STENTS: TECHNOLOGIES AND GLOBAL MARKETS

Transcription

1 STENTS: TECHNOLOGIES AND GLOBAL MARKETS HLC155A January 2015 Himani Singhi Wadhwa Project Analyst ISBN: BCC Research 49 Walnut Park, Building 2 Wellesley, MA USA (toll-free within the USA), or (+1) information@bccresearch.com

2 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY GOALS AND OBJECTIVES 2 REASONS FOR DOING THE STUDY 3 SCOPE OF REPORT 3 INTENDED AUDIENCE 4 INFORMATION SOURCES AND METHODOLOGY 4 ANALYST'S CREDENTIALS 5 RELATED BCC RESEARCH REPORTS 5 BCC RESEARCH WEBSITE 5 DISCLAIMER 5 CHAPTER 2 SUMMARY 7 SUMMARY TABLE GLOBAL STENTS MARKET BY REGION, THROUGH 2019 ($ SUMMARY FIGURE GLOBAL STENTS MARKET BY REGION, ($ 7 7 CHAPTER 3 OVERVIEW 10 STENTS MARKET EVOLUTION 10 STENTS TECHNOLOGY MATURITY STAGES 11 BARE-METAL STENTS - MATURE TO DECLINING PHASE 11 DRUG-ELUTING STENTS- MATURITY PHASE 12 BIOABSORBABLE STENTS-INTRODUCTORY TO GROWTH PHASE 12 GLOBAL STENT DEVICES MARKET ANALYSIS 12 FIGURE 1 MARKET SHARE OF GLOBAL STENT PRODUCTS MARKET, 2014 (%) 13 FIGURE 2 MARKET SHARE OF GLOBAL STENTS BY DEVICE TYPE, 2014 (%) 13 FIGURE 3 MARKET SHARE OF GLOBAL STENTS BY DEVICE TYPE, 2019 (%) 14 MARKET DRIVERS 15 TABLE 1 IMPACT OF MARKET DRIVERS ON STENTS MARKET, GROWING AGING POPULATION 16 TABLE 2 WORLDWIDE AGE 60 AND OVER POPULATION BY REGION, (THOUSANDS) TABLE 3 AGE 60 AND OVER POPULATION OF TOTAL POPULATION BY REGION, (%) RISING PREVALENCE OF DISEASES WORLDWIDE 17 GROWING NUMBER OF VASCULAR PROCEDURES 17 TABLE 4 PCI AND PERIPHERAL VASCULAR PROCEDURES, THROUGH 2019 (THOUSANDS) CONTINUOUS PRODUCT AND TECHNOLOGY DEVELOPMENTS 18 OTHER DRIVERS 19 MARKET RESTRAINTS 19 TABLE 5 IMPACT OF RESTRAINTS ON STENTS MARKET, ALTERNATIVE TECHNOLOGIES 19 DECLINE IN AVERAGE SELLING PRICES 20 HIGH COST OF PRODUCTS/PROCEDURES IMPEDE ADOPTION, ALONG WITH REIMBURSEMENT ISSUES REGULATORY ISSUES

