimizing Productivity and Reliability for Monocyclic Aromatic Hydrocarbon Purity Analysis According to ASTM D50 on the Agilent 0 GC System Authors Jie Pan, Lukas Wieder,
More informationFiehn GC/MS Metabolomics RTL Library IDENTIFY MORE METABOLITES
Fiehn GC/MS Metabolomics RTL Library IDENTIFY MORE METABOLITES A Comprehensive GC/MS Solution for Metabolite Identification To further facilitate identification of known metabolites through untargeted metabolomics,
More informationThe Agilent 6545 Q-TOF LC/MS System. The Answers You Need:
The Agilent 6545 Q-TOF LC/MS System The Answers You Need: Better, Faster, Easier The Agilent 6545 Q-TOF LC/MS System Faster Answers Better Measurements Easier High Performance Results The new 6545 Q-TOF
More informationThe Agilent 6545 Q-TOF LC/MS System. The Answers You Need:
The Agilent 6545 Q-TOF LC/MS System The Answers You Need: Better, Faster, Easier The Agilent 6545 Q-TOF LC/MS System Faster Answers Better Measurements Easier High Performance Results The new 6545 Q-TOF
More informationLC/MS Based Quantitation of Intact Proteins for Bioanalytical Applications
LC/MS Based Quantitation of Intact Proteins for Bioanalytical Applications Alex Zhu, Ph.D. Agilent Technologies Wilmington, DE ASMS,2017-06 1 Outline Introduction on intact protein quantitation Agilent
More information7890A An Essential Partner for the Trace
7890A An Essential Partner for the Trace Analysis of Complex Matrices Backflush An Essential Tool for Complex Matrices QuickSwap option for MS transferline Purged Ultimate Union Backflush option for the
More informationThe Fast Track to Success. Pesticides Workflow Solutions for Intuvo GC/TQ
The Fast Track to Success Pesticides Workflow Solutions for Intuvo GC/TQ Pesticide and Environment Pollutants Screening from Start to Finish Time is money, and starting up a new laboratory, analysis,
More informationDetermination of Pesticides in Water by SPE and LC/MS/MS in Both Positive and Negative Ion Modes. Application Note. Author. Abstract.
Determination of Pesticides in Water by SPE and LC/MS/MS in Both Positive and Negative Ion Modes Application Note Environmental Author Chin-Kai Meng Agilent Technologies, Inc. 850 Centerville Road Wilmington,
More informationInterlaboratory Validation Study for the Analysis of Nitrosamines in Drinking Water using GC-MS/MS
Interlaboratory Validation Study for the Analysis of Nitrosamines in Drinking Water using GC-MS/MS Diana Wong, PhD National Environmental Monitoring Conference Washington, D.C. August 7, 2017 1 Outline
More informationEPA Method 524 for Determination of VOCs in Drinking Water Using Agilent 5975T LTM GC/MSD with Static Headspace
EPA Method 524 for Determination of VOCs in Drinking Water Using Agilent 5975T LTM GC/MSD with Static Headspace Application Note Environmental Authors Xiaohua Li Agilent Technologies (Shanghai) Co., Ltd.
More informationTurboMass GC/MS Software
TurboMass GC/MS Software GAS CHROMATOGRAPHY / MASS SPECTROMETRY P R O D U C T N O T E Today s demanding laboratory requires software that is easy to learn yet offers sophisticated instrument control, robust
More informationQuantification of Host Cell Protein Impurities Using the Agilent 1290 Infinity II LC Coupled with the 6495B Triple Quadrupole LC/MS System
Application Note Biotherapeutics Quantification of Host Cell Protein Impurities Using the Agilent 9 Infinity II LC Coupled with the 6495B Triple Quadrupole LC/MS System Authors Linfeng Wu and Yanan Yang
More informationGC-MS (Multi-Residue) Screening for Pesticides; Emerging Organic Pollutants (EOP's) and Persistent Organic Pollutants (POP's).
