BR-10149B. Flexible solutions for confidence in results. BIOMEK FX LABORATORY AUTOMATION WORKSTATION

Transcription

1 BR-10149B Flexible solutions for confidence in results. BIOMEK FX P LABORATORY AUTOMATION WORKSTATION

2 High-capacity work surface, offering extraordinary flexibility Many configurations to suit application needs Biomek FX P workstation The Biomek FX P is the latest entry in the Biomek line. With an up-to-date hardware design for greater positional accuracy and increased robustness, it can meet the needs of just about any application. It can be configured with either one or two pipetting pods. With its large deck capacity, the Biomek FX P sets the standard for flexible laboratory solutions to meet your changing needs. It puts every aspect of liquid handling including pipetting, dilution, dispensing and integration into a single, automated system that is as powerful and flexible as it is efficient and economical. Combined with the proven Biomek Software and our ongoing applications development, Biomek FX P is bringing new possibilities to life. 96-well head The Biomek FX P continuum starts with a single-pod system. Equip the high-capacity deck with Automated Labware Positioners (ALPs) suited to your application to create a dedicated workhorse system. Choose a 96- or 384-multichannel pipetting head, or opt for a pin-tool system for high-density replication tasks. The multichannel pod heads are easily swapped out for maximum flexibility and system reconfiguration as your needs change. A Span-8 configuration featuring independent well access also is available for tube-based operations and where flexible access to wells in a plate is needed. Pin-tool head 384-well head With the Biomek FX P, the Biomek is just the beginning. Its open architecture allows for integrations of readers, plate washers, labware storage devices and robotic transport systems. The gripper built into the multichannel pod provides fast and reliable labware movement around the deck, as well as the capability to de-lid and re-lid plates, create vacuum manifold assemblies and access integrated devices. The right features right where you need them Knowing that the ability to adapt to changing situations is critical for today s labs, our systems are designed with the flexibility to accommodate whatever your needs may be. Build your Biomeksystem to handle today s requirements, make modifications as necessary, add accessories whenever and wherever extra capability is important, and use our wide variety of modules to manage tomorrow s needs with specifically targeted solutions. Interchangeable pipetting heads with Biomek NX P Multiple syringe and probe options

3 Two heads are better than one A dual-pod system is the smart choice for busy labs. Choose a hybrid system (multichannel pod and Span-8) for maximum process flexibility. Perform hit-picking operations quickly. Replicate plates with a 96- or 384-well head, then add reagents unique to each well with the Span-8 pod, using tubes, plates or reservoirs as sources. With new support for clot detection and septum piercing, the FX P Span-8 pod gives you confidence that your samples will be dispensed consistently and reliably to their proper locations. Efficient plate replication A dual-multichannel pod instrument makes plate replication tasks fast and efficient. A system with both 96 and 384 heads can rapidly condense and replicate 96-well library plates into 384- well dilution plates. Or, use the HDR Tool (pin-tool head) on one pod, and a pipetting head on the other. A dual-multichannel system also is an excellent choice for filtration applications. Scale up to a Biomek Assay Workstation The Biomek FX P can serve as the central component in an assay workstation a complete assay automation system including labware storage, incubation, plate washing, plate reading and other components. Powered by SAMI Workstation EX software, the Biomek Assay Workstation is the system of choice for ELISAs, cell-based assays or any other process containing time-critical incubations. Assay Workstations are tightly integrated to maximize capacity and throughput in a small footprint. Use intelligent software Simplify your assay development with SAMI Workstation EX, a powerful scheduling environment with an intuitive user interface.

