Clarity Genomics. Company Profile
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1 Clarity Genomics Clarity Genomics BVBA is a Belgian-based biotech contract research organization (CRO) providing host-microbiome data analysis and interpretation services for clinical research. Clarity Genomics supports translational and clinical development programs leveraging the therapeutic and diagnostic potential of the host microbiome. Clarity Genomics differentiates itself from existing contract research organizations through its expertise in performing integrative analysis of multi-omic data with expertise in longitudinal microbiome-metabolome interactions. With access to a manually curated database of thousands of human metagenomes and involvement in large-scale collaboration projects including the Earth Microbiome Project, the American Gut Project and the NIH Human Microbiome Project, Clarity Genomics is developing a platform that learns how human microbiome communities interact with the host through analysis of genetic, functional, and metabolic data. This knowledge, when combined with partnerships with leading research institutions, accelerates the development of biological insights for biomarker discovery, patient stratification and therapeutic response evaluation for better healthcare. For Clarity Genomics, Janssen s strategic interest in microbiome research and the direct access to the Janssen Human Microbiome Institute were key drivers to join JLINX. Dr. Evguenia Kopylova R&D Lead Clarity Genomics
2 Background Clarity Genomics Founded in 2016, Clarity Genomics Inc. is a spin-off company from Rob Knight s Lab at UC San Diego, worldrenowned for the development of computational and experimental techniques to characterize microbial life and interpret variability and diversity of microbial communities in complex ecosystems. In close collaboration with Pieter Dorrestein s Lab which develops mass spectrometry approaches for analysis of microbial metabolic exchange, new advances have been made toward understanding correlations between microbial communities and their local chemical signatures using DNA sequencing and mass spectrometry. Among other genomics services, Clarity Genomics leverages these novel technologies to provide insights into microbiome-metabolome interactions using a combination of DNA sequencing and metabolomic data. Before founding Clarity Genomics, Dr. Evguenia Kopylova co-developed multiple sequencing, analysis and profiling software tools in collaboration with academic experts including Rob Knight Professor, Dept. Pediatrics and Computer Science, University of California San Diego (UC San Diego), Hélène Touzet CNRS Research Director, Laurent Noé Associate Professor, Dept. Computer Science, University of Lille and Olivier Jaillon Researcher, Institute of Genomics - CEA, Genoscope. A number of these software are recognized worldwide as key tools for microbial data analysis as reflected by their large number of citations from the scientific community. Clarity Genomics management is affiliated with the Rady School of Management (UC San Diego) and Harvard Business School. In early 2017, Clarity Genomics BVBA joined the J&J Innovation JLINX incubation and investment model managed by Bioqube Ventures. This strategic partnership has allowed Clarity Genomics to rapidly expand it s analysis platform and launch service operations within months of joining. Technology Clarity Genomics leverages secure cloud computing, including security and privacy compliance in accordance with HIPPA, and reproducibility and documentation for CLIA compliance, for high-throughput data analysis. Clarity Genomics actively engages in collaborations with leading research institutions including UC San Diego, CNRS Lille and Center for Integrative Biology, Trento University to develop advanced multi-omic analysis tools including QIIME, deblur, curatedmetagenomicdata, GNPS, ili toolbox for 2-3D molecular mapping, MetaPhlAn and SortMeRNA. To stay on the forefront of host-microbiome data analysis innovation, Clarity Genomics recently began to accelerate integration of machine learning algorithms and leverage its data aggregation potential for smarter diagnostics across different microbiome ecosystems. 2
3 Clarity Genomics Services Clarity Genomics works together with well-established sequencing and mass spectrometry institutions to offer clients an end-to-end solution for host-microbiome data generation and analysis. Our clinical lab partners offer DNA sequencing (RNA-Seq, WGS, shotgun metagenomics, targeted gene) and mass spectrometry (LC-MS, GC-MS) data which is subsequently uploaded to our secure cloud platforms for analysis. Clarity Genomics offers analysis services to pharmaceutical, biotech, nutraceutical companies as well as healthcare institutions. Services include: Study experimental design and consulting Sequence (reads) and metabolomics data quality control Targeted gene analysis (16S taxonomy, abundance, diversity analysis) Untargeted metabolomics feature detection and statistical analysis Putative metabolite identification using spectral matching Annotation of unknown compounds using molecular networking 2D/3D molecular and microbial mapping Pathway mapping of metabolomics data Genome assembly and annotation (de novo and re-sequencing) Pan-genome and phylogeny analysis for gene presence/absence of specific strains Strain profiling against manually curated human metagenome database Time series multi-omic analysis (differential gene expression, differential metabolite abundance) Gene ontology and metabolic pathway analysis for function of up- or down-regulated genes Microbiome-metabolome correlation analysis for assessment of molecules associated with specific members of a microbial community Integration of proteomics and metaproteomics data for multi-omic analysis Analysis services are tailor-made to specific research needs of each client on a fee-for-service basis for established companies. For start-ups and strategic partners, Clarity Genomics is developing an innovative Equity or Data-for-Service offering. 3
4 Clarity Genomics Team Dr. Evguenia Kopylova Research and development Ph.D Computer Science University of Lille and Inria Lille-Nord Europe Developer of multiple high-profile software for analysis of DNA sequencing data. Josh Daulton Marketing and Analytics MBA UC San Diego Distribution Marketing Manager for Micron Technology with years of experience developing and optimizing digital marketing campaigns. Skyler Stein Financial and Operations MBA Harvard Business School Extensive experience in controlling private equity investments and has served on boards of several high growth ventures. Academic Collaborators Rob Knight Professor in the Department of Pediatrics and Department of Computer Science, and Faculty Director at the Center for Microbiome Innovation at UC San Diego Pieter C. Dorrestein Professor at the Skaggs School of Pharmacy and Pharmaceutical Sciences, and Faculty Director of the Collaborative Center for Mass Spectrometry Innovation at UC San Diego Nicola Segata Professor at the Center for Integrative Biology at University of Trento (Italy) with a postdoc in Huttenhower Lab at Harvard (United States) Rayan Chikhi CNRS junior researcher at University of Lille with a PhD in Computer Science from ENS Rennes (France) and a postdoc in Medvedev Lab at Penn State (United States) Alexey Melnik Research Associate at Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego with MS in Analytical Chemistry from Far Eastern Federal University, Vladivostok (Russia) Why JLINX For Clarity Genomics, Janssen s strategic interest in microbiome research and the direct access to the Janssen Human Microbiome Institute were key drivers to join JLINX. Access to the business development expertise from the Bioqube team managing the JLINX community, means an invaluable asset for a start-up that is focusing on translating a scientific breakthrough into a concept for a commercial services portfolio. Moreover, many collaboration opportunities with fellow JLINX residents in the microbiome field and access to shared Lab facilities form another important strategic reason why being part of this dynamic innovation ecosystem might accelerate the young company s efforts to make an earlystage idea work. 4
5 Clarity Genomics Partners Clarity Genomics develops its technological and business plan in close collaboration with the following partners: Highlights Dec 2016 Clarity Genomics Incorporated is founded Apr 2017 Clarity Genomics joins JLINX Jun 2017 Clarity Genomics offers to provide end-to-end host microbiome analysis services, including DNA sequencing and mass spectrometry (LC-MS and GC-MS) 5
6 Contact Clarity Genomics Evguenia Kopylova, CEO phone: +32 (0) Clarity Genomics BVBA Janssen Pharmaceutica Campus JLINX Incubator gebouw 019 postvak 430 Turnhoutseweg 30 B-2340 Beerse, Belgium supported by:
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