3 OTHER RESTRAINTS 22 MARKET TRENDS 23 MARKET REGULATIONS 24 MARKET COMPETITIVE ASSESSMENT 25 MARKET-ENTRY BARRIERS 26 TABLE 6 LEVEL OF THREAT FOR NEW ENTRANTS BY MARKET ASPECT 26 COMPETITIVE SCENARIO 27 SHIFTING MARKET FOCUS AND CHANGING COMPETITIVE SCENARIO 27 FUTURE OF THE STENTS MARKET 28 RECOMMENDATIONS 29 OFFER/MARKET INSURANCE-BACKED STENTS 29 EXPLORE AND FOCUS ON MERGERS AND ACQUISITIONS 29 FOCUS ON INVESTING IN PHYSICIAN TRAINING 29 INVEST IN DEVELOPING AND EMERGING NATIONS 29 EXPLORE PRODUCT DEVELOPMENT COLLABORATIONS 30 EVALUATE OPTIMAL SALES MODELS AND STRATEGIES TO ENTER ADDITIONAL REGIONS CONSIDER EXPANDING PRODUCT PORTFOLIOS AND ENTERING NEW REGIONS PATENT ANALYSIS 30 FIGURE 4 PATENT ANALYSIS BY REGION, 2012-MID-2014 (%) CHAPTER 4 STENTS PRODUCTS MARKET 33 INTRODUCTION 33 VASCULAR VS. NONVASCULAR STENTS 33 TABLE 7 GLOBAL VASCULAR AND NONVASCULAR STENTS DEVICES MARKET, TABLE 8 GLOBAL VASCULAR STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 9 GLOBAL NONVASCULAR STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 10 GLOBAL VASCULAR STENTS DEVICES MARKET BY CORONARY AND NON-CORONARY APPLICATIONS, STENT DESIGNS 35 Balloon-expanded Stents 35 TABLE 11 EXAMPLES OF BALLOON-EXPANDED STENTS 36 Self-expanding Stents 37 TABLE 12 EXAMPLES OF SELF-EXPANDABLE STENTS 37 Covered Stents 38 STENT PRODUCTS MARKET SEGMENTATION 38 TABLE 13 GLOBAL STENTS DEVICES MARKET BY CORONARY AND NON-CORONARY APPLICATIONS, TABLE 14 GLOBAL STENTS MARKET BY REGION, 39 CORONARY STENTS 39 Key Market Players 40 Key Coronary Stent Examples 40 Market Drivers and Restraints 40 TABLE 15 GLOBAL CORONARY STENTS MARKET BY DEVICE TYPE, THROUGH 2019 ($

4 TABLE 16 GLOBAL CORONARY STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 17 GLOBAL BARE-METAL CORONARY STENTS MARKET BY REGION, TABLE 18 GLOBAL DRUG-ELUTING CORONARY STENTS MARKET BY REGION, TABLE 19 GLOBAL FULLY ABSORBABLE CORONARY STENTS MARKET BY REGION, NON-CORONARY STENTS 43 Market Analysis by Type of Stent Device 44 TABLE 20 GLOBAL NON-CORONARY STENTS MARKET BY DEVICE TYPE, THROUGH 2019 ($ Market Products Analysis - Vascular and Nonvascular 44 TABLE 21 GLOBAL NON-CORONARY VASCULAR AND NONVASCULAR STENTS MARKET, TABLE 22 GLOBAL NON-CORONARY VASCULAR STENTS MARKET BY PRODUCT APPLICATION/INDICATION, TABLE 23 GLOBAL NON-CORONARY NONVASCULAR STENTS MARKET BY PRODUCT APPLICATION/INDICATION, TABLE 24 GLOBAL NON-CORONARY STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 25 GLOBAL NON-CORONARY VASCULAR STENTS MARKET BY REGION, TABLE 26 GLOBAL NON-CORONARY NONVASCULAR STENTS MARKET BY REGION, CAROTID/BRAIN STENTS 47 Market Drivers and Restraints 48 TABLE 27 GLOBAL CAROTID STENTS MARKET BY REGION, THROUGH 2019 ($ PERIPHERAL LOWER-EXTREMITY ARTERIAL STENTS 48 Market Analysis 49 TABLE 28 GLOBAL PERIPHERAL LOWER-EXTREMITY STENTS MARKET BY APPLICATION/INDICATION, TABLE 29 GLOBAL PERIPHERAL LOWER-EXTREMITY STENTS MARKET BY REGION, ILIAC ARTERY STENTS 50 Market Drivers and Restraints 51 TABLE 30 GLOBAL ILIAC STENTS MARKET BY REGION, 51 OTHER PERIPHERAL LOWER-EXTREMITY ARTERIAL STENTS 51 Market Drivers 52 Market Players 52 TABLE 31 GLOBAL OTHER PERIPHERAL LOWER-EXTREMITY STENTS BY APPLICATION/INDICATION, TABLE 32 GLOBAL OTHER PERIPHERAL LOWER-EXTREMITY STENTS MARKET BY REGION, TABLE 33 GLOBAL PERIPHERAL FEMOROPOPLITEAL STENTS MARKET BY REGION, TABLE 34 GLOBAL PERIPHERAL INFRAPOPLITEAL STENTS MARKET BY REGION, BILE DUCT/PANCREATIC STENTS 54 Plastic Bile Duct/Pancreatic Stents