4 Confirmatory barcode reads No deck space needed for barcode reader Error handling gives users recovery options Built-in barcode reader delivers on-the-fly plate tracking With the ability to scan plates being held by the gripper, sample integrity is ensured. Sample IDs can be imported based on the plate barcode and tracked throughout the run. If barcode inconsistencies are detected, Biomek Software allows a wide range of user-controlled corrective actions, logging and error handling instructions. Software for your needs First-time user of automated liquid handling technology? Experienced specialist? Either way, you ll find that BiomekSoftware is packed with easy-to-use features to meet any need. And with a single, consolidated user interface driving all Biomek liquid handlers, it is simple to move between platforms. Since many functions are combined into a single step, setup is fast and effortless. And specialized algorithms speed programming even more by suggesting the best settings for the job at hand. All of which lets any user make the most of everything that Biomek FX P has to offer. 21CFR Part 11compliance To help achieve regulatory compliance with 21CFR Part11 - and perform validation assays in a regulated environment - Biomek Software delivers the ability to set different user accounts and permissions, track revision control and enable electronic signatures. It also requires users to register any change to methods and stores all versions.

5 Unified software platform across all Biomek instruments With a single, consolidated user interface for all Biomek platforms, operator learning time is drastically reduced. Biomek Software also allows methods to be moved from one instrument platform to another, quickly and easily. Intuitive interface The flexibility built into Biomek s user interface puts the full range of its power into the hands of any user. It provides the ability to customize the interface, import and export methods, use icon-driven Step Palettes to create and configure methods with drag-and-drop ease, define new deck layouts and labware to make changing configurations fast and easy, and much more. As a result, switching between applications such as MALDI spotting and gdna purification is particularly easy. And new users get up-and-running faster than ever before. Point-and-click methods development The mouse-driven simplicity of our unique point-and-click programming avoids the long learning curve so common to other approaches. Alternatives such as pipetting techniques, liquid types and deck layouts can be chosen from drop-down lists. Method validation features will check your method and find any logical errors. The Estimated Time to Completion (ETC) feature will provide you with an accurate run time, enabling you to speed up methods development and efficiently plan your instrument use. Variables, worklists and if-then statements can be used to vary runs without reprogramming. All of which makes a wide variety of applications from plasmid purification to hit-picking extraordinarily efficient and streamlined.

6 Screening Solutions The Biomek FX P is the right instrument for screening both primary and secondary as well as all your replication and reformatting tasks in between. Choose a preconfigured Biomek FX P solution with validated or verified methods, or outfit a system tailored exactly for your unique needs. With an array of Beckman Coulter peripherals and ALPs from which to choose, plus a library of third-party integrations available, the Biomek FX P will deliver solid performance in your assay. Validated Solutions for ADMETox The ADMETox Workstation provides the automation for high-throughput ADMETox screening assays for qualifying leads and profiling potential drug candidates. The workstation supports in vitro assays to measure absorption, metabolism and toxicology. The supported absorption assays include pion's PAMPA and µsol technologies and cell-based assays using Caco-2 cells. The supported metabolism assays include Cytochrome P450 inhibition studies and microsomal stability assays. Toxicology assays include Promega's cell proliferation assay, CellTiter*; cytotoxicity measurements, CytoTox-ONE*; and apoptosis assays, Caspase-Glo*. The right applications the right way The demands of the life science world are changing daily. So at Beckman Coulter, we re continuously delivering new ways to accelerate your valuable research. Our dedicated applications group, for instance, is focused exclusively on creating automated solutions for a variety of commercially available kits. elabnotebook gives you quick access to a wide variety of in-house and customer-developed applications. And our renowned Biomek Software makes it easy to develop methods to meet your individual needs. Put it all together with our robust new Biomek FX P Laboratory Automation Workstation and it is easy to see we are giving you the tools to do your best science, your way. The ADMETox Workstation comes with an analysis package that enables the user to speed the decision-making process for further drug development. Detection assays Cytokines have been shown to regulate immunologic responses and cell-to-cell communication, as well as dose responses to infectious agents. Their presence at elevated levels can indicate disease progress. Combined with our Biomek FX P workstation, the Immunotech Cytokine kits deliver fast and efficient methods to measure the different types of Cytokines present in a cell, while adding to the proteomics and cellular analysis solutions available from Beckman Coulter. Use Span-8 device to add reagents individually, precisely when needed Optional integrated storage devices accommodate long incubation times