GC-MS (Multi-Residue) Screening for Pesticides; Emerging Organic Pollutants (EOP's) and Persistent Organic Pollutants (POP's). The GC-MS Target Based Screening methods allow for virtually all GC-amenable
More informationPesticide Analysis in Drinking Water with Disk Extraction and Large Volume Injection
Pesticide Analysis in Drinking Water with Disk Extraction and Large Volume Injection A Residue Application for GC/MS/MS Triple Quadrupole Analysis Application Note Food Testing and Agriculture Authors
More informationSimple Run Table Entry Cuts Sample onto Column 2. Method Developers Calculator to Tools correctly set flows and restrictor size
Introduction 2-D GC/MS and the Deans Switch: Theory and Applications Simplified 2-D GC can be used to accomplish the separation of specific analytes from very complex matrices. In complex sample matrices,
More informationENVIRONMENTAL ANALYSIS. Solutions for Your Analytical Business Markets and Applications Programs. Solution Note
ENVIRONMENTAL ANALYSIS A TURN-KEY GUARANTEED ANALYSER FOR THE ROUTINE MEASUREMENT OF GLYPHOSATE AND AMPA IN DRINKING WATER (EUROPEAN DRINKING WATER DIRECTIVE 98/83/EC) AND OTHER ENVIRONMENTAL WATER SAMPLES
More informationUsing the Pulsed Flame Photometric Detector (PFPD) for Low-level Analysis of Organophosphorus Pesticides
Application Note 25390206 Using the Pulsed Flame Photometric Detector (PFPD) for Low-level Analysis of Organophosphorus Pesticides Keywords Model 5380 Organophosphorus Pesticide PFPD PFPDView Phosphorus
More informationTabisam Khan 1, David R. Little 1, Liyu Yang 2, Jiwen Chen 2, Parya Nouri 2, Samy Tadros 2, Patrick J. Rudewicz 2
AIMS High throughput bioanalysis plays a central role in the drug discovery and development process. The resulting data are used to determine a drug candidate's pharmacokinetic parameters that are crucial
More informationApplication of Agilent AdvanceBio Desalting-RP Cartridges for LC/MS Analysis of mabs A One- and Two-dimensional LC/MS Study
Application of Agilent AdvanceBio Desalting-RP Cartridges for LC/MS Analysis of mabs A One- and Two-dimensional LC/MS Study Application note Biotherapeutics and Biologics Authors Suresh Babu C.V., Anne
More informationApplicationNOTE. Introduction. Liquid Chromatography. Method. Sample preparation
Introduction The Food and Veterinary Office of the European Commission has published a report (2001 pesticide residues monitoring programme 1 ) compiling EUwide analyses of pesticide residues in 46000
More informationPuzzled About LCMS? Sample. Sensitivity in Mass Spec Analysis. Prep. Adapting LC-UV. Optimizing and Maintaining Your Mass Spec LCMS
Puzzled About LCMS? Sensitivity in Mass Spec Analysis Sample Prep Adapting LC-UV Optimizing and Maintaining Your Mass Spec To LCMS Paul Altiero Alex Ucci Applications Phone Support Chemistry and Supplies
More informationENHANCED PROTEIN AND PEPTIDE CHARACTERIZATION
Agilent MassHunter BioConfirm Software ENHANCED PROTEIN AND PEPTIDE CHARACTERIZATION Spectrum Algorithm Peak Modeling Deconvolution Mass 16951.778 Sequence Name Myoglobin (horse) Target mass 16951.673
More informationOn-line SPE-LC/MS/MS to Detect Organonitrogen and Triazine Pesticides at 10ng/L in Drinking Water
application note On-line SPE-LC/MS/MS of Pesticides On-line SPE-LC/MS/MS to Detect Organonitrogen and Triazine Pesticides at 10ng/L in Drinking Water API 3200 LC/MS/MS System Overview The feasibility of
More informationDetermination of Table 3 Compounds by LC/MS/MS Chemours Fluoroproducts Analytical Method Revision date: 4/26/2018
Determination of Table 3 Compounds by LC/MS/MS Chemours Fluoroproducts Analytical Method Revision date: 4/26/2018 Instrument Setup (Note: Trapping column installed on Line A. Delay column installed between
More informationMinimize Method Development Time for Pesticide Screening Using LC/MS Application Kit
Minimize Method Development Time for Pesticide Screening Using LC/MS Application Kit Dr. Jerry Zweigenbaum Senior Applications Scientist Food Safety Page 1 Agilent 1260 LC SampliQ Extraction and Dispersive
More informationMultiQuant Software Version 3.0
MultiQuant Software Version 3.0 Improving Data Quality and Processing Throughput with Better Peak Integration, Quantitative and Qualitative Compound Review for the Analysis of Food, Drinking Water, and
More informationWaters Pesticide Screening Solutions: Nuove Frontiere nell Analisi di pesticidi Miguel Ángel Cortés, Waters Manuela Cuccurullo, Waters