5 Metal Bile Duct/Pancreatic Stents 55 Bile Duct/Pancreatic Stents 55 Market Drivers and Restraints 56 TABLE 35 GLOBAL BILE DUCT/PANCREATIC STENTS BY REGION, THROUGH 2019 ($ TRACHEOBRONCHIAL/PULMONARY STENTS 56 Plastic versus Metallic Trachael/Bronchial Stents 57 Trachael/Bronchial and Pulmonary Stents 58 Market Drivers and Restraints 58 TABLE 36 GLOBAL TRACHEOBRONCHIAL/PULMONARY MARKET BY REGION, URETERAL/RENAL STENTS 59 Market Drivers and Restraints 59 TABLE 37 GLOBAL URETERAL STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 38 GLOBAL RENAL ARTERY STENTS MARKET BY REGION, THROUGH 2019 ($ GASTROINTESTINAL STENTS MARKET 60 Gastrointestinal Stents 61 Market Drivers and Restraints 61 TABLE 39 GLOBAL GASTROINTESTINAL STENTS MARKET BY REGION, THROUGH 2019 ($ CHAPTER 5 STENT DEVICES MARKET 63 INTRODUCTION 63 TABLE 40 GLOBAL STENTS MARKET BY DEVICE TYPE, 63 BARE-METAL STENTS 63 DIFFERENT GENERATIONS OF BARE-METAL STENTS AND NEW DEVELOPMENTS BARE-METAL STENTS COMPARABLE WITH DRUG-ELUTING STENTS 65 MARKET PLAYERS 65 MARKET DRIVERS AND RESTRAINTS 66 TABLE 41 TYPES OF BARE-METAL STENTS BY PRODUCT, TYPE AND MANUFACTURER TABLE 42 GLOBAL CORONARY AND NON-CORONARY BARE-METAL STENTS DEVICES MARKET, DRUG-ELUTING STENTS 68 DES ADVANTAGES AND DISADVANTAGES 68 DES INDICATIONS 69 COMPONENTS OF DES 69 DIFFERENT GENERATIONS OF DES- FIRST VS. FOURTH GENERATION 69 FUTURE GENERATION OF DES 70 DRUG-CARRIER VEHICLES IN DES 71 TYPES OF DRUGS USED IN DES 71 TABLE 43 TYPES OF DRUGS USED IN DES 71 MARKET DRIVERS AND RESTRAINTS 72 MARKET PLAYERS 72 TABLE 44 TYPES OF DRUG-ELUTING STENTS BY PRODUCT, TYPE AND MANUFACTURER

6 TABLE 45 TYPES OF BIOABSORBABLE DES BY PRODUCT, TYPE AND MANUFACTURER TABLE 46 GLOBAL CORONARY AND NON-CORONARY DRUG-ELUTING STENTS DEVICES MARKET, BIORESORBABLE STENTS/FULLY BIOABSORBABLE (FAS) 74 ABSORB, THE WORLD S FIRST LAUNCHED FULLY ABSORBABLE (BIORESORBABLE) STENT FOR CORONARY ARTERY DISEASE FUTURE OF FULLY ABSORBABLE STENTS 76 DIFFERENT MODELS OF BIOABSORBABLE/BIODEGRADABLE STENTS UNDER RESEARCH AND DEVELOPMENT MARKET PLAYERS 76 MARKET COMPETITION 77 MARKET DRIVERS AND RESTRAINTS 77 TABLE 47 TYPES OF BIORESORBABLE STENTS/FULLY BIOABSORBABLE (FAS) BY PRODUCT, TYPE AND MANUFACTURER TABLE 48 GLOBAL BIORESORBABLE STENTS/FULLY CORONARY AND NON-CORONARY BIOABSORBABLE (FAS) MARKET, OTHERS 79 PLASTIC STENTS VS. SELF-EXPANDING METAL STENTS 79 MARKET PLAYERS 79 TABLE 49 OTHER MATERIAL-BASED STENTS BY PRODUCT AND MANUFACTURER CHAPTER 6 COMPETITIVE DEVELOPMENTS 82 INTRODUCTION 82 FIGURE 5 DEVELOPMENTS IN GLOBAL STENT DEVICES MARKET, 2012-MID-2014 (%) 82 TABLE 50 PRODUCT LAUNCHES/INTRODUCTIONS, 2012-MID TABLE 51 PARTNERSHIPS/AGREEMENTS, 2012-MID TABLE 52 ACQUISITIONS, 2012-MID TABLE 53 MISCELLANEOUS DEVELOPMENTS, 2012-MID TABLE 54 GLOBAL STENTS MARKET PRODUCT PIPELINE 90 CHAPTER 7 REGIONAL ANALYSIS 94 NORTH AMERICA 94 TABLE 55 NORTH AMERICAN CORONARY AND NON-CORONARY STENTS MARKET, TABLE 56 NORTH AMERICAN VASCULAR AND NONVASCULAR NON-CORONARY STENTS MARKET, TABLE 57 NORTH AMERICAN CORONARY STENTS MARKET BY DEVICE TYPE, TABLE 58 NORTH AMERICAN CORONARY STENTS MARKET SHARE BY DEVICE TYPE, 2014 VS (%) TABLE 59 NORTH AMERICAN NON-CORONARY VASCULAR STENTS MARKET BY APPLICATION/INDICATION, TABLE 60 NORTH AMERICAN PERIPHERAL STENTS MARKET BY APPLICATION/INDICATION, TABLE 61 NORTH AMERICAN NONVASCULAR STENTS MARKET BY APPLICATION/INDICATION, EUROPE 97 TABLE 62 EUROPEAN CORONARY AND NON-CORONARY STENTS MARKET,