7 Sample preparation The need for increased throughput for molecular techniques particularly DNA/RNA purification methods has led to a number of purification protocols on automated platforms. These automated methods, however, must generate high-quality results in order to be used by downstream applications such as sequencing, PCR* and transfection. The Biomek FX P provides a complete portfolio of nucleic acid sample preparation solutions for DNA and RNA with the magnetic bead-based Agencourt SPRI technology. Automated PCR and sequencing reaction setup Biomek FX P s reliable, repeatable pipetting, tube-to-plate capability and efficient automation combine to provide the ideal automation solution for this routine process, while fitting seamlessly into any lab s workflow. And its low-volume capability helps miniaturize reaction setups and save on costly reagents. PCR & sequencing applications Submicroliter transfers Reaction setup in less than 30 minutes Magnetic bead technology Validated methods for SPRI protocols Up to 17 plates per hour PCR and sequencing reaction cleanup Reaction cleanup is a simple process, to remove unwanted nucleotides and primers before running samples on a DNA analyzer, such as the CEQ Series from Beckman Coulter or other sequencing platforms from Applied Biosciences or GE Healthcare. To accommodate a wide variety of cleanup protocols, the Biomek FX P has been optimized for automation of paramagnetic technology. Configure a Biomek FX P with the Agencourt CleanSEQ Dye Terminator Removal kit to process up to 17 plates per hour for your high-throughput sequencing needs.

8 Biomek FX P Laboratory Automation Workstation The Biomek FX P and all our Systems Biology offerings are an important part of a broad continuum of Beckman Coulter products, including automated liquid handling, capillary electrophoresis, centrifugation, ultracentrifugation, DNA sequencing, electrochemistry, flow cytometry, fragment analysis, HPLC, integrated core systems, microarrays, particle characterization, scintillation counting, and spectrophotometry. For information about our comprehensive line of Laboratory Automation Workstations, please contact your local Beckman Coulter representative or visit our web site at *The PCR process is covered by patents owned by Roche Molecular Systems and E. Hoffman-La Roche, Ltd. All other trademarks are the property of their respective owners. For laboratory use only. Not for use in diagnostic procedures. Specifications Workstation Weight 125 kg (275 lb) one bridge, one pod and canopy Height cm (43 in) Height with canopy cm (55 in) Width cm (60 in) Width with canopy cm (64 in) Depth 81.3 cm (32 in) Power Requirements 50/60 Hz, VAC Pipetting Options High-Density Replication Tool 96-Channel Disposable Tip Pipetting Head 384-Channel Disposable Tip Pipetting Head Span-8Fixed 100 Probes Span-8Fixed 60 Probes Span-8 P250 Disposable Tips Span-8 P250 Liquid Level Sensing Tips Span-8 P20 Disposable Tips Span-8 P20 Liquid Level Sensing Tips Septum Piercing Probes Gripper Tool Used to move labware and devices around the Biomek worksurface to automate fully filtration-based processes such as nucleic acid purification, and provide access to integrated plate readers. Minimal Table Requirements 92 cm (36 in) Width x 77 cm (30 in) Depth. Sufficient to support kg (400 lb) B IOMEK FX P P IPETTING P ERFORMANCE S PECIFICATIONS S PAN-8 SYSTEMS Transfer Span-8 Tip Accuracy Precision Volume Syringe Volume Types ± % < % 0.5 µl 250 µl P20, Fixed 60 mm µl 250, 500, 1000 µl P20, P50, Fixed 60 mm µl 250, 500, 1000 µl P20, Fixed 60 mm µl 500 µl P50, P µl 500 µl P µl 500 µl P250, P µl 500 µl P µl 1000 µl P M ULTICHANNEL S YSTEMS Transfer Multichannel Tip Accuracy Precision Volume Configuration Types ± % < % 0.5 µl 384 P µl 96 & 384 P20, P50, P µl 96 & 384 P20 & P B MerG-15k 2006 Beckman Coulter, Inc. Printed in U.S.A. on recycled paper.

