ROBOX 240 Automation Platform for Sample Oxidation and Scintillation Counting 2010 ZINSSER ANALYTIC

Transcription

1 ROBOX 240 Automation Platform for Sample Oxidation and Scintillation Counting 2010 ZINSSER ANALYTIC 1

2 The Robox Workcell 2

3 Automatic Sample Preparation with Robox 240 Compact workcell 180 x 100 x 190 in cm Catalytic sample oxidizer Oxygen regulator for enhanced combustion Storage racks for 240 sample boats Original LSC-counter racks Capping/decapping station for LSC-vials 2D-Barcode reader for the LSC-vials 2D-Barcode reader for the sample boats Triathler scintillation counter (option) 5-axes robot on 1m track with controller PC with WinLissy software UPS power supply 3

4 Robot Work... 6-Axis Denso Robot OX-500 Oxidizer 24 Vial racks for 10 vials 4

5 The Workbench CRS Robot on Track Oxidizer LSC Counter Capping Station with Barcode Reading Sample Boats Vials in/out Robot transfers up to 240 samples to the oxidizer Robot handles scintillation vials and transports trays Automatic capping and decapping of vials Controls combustion efficiency with integrated LSC-counter Barcode reading Integrated into mobile safety cabinet 5

6 The Oxidizer is the Heart...Ox 700 Combusts up to 300mg of wet or dry sample Single or dual labelled samples (H-3, C-14) High combustion temperature 900 C Recovery 98%, reproducibility ± 1% Low memory (less than 50 d.p.m. for d.p.m. samples) Catalyst removes quenchers as SO 2, NO 2 Automatic feeding of 12 samples 6

7 The Oxidizer is the Heart... OX Catalytic combustion High combustion temperature (900 C) High recovery (C-14: 97%) Small footprint Easy to operate Minimum maintenance Very low service cost Labor intensive Less Consumables Catalyst 1 & 2 Oxygen, Nitrogen 7

8 Spare Parts & Consumables... Combustion tube Quartz ladles Catalyst 1 (Copper dioxide) Catalyst 2 (Special Catalyst) Catalyst 3 (Platinum mesh) 8

9 Samples in & samples out... Storage racks for 240 barcoded sample boats Original counter racks with barcoded vials 9

10 Capping and Decapping of Vials... 10

11 2D-Barcode Reading of LSC-Vials... 11

12 2D-Barcode Reading of Sample Boats... 12

13 Recovery Control... 13

14 Triathler Features channel Multi Channel Analyzers 2keV 2000 kev energy range Up to 95% counting efficiency for C-14 Luminescence interference in beta counting typically < 0.1 % Preset nuclides:h-3, C-14, P-32, S-35, P-33, I-125, Cr ml LSC vials 14

15 Robot on 1m Track... Smooth movements Fast Precision positioning Reliable (24h, 7 days...) 15

16 Easy to Operate with WinLISSY... Graphic user interface Controlled restart option Scheduling User level administration Complete audit trail 21 CFR Ch. 11 compliant Download & upload of Excel -files Communication with Oracle etc. Easy to operate 16

17 Result File... Sample number Source rack position Sample I.D. LSC rack number LSC rack position Vial I.D. CPM of counted samples Error messages 17

18 Run File... Action Start of action End of action Flag 18

19 Step 1: Prepare the Sample... Weigh sample material onto sample boat Prepare standards for recovery control Place sample boats on carriers 19

20 Step 2: Fill Counter Racks with Vials Barcoded 20ml vials (Polyvials ) with caps on LSC-Counter racks 20

21 Oxysolve C-400 for C-14 Step 3: Get the Cocktail... A complete scintillator for counting C-14. It contains a specially sourced CO2 absorber for quick uptake of CO2. The high CO2 capacity ensures complete absorption of 1.8g CO2 per 15ml Oxysolve C-400. It is recommended for use with the Harvey Oxidisers (OX-300, OX-400, OX- 500) and can also be used for any type of 14CO2 measurement. It is packaged under nitrogen in 2.5 litre amber glass bottles. Flashpoint (PMCC) 34oC Pack Size 4 x 2.5 litres Irgasafe for H-3 21

22 The better Way of Sample Preparation... Achieve quench free counting samples Completely inhoused system, protecting workers from benzene fumes*! Takes the stress away from the staff Can handle extreme sample materials (motor oil, paint, soil, concrete (!)) Highly reproducible Separation of H-3 and C-14 for better results for dual label samples * 2 former emloyees against ABC-Lab 22

23 Conclusion Robox 240 is an ideal solution for sample combustion Online quality control for the sampling process High throughput (240 to 320 samples per day) Barcode labelled sample boats and scintillation vials Integrated scintillation counter GLP data management Easy to operate Proven & reliable software WinLISSY Easy to integrate into existing infrastructure With its enclosure it is a remote enclosed workstation providing a safe environment for the user 23