BIOSTAT B-DCU. Product Presentation. Page 1
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1 BIOSTAT B-DCU Product Presentation Page 1
2 BIOSTAT B-DCU Features and Benefits Advanced sensor and software integration Reveal more information about your process Facilitate development of advanced, automated process control strategies Increase manufacturing efficiency and productivity Industry standard technologies Reliable technologies ensure hassle-free process optimization and characterization Benefit from decades of experience in the biopharmaceutical industry Connectivity to supervisory systems Easily connect your BIOSTAT B-DCU to... Sartorius BioPAT MFCS Third party supervisory software like DeltaV Data consistency across scales and throughout the entire development process Broad range of process control strategies Mimic your large scale process control approach and generate representative data Benefit from our fully flexible aeration and feeding options Page 2
3 Advanced Process Solutions Scalability from process development to production scale Process Development Clinical Trial Manufacturing Pilot Plant Process Characterization Commercial Manufacturing Geometrical similarity of vessel design Consistent mixing and gassing strategies Similar user interface and controllers BioPAT MFCS Turnkey SCADA solution for reliable supervisory control and data acquisition Accelerated process development and process transfer require seamless scalability and integration of process data & controls DoE S88 recipe Network BioPAT MFCS is designed as a plug-and-play tool Ideally suited for capturing, storing and visualizing process data of all BIOSTAT and ambr bioreactors as well as other process equipment MVDA Connectivity 21 CFR Part 11 Page 15
4 Advanced Bioreactor Solutions Features of the new BIOSTAT B-DCU Intelligent mass flow controllers with a flow range of 1:200 Comfortable operation with a 19 display that can also be operated with gloves Fast load pump heads for fast and secure handling of tubings Optional flow meters Connect your Sartorius Cubis, Quintix or Secura balance and other Sartorius standard balances. Manual operation buttons for tube loading unloading Choose up to four variable speed pumps with a wide range of rpm and up to four fixed speed pumps Page 2
5 Advanced Aeration Strategies Cell Culture Aeration Modules Advanced Additive Flow - Single Gas Outlets Advanced Additive Flow - 2 Gas Outlets Advanced DO Control Page 9
6 Advanced Aeration Strategies Make your BIOSTAT B-DCU totally universal Digital Mass Flow Controllers 1 : 200 flow range Digital data communication enables precise control of MFC by DCU Closes securely (no difference to solenoid valves) Aeration line freely configurable Each line can be equipped with: MFC, solenoid valve, flow meter 4 standard sparger lines with optional 3/2 way gas switch valve Optional 5th and 6th gassing line Air, O 2, CO 2 or N 2 on sparger, overlay or single output Can be configured to become part of DO-controller Integrated variable speed pumps with wide flow range Switch between rpm and rpm Realize a 0.01 ml/min 127 ml/min flow range with a single pump A single system for 1 L cell cultivation and 10 L microbial fermentation Gas flow range of 1 : 20,000 Integrated pumps with a range of rpm No additional equipment or software changes needed Page 8
7 Advanced Sensor Technologies Risk is inverse to process understanding Unlock the superior potential of your BIOSTAT B-DCU by incorporating our advanced BioPAT sensor technologies Maximum in process understanding Effective automation of your cell cultivation or fermentation process BioPAT ViaMass BioPAT Trace BioPAT Xgas BioPAT Fundalux Determine the viable biomass volume inline and continuously Based on the proven principle of capacitance measurement Reduce operator-to-operator variability Reduce manual sampling and lower risk of contamination Ideal for simultaneous online monitoring of glucose, lactate and alcohol during cultures of microorganisms or animal cells Fully disposable sensor and fluidics set for easy setup and immediate use Fast concentration determination without any loss of volume Precisely track O 2 CO 2 concentration changes in respiratory gas emission Highest accuracy by automatic moisture and pressure compensation Compact design and parallel measurement in a single analyzer saves space in your lab Absorption-based probe using near infrared light for total biomass determination Range of optical path lengths (1, 5 and 10 mm) yields optimal total biomass coverage for your specific process Robust LED light source with up to 10-year lamp lifetime Page 16
8 Advanced Process Control Solutions Advanced and automated process control strategies for CELL CULTIVATION Reveal more information about your process Realize enhanced feeding strategies by using up to four internal feed pumps Mass flow controllers with a 1:200 flow range enable high-cell density cultivations and working in different scales applications with the same bioreactor controller Page 3
9 Advanced Process Control Solutions Advanced and automated process control strategies for MICROBIAL FERMENTATION Reveal more information about your process Realize enhanced feeding strategies by using up to four internal feed pumps Mass flow controllers with a 1:200 flow range enable high-cell density cultivations and working in different scales applications with the same bioreactor controller Page 3
10 Advanced Process Characterization Solutions Process characterization made easy with BIOSTAT B-DCU and our BioPAT Chemometrics Toolbox Integrate advanced multivariate methods into your process control software BioPAT MFCS win Transfer data from your BIOSTAT B-DCU to BioPAT MODDE and SIMCA Reduce effort associated with data management and comparison of current and historical batches Page 16
11 Advanced Communication Options Integration and Connectivity to SCADA and DCS BioPAT MFCS Turnkey solution for reliable supervisory control and data acquisition Specialized for bioprocesses Designed as a plug-and-play tool for advanced SCADA functionalities Ideally suited for capturing, storing and visualizing process data of all BIOSTAT and ambr bioreactors as well as other process equipment Integration into DeltaV Modbus mapping of your BIOSTAT system in digital format Access process values Set controller parameters Access actuators in a direct manner (e.g. pumps or valves) Page 16
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