9 BR-10150B Bringing power and flexibility down to size. BIOMEK NX P LABORATORY AUTOMATION WORKSTATION

10 Small footprint Easy fit on standard lab benches Many configurations to suit application needs Biomek NX P workstation By incorporating a wide range of next-generation features into a smallfootprint design, Biomek NX P sets the standard for flexible laboratory solutions. It puts every aspect of liquid handling including pipetting, dilution, dispensing and integration into a single, automated system that is as powerful and flexible as it is efficient and economical. All while offering unprecedented flexibility for changing needs. Combined with robust Biomek Software and our ongoing applications development, Biomek NX P is bringing new possibilities to life. The right features right where you need them Knowing that the ability to adapt to changing situations is critical for today s labs, our systems are designed with the flexibility to accommodate whatever your needs may be. Build your Biomek system to handle today s requirements, make modifications as necessary, add accessories whenever and wherever extra capability is important, and use our wide variety of modules to manage tomorrow s needs with specifically targeted solutions. From standalone to industrial robotics solutions, it is no wonder our flexible liquid handling systems are the foundation of discovery solutions worldwide. Eight-probe, 96- or 384-channel pipetting The NX P workstation offers multiple configurations, including multichannel, Span-8 and Span-8 with an optional gripper. The multichannel model is available with 96- and 384-channel pipetting heads for rapid plate-to-plate applications and assay miniaturization. Interchangeable pipetting heads with Biomek FX P Optional gripper mechanism on Span-8 Multiple syringe and probe options

11 360 rotating gripper for maximum flexibility With the ability to rotate a full 360, the optional gripper handle provides access from the left, right or from integrated devices on the back of the instrument. It turns to pick up plates in different orientations, enhances on-the-fly barcode reading and saves deck space by moving titer lids while the Span-8 is pipetting. Open frame design allows future integration of additional devices The flexible, open architecture of Biomek NX P simplifies integration, as plate readers, washers and storage devices can be located on the left, right or back of the instrument. The open frame design allows future vertical workspace integration, for applications where limited lab space is an issue. Open base for vertical integration Gripper allows device integration for Span-8 configuration Open platform for flexible integration Pipetting performance Biomek NX P offers proven pipetting performance for low-volume reaction setup and assay miniaturization, as well as accurate and repeatable results extending into the submicroliter range. Different techniques can be used for various volume ranges, to enhance liquid handling capabilities. Improved X, Y and Z stability delivers reliable results for small volumes and, to ensure optimum pipetting performance, an integrated pump purges air from the lines.

12 Confirmatory barcode reads No deck space needed for barcode reader Error handling gives users recovery options Built-in bar code reader delivers on-the-fly tracking With the ability to scan plates being held by the gripper, sample integrity is ensured. Sample IDs can be imported based on the plate barcode and tracked throughout the run. If barcode inconsistencies are detected, Biomek Software allows a wide range of user-controlled corrective actions, logging and error handling instructions. Software for your needs First-time user of automated liquid handling technology? Experienced specialist? Either way, you ll find that Biomek Software is packed with easy-to-use features to meet any need. And with a single, consolidated user interface driving all Biomek liquid handlers, it s simple to move between platforms. Since many functions are combined into a single step, setup is fast and effortless. And specialized algorithms speed programming even more by suggesting the best settings for the job at hand. All of which lets any user make the most of everything that Biomek NX P has to offer. 21 CFR Part 11 compliance To help achieve regulatory compliance with 21 CFR Part 11 and perform validation assays in a regulated environment Biomek Software delivers the ability to set different user accounts and permissions, track revision control and enable electronic signatures. It also requires users to register any change to methods and stores all versions.

