PROTEOMICS: TECHNOLOGIES AND GLOBAL MARKETS. BIO034C May John Bergin Project Analyst ISBN:

Transcription

1 PROTEOMICS: TECHNOLOGIES AND GLOBAL MARKETS BIO034C May 2013 John Bergin Project Analyst ISBN: BCC Research 49 Walnut Park, Building 2 Wellesley, MA , Custom Reports: carol.laverty@bccresearch.com

2 TABLE OF CONTENTS CHAPTER 1 INTRODUCTION 2 STUDY GOALS AND OBJECTIVES 2 REASONS FOR DOING THE STUDY 2 CONTRIBUTION OF THE STUDY AND INTENDED AUDIENCE 3 SCOPE AND FORMAT 3 METHODOLOGY 3 INFORMATION SOURCES 4 ANALYST'S CREDENTIALS 4 RELATED BCC REPORTS 4 BCC ONLINE SERVICES 5 DISCLAIMER 5 CHAPTER 2 SUMMARY 7 SUMMARY TABLE GLOBAL PROTEOMIC MARKET BY END-USE INDUSTRY, THROUGH 2017 ($ SUMMARY FIGURE GLOBAL PROTEOMIC MARKET BY END-USE INDUSTRY, THROUGH 2017 ($ 7 7 CHAPTER 3 OVERVIEW 10 PROTEOMIC TECHNOLOGIES 10 TABLE 1 ARRAY VERSUS LOAC BIOCHIPS 11 TABLE 2 SCOPE OF REPORT 12 PROTEOMIC MARKET 12 TABLE 3 GLOBAL PROTEOMIC MARKET BY END-USE INDUSTRY, THROUGH 2017 ($ TABLE 4 GLOBAL PROTEOMIC MARKET BY PLATFORM, THROUGH 2017 ($ 14 DRIVING FORCES FOR PROTEOMIC INDUSTRY GROWTH 15 TABLE 5 PROTEOMIC INDUSTRY GROWTH DRIVERS 15 PROTEOMIC INDUSTRY 16 TABLE 6 BIOCHIP INDUSTRY COMPARISONS CHAPTER 4 PROTEOMIC TECHNOLOGIES 19 INTRODUCTION TO TECHNOLOGY PLATFORMS 19 FIGURE 1 MASS SPECTROMETRY-BASED PROTEOMIC WORKFLOW 19 FIGURE 2 PROTEOMIC BIOCHIP AND ARRAY FORMATS 21 MASS SPECTROMETRY-BASED PROTEOMIC TECHNOLOGIES 22 SAMPLE PREPARATION ASSAYS 22 TAGGING AND AFFINITY METHODS 23 MASS SPECTROMETRY INSTRUMENTS AND CONSUMABLES 23 TABLE 7 MASS SPECTROMETER PLATFORMS 25 BIOCHIP-BASED PROTEOMIC TECHNOLOGIES 25 TABLE 8 BIOCHIP-BASED PROTEOMIC TECHNOLOGIES 25 TABLE 9 PLANAR-BASED VERSUS BEAD-BASED ARRAYS 26 ADVANCES IN PROTEOMIC TECHNOLOGIES 27 TABLE 10 TECHNICAL ADVANCES IN PROTEOMICS 27