7 TABLE 63 EUROPEAN VASCULAR AND NONVASCULAR NON-CORONARY STENTS MARKET, TABLE 64 EUROPEAN CORONARY STENTS MARKET BY DEVICE TYPE, THROUGH 2019 ($ TABLE 65 EUROPEAN CORONARY STENTS MARKET SHARE BY DEVICE TYPE, 2014 VS (%) TABLE 66 EUROPEAN NON-CORONARY VASCULAR STENTS MARKET BY APPLICATION/INDICATION, TABLE 67 EUROPEAN PERIPHERAL STENTS MARKET BY APPLICATION/INDICATION, TABLE 68 EUROPEAN NONVASCULAR STENTS MARKET BY APPLICATION/INDICATION, ASIA 100 TABLE 69 ASIAN CORONARY AND NON-CORONARY STENTS MARKET, THROUGH 2019 ($ TABLE 70 ASIAN VASCULAR AND NONVASCULAR NON-CORONARY STENTS MARKET, TABLE 71 ASIAN CORONARY STENTS MARKET BY DEVICE TYPE, THROUGH 2019 ($ TABLE 72 ASIAN CORONARY STENTS MARKET SHARE BY DEVICE TYPE, 2014 VS (%) TABLE 73 ASIAN NON-CORONARY VASCULAR STENTS MARKET BY APPLICATION/INDICATION, TABLE 74 ASIA-PACIFIC PERIPHERAL STENTS MARKET BY APPLICATION/INDICATION, TABLE 75 ASIAN NONVASCULAR STENTS MARKET BY APPLICATION/INDICATION, REST OF THE WORLD 104 TABLE 76 ROW CORONARY AND NON-CORONARY STENTS MARKET, THROUGH 2019 ($ TABLE 77 ROW VASCULAR AND NONVASCULAR NON-CORONARY STENTS MARKET, TABLE 78 ROW CORONARY STENTS MARKET BY DEVICE TYPE, THROUGH 2019 ($ TABLE 79 ROW CORONARY STENTS MARKET SHARE BY DEVICE TYPE, 2014 VS (%) TABLE 80 ROW NON-CORONARY VASCULAR STENTS MARKET BY APPLICATION/INDICATION, TABLE 81 ROW NONVASCULAR STENTS MARKET BY APPLICATION/INDICATION, CHAPTER 8 PATENTS 108 TABLE 82 LIST OF U.S. PATENTS 108 TABLE 83 LIST OF EUROPE PATENTS 112 TABLE 84 LIST OF JAPAN PATENTS 116 CHAPTER 9 COMPANY PROFILES 119 ABBOTT LABORATORIES 119 COMPANY AND BUSINESS OVERVIEW 119 PRODUCTS AND FINANCIALS 119 TABLE 85 ABBOTT'S STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 119