13 Unified software platform across all Biomek instruments With a single, consolidated user interface for all Biomek platforms, operator learning time is drastically reduced. Biomek Software also allows methods to be moved from one instrument platform to another, quickly and easily. Intuitive interface The flexibility built into Biomek s user interface puts the full range of its power into the hands of any user. It provides the ability to customize the interface, import and export methods, use icon-driven Step Palettes to create and configure methods with drag-and-drop ease, define new deck layouts and labware to make changing configurations fast and easy, and much more. As a result, switching between applications such as MALDI spotting and gdna purification is particularly easy. And new users get up-and-running faster than ever before. Point-and-click methods development The mouse-driven simplicity of our unique point-and-click programming avoids the long learning curve so common to other approaches. Alternatives such as pipetting techniques, liquid types and deck layouts can be chosen from drop-down lists. Method validation features will check your method and find any logical errors. The Estimated Time to Completion (ETC) feature will provide you with an accurate run time, enabling you to speed up methods development and efficiently plan your instrument use. Variables, worklists and logicals can be used to vary runs without reprogramming. All of which makes a wide variety of applications from nucleic acid purification to cell-based assays extraordinarily efficient and streamlined.

14 The right applications the right way The demands of the life science world are changing daily. So at Beckman Coulter, we re continuously delivering new ways to accelerate your valuable research. Our dedicated applications group, for instance, is focused exclusively on creating automated solutions for a variety of commercially available kits. elabnotebook gives you quick access to a wide variety of in-house and customerdeveloped applications. And our renowned Biomek Software makes it easy to develop methods to meet your individual needs. Put it all together with our robust new Biomek NX P Laboratory Automation Workstation and it is easy to see we are giving you the tools to do your best science, your way. Septum piercing and clot detection To maintain the sample integrity so important to any application, Biomek NX P offers advanced septum piercing abilities. Clot detection circuitry ensures that samples are consistently and reliably dispensed to their proper location in a non-contaminated form ideal for applications such as gdna purification from whole blood. Detection assays Cytokines have been shown to regulate immunologic responses and cell-tocell communication, as well as dose responses to infectious agents. Their presence at elevated levels can indicate disease progress. Combined with our Biomek NX P workstation, the Immunotech Cytokine kits deliver fast and efficient methods to measure the different types of Cytokines present in a cell, while adding to the proteomics and cellular analysis solutions available from Beckman Coulter. Use Span-8 device to add reagents individually, precisely when needed Optional integrated storage devices accommodate long incubation times

15 96 samples in less than one hour DNA yield 8-10 µg Expandable system for higher throughput Sample preparation The need for increased throughput for molecular techniques particularly DNA/RNA purification methods has led to a number of purification protocols on automated platforms. These automated methods, however, must generate high-quality results in order to be used by downstream applications such as sequencing, PCR* and transfection. The Biomek NX P provides a complete portfolio of nucleic acid sample preparation solutions for DNA and RNA with the magnetic bead-based Agencourt SPRI technology. Automated PCR and sequencing reaction setup Biomek NX P s reliable, repeatable pipetting, tube-to-plate capability and efficient automation combine to provide the ideal automation solution for this routine process, while fitting seamlessly into any lab s workflow. And its low-volume capability helps miniaturize reaction setups and save on costly reagents. PCR & sequencing applications Submicroliter transfers Reaction setup in less than 30 minutes Magbead technology Validated methods for SPRI protocols Up to 17 plates per hour PCR and sequencing reaction cleanup Reaction cleanup is a simple process, to remove unwanted nucleotides and primers before running samples on a DNA analyzer, such as the CEQ Series from Beckman Coulter or other sequencing platforms from Applied Biosciences or GE Healthcare. To accommodate a wide variety of cleanup protocols, the Biomek FX P has been optimized for automation of paramagnetic technology. Configure a Biomek FX P with the Agencourt CleanSEQ Dye Terminator Removal kit to process up to 17 plates per hour for your highthroughput sequencing needs.

