Thermo Scientific ARM Automation Platform

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1 Thermo Scientific ARM Automation Platform Superior dexterity and proven robotics come together on one platform to automate the most challenging drug discovery applications.

2 The Trusted Choice to Automate All Your Application Needs The proven Thermo Scientific ARM automation platform helps you accelerate drug discovery by automating a variety of assays, including those requiring specialized equipment. Designed with a greater degree of freedom and wider range of motion, the system s articulated arm achieves even your most difficult automation tasks with ease. It integrates readily with a wide range of devices from simple to hard-to-reach and non-robot-friendly instruments. The ARM automation platform is ideal for applications requiring complex movements and efficient use of three-dimensional space. With our 20-year heritage of trusted life science robotic technology, you have the confidence of low-risk installation, fast startup, future expansion capability, and highly reliable, continuous operation. Flexible Automation for Multiple Applications The flexible and highly dexterous system enables researchers to automate any assay, method, or protocol, and it will handle multiple applications simultaneously. Our integration experts provide turnkey ARM solutions that seamlessly integrate existing instruments, best-in-class technologies, and custom peripherals to handle your most critical and sensitive applications including but not limited to: Genomics DNA Purification Gene Expression Sequencing Reaction Setup Proteomics Protein Purification Protein Crystallography Protein Digestion/MALDI Sample Prep High-Content/Cell-Based Screening Primary and Secondary High-Throughput Screening ADME/Tox ELISA Sample Preparation/Solid Phase Extraction Barcode Print and Apply

3 The ARM system is ideal for automating very sensitive assays, such as highcontent screening and protein crystallography. (Left) All articulated arms can be mounted on a high-speed linear track for countless expansion configurations. (Above) The ARM system automates sensitive assays, such as protein crystallography and HCS. (Right) The Thermo Scientific F3 can handle a stack of microtiter plates. Thermo Scientific ARM Automation Platform Proven Robotic Technologies Thermo Scientific ARM automation technology is designed to provide highly precise movement without sacrificing speed or throughput. With smooth, human-like movement and six axes of motion, the system s articulated robots offer unmatched levels of dexterity. This design provides extreme flexibility to access difficult-to-reach instruments. The robots can be mounted upright or upside down for highly efficient use of space. In addition, the platform s available grippers and end-of-arm devices permit the use of an almost endless variety of tubes, plates, and other containers. Thermo Scientific F3 Robot Arm The Thermo Scientific F3 robot has six degrees of freedom and a 900 mm reach that allow for greater dexterity and increased range. The robot performs with exceptional precision and repeatability (±0.05 mm), allowing for very exact plate placement every time. A 360- degree range of motion gives users the freedom to build applications that entirely surround the robot. With its 3 kg payload capacity, the F3 can handle virtually any container type including heavy stacks of microtiter plates. Thermo Scientific CataLyst-5 Robot Arm The Thermo Scientific CataLyst-5 robot offers reliability, precision, and 360-degree range of motion for the efficient integration of instruments and storage devices. Its 735 mm reach, 5-axis degree of freedom, and 1 kg payload provide the flexibility to automate a wide range of laboratory applications and handle almost all microtiter plates. The CataLyst-5 robot represents an exceptional value at a highly affordable price. Tracks & Grippers A wide array of linear tracks allows for system expansion and the addition of more instruments. The high-speed tracks can be added to a stand-alone robot. They give the robot greater range and additional instrument capacity. Available in multiple sizes up to 5 m, the tracks enable easy and efficient system expansion. Optional grippers allow for the handling of an endless variety of plate, tube, and container types and provide access to non-standard instruments. The grippers come with pneumatic or servo control, and feature constant feedback for greater error prevention. They can be combined with different end-of-arm devices such as force/torque sensors and collision detectors. With virtually unlimited options, the ARM platform automates applications previously thought impossible.

4 Applications Support Our applications support team helps transform your research ideas into reliable, effective automation solutions. Our scientists have managed laboratories and know how to solve the complex problems you face. Their expertise in biology, chemistry, and assay development creates the systems and processes that best meet your most demanding needs. Our team identifies your research requirements, checks your specifications for accuracy, conducts throughput analysis, and designs the system layout to ensure the automation platform is optimized for your application at the lowest cost. With the experience of countless system integrations, our applications support group can provide counsel on third-party equipment, suggest the best instruments/peripherals, facilitate future upgrades, and expedite integration with upstream and downstream data. Optimize Laboratory Space The system s greater reach and precise movement allow efficient use of vertical space and high-density instrument and storage configurations. Reagents, plates, and instrument controllers are stored under the table to conserve space and provide easy access. With the robot s wide range of motion, instruments may be stacked up to four-high on mezzanines located above the table. Expert Integration With over two decades of robotic system integration expertise, we can incorporate any Thermo Scientific or third-party instrument into our ARM automation platform for best-in-class performance and maximum use of existing assets. With our in-house mechanical, software, and applications experts, we can also design custom components for your most demanding applications.

5 Rapidly expand the platform for increased capacity and additional assays while retaining the flexibility for future expansion. Thermo Scientific POLARA Software Our proven POLARA scheduling software controls all system components and instruments to handle a broad range of applications from small benchtop automation to complete turnkey solutions. A single POLARA package automates multiple applications and schedules them simultaneously for high-throughput processing. The software supports overlapping operations to maximize component usage and minimize wait times. In addition, POLARA software features robust error handling, run recovery, and batch extension that allow users to continuously run the system. The package provides consistent scheduling of each sample and operates in attended and unattended modes. Prewritten instrument interfaces are available. The software is compatible with more than 120 instruments and is 21 CFR Part 11 compliant. Before CASE STUDY A leading pharmaceutical company wanted to expand its ARM automation platform to run additional assays and increase throughput. We quickly increased the capability of the platform s F3 robot by adding a high-speed 2 m track for greater workspace plus range and flexibility. The overall system was lengthened by 1.2 m, allowing the addition of more instruments to the automated solution. Incubator capacity was tripled, allowing longer walk-away time. The tripling of bulk dispensing capacity permitted the lab to run a wider range of methods with faster assay changeover. The POLARA software also was upgraded, enabling features such as Batch Addition and Run Resume. As a result, the company rapidly expanded the platform s capacity to run additional assays and retained the flexibility for still more expansion. After

6 Thermo Services Scientific Services We Thermo are committed is committed to helping to helping your your laboratory laboratory achieve achieve success. Our solutions ensure that your Thermo automation automation systems are optimized for accuracy, productivity, and performance. We offer flexible solutions: Service agreements Preventative maintenance plans Software upgrades Software application support Technical support Integration services Relocation services Training Contact a Thermo representative Fisher Scientific to representative tailor the service to tailor solution that best the service meets your solution needs. that best meets your needs. Integrative Technologies Division Laboratory Automation and Cellular Imaging North America: info.labautomation@thermofisher.com Europe: info.labautomation.de@thermofisher.com Asia: info.labautomation.asia@thermofisher.com 2007 Thermo Fisher Scientific Inc. All rights reserved. All trademarks are the property of Thermo Fisher Scientific Inc. and its subsidiaries. BRO-LACI-ARM