Trans-omics for a better life

Trans-omics for a better life

History From 1% to World Leading The largest genomic organization in the world Focus on research and applications in the healthcare, agriculture, conservation, and environmental fields Has made a significant contribution to the development of genomics throughout the world Make state-of-the-art genomics highly accessible to the global community and benefit mankind BGI was established on 9,9, 1999 Following HGP The First Stage 1990 1998 With a focus on scientific research in biotechnology, during this period BGI closely followed global genomics research in order to participate in the Human Genome Project. 1998 2006 BGI was established on September 9, 1999. Accompanied with the development of sequencing technology, BGI has formed the BT+IT model to achieve industrial scale output. Electrophoresis Cost: $3 billion Data output: ~200 Capillary sequencing Cost: $0.3 billion Data output: 10 3 In 2007, HQ moved from BJ to SZ The Second Stage 2006 2013 Keeping up with the tide of new technological revolution, in 2007 BGI moved its headquarters to Shenzhen and since then have accomplished many milestones. Outlook 2014 today BGI s contribution has grown from research collaboration and science technology services to health care services, with the ultimate goal of building a better future for everyone. Synthesis sequencing Cost: $3 million Data output: 10 9 ~ 10 12 CG sequencing Cost: $1000 Data output: 10 15 ~ 10 18

Global Presence Headquartered in Shenzhen, BGI has branches and affiliates in over 50 countries. BGI has established 47 labs (including joint-lab) globally, and 1/3 are located overseas. Over 5000 employees globally

Organizations BGI Research BGI College China National Genebank GigaScience BGI Genomics BGI Agriculture BGI Forensics Complete Genomics BGISEQ Sports Genomics Institute education Agriculture Group research application BGISEQ

Technology Platforms From genomics to trans-omics, develop a systematic infrastructure to Store, Decode, Read, Interpret and Apply genetic information Sequencing Platform BGI owns 295 sequencers, with the data output capability of ~30 T/Day (as of Feb 2016). Platforms include BGISEQ, Complete Genomics, Illumina HiSeq 2500, Illumina HiSeq 2000, Illumina Miseq, Ion Torrent, 454 sequencing system, ABI3730XL and Genotyping platform. Certifications: ISO9001 ISO14001 OHSAS18001 ISO27001 ISO17025 Mass Spectrometry Platform BGI has 18 MS sequencers, including Triple Quadrupole Mass Spectrometer (QMS), MALDI mass spectrometer, Orbitrap and Q-TOF mass spectrometer (as of Feb 2016). The platform is used for industrial-scale proteomics, metabolomics research and targeted molecule detection. Certifications: OHSAS18001 ISO14001 ISO9001

Computing Platform BGI s total peak performance of computing is up to 239.5 Tflop, the total memory capacity 58.6 TB and the total storage capacity 27.8 PB (as of Feb 2016). BGI has several supercomputing centers, located in Shenzhen, Hong Kong, Beijing, Wuhan, and Hangzhou. It has established the TH-BGI Bioinformatics Union Lab with the National Supercomputing Center in Tianjin. Informatics Platform Through alliance with leading IT enterprises, BGI online integrates high-performance computing, secure networking and large-capacity storage, allowing data analysis, visualization and reporting on the cloud, which assists researchers to obtain actionable insights quickly and easily. 2016 BGI-Shenzhen All Rights Reserved

BGI Research Pioneer in Omics Science & Technology Areas of research focus: Personal genomics; Cancer; Reproductive health; Molecular breeding Develop the high-throughput, low-cost transomics platform; Lead technology development; Achieve breakthroughs in fundamental research; Support the applications of health care and breeding; Drive biotech s application growth; Assist in the setting up of industrial standard.

