Physics Department, Alma Mater Studiorum University of Bologna 3

Size: px

Start display at page:

Download "Physics Department, Alma Mater Studiorum University of Bologna 3"

Liliana Spencer
6 years ago
Views:

Scuola di Specializzazione in Fisica Medica Nicola Maffei 1 G Guidi,2, A Ciarmatori 1,3, G M Mistretta 1, F Bertoni 4, T Costi 1 1 Medical Physics Department Az.

Bologna 4 Radiation Oncology Department., Az.

1 Scuola di Specializzazione in Fisica Medica Nicola Maffei 1 G Guidi,2, A Ciarmatori 1,3, G M Mistretta 1, F Bertoni 4, T Costi 1 1 Medical Physics Department Az. Ospedaliero Universitaria di Modena 2 Physics Department, Alma Mater Studiorum University of Bologna 3 Post-graduate school in medical physics, Alma Mater Studiorum University of Bologna 4 Radiation Oncology Department., Az. Ospedaliero Universitaria di Modena Disclosures No conflicts of interest to disclose Co-Funding: Italian Ministry of Health (MoH2010, GR ) Dose warping methods for IGRT and Adaptive RT: dose accumulation based on organ motion and anatomical variations of the patients during radiation therapy treatments Tecnologie Avanzate S.r.l. (Italy) 2 1

Adaptive Radiation Therapy Adaptive Radiation Therapy (ART) is a state-of-the-art approach that uses a feedback process to

for cancer patients. Needs for Clinical Practice: 1. Image Guided System 2. Fast Re-Contouring 3. Fast Re-Calculation 4.

Predictive Tools for Biomechanical Approach What is ready at Policlinico (SEE THE POSTER!!!) 1. Daily Setup Image

Hybrid deformable algorithms - Bayesian Network validation 5. Workflow automation (Scripting, GPU, Cluster, icloud) 6.

First Step on Dose Accumulation [Malone 2014] Malone C, Rock L, Skourou C, Efficacy evaluation of retrospectively applying

2 Adaptive Radiation Therapy Adaptive Radiation Therapy (ART) is a state-of-the-art approach that uses a feedback process to account for patient-specific anatomic and/or biological changes, thus, delivering highly individualized radiation therapy for cancer patients. Needs for Clinical Practice: 1. Image Guided System 2. Fast Re-Contouring 3. Fast Re-Calculation 4. Tools for Real-Time QA or Simulation 5. Predictive Tools for Biomechanical Approach What is ready at Policlinico (SEE THE POSTER!!!) 1. Daily Setup Images (e.g. MVCT/kVCT) 2. Automatic PTV/OARs contouring 3. DIR and/or Warping methods 4. Hybrid deformable algorithms - Bayesian Network validation 5. Workflow automation (Scripting, GPU, Cluster, icloud) 6. Predictive analysis Neural Networks 7. First Step on Dose Accumulation [Malone 2014] Malone C, Rock L, Skourou C, Efficacy evaluation of retrospectively applying the Varian normal breathing predictive filter for volume definition and artifact reduction in 4D CT lung patients, Journal of Applied Clinical Medical Physics, vol 15, num 3. Biomechanical Approach Aim: 4DCT Breathing Motion Contour GTV Spatial-time position Vision RT 4D function correlate to BPM Simulate irregular BREATHING + GTV spatial positions phases 2

Real Time Robot InfraRed /UltraSound SENSOR 8 RIBs with 4 angular speed 2 TUMOR with 4 DOF 30

Engineering And Technology, Vol.43 No.4, 2011. Lego Approach: Which PRO?

3 Real Time Robot InfraRed /UltraSound SENSOR 8 RIBs with 4 angular speed 2 TUMOR with 4 DOF 30 cm Prototype LINAC EV3 BRICK: Linux wireless CPU, LabVIEW programmable 24 cm [Jeong 2011] Jeong H S, Han Y, Kum O et al., Development And Evaluation of a Phantom for Multi-purpose Dosimetry in IMRT, Nuclear Engineering And Technology, Vol.43 No.4, Lego Approach: Which PRO? Freedom offered by building bricks Low-cost/home-made solution Pediatric scale Plastic materials avoid artifacts Complete versatility with LabVIEW dedicated software Human 4D simulation reproducible 3

Didactic Phantom Standard Treatment Simulation

Cruz-Martín A, Fernández-Madrigal J A, Galindo

, A LEGO Mindstorms NXT approach for teaching

Engineering and Real-Time Systems undergraduate

4 Didactic Phantom Standard Treatment Simulation Tracking Tumor Simulation [Cruz-Martín 2012] Cruz-Martín A, Fernández-Madrigal J A, Galindo C et al., A LEGO Mindstorms NXT approach for teaching at Data Acquisition, Control Systems Engineering and Real-Time Systems undergraduate courses, Computers & Education 59 (2012) DCT, Mesh Reconstruction and ROI Tracking/Contouring 4

reproduces BPM Through sensors, the ROBOT

motion 4D Breathing Simulation Preliminary

5 Breathing Real Time Simulation Quasar phantom, interfaced with VisionRT software, reproduces BPM Through sensors, the ROBOT emulates in real-time patient s breathing motion 4D Breathing Simulation Preliminary results (12 BPM) [Castillo 2014] Castillo S J, Castillo R, Balter P, et al., Assessment of a quantitative metric for 4D CT artifact evaluation by observer consensus, Journal of Applied Clinical Medical Physics, vol 15, num 3. 5

Conclusions Organ motion and deformation

localization) An anthropomorphic phantom

6 Conclusions Organ motion and deformation can lead divergence of treatments compared to the initial constraints Standard CT freeze images of Tumor and OAR 4DCT allows to follow dynamics parameters of breathing (spatial time localization) An anthropomorphic phantom can simulate the human physiology to follow and predict changes in morpho-dosimetry using external surrogate! 4D QA LEGO MINDSTOMRS can help to prototype idea and make some experimental with low cost Suggestions Questions? Collaborations? 6

N.MAFFEI, G.GUIDI, C.VECCHI, G.BALDAZZI Physics Department, University of Bologna, via Irnerio Bologna, Italy

AN ARTIFICIAL NEURAL NETWORK TO PREDICT TIME OF REPLANNING FOR TOMOTHERAPY TREATMENTS N.MAFFEI, G.GUIDI, C.VECCHI, G.BALDAZZI Physics Department, University of Bologna, via Irnerio 40 40138 Bologna, Italy