Waters Pesticide Screening Solutions: Nuove Frontiere nell Analisi di pesticidi Miguel Ángel Cortés, Waters Manuela Cuccurullo, Waters MS Technology day, Milan March 12 2013 Waters Corporation 1 The purpose
More informationBenefits of 2D-LC/MS/MS in Pharmaceutical Bioanalytics
Application Note Small Molecule Pharmaceuticals Benefits of 2D-LC/MS/MS in Pharmaceutical Bioanalytics Avoiding Matrix Effects Increasing Detection Sensitivity Authors Jonas Dinser Daiichi-Sankyo Europe
More informationImplement High Quality, Routine GC-MS/MS Multi-Residue Pesticides Analysis with Ease Paul Silcock & Jason Cole
Implement High Quality, Routine GC-MS/MS Multi-Residue Pesticides Analysis with Ease Paul Silcock & Jason Cole 1 The world leader in serving science Some discussion points for today.. Trend towards GC
More informationValidated Multi-Residue Method for Extraction and Analysis of Trace-Level Pesticides in Surface Water Application
Validated Multi-Residue Method for Extraction and Analysis of Trace-Level Pesticides in Surface Water Application Environmental Authors Stephen Siegel and Mark Lee California Department of Food and Agriculture
More informationIsotopic Resolution of Chromatographically Separated IdeS Subunits Using the X500B QTOF System
Isotopic Resolution of Chromatographically Separated IdeS Subunits Using the X500B QTOF System Fan Zhang 2, Sean McCarthy 1 1 SCIEX, MA, USA, 2 SCIEX, CA USA Analysis of protein subunits using high resolution
More informationTyler Trent, Applications Sales Specialist; Teledyne Tekmar Page 1
Application Note Method Validation of the AutoMate-Q40 for Pesticide Residues in Grapes Tyler Trent, Applications Sales Specialist; Teledyne Tekmar Page 1 Abstract The QuEChERS (Quick-Easy-Cheap-Effective-Rugged-Safe)
More informationTHE SOURCE OF NEW POSSIBILITIES
The Agilent 5977B GC/MSD THE SOURCE OF NEW POSSIBILITIES The Measure of Confidence The Agilent 5977B GC/MSD INSTRUMENT RELIABILITY AND PERFORMANCE: THE KEY TO A GOOD DAY IN THE LAB Most Popular Instrument
More informationResidue Analysis of Dicamba and its Metabolites in Vegetation and Soil
1 Office of Pesticide Programs (OPP) Biological & Economic Analysis Division Analytical Chemistry Branch Environmental Science Center Fort Meade, Maryland Residue Analysis of Dicamba and its Metabolites
More informationAgilent E-seminar on Emerging Contaminants 9 to 12 11am Singapore time
Agilent E-seminar on Emerging Contaminants 9 to 12 March @ 11am Singapore time NOW AVAILABLE: AUDIO BROADCAST - Audio will be broadcasted through your computer speakers, please un-mute your speaker settings.
More informationCertified Reference Material - Certificate of Analysis
Certified Reference Material - Certificate of Analysis Page 1 of 9 Fluconazole- 13 C 3, Primary Standard Catalog Number: Lot: Retest: July 2015 Description: Fluconazole- 13 C 3 in Methanol Packaging: Solution
More informationOptimization of Volatile Petroleum Hydrocarbons Analysis by Automated Headspace Using Method Development Tools
Optimization of Volatile Petroleum Hydrocarbons Analysis by Automated Headspace Using Method Development Tools Application Note Abstract The Commonwealth of Massachusetts Department of Environmental Protection
More informationApplication Note. Authors. Abstract. Ravindra Gudihal Agilent Technologies India Pvt. Ltd. Bangalore, India
Quantitation of Oxidation Sites on a Monoclonal Antibody Using an Agilent 1260 Infinity HPLC-Chip/MS System Coupled to an Accurate-Mass 6520 Q-TOF LC/MS Application Note Authors Ravindra Gudihal Agilent
More informationAgilent Consumables Improve Performance with Shimadzu GC/MS
Agilent Consumables Improve Performance with Shimadzu GC/MS Application Note Environmental & Food Safety Author Ken Lynam Agilent Technologies, Inc. Abstract Leak-free performance over 150 heat cycles
More information2018 NACRW VENDOR SEMINARS Food and beverage provided by each company (PRE-REGISTRATION IS REQUIRED)
2018 NACRW VENDOR SEMINARS Food and beverage provided by each company (PRE-REGISTRATION IS REQUIRED) V-1 Sunday Evening, July 22, 2018, 6:15 p.m. to 7:15 p.m. SCIEX DuoSpray Ionization: A Novel Approach
More informationKey Words Pesticides analysis, food safety, TSQ Endura, TraceFinder, MRL, tsrm, residue analysis
Increased Productivity in Pesticide Residue nalysis Quantifying 440 Pesticides Following China GB 2763-2014: The Pesticide Explorer Collection Standard Quantitation Zeming Wu 1, Charles T. Yang 2, Zheng
