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The appropriate solution for every requirement. Our LA160, LA300 LA400 and LA500 Sachet Packaging Machines www.mediseal.de

Contents 04 Able to provide solutions Professional product development. 06 Rich in innovation Dosing systems developed by experts. 08 Performance at a glance 10 LA160 Flexible, reliable and compact. 12 LA300 The profit centre. 14 LA400 Incomparable flexibility. 16 LA500 Highest performance in the smallest space. 18 Sachet lines A successful connection. Customer-focused You know what you want, we have the solution. Professional product development is focused on customer needs One of the key factors in the success of your business is profitability. To achieve this, you have to identify trends, react flexibly to market develop-ments and meet any requirements that are imposed with quality and reliability. We can help. Because Mediseal s vertical sachet machines have been recognized for decades as the first choice for packaging pharmaceutical and cosmetic products. Dosing systems developed in-house demonstrably achieve the highest dosing accuracy and are perfectly suited to packaging high-value products.

ABLE TO PROVIDE SOLUTIONS PROFESSIONAL PRODUCT DEVELOPMENT To create something new which strikes a chord with our customers and which benefits them - that s what makes up our daily work. And so, Mediseal has developed the LA160, LA300, LA400 and LA500 sachet machines. Everything becomes feasible, with a wide range of options and performance ranges, from 2 to 16 lanes GMP-compliant, naturally. The foil handling system, thanks to servo-driven roll draw-off systems, is always guided in operation. A simple sealing tool change is possible at any time, thanks to the quick-release device. Sachets, single or double, as well as contour-punched easy-tear sachets and perforations, are no problem. Appropriate transfer solutions ensure a problem-free line link to a side-load cartoning machine. Naturally, complete project solutions can be provided or developed to meet all requirements. Well equipped - Laterally controlled unwinding of foil rolls - Splice detected independently of background colour contrast - Servomotor-driven roll draw-offs - Platen sealing tools mounted on rapid attachment devices - Lengthwise and transverse cutting device - Embossing coding system - Perforating device - Punching stations for easy tear-off - Transfer systems that feed good sachets to the cartoning machine 4

RICH IN INNOVATION DOSING SYSTEMS DEVELOPED BY EXPERTS. The right configuration for every product: liquid or paste products, powders or wipes, tablets or special forms of products. With a wide range of available dosing systems, Mediseal s sachet machines are able to package pharmaceutical and cosmetic products of all kinds. Tests and feasibility studies can be carried out quickly and professionally in our purpose-built technical laboratory. Pump-based dosing systems can be mobile and rack-mounted on request, so that at the end of a production batch they can be changed quickly and simply for a new dosing system prepared for the next batch. The dosing systems are easy to clean and fill volume is adjustable even during production. Consequently, cleaning and change-over times no longer have any notable effect on machine availability. Dosing features: - Pump-based dosing systems for liquid and paste products - Auger dosing for products which do not flow freely - Microsphere for free-flowing products - Tablet dosing system 6

Performance at a glance: Machine type Output in sachets/min.* Applications As a line in combination with a cartoning machine LA160 240 Small lot sizes, clinical trials, several various dosing systems on one machine P1600 LA300 360 A classic sachet machine especially recommended for the cosmetic industry P1600 LA400 480 Highly flexible, latest generation for high output quantities, highly modular construction, especially suitable for packaging liquid products P1600 LA500 600 A high-performance machine, especially suitable for packaging granulates P1600/P3200 * depending on format and product

LA160 FLEXIBLE, RELIABLE AND COMPACT. The LA160, with a footprint of 1 m², is a compact, general-purpose sachet machine. Whether it is used for validation runs, new product launches or efficiently packaging small lots, the LA160 is the ideal entry-level solution to top-quality production for all pharmaceutical and cosmetic products. The LA160 is very simple to operate and reconfigure. The possible simultaneous arrangement of multiple dosing systems on the machine highlights its flexibility and explains why many pharmaceutical manufacturers use the LA160 for producing samples. It is equally suitable for tablets, liquids, granules or special objects in sachets. The vertical, balcony construction workstations can be pivoted forward through 90. All the working areas of the LA160 are easy to access and designed to comply with GMP standards. Precision tools mounted on quick-tensioning devices ensure quick and simple format conversion. In addition, for packaging of new and challenging products, Mediseal offers test facilities. Special features of the LA160 at a glance: - A small footprint: highly compact with a surface area of only 1m 2 - A wide range of applications: pharmaceuticals and cosmetics, small lots and validation - Simple to operate - Flexible, thanks to a wide range of dosing systems - Quick and easy format changeovers - S ealing station pivots through 90 for perfect accessibility - Optional: Edge control for automatic, congruent sealing of packaging foils - Optional: A range of printing and inspection systems are available for application of variable data 10

