INDIAN PHARMACEUTICAL INDUSTRY IN THE NEW PARADIGM
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1 INDIAN PHARMACEUTICAL INDUSTRY IN THE NEW PARADIGM Tapan Ray Director General Organisation of Pharmaceutical Producers of India 2010 Health & Youth Conference, South Korea 15 th April, 2010
2 Content India Today Healthcare and Regulatory Environment Pharmaceutical/Biotech Industry R&D Outsourcing Opportunities Drivers and Barriers Advantage India
3 Temptation of the West If you don t know INDIA, you don t know the WORLD - Andre Malraux
4 India Today
5 The Wise Elephant
6 India Market Pyramid Rich India Middle India BOP India
7 Opportunities in Each Tier Income Percentile Population (MM) % of Income GDP per capita ($) Class (Top 10%) Mass (Next 30 %) BOP (Last 60%) , Source: Rama Bijapurkar, We are like that only
8 28 Years of High Growth India is the 4 th Largest economy (%) Average Annual GDP Growth
9 Population Growth is Slowing Down India is the 2 nd Largest population (%) Sources: : Angus Maddison (1995), Monitoring the World Economy, :Census of India (2001)
10 Literacy is Rising India is the 4 th Largest economy (%) (proj.) Source: Census of India (2001)
11 Growing Middle Class Population India is the Largest consumer base (m) 400 8% 22% 32% Source: The Consuming Class, National Council of Applied Economic Research, 2002
12 Poverty is Declining India is the 4 th Largest economy (%) % population crossing poverty line each year for 25 years Equals ~ 200m
13 Per Capita Income Gains US$ ppp 1, , Source: World Bank
14 India s GDP Growth India will overtake Japan by 2014 Emerging Market GDP Growth Deloitte : Pharmaceutical Market Entry in India India growing by 6% + despite the current global recession Indian growth story is still intact
15 Key Reforms India will overtake Japan by 2014 Globalization of economy Dismantling license regime Lowering tariffs / taxes Breaking public sector monopolies Indigenous R&D New IPR Regime
16 India is Changing Fast setting the pace for growth and stability TODAY YESTERDAY Slow rate of growth Bureaucratic Protected Small markets Under-developed infrastructure No Product Patent One of the fastest growing world economies Less impacted by financial meltdown Significant outsourcing opportunities Fast growing markets Significant investment in infrastructure creation for industry Product patent regime / R&D
17 Healthcare and Regulatory Environment
18 Value Chain Developments Across the Value Chain Consumers Better informed & aware consumers Healthcare spend up to 6% of GDP per capita (from 3% in 02) Customers Improved doctor density per 1000 patients Corporate hospitals / hospitals chain Marketing Increased focus on brand building Fast developing rural markets Distribution Chains R&D and Manufacturing Organization of the retail sector - opening up of retail chains Entry of international players into the distribution chains Largest number of FDA approved manufacturing plants outside the US Maximum ANDAs and DMFs Legal IPR Regime
19 Healthcare Sector Insulated From Global Meltdown. Pharma Domestic Market size USD % Health Insurance 10% population has Health Insurance USD 1 Hospitals No. of beds ~65,500 Increase in Private Sector Indian Healthcare Indian Healthcare Industry Industry OTC Market India ranks 11 th in global OTC market USD 1.8 Bn. Medical Tourism Infertility, Cardiac Management are big contributors. In 2007, India treated 4,50,000 foreign patients USD 2 30% by 2012 Medical Devices Small but maturing market USD % Source: ORG IMS Intelligence, various data sources, IBEF
20 Access to Healthcare Lower access to medicines than African countries Percentage of WHO regions lacking access to essential medicines All Countries 30 India 65 Africa 47 East Mediterranean 29 Sourth-East Asia 26 America 22 China West Pacific Europe Source: Diseases of Poverty and the 10/90 Gap, International Policy Network, November 2004