16 The Biomek NX P and all our Systems Biology offerings are an important part of a broad continuum of Beckman Coulter products, including automated liquid handling, capillary electrophoresis, centrifugation, ultracentrifugation, DNA sequencing, electrochemistry, flow cytometry, fragment analysis, HPLC, integrated core systems, microarrays, particle characterization, scintillation counting, and spectrophotometry. Biomek NX P Laboratory Automation Workstation Specifications Workstation Weight kg (190 lb.) Height cm (44 in.) Width 91.44cm (36 in.) Depth cm (32 in.) Power Requirements 50/60 Hz, VAC Pipetting Options 96-Channel Disposable Tip Pipetting Head 384-Channel Disposable Tip Pipetting Head Span-8 Fixed 100 Probes Span-8 Fixed 60 Probes Span-8 P250 Disposable Tips Span-8 P250 Liquid Level Sensing Tips Span-8 P20 Disposable Tips Span-8 P20 Liquid Level Sensing Tips Septum Piercing Probes Gripper Tool Used to move labware and devices around the Biomek worksurface to automate fully filtration-based processes such as nucleic acid purification and provide access to integrated plate readers. Minimal Table Requirements 64 cm(25 in.) Width 61 cm(24 in.) Depth Sufficient to support kg (300 lb.) B IOMEK NX P P IPETTING P ERFORMANCE S PECIFICATIONS For information about our comprehensive line of Laboratory Automation Workstations, please contact your local Beckman Coulterrepresentativeorvisit our web site at *The PCR process is covered by patents owned by Roche Molecular Systems and E. Hoffman-La Roche, Ltd. All other trademarks are the property of their respective owners. For laboratory use only. Not for use in diagnostic procedures. S PAN-8 SYSTEMS Transfer Span-8 Tip Accuracy Precision Volume Syringe Volume Types ± % < % 0.5 µl 250 µl P20, Fixed 60 mm µl 250, 500, 1000 µl P20, P50, Fixed 60 mm µl 250, 500, 1000 µl P20, Fixed 60 mm µl 500 µl P50, P µl 500 µl P µl 500 µl P250, P µl 500 µl P µl 1000 µl P M ULTICHANNEL S YSTEMS Transfer Multichannel Tip Accuracy Precision Volume Configuration Types ± % < % 0.5 µl 384 P µl 96 & 384 P20, P50, P µl 96 & 384 P20 & P Developing innovative solutions in Systems Biology. B MerG Beckman Coulter, Inc. Printed in U.S.A. on recycled paper.

17 Biomek 3000 Laboratory Automation Workstation FEATURES: Genomic DNA Purification from Whole Blood Process hundreds of extractions per day Purify and amplify samples in one easy step Go from raw sample to SNP analysis in a matter of hours 96 samples/1 primer pair/75 minutes 48 samples/48 primer pairs/90 minutes

18 BIOMEK 4000 LABORATORY AUTOMATION WORKSTATION INTUITIVE SOFTWARE. MAXIMUM VERSATILITY. BR-16994A

19 FAST AND SIMPLE SETUP EASY DEVICE INTEGRATION APPLICATIONS EXCELLENCE ICON-DRIVEN USER INTERFACE EXPANDABLE WORKSURFACE IT S TIME TO STREAMLINE YOUR WORKFLOW

20 1986 Biomek 1000 Laboratory Automation Workstation 1992 Patent for Interchangeable Tools Granted 1994 Biomek 2000 Laboratory Automation Workstation 2004 Biomek 3000 and Biomek NX Laboratory Automation Workstations Biomek 4000 Laboratory Automation Workstation > Designed for the demands of today. And tomorrow. As our world becomes a faster and fasterpaced environment, businesses from banking to manufacturing have turned to automation to reduce costs and create efficiencies in their daily operations. And life sciences are no exception the pressure to streamline workflow and automate laboratories is greater than ever. Delivering a more efficient discovery process is at the heart of every solution we at Beckman Coulter create. Since the launch of the Biomek 1000 Laboratory Automation Workstation in 1986, we have continued to develop more accurate, versatile and intuitive platforms. And today, the evolution continues. The Biomek 4000 Laboratory Automation Workstation is truly intelligent automation. From its enhanced worksurface with interchangeable tools to its flexible, icon-driven software, the Biomek 4000 system adapts to your ever-changing research needs. It revolutionizes everything, from the speed at which you can conduct your research to the ease with which you can complete it all to move your discovery process forward at an incredible pace.