8 BUSINESS STRATEGY 120 AMG INTERNATIONAL GMBH 120 COMPANY AND BUSINESS 120 PRODUCTS 121 TABLE 86 AMG INTERNATIONAL GMBH STENTS PRODUCT PORTFOLIO BY APPLICATION AREA BUSINESS STRATEGY 121 ARTERIUS 121 COMPANY AND BUSINESS OVERVIEW 121 PRODUCTS 122 B. BRAUN 122 COMPANY AND BUSINESS OVERVIEW 122 PRODUCTS AND FINANCIALS 122 TABLE 87 B. BRAUN STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 122 BUSINESS STRATEGY 122 BIOSENSORS INTERNATIONAL 123 COMPANY AND BUSINESS OVERVIEW 123 PRODUCTS AND FINANCIALS 123 TABLE 88 BIOSENSORS INTERNATIONAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA BUSINESS STRATEGY 123 BIOTRONIK 124 COMPANY AND BUSINESS OVERVIEW 124 PRODUCTS 124 TABLE 89 BIOTRONIK STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 124 BUSINESS STRATEGY 124 BOSTON SCIENTIFIC CORP. 125 COMPANY AND BUSINESS OVERVIEW 125 PRODUCTS OVERVIEW 125 TABLE 90 BOSTON SCIENTIFIC CORP. STENTS PRODUCT PORTFOLIO BY APPLICATION AREA BUSINESS STRATEGY 126 CELONOVA BIOSCIENCES 127 COMPANY AND BUSINESS OVERVIEW 127 PRODUCTS 127 COOK MEDICAL 127 COMPANY AND BUSINESS OVERVIEW 128 PRODUCTS AND FINANCIALS 128 TABLE 91 COOK MEDICAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 128 BUSINESS STRATEGY 129 CORDIS CORP. 129 COMPANY AND BUSINESS OVERVIEW 129 PRODUCTS 130 TABLE 92 CORDIS STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 130 BUSINESS STRATEGY 130 COVIDIEN/EV3 131 COMPANY AND BUSINESS OVERVIEW 131 PRODUCTS

9 TABLE 93 EV3/COVIDIEN STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 131 BUSINESS STRATEGY 132 C.R. BARD INC. 132 COMPANY AND BUSINESS OVERVIEW 132 PRODUCTS AND FINANCIALS 132 TABLE 94 C.R. BARD STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 133 BUSINESS STRATEGY 133 ELIXIR MEDICAL CORP. 133 COMPANY AND BUSINESS OVERVIEW 133 PRODUCTS 134 TABLE 95 ELIXIR MEDICAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 134 BUSINESS STRATEGY 134 INSPIREMD 134 COMPANY OVERVIEW 134 PRODUCTS 134 KYOTO MEDICAL PLANNING CO. LTD. 135 COMPANY AND BUSINESS OVERVIEW 135 PRODUCTS 135 LEPU MEDICAL TECHNOLOGY CO. LTD. 135 COMPANY AND BUSINESS OVERVIEW 135 PRODUCTS 135 TABLE 96 LEPU MEDICAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 135 BUSINESS STRATEGY 136 MICROPORT SCIENTIFIC CORP. 136 COMPANY AND BUSINESS OVERVIEW 136 PRODUCTS AND FINANCIALS 136 TABLE 97 MICROPORT SCIENTIFIC STENTS PRODUCT PORTFOLIO BY APPLICATION AREA BUSINESS STRATEGY 137 MEDTRONIC 137 COMPANY AND BUSINESS OVERVIEW 137 PRODUCTS AND FINANCIALS 137 TABLE MEDTRONIC STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 138 BUSINESS STRATEGY 138 OLYMPUS CORP.-OLYMPUS MEDICAL 138 COMPANY AND BUSINESS OVERVIEW 138 PRODUCTS 139 TABLE 99 OLYMPUS MEDICAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 139 BUSINESS STRATEGY 139 ORBUSNEICH 139 COMPANY AND BUSINESS OVERVIEW 139 PRODUCTS 140 TABLE 100 ORBUSNEICH STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 140 BUSINESS STRATEGY 140 SAHAJANAND MEDICAL TECHNOLOGIES 140 COMPANY AND BUSINESS OVERVIEW 140 PRODUCTS