LA300 THE PROFIT CENTRE. The LA300 is the all-rounder of sachet packaging machines. It stands out for its high performance and flexibility and is able to cope with almost any requirement. It has been tried and tested in hundreds of installations around the world. The basic concept is proven in practice: a balcony construction machine with workstations fitted with a wide range of tools and which can be pivoted through 90 on both sides. The GMP-compliant design eliminates any hidden areas in which unseen product can accumulate. All stations are easily accessible and therefore easy to clean, maintain and set up. Speed and sealing pressure can be optimally matched to the product. Absolutely identical sealing of all packaging materials is achieved using edge control; the height of the cross-cutter can be adjusted using motor drive even during operation. This guarantees the highest sachet quality! Special features of the LA300 at a glance: - Extremely robust - Long stations (850 mm) for maximum flexibility - Contour cutting available as an option - Flexible dosing systems for all pharmaceutical and cosmetic products - Very compact: minimal space requirements - Cross cutter is height-adjustable, even during machine operation - Variable sealing pressure for quiet machine operation with no vibration - S emi-automatic cartoning module as an alternative to the complete packaging line 12

LA400 UNEQUALLED FLEXIBILITY. With the LA400, Mediseal sets new standards in terms of flexibility of equipment, format conversion and cleaning. The precursors of the new developments are its two successful predecessors, the LA300 and LA500, combined with the practical experience of our customers. The LA400 is modular in design, so subsequent adaptation to changing production requirements or products is very easy: contour punching, bevel cuts and perforations, printing and inspection of variable data, plus alternative dosing systems. For every application, Mediseal has triedand-tested solutions which can be quickly integrated. A plug-and-play principle allows complete dosing units to be removed quickly for cleaning without having to interrupt production. Control programs, special bearing caps, pneumatic tensioning shafts and an ergonomically designed cutting and splicing table facilitate foil changing. The printed side of the packaging material is fully visible to the operator; this enables accurate joining of the packaging lanes. Special features of the LA400 at a glance: - Future-proof, thanks to adaptable functionality - Flexibility, thanks to interchangeable dosing unit using the plug-and-play principle - High availability, thanks to cleaning of the dosing unit without interrupting production - Faster foil change thanks to the ergonomically designed splicing table - Patented foil guide - fully encapsulated in accordance with the most stringent pharmaceutical requirements - Guaranteed sachet quality: the deviation triangle and cross-cutting device are motor-driven and can be operated via the HMI - even when the machine is running 14

LA500 MAXIMUM PERFORMANCE IN THE SMALLEST SPACE. The LA500 is a high-speed packaging machine. The vertical design allows maximum performance with minimum space requirements. The machine is especially suitable for packaging granulates for the pharmaceutical industry or food supplements. In addition to the high-precision micro-piston dosing system, other dosing systems are available, ensuring maximum flexibility in the packaging of many different products. The LA500 is powered by servo motors and can therefore easily be linked to a cartoning machine. Its balcony-type construction and the high-visibility design of the machine comply with the stringent GMP standards of the pharmaceutical industry. The overall height of the vertical LA500 vertical sachet machine has been reduced by a combination of a longitudinal and transverse sealing station. Accessibility and monitoring of the entire production process have been improved enormously. A servo motor drive system unwinds the foil. This means that the draw-off length can be varied from the control panel. The unique advantage of this concept is that the machine runs free from vibration and noise. Depending on the product to be manufactured, up to 10 lanes can be used. Special features of the LA500 at a glance: - A large selection of dosing systems - Pivoting sealing station for high product safety: no unnecessary heat affecting filler tubes or product - Two-component dosing system enables automatic mixing of components on the machine: this saves time and costs in upstream processes, as well as in quality assurance - Fast change-overs - Low machine height for excellent machine access and ease of operation - Ideal in conjunction with a cartoning machine - For the most demanding high-performance requirements, two LA500 machines can also be linked to one cartoning machine 16

Sachet lines a successful connection. Mediseal has developed quickly adaptable sachet transfer systems, providing a smooth-running link to the cartoner to meet the customer s specific performance requirements. Up to 25 sachets can be passed directly into the cartoner s product cell chain using a Pick & Place system. The illustration shows a line consisting of two LA500 sachet machines and a P1600 cartoner. Transfer Station - developed for absolutely reliable transfer of single or multiple sachets - Designed for maximum outputs - transfer uses a Pick & Place system - A levelling station ensures the optimum distribution of the product in the sachet: saves space, allows smaller packs and guarantees reliable insertion of the stack of sachets into the carton A customised solution Do you have special requirements? No problem! To date, Mediseal has found a solution to every requirement stackable or non-stackable sachets, special spatial conditions, a requirement for inline weighing systems, bulk packaging in outer cartons, inline leak detection, special product inserts, side-load-top opening and much more talk to us! We will gladly design your packaging for you.