21 THE BIOMEK 4000 WORKSTATION EMPOWERING DISCOVERY. The world of life sciences grows more sophisticated and competitive every day. The desire to find answers, to leave a mark and make a contribution only gets stronger. That s why at Beckman Coulter, we are dedicated to providing products that Biomek 4000 Hardware The embodiment of adaptability. At the heart of the Biomek 4000 Workstation is its hardware. Built with rugged, robust features, this liquid handling system offers reliable performance that flexes and grows with your needs. The hardware was designed with adaptability in mind. Interchangeable tools in various volume ranges cover the breadth and depths of today s life sciences applications. The modular deck configuration allows you to tailor the device according to your specific application. Up to 12 deck positions provide sufficient space for the automation of all major life sciences tasks. Storage is moved out of the deck area for more efficient use of the space. New and improved tools offer even higher throughput for assays greater than 200 μl and up to 1000 μl volume transfers. The improved wash tool enables tip touches and more accurate volume dispenses. And as with all Biomek systems, the Biomek 4000 Workstation can be easily integrated with other accessories or devices as your research demands

22 enable powerful discoveries. With instrumentation that performs applications in science, industry and medicine, our history is rich with innovations that produce far-reaching benefits. As part of the Beckman Coulter family of liquid handling solutions, the Biomek 4000 system delivers precise, efficient and reliable performance so that you can find the answers you need, when you need them, and trust in your results. 1 2 Enclosure* Even though the Biomek 4000 Workstation fits comfortably into a laminar flow hood, it s also available with an enclosure. The small footprint of the enclosure will fit neatly on your lab bench. Expanded dynamic volume range From 1 μl to 1000 μl, the Biomek 4000 Workstation offers precise and robust pipetting, both singlechannel and 8-channel Maximizes deck space The off-deck tool rack and liquid waste disposal uses the workstation s space more efficiently and allows for 12 deck positions to hold labware. Improved wash tool performance Allows for dispensing against the wall of a well, tip touches, bulk dispense and per liquid volume calibration to maximize the efficiency of your assay. Accessories For complete automation, optional accessories for cooling, heating and shaking are available. 6 Fully automated deck framing The AccuFrame tool provides increased accuracy using three-dimensional positioning. 7 Additional storage Storage provided beneath the deck frees up even more precious lab space and keeps all your tools close at hand. *In development

23 Biomek 4000 Software Thinks the way you think. Works the way you work. Whether you are a first-time automation user or a seasoned professional, the intuitive simplicity and power of Biomek software make it easy to set up, edit and run even the most demanding applications. Pre-written methods for common life sciences tasks, such as PCR setup and cell staining ensure successful operation from the beginning. Biomek software offers regulatory compliance with 21 CFR Part II. Access to the system can be controlled and monitored to allow multiple user accounts, grant permission, track revisions and system usage, and enable electronic signatures.

24 The power to adapt If your application is beyond the usual, the Biomek Method Editor offers powerful features to cope with such challenges. Fine-tuning pipetting with techniques and templates is user-accessible. Guided method editing Building blocks for common pipetting tasks, such as liquid transfers or serial dilutions, guide you intuitively through method editing. Auto tool picker Gives the Biomek 4000 the ability to make intelligent tool choices. The system will pick the appropriate tool for the job based on the pipetting volume, tips, well-selection pattern and tool class/category. Confidence in data Your Biomek 4000 workstation will keep track of all labware and sample data automatically. But it actually does more for you. During a run, it can make decisions about how to proceed with a given sample based on data, e.g., a readout indicating the concentration. Error-prone applications, such as normalization, are easily automated using this feature. Windows 7-based operating system Compatible with the 64-bit version of Windows 7 software.

25 Evolving Applications For evolving demands. The challenge in today s life science laboratory is to accomplish more with fewer resources. That s why Beckman Coulter s automation platform is designed to minimize the time you spend on routine laboratory tasks and maximize the time you spend searching for a new drug, making a powerful scientific discovery or finding the next breakthrough in Genomics. Developed as a result of listening to researchers unique needs, the Biomek 4000 system utilizes automated methods that help you achieve greater efficiency, greater throughput and improved turnaround time. Use our preconfigured methods, or easily create your own. No matter what you choose, the Biomek 4000 system is bound to take your productivity to new levels.