More informationClone Selection Using the Agilent 1290 Infinity Online 2D-LC/MS Solution
Clone Selection Using the Agilent 9 Infinity Online D-LC/MS Solution Application Note Biopharmaceuticals Authors Abstract Ravindra Gudihal and This Application Note describes the Agilent 9 Infinity online
More informationDetermination of Pesticide Residue in Apple Juice Using the AutoMate-Q40
Application Note Abstract QuEChERS is a Quick-Easy-Cheap-Effective-Rugged-Safe extraction method that has been developed for the determination of pesticide residues in agricultural commodities. While the
More informationAnalytical Method of Limit Test for Hexachlorobenzene. in Picloram TC and Method Validation Data*
Analytical Method of Limit Test for Hexachlorobenzene in Picloram TC and Method Validation Data* Test Method (ABCTM-2010-01-07) 1. Apparatus Electronic Balance GC/MS System with NCI Ultrasonic Water Bath
More informationDetermination of Pesticide Residue in Vegetables Using the AutoMate-Q40. Application Note. Abstract. Introduction
Application Note Abstract Determination of Pesticide Residue in Vegetables Using the AutoMate-Q40 Page 1 QuEChERS is a Quick-Easy-Cheap-Effective-Rugged-Safe extraction method that has been developed for
More informationENVIRONMENTAL analysis
ENVIRONMENTAL analysis A comparison of GC/MS-MS using the Agilent 7000 GC-QQQ and GC/HRMS for the trace level analysis of Dioxins in Environmental Samples Solutions for Your Analytical Business Markets
More informationEPA Method 543: Selected Organic Contaminants by Online SPE LC/MS/MS Using the Agilent Flexible Cube
EPA Method 543: Selected Organic Contaminants by Online SPE LC/MS/MS Using the Agilent Flexible Cube Application Note Environmental Authors Don Noot, Ralph Hindle Vogon Laboratory Services Cochrane, AB
More informationA Novel Approach to the Reduction of False Positive and Negative Identifications in Screening of Pesticide Residues in Food Analysis
A Novel Approach to the Reduction of False Positive and Negative Identifications in Screening of Pesticide Residues in Food Analysis M McCullagh, Severine Goscinny, Ramesh Rao and Vincent Hanot 2013 Waters
More informationAgilent Solutions for Metabolomics EMERGING INSIGHTS
Agilent Solutions for Metabolomics EMERGING INSIGHTS Understanding Metabolic Fingerprints A Powerful Way to Investigate Biology What is Metabolomics? Metabolomics is the study of the metabolite content
More informationClarus SQ 8 GC/MS. The NEW
The NEW Clarus SQ 8 GC/MS Optimizing EPA Method 8270: PerkinElmer Clarus SQ8 Gas Chromatograph/Mass Spectrometer (GC/MS) Meeting the Challenges and Optimizing Results and Profitability Lee Marotta, Sr
More informationAnalysis of styrene leached from polystyrene cups using GCMS coupled with Headspace (HS) sampler
PO-CON464E Analysis of styrene leached from polystyrene cups using GCMS coupled with Headspace (HS) sampler ASMS 204 TP763 Ankush Bhone (), Dheeraj Handique (), Prashant Hase (), Sanket Chiplunkar (),
More informationDirect Injection of Fish Oil for the GC-ECD Analysis of PCBs: Results Using a Deans Switch With Backflushing. Application. Author.
Direct Injection of Fish Oil for the GC-ECD Analysis of PCBs: Results Using a Deans Switch With Backflushing Application Environmental and Pharmaceutical Author Philip L. Wylie Agilent Technologies, Inc.
More informationTargeted and Untargeted Screening of Microcystins in Lake Water Samples Using High Resolution Mass Spectrometry INTRODUCTION
Targeted and Untargeted Screening of Microcystins in Lake Water Samples Using High Resolution Mass Spectrometry Lauren Mullin, 1 Xavier Ortiz Almirall, 2 Stuart Oehrle, 1 and Adam Ladak 1 1 Waters Corporation,
More informationAgilent Software Tools for Mass Spectrometry Based Multi-omics Studies
Agilent Software Tools for Mass Spectrometry Based Multi-omics Studies Technical Overview Introduction The central dogma for biological information flow is expressed as a series of chemical conversions
More informationClearly better LC/MS solutions
Agilent 6000 Series LC/MS Clearly better LC/MS solutions Our measure is your success. products applications soft ware services Agilent: the clearly better choice for qualitative and quantitative LC/MS.
More informationAgilent Solutions for Metabolomics YOUR PATH TO SUCCESS
Agilent Solutions for Metabolomics YOUR PATH TO SUCCESS UNDERSTANDING METABOLOMICS Agilent is the leading global metabolomics vendor, offering our customers a broad array of cutting-edge instrumentation
More information