3 CHAPTER 5 PROTEOMIC APPLICATIONS IN DRUG DISCOVERY AND DEVELOPMENT 30 TABLE 11 PROTEOMIC APPLICATIONS IN DRUG DISCOVERY AND DEVELOPMENT 30 TARGET DISCOVERY 30 LEAD IDENTIFICATION 32 LEAD OPTIMIZATION 33 PRECLINICAL STUDIES 33 CHAPTER 6 PROTEOMIC SCIENTIFIC INITIATIVES 35 TABLE 12 LARGE-SCALE PROTEOMIC INITIATIVES 35 CHAPTER 7 CLINICAL PROTEOMIC APPLICATIONS 39 TABLE 13 STRATEGIES FOR OVERCOMING HIGH-ABUNDANCE PROTEINS IN CLINICAL SAMPLES CANCER APPLICATIONS 40 CANCER OVERVIEW 40 TABLE 14 U.S. INCIDENCE OF SELECTED CANCERS, BLADDER CANCER 41 TABLE 15 STATUS OF ADVANCED BLADDER CANCER DIAGNOSTICS 41 BREAST CANCER 43 Breast Cancer Screening 43 Prognosis and Pharmacogenetics Tests 43 TABLE 16 U.S. ANNUAL BREAST CANCER TREATMENT DECISIONS BY CLASSIFICATION Breast Cancer MDx Platforms 45 TABLE 17 BREAST CANCER MDX TECHNOLOGY PLATFORMS 45 TABLE 18 STATUS OF ADVANCED BREAST CANCER DIAGNOSTICS 46 LUNG CANCER 50 TABLE 19 FIVE-YEAR SURVIVAL RATES FOR NON-SMALL-CELL LUNG CANCER (%) 50 TABLE 20 STATUS OF ADVANCED LUNG CANCER DIAGNOSTICS 51 OVARIAN CANCER 55 TABLE 21 EARLY SCREENING OVARIAN CANCER TESTS 55 TABLE 22 STATUS OF ADVANCED OVARIAN CANCER DIAGNOSTICS 56 PROSTATE CANCER 58 TABLE 23 STATUS OF ADVANCED PROSTATE CANCER DIAGNOSTICS 59 THYROID CANCER 62 GENERAL CANCER 62 INFECTIOUS DISEASE APPLICATIONS 62 NEUROLOGICAL APPLICATIONS 63 ALZHEIMER'S DISEASE 63 TABLE 24 ALZHEIMER'S DISEASE DIAGNOSTIC APPROACHES 63 TABLE 25 STATUS OF ALZHEIMER'S DISEASE ADVANCED DIAGNOSTIC TESTS 64 SCHIZOPHRENIA 65 IMMUNE DISEASE APPLICATIONS 66 HUMAN LEUKOCYTE ANTIGEN TYPING TESTS 66 TABLE 26 HUMAN LEUKOCYTE ANTIGEN TESTING MARKET 67 ALLERGY AND AUTOIMMUNE DISEASE CHAPTER 8 PROTEOMIC INDUSTRY 71

4 INDUSTRY ACQUISITIONS 71 TABLE 27 PROTEOMIC INDUSTRY ACQUISITIONS, INDUSTRY STRATEGIC ALLIANCES 73 TABLE 28 STRATEGIC ALLIANCES IN THE PROTEOMIC INDUSTRY, MASS SPECTROMETRY INDUSTRY 77 TABLE 29 FIRST-TIER MASS SPECTROMETRY COMPANIES 77 TABLE 30 SECOND-TIER MASS SPECTROMETRY COMPANIES 78 PROTEOMIC CHROMATOGRAPHY INDUSTRY 79 FIGURE 3 CHROMATOGRAPHY RESINS IN MS WORKFLOW 79 TABLE 31 GLOBAL HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY COLUMN MANUFACTURING COMPANIES TABLE 32 JAPANESE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY COLUMN LEADING MANUFACTURING COMPANIES PROTEOMIC-BASED DRUG DISCOVERY AND DEVELOPMENT INDUSTRY 82 TABLE 33 GLOBAL PHARMACEUTICAL RESEARCH AND DEVELOPMENT OUTSOURCING ($ BILLIONS) TABLE 34 PROTEOMIC-BASED DRUG DISCOVERY INDUSTRY 83 PROTEOMIC BIOCHIP INDUSTRY 84 PEPTIDE MICROARRAY INDUSTRY 84 TABLE 35 KEY PEPTIDE MICROARRAY COMPANIES 85 ANTIBODY MICROARRAY INDUSTRY 86 TABLE 36 KEY ANTIBODY MICROARRAY COMPANIES 86 CHINA BIOCHIP INDUSTRY 87 TABLE 37 CHINESE BIOCHIP INDUSTRY 88 LAB-ON-A-CHIP PROTEOMIC INDUSTRY 89 TABLE 38 LAB-ON-A-CHIP COMPETITOR LANDSCAPE 90 ANTIBODY REAGENT INDUSTRY 91 TABLE 39 ANTIBODY REAGENT MARKET, 2012 (%) 92 MULTIPLEX PROTEIN DIAGNOSTICS INDUSTRY 92 TABLE 40 MULTIPLEX PROTEIN IN VITRO DIAGNOSTIC COMPANIES CHAPTER 9 PROTEOMIC MARKETS 97 DRIVING FORCES OF PROTEOMIC INDUSTRY GROWTH 97 TABLE 41 PROTEOMIC INDUSTRY GROWTH DRIVERS 97 GLOBAL PROTEOMIC MARKETS 98 PROTEOMIC MARKET SUMMARY 98 TABLE 42 GLOBAL PROTEOMIC MARKET BY PLATFORM, THROUGH 2017 ($ TABLE 43 GLOBAL PROTEOMIC MARKET BY END-USE INDUSTRY, THROUGH 2017 ($ PROTEOMIC RESEARCH MARKETS 101 TABLE 44 GLOBAL PROTEOMIC RESEARCH PRODUCT MARKET BY PLATFORM, THROUGH 2017 ($ TABLE 45 GLOBAL PROTEOMIC RESEARCH MARKET BY BIOCHIP PLATFORM, THROUGH 2017 ($ PROTEOMIC DRUG DISCOVERY AND DEVELOPMENT MARKETS 103 TABLE 46 GLOBAL PROTEOMIC DRUG DISCOVERY AND DEVELOPMENT PRODUCT MARKET BY PLATFORM, THROUGH 2017 ($