26 Biomek Methods Turnkey solutions for standard applications. While the Biomek 4000 Workstation adapts to almost any life sciences research protocol, Beckman Coulter offers ready-to-go methods for the most abundant applications in the laboratory. PCR Setup Method Automating the PCR assay setup process certainly has its advantages: Time-consuming and error-prone manual pipetting tasks can be omitted and the risk of crosscontamination is minimized. The Biomek 4000 PCR setup method creates a PCR application based on your specific input. Standardized results and increased productivity are just the beginning. You ll get high sample-to-sample and lab-to-lab reproducibility as well as fast PCR setup. Cell-Staining Method Many researchers use cell-staining techniques in order to better visualize cells and their components under a microscope, but the process can be labor intensive and time consuming when done manually. With the Biomek 4000 system, you can easily automate numerous wash and incubation steps. The intuitive software will show you exactly how to set up the Biomek worksurface, while still giving you the flexibility to create your own method based on your defined application. Note: The PCR Cleanup Method with the AMPure XP kit is in development.

27 The Biomek 4000 Workstation Adaptable. Modular. Reliable. At Beckman Coulter, our legacy of designing and manufacturing quality instrumentation is unparalleled in the industry. Our commitment to maintaining integrity applies to every part of the development process. Using Lean principles, we strive to achieve near perfection. The Biomek 4000 system is no exception. With more functionality, reliability and versatility, our newest automation workstation is incredibly intelligent and adaptable. Because we realize that as your needs grow and change, you need a platform that grows right along with you. Service and Support Laboratories around the world rely on Beckman Coulter s promise of quality, integrity and innovation. Providing excellent customer support is also one of our hallmarks. Our diverse portfolio of laboratory solutions provides researchers with a comprehensive line of life science tools. Our state-of-the-art customer support center was created to provide an incomparable level of support, because we know your instrumentation needs to be running at its top efficiency at all times. In addition to instrument maintenance, we also offer product training, webinars, applications support and preventative maintenance agreements to ensure your instrumentation is at its peak performance at all times. There is no satisfactory substitute for excellence. Arnold O. Beckman, Ph.D.

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29 A legacy of innovation. A passion for excellence. At Beckman Coulter Life Sciences, we re focused on discovering new ways to help scientists streamline and automate their research. In the words of our founder, Dr. Arnold O. Beckman, There is no satisfactory substitute for excellence. We pride ourselves in using groundbreaking technology to manufacture research instrumentation to the highest standards and providing excellent applications support to our customers. For over 75 years, we ve been building a global reputation in academic and biopharmaceutical laboratories, where our life science research instrumentation is relied upon to help scientists execute vital research. Whether helping to solve complex biological problems, investigate the causes of disease, or find potential new cures, Beckman Coulter Life Sciences is focused on combining state-of-the-art technology with leading-edge science to produce total-system solutions for laboratory researchers. All trademarks are the property of their respective owners. Beckman Coulter, the stylized logo, AMPure and Biomek are trademarks of Beckman Coulter, Inc. and are registered with the USPTO.

30 PCR and Sequencing Reaction Cleanup Purify PCR products from reaction contaminants using Promega's MagneSil* Paramagnetic Particles (PMPs) Integrated shaking for consistent results Save time by avoiding pipetting-based mixing Virtually no primer-dimer contamination Over 72% recovery of sample 1 plate in about 100 minutes High-quality yield for cycle sequencing Plasmid Purification Fully automate and rapidly purify plasmid DNA samples using the Promega Wizard* SV 96 Wizard SV96 Single Plate 1 plate per 80 minutes A 260/280 is 1.8 DNA yield 8-10 μg User-Friendly Software information as method progresses Sample tracking reporting at any time Port to other Biomek platforms with ease Helps achieve 21 CFR Part 11 compliance Icon-driven Step Palettes Point-and-click method development Flexible Hardware Perform easy system modifications to help meet expanding research requirements Easily integrate additional devices to customize your liquid handling application needs 9 mm center-to-center spacing Use with SBS/ANSI standard labware Standardized tips for simplified ordering and storage issues