21 Proportion of Health Expenditure by Financing Source Central Government 6% State Government 13% Local Government 2% Firms 5% Households 72% External Aid 2% Source: National Health Accounts , MoHFW, GoI
22 Government: Changing Role From Healthcare Provider to Healthcare Facilitator Private Healthcare Spending (U.S.$ Bn.) Source: India Trade Promotion Organization (ITPO)
23 Regulatory Structure Pharma & Biotech Industry Ministry of Chemicals & Fertilizers Ministry of Health & Family Welfare Ministry of Commerce & Industry Ministry of Science & Technology Ministry of Finance Dept. of Pharmaceuticals DCGI DIPP Dept. of Science & Technology Pharma Policy NPPA Pricing Drugs & Cosmetics Act Drugs & Magic Remedies Act Marketing Approval IPR Patents Act FDI R&D Biotech Policy Tax & Duty Transfer Pricing Clinical Trials
24 Policy Framework - Indian Pharmaceutical Industry Policy-sets that influence the Pharmaceutical Industry Healthcare Policy Industrial Policy Health Safety Policy Access to medicines Cost-effective medication Regulating the physician and consumer behaviour Generic promotion/ substitution Promoting SMEs Strengthening R&D Protection of IPR Sustaining Industry - Institution Linkages Supporting technology transfer and capacity development Ensuring Quality in manufacturing Efficacious treatments Innovations in drug delivery Safety in medicines Source: EXIM Research
25 Pharmaceutical Industry
26 USD Billion Indian Pharmaceutical Market The domestic market grew by 10.4% in last ten years and 9.4% in last 5 years Contract Research Bulk Drug Exports Formulation Exports Domestic API Domestic Formulation
27 Indian Pharmaceutical Industry is doubling every 6 years Dec MAT Total retail market size: US $ 8.9 bn; >23,000 companies; over 60,000 Brands
28 India Pharma Market Will maintain healthy growth momentum Growth enablers Income growth Growth in medical infrastructure Rising prevalence of chronic diseases 12-14% 24.0 Aggressive market creation Rise in insurance coverage 10.6 April, 2009 US$ billion
29 Key Market Types Market Size US$ 8.9 Bn. Branded Generics 84% OTC 8% Source : IMS Feb. 2010
30 Market Characteristics Highly fragmented industry USD 8.9 GR 17.6% Over 60,000 Rx Brands; 23,000 Companies Top 10 Companies contribute to 38% Top 300 brands contributing to 33% Top 10 brands contributing to 3.6% Source : IMS February 2010
31 Top 10 Pharma Companies Top 35 Companies contribute to 75% Rank Company Sales (USD Mn.) % M.S. % Growth Market No. of Products 1 Cipla Ranbaxy GSK Piramal Healthcare Zydus Cadila Sun Pharma Alkem Pfizer Mankind Lupin Labs Source: IMS Feb. 2010
32 Market By Therapy Area Key Therapeutic Segments Dermatological 5.5% Others 16.8% Alimentary T & Metabolism 24.6% Central Nervous 7.0% +19.6% +20.2% 16.5% +17.8% +20.8% +19.9% +17.6% +14.2% Musculoskeletal 7.2% US$ : INR 46 *Annual Income >$ 5000 Source: IMS Feb Respiratory 9.0% Cardiovascular 10.6% Total Market US$ 8.9 Bn. (Growth 17.6%) [13 th in value and 4 th in volume globally] Systemic Antiinfectives 19.2%
33 Top 10 Pharma Products Top 300 brands = 32%, Top 10 brands = 3.6% Rank Products TG Company Value (USD Mn.) %GR 1 Corex Cough Preparation 2 Phensedyl Cough Preparation Pfizer Piramal Healthcare Voveran NSAID Novartis Augmentin Amoxy+Clav GSK Human Mixtard 30/70 Insulin Abbott Revital Nutritional Ranbaxy Zifi Cephalosporin FDC Monocef Cephalosporin Aristo Dexorange Haematinic Franco Indian Taxim Cephalosporin Alkem Source: IMS February 2010
34 Age-standardized death rates (per 100,000) Changing Disease Pattern Increase in life expectancy and rapid urbanization leading to epidemic in chronic diseases Therapy Transition in IPM WHO Chronic Disease Projection -2 Projected number of Deaths attributed to Chronic disease 3.78 Mn. (40.4% to all deaths) in 1999 to 7.63 Mn. (66.7% of all deaths) in 2020 Diabetes number up from estimated 19.3 Mn. in 1995 to 57.2 Mn. in 2025 Source IMS Plus SSA data March-09- Dataset, WHO Chronic Disease Report-2009
