Vlassis Vlazakis, May 2018 Total Lab Automation
30 May 2018 page 2 2009 Roche
What is Total Lab Automation? TLA refers to automation of all laboratory testing processes that occur from the time of sample receipt by the laboratory to archiving of the sample post analysis via robotics. In addition to sample analysis, TLA includes the pre-analytical and the post-analytical testing phase, using track systems The concept of TLA was developed in the early 1980s by Dr Masahide Sasaki at the Kochi Medical School Laboratory (Japan). He designed the first continuously moving conveyer belt/track system for the delivery of samples to interfaced analyzers. Presented in 1989 AACC Annual meeting Page 3
TLA ingredients 1. Specimen input area 2. Bar code reading stations 3. Transport system 4. A high-level device to sort or route specimens 5. Automated centrifuge 6. Level detection and evaluation of specimen adequacy (specimen integrity) 7. Decapper station 8. Recapper station 9. Aliquotter 10. Interface to automated analyzers 11. Sorter 12. Take-out stations 13. Storage and retrieval system Page 4
More TLA ingredients Data flow 14. Middleware LIS interface 15. Expert System - IT 16. Process Manager - IT 17. Inventory Manager - IT Page 5
Lab considerations & criteria to go for TLA 3.800 TLA Systems installed globally (CAP Today report) excl. Hematology Daily volumes from 1.000 tubes/day up to app. 25.000 tubes/day on one track High test volume, overall cost pressure, improve TAT, lack of qualified personnel, quality requirements, lab & hospital consolidations, processes standardization, error reduction. Closed vs. Open TLA system - Back-up solution Reagent rental contract vs. Track purchasing - ROI? Page 6
Why is TLA needed - Advantages of TLA Page 7
Map lab s sample & data workflow What to keep in mind Page 8
Benefits for all stakeholders - Employee engagement Change management Page 9
Workflow Consultant required for Workflow Assessment Goals : What needs to be accomplished? KPIs Current state analysis: How is your lab working today? Conclusions: Identifying problems and recommending holistic solutions for an improved future state Page 10
Workflow Consultant recommendations Pre-analytical processes Analytical systems Post-analytical processes Floorplan design(s) Page 11
Main TLA vendors GLP Systems Sysmex partner ARUP Automation Page 12
Powerful sample flow efficiency with Roche Personalized Lab Automation Page 13
ACCELERATOR a3600 SCALABLE AND CONFIGURABLE SOLUTIONS Page 14
Aptio Automation Advance your laboratory s productivity Page 15
Power Express Laboratory Automation System Workflow without the work Page 16
VITROS Automation Solutions Run your lab your way Page 17
Middlewares - Process Managers Inventory Managers Page 18
Labs need Seamless Integration Unrestricted Siemens Healthcare Diagnostics Inc., 2018 HOOD05162002718279
TLA trends set new criteria Open Connectivity for 3 rd parties Risk sharing business models Services/Education Multidiscipline connectivity & expandability Advanced IT solutions/mobile apps Artificial Intelligence to reduce downtime Page 20
TLA trends set new criteria Advanced IT Solutions - AI Proactive maintenance Self recovery Remote support Monitoring lab KPIs On-line education On-line upgrades Open Connectivity for 3rd parties & expandability Customers demand freedom of analyzer choice Vendors assay performance varies Grow the solution with the lab Multidiscipline connectivity One TLA connecting most disciplines Economies of scale Optimizing workflow & TAT Personnel shortages Move staff to higher duties Page 21
TLA trends set new criteria Huge freezers for sample storage & retrieval Gamma rays for HILs volume check? New ways of sample transport / input (e.g TEMPUS 600) RFIDs for sample/carrier identification CLSI has 13 standards for Automation - updated since 2000. The Clinical and Laboratory Standards Institute (CLSI) promotes the development and use of voluntary laboratory consensus standards and guidelines within the health care community. Page 22
Aristotle, philosopher & scientist (384-322 BC) Greatest mind of all times, founder of formal logic Plato s student, teacher of Alexander the Great 23 Page 23
References 1. Clinical Chemistry 63:6, 1074-1082 (2017) Nonanalytic Laboratory Automation : A Quarter Century of Progress (Hawker Charles) 2. Automation in the Clinical Laboratory (Hawker Charles. et al) https://www.researchgate.net/publication/314089643_automation_in_the_clinical_laboratory 3. Clinical Chemistry 64:62, 259-264 (2018) Challenges and Opportunities in Implementing TLA (Genzen J.R moderator Expert panel) 4. Medical Laboratory Observer, Oct 2017.The role of lab automation in reducing diagnostic errors (Tieman Brad, MBA) 5. CLSI Standards https://clsi.org/standards/products/automation-and-informatics/documents/ 6. CAP Today 2016:30 28-48, Lab Automation systems & workcells (product guide) 7. https://www.glp-systems.com/ 8. https://www.aruplab.com/testing/automation 9. https://www.tempus600.com/one-touch-system/one-touch-handling Page 24
Contact Vlassis Vlazakis CAI PM HC WEA GRE LD Agisilaou str. 6-8, 151 23Maroussi, Athens, GREECE M +30 6949 989910 E vlasios.vlazakis@siemens.com Page 25