BGI College Innovative Education and Training Programs includes: Joint education in collaboration with many domestic and international universities External training bioinformatics training, medical related training & genetic counselor training Public education popular science education & summer/winter internship >110 Ph.D. Students >300 MSc Students >370 Undergraduate Students BGI Certified Professionals Genetic Counseling BGI Certified Professionals Bio-information Analysis

Life Science Services Premier Scientific Partner Research services business Global leader in omics research projects (genomics, proteomics, metabolomics, ) Bioinformatic expertise across broad range of organisms and applications Provide One Stop and Total Solution services for its global biomedical, agricultural, and environmental research customers 800 professionals 20 branches and offices 4.000 organizations 13,000 partners Thousands of research projects

Clinical Medicine Excellence in Genetic Diagnostics Preconception Testing Prenatal Testing Neonatal Testing Hematology Testing Cancer Testing Pathogenic Microorganism Testing Global Leader in Genetic Testing Non-Invasive Prenatal Trisomy (NIFTY) test: - Over 1million tests performed to date - First NGS NIPT test approved by CFDA - Performs best in NIPT according to NEJM study BGI owns 29 clinical laboratories around the world and more than 10 joint labs BGI labs have been certificated by ISO9000, ISO14001, OHSAS18001, ISO/IEC17025, ISO27001, CAP/CLIA, GMP, IVD etc.

BGI sequenced 130 out of 188 major crops,contributing >70% Ag genomics data globally 100,000+ accessions resequencing 300+ trait genes mapped 20+ species under molecular breeding

BGI Agro Before After Well equipped with facilities applicable for various breeding needs, BGI Agro has an extensive scope including animal & plant new variety development, plantation, livestock breeding, agricultural product processing as well as circular ecological research and application. It has a lab area of over 8000 square meters, ~1 kilometer square breeding field, well equipped with advanced experimental instruments. BGI-Agro has 4 production bases: Baguang in Shenzhen, Yangling in Shanxi province, Huidong in Guangdong province and Laos. The mission is to establish sustainable agricultural industry and ensure national food security. Baguang Aquatic Base Huidong Experimental Base Laos Agroforestry Demonstration Base Yangling Breeding Base

BGI Named to MIT Technology Review s 2013 50 Disruptive Companies List Recognizing World s Most Innovative Companies BGI Ranked 2 nd of Fast Company s 2014 The World's Top 10 Most Innovative Companies in China

Recognitions 2012 Nature BGI was established in 1999 to support the Human Genome Project. It went from accounting for about 1% of the genomics community s sequencing capacity at that time, to more like 50% today, says George Church, a geneticist at Harvard University in Cambridge, Massachusetts. BGI-Shenzhen has emerged as a genomics superpower. Since its inception in 1999, BGI has focused on developing its sequencing and bioinformatics capabilities while turning to outside teams in crop science, human disease, and microbiology to help define its research objectives. As a result, BGI has become the go-to organization for groups in need of sequencing. 2012 Science: China's Sequencing Powerhouse Comes of Age 2014 New Yorker: The Gene Factory As the world s scientists focus with increasing intensity on transforming the genetic codes of every living creature into information that can be used to treat and ultimately prevent disease, Shenzhen is home to a different kind of factory: B.G.I., the world s largest genetic-research center...b.g.i. produces at least a quarter of the world s genomic data ore than Harvard University, the National Institutes of Health, or any other scientific institution. I m impressed by the achievements BGI made in genetic sequencing, genomics and bioinformatics since its founding I knew a lot of people who dropped out of the university and did technical and business work. But it s my first time to see, in BGI, people dropped out of the university to do basic research and could achieve remarkable success. 2013 Bill Gates 2013 Boao Forum for Asia Dialogue with Bill Gates: Investment for the poor There are so many examples of great innovative works have been done here. One becoming a partner of our Foundation recently is BGI, the biotechnology institute headquartered in Shenzhen. It s very interesting how they ve gone after very young people and talented people, reminds me of the early days of Microsoft - the great energy, the minds thinking in the new ways all committed to solve the top problems in science.

BGI Model Integrated platform to support research discoveries and industry applications Research organizations Clinical Breeding Genetic testing Genetic editing National Decode Interpret Apply Sample bank Data bank Live bank Global partnership International Applications

BGI (Headquarters) Tel: 400-706-6615/+86-0755-25273620 Fax: +86-0755-25273620 Address: Building 11, Beishan Industrial Zone, Yantian District, Shenzhen (518083) Website: http://www.genomics.cn/ Email: info@genomics.org.cn