35 Value in US$ Mn. Extra Urban Market Improved Extra-urban market access would be crucial for the next growth wave Extra-Urban Market Contribution Extra-Urban Market Forecast US$ 4130 Mn. US$ 869Mn (Proj.) Source: IMS Plus March-09 Dataset, IMS Thought Leadership
36 Biotech Industry
37 Indian Biotech Industry Biotech growth18% Biopharma 67%, average 14% growth (1.85) (3.99) (1.8) (5.8 ) (9.2) 1857 (1.7) (4.6) (10.9) (12.9) (1.85) (3.99) (11.70) (15.30) (11.70) (15.3) Bio Informatics Bio Industrial Bio Agri Bio Services Bio Pharma 4000 (11) (69.9) (67.16) (67 ) 2000 (72.2) 0 FY FY FY FY Source: BioSpectrum USD Mn. ( % )
38 Top 10 Indian Biotech Companies Rank 2008 USD Mn. Company % Change over Serum Institute of India Biocon Panacea Biotech Rasi Seeds Nuziveedu Seeds Novo Nordisk Siro Clinpharm Novozymes South Asia Shantha Biotech Jubilant Source: BioSpectrum
39 R&D
40 R&D Trends Innovation through R&D is the life blood of Pharma Industry Move from process to basic research Exploit human resource pool Tie up with MNCs for collaboration or out licensing Recent times NCEs and NDDS Leverage cost advantage The Government in the 11 th year plan estimates industrial R&D spend to be 5% of turnover Source : Yes Bank
41 R&D Indian Pharma Companies Innovation through R&D is the life blood of Pharma Industry Company NCE Pipeline Key Therapeutic Area Biocon Preclinical 2 Phase II 2 Phase III 1 Piramal Healthcare 13 Compounds in Clinical Trials Glenmark Discovery 4 Preclinical 5 Phase I 1 Phase II 3 Ranbaxy Preclinical 4-6 Molecules Phase II 1 Suven Life Sciences Discovery 2 Preclinical 4 Phase I 1 Inflammatory Diseases, Oncology, Diabetes Oncology, Infectious Diseases, Diabetes, Inflammatory Diseases, Metabolic Disorders, Dermatology, Inflammatory Diseases Metabolic Diseases, Infectious Diseases, Respiratory Diseases, Oncology Neurodegenerative Diseases, Obesity, Diabetes, Inflammatory Diseases Source: March 23, 2009, Financial Express
42 R&D Indian Pharma Companies Innovation through R&D is the life blood of Pharma contd.. Industry Company NCE Pipeline Key Therapeutic Area Dr Reddy s Lab Pre-clinical 1 Phase II 2 Phase III 1 Metabolic Disorders, Cardiac, Oncology Advinus Pre-clinical 3 Diabetes, Cardiac, Lipid Disorders Wockhardt Preclinical 10 Phase II 1 Lupin Discovery 2 Pre-clinical 1 Sun Pharma Discovery 2 NDDS 1 Infectious Diseases, Migraine, Psoriasis,T.B. Allergy, Muscle Relaxant,, Inflammatory Diseases, Pain Management Source: March 23, 2009, Financial Express
43 R & D Spend by Indian Pharma Companies Innovation through R&D is the life blood of Pharma Industry Company Sales USD Mn. FY 2009 R&D USD Mn. As % of Sales Ranbaxy Laboratories Dr. Reddy s Laboratories Cipla Sun Pharmaceuticals Lupin Wockhardt Piramal Health Care Cadila Health Care Aurobindo Pharma Matrix Laboratories Total Source: Prowess Business World February 8, 2010
44 Far low operating cost Clinical Trials Phase Study US ($. Mn) India I 20 < 50% II 50 < 60% III 100 < 60% Hiring investigators, nurses, computer staff and recruiting patients (50% of US cost)
45 R&D Indian Pharma Companies Innovation through R&D is the life blood of Pharma contd.. Industry Specialities Comments R&D Exp. as a % of sales R&D Exp. in absolute terms 1.4% 9.9% 7 times times Source: Ernst & Young analysis of top 25 pharmaceutical companies operating in India
46 Indian Players Building Global Assets Innovation through R&D is the life blood of Pharma Industry Indian Player Acquisitions / Expansion Geographies Biocon 30% stake in IATRICa US Nobex Corporation US Dishman Carbogen and Amcis Switzerland Jubilant Target Research Associates US Kemwell Pfizer s Site in Uppsala Sweden Piramal Healthcare Ltd. Shasun Avecia Ltd. Pfizer s facility in Morpeth Rhodia (Pharmaceutical custom synthesis business) Billingham, UK Torcan (Canada) Grangemouth (Scotland) Morpeth, UK France Source : Ernst & Young Research and Analysis