5 TABLE 47 GLOBAL PROTEOMIC DRUG DISCOVERY AND DEVELOPMENT BIOCHIP MARKET BY PLATFORM, THROUGH 2017 ($ PROTEOMIC DIAGNOSTIC MARKETS 105 TABLE 48 GLOBAL PROTEOMIC DIAGNOSTIC PRODUCT MARKET BY PLATFORM, THROUGH 2017 ($ TABLE 49 GLOBAL BIOCHIP DIAGNOSTIC MARKET BY TYPE, THROUGH 2017 ($ TABLE 50 GLOBAL PROTEOMIC DIAGNOSTIC PRODUCT MARKET BY DISEASE TYPE, THROUGH 2017 ($ TABLE 51 STATUS OF PROTEOMIC-BASED DIAGNOSTICS FOR CARDIOLOGY, IMMUNE SYSTEM AND NEUROLOGY APPLICATIONS TABLE 52 GLOBAL PROTEOMIC CANCER DIAGNOSTIC PRODUCT MARKET BY INDICATION, THROUGH 2017 ($ TABLE 53 STATUS OF PROTEOMIC-BASED DIAGNOSTICS FOR CANCER APPLICATIONS MASS SPECTROMETRY-BASED PROTEOMIC MARKETS 112 TABLE 54 GLOBAL MASS SPECTROMETRY MARKET BY PRODUCT TYPE, THROUGH 2017 ($ TABLE 55 GLOBAL MASS SPECTROMETRY MARKET BY END USER INDUSTRY, THROUGH 2017 ($ TABLE 56 GLOBAL MASS SPECTROMETRY INSTRUMENT MARKET BY TECHNIQUE, THROUGH 2017 ($ TABLE 57 GLOBAL MASS SPECTROMETRY CONSUMABLE MARKET BY TYPE, THROUGH 2017 ($ BIOCHIP-BASED PROTEOMIC MARKETS 117 TABLE 58 GLOBAL PROTEOMIC BIOCHIP MARKET BY TYPE, THROUGH 2017 ($ TABLE 59 GLOBAL PROTEOMIC ARRAY MARKET BY TYPE, THROUGH 2017 ($ TABLE 60 GLOBAL PROTEOMIC BIOCHIP MARKET BY END USER, THROUGH 2017 ($ TABLE 61 GLOBAL PROTEOMIC ARRAY MARKET BY END USE, THROUGH 2017 ($ TABLE 62 GLOBAL PROTEOMIC LAB-ON-A-CHIP MARKET BY END USE, THROUGH 2017 ($ PROTEOMIC GEOGRAPHIC MARKETS 124 TABLE 63 GLOBAL PROTEOMIC MARKET BY REGION, THROUGH 2017 ($ 124 TABLE 64 GLOBAL PROTEOMIC DIAGNOSTIC MARKET BY REGION, THROUGH 2017 ($ CHAPTER 10 PROTEOMIC PATENTS 127 BIOCHIP PATENTS 127 PROTEIN ARRAY PATENTS 127 TABLE 65 ARRAY-RELATED PROTEOMIC PATENTS BY REGION, LAB-ON-A-CHIP PATENTS 128 TABLE 66 LAB-ON-A-CHIP-RELATED PROTEOMIC PATENTS BY REGION, MASS SPECTROMETRY PATENTS 128 TABLE 67 MASS SPECTROMETRY-RELATED PROTEOMIC PATENTS BY REGION, CHAPTER 11 COMPANY PROFILES 131