10 TABLE 101 SAHAJANAND MEDICAL TECHNOLOGIES STENTS PRODUCT PORTFOLIO BY APPLICATION AREA BUSINESS STRATEGY 141 STENTYS SA 141 COMPANY AND BUSINESS OVERVIEW 141 PRODUCTS 141 BUSINESS STRATEGY 142 TAEWOONG MEDICAL CO. LTD. 142 COMPANY AND BUSINESS OVERVIEW 142 PRODUCTS 142 TABLE 102 TAEWOONG MEDICAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA BUSINESS STRATEGY 143 TERUMO CORP. 143 COMPANY AND BUSINESS OVERVIEW 143 PRODUCTS AND FINANCIALS 144 TABLE 103 TERUMO STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 144 BUSINESS STRATEGY 145 VASCULAR CONCEPTS LIMITED 145 COMPANY OVERVIEW 145 PRODUCTS 145 TABLE 104 VASCULAR CONCEPTS STENTS PRODUCT PORTFOLIO BY APPLICATION AREA BUSINESS STRATEGY 146 W. L. GORE & ASSOCIATES-GORE MEDICAL 146 COMPANY AND BUSINESS OVERVIEW 146 PRODUCTS 147 TABLE 105 GORE MEDICAL KEY STENTS BY APPLICATION AREA 147 BUSINESS STRATEGY

11 LIST OF TABLES TABLE HEADING SUMMARY TABLE GLOBAL STENTS MARKET BY REGION, 7 TABLE 1 IMPACT OF MARKET DRIVERS ON STENTS MARKET, TABLE 2 WORLDWIDE AGE 60 AND OVER POPULATION BY REGION, (THOUSANDS) TABLE 3 AGE 60 AND OVER POPULATION OF TOTAL POPULATION BY REGION, (%) TABLE 4 PCI AND PERIPHERAL VASCULAR PROCEDURES, THROUGH 2019 (THOUSANDS) TABLE 5 IMPACT OF RESTRAINTS ON STENTS MARKET, TABLE 6 LEVEL OF THREAT FOR NEW ENTRANTS BY MARKET ASPECT 26 TABLE 7 GLOBAL VASCULAR AND NONVASCULAR STENTS DEVICES MARKET, TABLE 8 GLOBAL VASCULAR STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 9 GLOBAL NONVASCULAR STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 10 GLOBAL VASCULAR STENTS DEVICES MARKET BY CORONARY AND NON-CORONARY APPLICATIONS, TABLE 11 EXAMPLES OF BALLOON-EXPANDED STENTS 36 TABLE 12 EXAMPLES OF SELF-EXPANDABLE STENTS 37 TABLE 13 GLOBAL STENTS DEVICES MARKET BY CORONARY AND NON-CORONARY APPLICATIONS, TABLE 14 GLOBAL STENTS MARKET BY REGION, 39 TABLE 15 GLOBAL CORONARY STENTS MARKET BY DEVICE TYPE, THROUGH 2019 ($ TABLE 16 GLOBAL CORONARY STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 17 GLOBAL BARE-METAL CORONARY STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 18 GLOBAL DRUG-ELUTING CORONARY STENTS MARKET BY REGION, TABLE 19 GLOBAL FULLY ABSORBABLE CORONARY STENTS MARKET BY REGION, TABLE 20 GLOBAL NON-CORONARY STENTS MARKET BY DEVICE TYPE, THROUGH 2019 ($ TABLE 21 GLOBAL NON-CORONARY VASCULAR AND NONVASCULAR STENTS MARKET, TABLE 22 GLOBAL NON-CORONARY VASCULAR STENTS MARKET BY PRODUCT APPLICATION/INDICATION, TABLE 23 GLOBAL NON-CORONARY NONVASCULAR STENTS MARKET BY PRODUCT APPLICATION/INDICATION, TABLE 24 GLOBAL NON-CORONARY STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 25 GLOBAL NON-CORONARY VASCULAR STENTS MARKET BY REGION, TABLE 26 GLOBAL NON-CORONARY NONVASCULAR STENTS MARKET BY REGION, TABLE 27 GLOBAL CAROTID STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 28 GLOBAL PERIPHERAL LOWER-EXTREMITY STENTS MARKET BY APPLICATION/INDICATION,