47 New Drug Discovery and Biopharmaceuticals Source: Pharma Summit Report 2009
48 Outsourcing Opportunities
49 Outsourcing Opportunities Costcompetitive research base Maximum US FDA approved plant Globally harmonized regulations Process chemistry skills cgmp compliance Large, skilled workforce IT enabled
50 Highly Skilled Manpower Annual Graduates Chemical Engg 9% 2500 Biotech/biochem 4% 1000 Ph.D in Chemistry 4% 1000 B.Pharm 45% Chemistry Postgraduates 38% Source: Grant Thorton
51 Collaborative Research Contract Manufacturing Key Opportunity Segments Clinical Research/ Trials Indian Pharmaceutical Industry Contract Research
52 INDIA.The Twin Opportunity India as a Market Significant unmet needs 20 Bn. USD by 2015 One of the Top 10 markets by 2015 Top 3 in growth opportunity India as a Service Provider Resources Competence Cost Arbitrage Experience Young population Growing economy Pharmaceutical expertise Democratic set up IP Protection McKinsey / BCG, 2006
53 India Well-Positioned for New Opportunities Clinical research Most common and important diseases Large pool of treatment-naive patients Rapid patient recruitment Genomic research Many isolated populations, varied lifestyles, genetic endowments and numbers Large endogamous families for disease linked gene analyses Availability of DNA samples from closely and distantly-related sufferers of a disease
54 Regulatory Requirements For all New drugs Clinical trial approval Import license Export license Safety reporting Annual report
55 Overall Country Attractiveness Index alternative clinical trial destinations India (O.C.A.I 5.58) USA (O.C.A.I 6.88) India tops the list Patient pool Cost efficiency Regulatory conditions scale 1-10 Relevant expertise Infrastructure and environment Source: PharmaExec.
56 Drivers & Barriers
57 Drivers & Barriers Will maintain healthy growth momentum DRIVERS BARRIERS Income Growth Expanding Healthcare Infrastructure Increasing Health Awareness 368 Mn. strong Middle Class 90 Mn. estimated to be able to afford the best medicines Penetration of Health Insurance DPCO IPR related issues Access to Modern Medicines Long pending Regulatory Reform
58 Advantage India
59 Advantage India (1) Over 50% of shortages expected from English-speaking countries Note: Pakistan, Bangladesh and Vietnam have not been represented for lack of reliable data on productivity and cost of service employees Source: World Competitiveness Yearbook 2001; Britannica Yearbook; Literature search; BCG analysis
60 Cost-Competitiveness Cost Competitiveness Lower Filing Cost Process Innovation Manpower Cost Advantage Capital Efficiency
61 Significant Cost Arbitrage Production cost in India 50% lower than US FDA approved plans can be constructed in India for 30 % to 50 % lower cost Higher utilization of equipment due to improved process 85% to 90% manpower cost savings Labor costs 10% to 15% of US cost Increased efficiency contributes to low labor costs per unit
62 Manufacturing Development/ Pre-clinical Support for NCEs APIs/Intermediates of Patented Drugs Mature APIs/ Intermediates/ Finished Forms Finished Forms for Generic Players Emerging Biopharma Capabilities
63 Country-wise ANDAs Source: Pharma Matters-Movers and Shakers Oct-Dec 2008
64 Global DMF with U.S. FDA 2500 (29.25%) Fig in No., % in ( ) (15.62%) 1122 (10.19%) (9.23%) (15.84%) (4.57%) (4.18%) (3.68%) (2.83%) (2.42%) (2.20%) Updated to September 2009 Source: Pharmexcil research on CDER US-FDA data base
65 India to be in Top 10.
66 India Poised India lives in the growing optimism in the hearts of its people.. the world is now looking at this optimistic, pulsating, dynamic and democratic new India as a future economic global superpower
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