6 ABLYNX NV 131 ACTIVIOMICS LTD. 131 ACTIVX BIOSCIENCES INC. 132 ADNEXUS THERAPEUTICS 132 ADVANCED PROTEOME THERAPEUTICS INC. 132 AGILENT TECHNOLOGIES INC. 133 APPLIED PROTEOMICS 134 AYOXXA BIOSYSTEMS GMBH 134 BIODESIX 135 BIOGNOSYS AG 136 BIOPROXIMITY LLC 136 BIO-RAD LABORATORIES INC. 137 BIOSYSTEMS INTERNATIONAL SAS 137 BRUKER CORPORATION 138 CALIBRANT BIOSYSTEMS INC. 138 CAMBRIDGE PROTEIN ARRAYS LTD. 139 CAPRION PROTEOMICS 139 CAPROTEC BIOANALYTICS GMBH 140 CRELUX GMBH 140 CRYSTALGENOMICS INC. 141 DANAHER CORP. 142 DIASSESS 142 DIGILAB INC. 143 DNANO SYSTEMS LLC 143 DURIN TECHNOLOGIES INC. 144 DVS SCIENCES INC. 144 EVOTEC AG 144 GENERAL ELECTRIC CO. 145 GLAXOSMITHKLINE PLC 145 GL SCIENCES INC. 146 GWC TECHNOLOGIES 146 IMMUNOVIA AB 147 IMTAKT CORPORATION 147 INTEGRATED DIAGNOSTICS 148 IRIS INTERNATIONAL INC. 148 LEAP TECHNOLOGIES INC. 149 LIFE TECHNOLOGIES INC. 149 LUMINEX CORPORATION 150 MERCK KGAA 150 MICROLYTIC APS 151 MRM PROTEOMICS INC. 151 MOSAIQUES DIAGNOSTICS AND THERAPEUTICS AG 152 MYRIAD GENETICS INC. 152 NEXTGEN SCIENCES INC. 152 OLINK BIOSCIENCE 153 ONCOPLEX DX 153 OPKO HEALTH INC. 154

7 PERKIN ELMER INC. 154 PFIZER INC. 155 PHENOMENEX 156 PHYLOGICA LTD. 156 PRESSURE BIOSCIENCES INC. 157 PRONOTA NV 157 PROTEA BIOSCIENCES INC. 158 PROTEOME SCIENCES 159 PROTEOMICS INTERNATIONAL PTY LTD 159 PROVISTA DIAGNOSTICS INC. 160 QIAGEN NV 160 QUANTERIX INC. 161 QUEST DIAGNOSTICS INC. 161 REPLIGEN CORPORATION 162 SAMDI TECH INC. 162 SHIMADZU CORPORATION 163 SHISEIDO COMPANY LTD. 163 SHOWA DENKO KK 164 SIGMA ALDRICH 164 SINGULEX INC. 165 SISCAPA ASSAY TECHNOLOGIES 165 SOMALOGIC INC. 165 TABLE 68 SOMALOGIC PROTEOMIC METHODS 166 SPHERE FLUIDICS LTD. 166 SPOTON CLINICAL DIAGNOSTICS LTD. 167 SYNAGEVA BIOPHARMA 167 TALKING20 INC. 168 TABLE 69 PERSONALIZED PROTEOMIC COMPANIES 168 THERANOSTICS HEALTH 169 THERMO FISHER SCIENTIFIC INC. 169 TABLE 70 THERMO FISHER SCIENTIFIC RECENT ACQUISITIONS 170 THORNE DIAGNOSTICS INC. 171 TOSOH CORPORATION 171 UNIVERSAL BIOSENSORS LTD. 171 TABLE 71 UNIVERSAL BIOSENSORS DIAGNOSTIC PIPELINE 171 VERMILLION INC. 172 VIRAL GENETICS INC. 173 WATERS CORP. 173 XENCOR INC. 174 YMC CO. LTD. 174