12 TABLE HEADING TABLE 29 GLOBAL PERIPHERAL LOWER-EXTREMITY STENTS MARKET BY REGION, TABLE 30 GLOBAL ILIAC STENTS MARKET BY REGION, 51 TABLE 31 GLOBAL OTHER PERIPHERAL LOWER-EXTREMITY STENTS BY APPLICATION/INDICATION, TABLE 32 GLOBAL OTHER PERIPHERAL LOWER-EXTREMITY STENTS MARKET BY REGION, TABLE 33 GLOBAL PERIPHERAL FEMOROPOPLITEAL STENTS MARKET BY REGION, TABLE 34 GLOBAL PERIPHERAL INFRAPOPLITEAL STENTS MARKET BY REGION, TABLE 35 GLOBAL BILE DUCT/PANCREATIC STENTS BY REGION, THROUGH 2019 ($ TABLE 36 GLOBAL TRACHEOBRONCHIAL/PULMONARY MARKET BY REGION, TABLE 37 GLOBAL URETERAL STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 38 GLOBAL RENAL ARTERY STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 39 GLOBAL GASTROINTESTINAL STENTS MARKET BY REGION, THROUGH 2019 ($ TABLE 40 GLOBAL STENTS MARKET BY DEVICE TYPE, 63 TABLE 41 TYPES OF BARE-METAL STENTS BY PRODUCT, TYPE AND MANUFACTURER 66 TABLE 42 GLOBAL CORONARY AND NON-CORONARY BARE-METAL STENTS DEVICES MARKET, TABLE 43 TYPES OF DRUGS USED IN DES 71 TABLE 44 TYPES OF DRUG-ELUTING STENTS BY PRODUCT, TYPE AND MANUFACTURER TABLE 45 TYPES OF BIOABSORBABLE DES BY PRODUCT, TYPE AND MANUFACTURER 73 TABLE 46 GLOBAL CORONARY AND NON-CORONARY DRUG-ELUTING STENTS DEVICES MARKET, TABLE 47 TYPES OF BIORESORBABLE STENTS/FULLY BIOABSORBABLE (FAS) BY PRODUCT, TYPE AND MANUFACTURER TABLE 48 GLOBAL BIORESORBABLE STENTS/FULLY CORONARY AND NON-CORONARY BIOABSORBABLE (FAS) MARKET, TABLE 49 OTHER MATERIAL-BASED STENTS BY PRODUCT AND MANUFACTURER 79 TABLE 50 PRODUCT LAUNCHES/INTRODUCTIONS, 2012-MID TABLE 51 PARTNERSHIPS/AGREEMENTS, 2012-MID TABLE 52 ACQUISITIONS, 2012-MID TABLE 53 MISCELLANEOUS DEVELOPMENTS, 2012-MID TABLE 54 GLOBAL STENTS MARKET PRODUCT PIPELINE 90 TABLE 55 NORTH AMERICAN CORONARY AND NON-CORONARY STENTS MARKET, TABLE 56 NORTH AMERICAN VASCULAR AND NONVASCULAR NON-CORONARY STENTS MARKET, TABLE 57 NORTH AMERICAN CORONARY STENTS MARKET BY DEVICE TYPE, TABLE 58 NORTH AMERICAN CORONARY STENTS MARKET SHARE BY DEVICE TYPE, 2014 VS (%) TABLE 59 NORTH AMERICAN NON-CORONARY VASCULAR STENTS MARKET BY APPLICATION/INDICATION,

