Future proof Healthcare through innovation?

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1 Future proof Healthcare through innovation? Approaches to address Health & Wealth in our society Rob van Leen Chief Innovation Officer, Royal DSM Boegbeeld Life Science & Health February 2014

2 Topsector Life Sciences & Health 1

3 Wealth Health Regiegroep Life Sciences & Health Topsector vision: Health and wealth for society and economy Vision The topsector envisions a thriving Dutch Life Sciences & Health sector that develops innovative health solutions based on scientific excellence that: Society Economy > improve QUALITY OF LIFE of patients QUALITY OF LIFE PRODUCTIVITY > support the AFFORDABILITY of healthcare LIFE SCIENCES & HEALTH > increase PRODUCTIVITY within and beyond healthcare AFFORDABILITY BUSINESS > create BUSINESS VALUE in the Netherlands Source: topsectorplan; cahier no. IV 2

4 3 Regiegroep Life Sciences & Health Three objectives which together contribute to affordable, high-quality healthcare PREVENTION CURE CARE 1. Maintain health, prevent healthcare 2. Maximize effect, minimize trauma 3. Manage disease extramurally

5 Regiegroep Life Sciences & Health LSH Roadmaps Molecular Diagnostics Imaging and image guided therapies Home care and self-management Regenerative medicine Pharmacotherapy One health Specialized nutrition, health and disease Health technology assessment & quality of life Enabling technologies & infrastructure Solutions to neglected diseases 4

6 5 Regiegroep Life Sciences & Health Efficient valorization requires 7 critical success factors IDEA GENERATION Increase the number of promising ideas DEVELOPMENT Accelerate the development process and heighten the chance of success 2 1 APPLICATION Accelerate and broaden effective application (nationally and internationally) Demanding Dutch market and patients, a portal into Europe/ the rest of the World Optimized legal and regulatory landscape Sufficient well educated, entrepreneurial people 4 Good accessibility to the right capital Strong, accessible (fundamental) knowledge base 7 Shared public-private innovation infrastructure The Netherlands as one self-organized Life Sciences & Health sector

7 6

8 7 Regiegroep Life Sciences & Health Transition from TopInstitutes BMM, CTMM, TiP & NGI Transition period is necessary: Identify pearls and continue support, safeguard data infrastructure and valorization initiatives. Capitalize on built up PPS expertise and networks to attract EU money (Horizon 2020, in e.g. IMI-2) Strenghten operational capacity of the Topsector (TKI-Office) Budget made available by EZ efforts to include VWS and OCW

9 Meer informatie:

10 @DSM > 23K People: Living our Passion

11 People Health Food & Nutrition Security Sustainable Innovation Themes a Sustainable Company Profit Planet Energy Security Sustainable Manufacturing/ Raw Materials

12 Building an intrinsically innovative company 20% Top Quartile McKinsey Innovation Benchmark 2012 Innovation Sales 2015 ~5% higher Gross Margins Disruptive Platforms, 2020

13 Accelerating and supporting innovation DSM Innovation Center New Business Development Accelerators EBA Biomedical Excellence in Innovation EBA Bio-based Products & Services CTO Office EBA Advanced Surfaces Licensing Business Incubator Venturing

14 Why do we need Open Innovation? DSM % of world population outside DSM! Networks needed!

15 Open Innovation in biomedical materials Joint R&D Joint Business Developments Licensing In Venturing Spin in Actamax Joint-venture Acquisitions Divestments R&D services Licensing Out Spin out/off Device design; Exclusive material developments Scientific Advisory Board & other Consultants

16 DSM Biomedical materials improve over 4.4 million people s lives, every day.

17 A world class portfolio of biomedical materials Silicone hydrogels Biomedical polyurethanes UHMWPE biomaterials Drug delivery Coatings Natural Materials Mechanical Devices ECMs Polymers & Metals Bio Commercialization

18 Cost per intervention Escalation of healthcare costs Healthy Life style Food & Sport Medication & non-invasive treatment Surgery Restore Repair Maintain Health Total disease cost Nurture Health preventive curative Severity / Invasiveness of intervention Page

19 Micronutrient intake in Western countries Germany United States United Kingdom The Netherlands Source: Troesch et al BJN 2012

20 Example vitamin D: the inadequate status impacts a number of body functions Classical role of vitamin D: bone health normal Improves bone mineral density through calcium absorption and deposition Necessary to prevent rickets & osteomalacia Emerging health benefits of vitamin D Muscle - Reduces risk of falling by improving muscle strength Immunity - Strengthens the immune system - Reduces risk of multiple sclerosis and diabetes type I and II Cardiovascular - Lowers blood pressure Cancer - Inhibits cell proliferation osteoporotic

21 The health continuum : example of the knee Restore HALS-UH Repair Maintain Health Nurture Health Page 20

22 To conclude Prevention, Cure and Care, together with Diagnostics all need integrated attention to improve peoples lives and get a hold on healthcare costs Open Innovation and Collaboration between all parts of the health value chain is essential to accomplish breakthrough solutions Topsector LSH increasingly integrates, facilitates and stimulates the complete public private innovation infrastructure with all parties involved DSM has competences in both Life Sciences and Materials Sciences which contribute to a brighter life for people today and generations to come

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