8 LIST OF TABLES TABLE HEADING SUMMARY TABLE GLOBAL PROTEOMIC MARKET BY END-USE INDUSTRY, THROUGH 2017 ($ TABLE 1 ARRAY VERSUS LOAC BIOCHIPS 11 TABLE 2 SCOPE OF REPORT 12 TABLE 3 GLOBAL PROTEOMIC MARKET BY END-USE INDUSTRY, THROUGH 2017 ($ TABLE 4 GLOBAL PROTEOMIC MARKET BY PLATFORM, THROUGH 2017 ($ 14 TABLE 5 PROTEOMIC INDUSTRY GROWTH DRIVERS 15 TABLE 6 BIOCHIP INDUSTRY COMPARISONS 16 TABLE 7 MASS SPECTROMETER PLATFORMS 25 TABLE 8 BIOCHIP-BASED PROTEOMIC TECHNOLOGIES 25 TABLE 9 PLANAR-BASED VERSUS BEAD-BASED ARRAYS 26 TABLE 10 TECHNICAL ADVANCES IN PROTEOMICS 27 TABLE 11 PROTEOMIC APPLICATIONS IN DRUG DISCOVERY AND DEVELOPMENT 30 TABLE 12 LARGE-SCALE PROTEOMIC INITIATIVES 35 TABLE 13 STRATEGIES FOR OVERCOMING HIGH-ABUNDANCE PROTEINS IN CLINICAL SAMPLES TABLE 14 U.S. INCIDENCE OF SELECTED CANCERS, TABLE 15 STATUS OF ADVANCED BLADDER CANCER DIAGNOSTICS 41 TABLE 16 U.S. ANNUAL BREAST CANCER TREATMENT DECISIONS BY CLASSIFICATION TABLE 17 BREAST CANCER MDX TECHNOLOGY PLATFORMS 45 TABLE 18 STATUS OF ADVANCED BREAST CANCER DIAGNOSTICS 46 TABLE 19 FIVE-YEAR SURVIVAL RATES FOR NON-SMALL-CELL LUNG CANCER (%) 50 TABLE 20 STATUS OF ADVANCED LUNG CANCER DIAGNOSTICS 51 TABLE 21 EARLY SCREENING OVARIAN CANCER TESTS 55 TABLE 22 STATUS OF ADVANCED OVARIAN CANCER DIAGNOSTICS 56 TABLE 23 STATUS OF ADVANCED PROSTATE CANCER DIAGNOSTICS 59 TABLE 24 ALZHEIMER'S DISEASE DIAGNOSTIC APPROACHES 63 TABLE 25 STATUS OF ALZHEIMER'S DISEASE ADVANCED DIAGNOSTIC TESTS 64 TABLE 26 HUMAN LEUKOCYTE ANTIGEN TESTING MARKET 67 TABLE 27 PROTEOMIC INDUSTRY ACQUISITIONS, TABLE 28 STRATEGIC ALLIANCES IN THE PROTEOMIC INDUSTRY, TABLE 29 FIRST-TIER MASS SPECTROMETRY COMPANIES 77 TABLE 30 SECOND-TIER MASS SPECTROMETRY COMPANIES 78 TABLE 31 GLOBAL HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY COLUMN MANUFACTURING COMPANIES TABLE 32 JAPANESE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY COLUMN LEADING MANUFACTURING COMPANIES TABLE 33 GLOBAL PHARMACEUTICAL RESEARCH AND DEVELOPMENT OUTSOURCING ($ BILLIONS) TABLE 34 PROTEOMIC-BASED DRUG DISCOVERY INDUSTRY 83 TABLE 35 KEY PEPTIDE MICROARRAY COMPANIES 85 TABLE 36 KEY ANTIBODY MICROARRAY COMPANIES 86 TABLE 37 CHINESE BIOCHIP INDUSTRY 88 TABLE 38 LAB-ON-A-CHIP COMPETITOR LANDSCAPE 90 TABLE 39 ANTIBODY REAGENT MARKET, 2012 (%) 92 TABLE 40 MULTIPLEX PROTEIN IN VITRO DIAGNOSTIC COMPANIES