13 TABLE HEADING TABLE 60 NORTH AMERICAN PERIPHERAL STENTS MARKET BY APPLICATION/INDICATION, TABLE 61 NORTH AMERICAN NONVASCULAR STENTS MARKET BY APPLICATION/INDICATION, TABLE 62 EUROPEAN CORONARY AND NON-CORONARY STENTS MARKET, THROUGH 2019 ($ TABLE 63 EUROPEAN VASCULAR AND NONVASCULAR NON-CORONARY STENTS MARKET, TABLE 64 EUROPEAN CORONARY STENTS MARKET BY DEVICE TYPE, THROUGH 2019 ($ TABLE 65 EUROPEAN CORONARY STENTS MARKET SHARE BY DEVICE TYPE, 2014 VS (%) TABLE 66 EUROPEAN NON-CORONARY VASCULAR STENTS MARKET BY APPLICATION/INDICATION, TABLE 67 EUROPEAN PERIPHERAL STENTS MARKET BY APPLICATION/INDICATION, TABLE 68 EUROPEAN NONVASCULAR STENTS MARKET BY APPLICATION/INDICATION, TABLE 69 ASIAN CORONARY AND NON-CORONARY STENTS MARKET, THROUGH 2019 ($ TABLE 70 ASIAN VASCULAR AND NONVASCULAR NON-CORONARY STENTS MARKET, TABLE 71 ASIAN CORONARY STENTS MARKET BY DEVICE TYPE, THROUGH 2019 ($ TABLE 72 ASIAN CORONARY STENTS MARKET SHARE BY DEVICE TYPE, 2014 VS (%) TABLE 73 ASIAN NON-CORONARY VASCULAR STENTS MARKET BY APPLICATION/INDICATION, TABLE 74 ASIA-PACIFIC PERIPHERAL STENTS MARKET BY APPLICATION/INDICATION, TABLE 75 ASIAN NONVASCULAR STENTS MARKET BY APPLICATION/INDICATION, TABLE 76 ROW CORONARY AND NON-CORONARY STENTS MARKET, THROUGH 2019 ($ TABLE 77 ROW VASCULAR AND NONVASCULAR NON-CORONARY STENTS MARKET, TABLE 78 ROW CORONARY STENTS MARKET BY DEVICE TYPE, THROUGH 2019 ($ TABLE 79 ROW CORONARY STENTS MARKET SHARE BY DEVICE TYPE, 2014 VS (%) TABLE 80 ROW NON-CORONARY VASCULAR STENTS MARKET BY APPLICATION/INDICATION, TABLE 81 ROW NONVASCULAR STENTS MARKET BY APPLICATION/INDICATION, TABLE 82 LIST OF U.S. PATENTS 108 TABLE 83 LIST OF EUROPE PATENTS 112 TABLE 84 LIST OF JAPAN PATENTS 116 TABLE 85 ABBOTT'S STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 119 TABLE 86 AMG INTERNATIONAL GMBH STENTS PRODUCT PORTFOLIO BY APPLICATION AREA TABLE 87 B. BRAUN STENTS PRODUCT PORTFOLIO BY APPLICATION AREA

14 TABLE HEADING TABLE 88 BIOSENSORS INTERNATIONAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA TABLE 89 BIOTRONIK STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 124 TABLE 90 BOSTON SCIENTIFIC CORP. STENTS PRODUCT PORTFOLIO BY APPLICATION AREA TABLE 91 COOK MEDICAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 128 TABLE 92 CORDIS STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 130 TABLE 93 EV3/COVIDIEN STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 131 TABLE 94 C.R. BARD STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 133 TABLE 95 ELIXIR MEDICAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 134 TABLE 96 LEPU MEDICAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 135 TABLE 97 MICROPORT SCIENTIFIC STENTS PRODUCT PORTFOLIO BY APPLICATION AREA TABLE MEDTRONIC STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 138 TABLE 99 OLYMPUS MEDICAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 139 TABLE 100 ORBUSNEICH STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 140 TABLE 101 SAHAJANAND MEDICAL TECHNOLOGIES STENTS PRODUCT PORTFOLIO BY APPLICATION AREA TABLE 102 TAEWOONG MEDICAL STENTS PRODUCT PORTFOLIO BY APPLICATION AREA TABLE 103 TERUMO STENTS PRODUCT PORTFOLIO BY APPLICATION AREA 144 TABLE 104 VASCULAR CONCEPTS STENTS PRODUCT PORTFOLIO BY APPLICATION AREA TABLE 105 GORE MEDICAL KEY STENTS BY APPLICATION AREA

15 LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL STENTS MARKET BY REGION, ($ 7 FIGURE 1 MARKET SHARE OF GLOBAL STENT PRODUCTS MARKET, 2014 (%) 13 FIGURE 2 MARKET SHARE OF GLOBAL STENTS BY DEVICE TYPE, 2014 (%) 13 FIGURE 3 MARKET SHARE OF GLOBAL STENTS BY DEVICE TYPE, 2019 (%) 14 FIGURE 4 PATENT ANALYSIS BY REGION, 2012-MID-2014 (%) 31 FIGURE 5 DEVELOPMENTS IN GLOBAL STENT DEVICES MARKET, 2012-MID-2014 (%) 82