9 TABLE HEADING TABLE 41 PROTEOMIC INDUSTRY GROWTH DRIVERS 97 TABLE 42 GLOBAL PROTEOMIC MARKET BY PLATFORM, THROUGH 2017 ($ 98 TABLE 43 GLOBAL PROTEOMIC MARKET BY END-USE INDUSTRY, THROUGH 2017 ($ TABLE 44 GLOBAL PROTEOMIC RESEARCH PRODUCT MARKET BY PLATFORM, THROUGH 2017 ($ TABLE 45 GLOBAL PROTEOMIC RESEARCH MARKET BY BIOCHIP PLATFORM, THROUGH 2017 ($ TABLE 46 GLOBAL PROTEOMIC DRUG DISCOVERY AND DEVELOPMENT PRODUCT MARKET BY PLATFORM, THROUGH 2017 ($ TABLE 47 GLOBAL PROTEOMIC DRUG DISCOVERY AND DEVELOPMENT BIOCHIP MARKET BY PLATFORM, THROUGH 2017 ($ TABLE 48 GLOBAL PROTEOMIC DIAGNOSTIC PRODUCT MARKET BY PLATFORM, THROUGH 2017 ($ TABLE 49 GLOBAL BIOCHIP DIAGNOSTIC MARKET BY TYPE, THROUGH 2017 ($ TABLE 50 GLOBAL PROTEOMIC DIAGNOSTIC PRODUCT MARKET BY DISEASE TYPE, THROUGH 2017 ($ TABLE 51 STATUS OF PROTEOMIC-BASED DIAGNOSTICS FOR CARDIOLOGY, IMMUNE SYSTEM AND NEUROLOGY APPLICATIONS TABLE 52 GLOBAL PROTEOMIC CANCER DIAGNOSTIC PRODUCT MARKET BY INDICATION, THROUGH 2017 ($ TABLE 53 STATUS OF PROTEOMIC-BASED DIAGNOSTICS FOR CANCER APPLICATIONS 111 TABLE 54 GLOBAL MASS SPECTROMETRY MARKET BY PRODUCT TYPE, THROUGH 2017 ($ TABLE 55 GLOBAL MASS SPECTROMETRY MARKET BY END USER INDUSTRY, THROUGH 2017 ($ TABLE 56 GLOBAL MASS SPECTROMETRY INSTRUMENT MARKET BY TECHNIQUE, THROUGH 2017 ($ TABLE 57 GLOBAL MASS SPECTROMETRY CONSUMABLE MARKET BY TYPE, THROUGH 2017 ($ TABLE 58 GLOBAL PROTEOMIC BIOCHIP MARKET BY TYPE, THROUGH 2017 ($ TABLE 59 GLOBAL PROTEOMIC ARRAY MARKET BY TYPE, THROUGH 2017 ($ TABLE 60 GLOBAL PROTEOMIC BIOCHIP MARKET BY END USER, THROUGH 2017 ($ TABLE 61 GLOBAL PROTEOMIC ARRAY MARKET BY END USE, THROUGH 2017 ($ TABLE 62 GLOBAL PROTEOMIC LAB-ON-A-CHIP MARKET BY END USE, THROUGH 2017 ($ TABLE 63 GLOBAL PROTEOMIC MARKET BY REGION, THROUGH 2017 ($ 124 TABLE 64 GLOBAL PROTEOMIC DIAGNOSTIC MARKET BY REGION, THROUGH 2017 ($ TABLE 65 ARRAY-RELATED PROTEOMIC PATENTS BY REGION, TABLE 66 LAB-ON-A-CHIP-RELATED PROTEOMIC PATENTS BY REGION, TABLE 67 MASS SPECTROMETRY-RELATED PROTEOMIC PATENTS BY REGION, TABLE 68 SOMALOGIC PROTEOMIC METHODS 166 TABLE 69 PERSONALIZED PROTEOMIC COMPANIES 168 TABLE 70 THERMO FISHER SCIENTIFIC RECENT ACQUISITIONS

10 TABLE HEADING TABLE 71 UNIVERSAL BIOSENSORS DIAGNOSTIC PIPELINE 171

11 LIST OF FIGURES FIGURE TITLE SUMMARY FIGURE GLOBAL PROTEOMIC MARKET BY END-USE INDUSTRY, THROUGH 2017 ($ FIGURE 1 MASS SPECTROMETRY-BASED PROTEOMIC WORKFLOW 19 FIGURE 2 PROTEOMIC BIOCHIP AND ARRAY FORMATS 21 FIGURE 3 CHROMATOGRAPHY RESINS IN MS WORKFLOW 79 7