The Direction of Thermo Fisher Scientific

Transcription

1 The Direction of Thermo Fisher Scientific Iain Mylchreest Ph.D, VP GM Life Sciences MS Thermo Scientific Mass Spectrometry Users Meeting Indianapolis September 22 th, 2011

2 The World Leader in Serving Science We are the leading provider of analytical instruments, equipment, reagents and consumables, software and service for research, analysis, discovery and specialty diagnostics Scale Nearly $11 billion in revenues 37,000 employees in 40 countries 350,000 customers in 150 countries #227 on Fortune 500 Depth of Capabilities Innovative technologies Applications expertise Laboratory productivity partner Leading Brands 2

3 Enabling Our Customers to Make the World Healthier Cleaner Safer 3

4 Markets, Products and Global Presence Attractive End Markets Complete Portfolio Global Reach Healthcare & Diagnostics 24% Industrial & Applied 26% Pharma & Biotech 24% Academic & Government 26% Services 15% Instruments, Equipment & Software 33% Consumables 52% APAC 12% Europe 24% ROW 4% North America 60% 4 NOTE: Based on 2010 full year revenues.

5 Six Complementary Growth Areas Analytical Instruments $2.3B Specialty Diagnostics $1.5B Biosciences $0.8B Laboratory Products $1.9B Customer Channels $4.5B Biopharma Services $0.7B Provides many opportunities for connections projects to enhance customer solutions NOTE: Revenue amounts for full year 2010 before inter-company eliminations 5

6 Continuing to Invest in Many Opportunities New Technologies Q Exactive GP1 & 3 Centrifuge with Carbon Fiber Rotors Automated IR and Raman Microscopes Commercial Capabilities fishersci.com Beijing Demo Lab thermoscientific.com Complementary Acquisitions Ahura Scientific (Portable Raman) Fermentas, Finnzymes (qpcr) TREK Diagnostic Systems (Microbiology) Solaris qpcr and protein expression consumables Food Safety Response Center Phadia Dionex (Allergy/Autoimmunity) (Chromatography) 6

7 Solving the Toughest Analytical Challenges Laboratory Line Field In research and analysis Advanced analytical instrument technologies Solutions to improve laboratory productivity In healthcare and clinical laboratories Diagnostic kits, reagents and consumables Clinical trial support and total supply chain management In manufacturing and the field Safety-related products and personal protection Environmental and process instruments World-class analytical technologies and the most complete portfolio of laboratory products and services 7

8 Applications of Mass Spectrometry LIFE SCIENCES EARTH & CLIMATE SCIENCES Large Organic Molecules Small Organic Molecules Trace Inorganic Molecules Stable Isotope Ratio Analysis Thermal Ionization Analysis Protein structure and sequence Biomarker discovery PTM analysis Signal transduction Drug discovery & development Metabolism Forensics Food safety Clinical Metabolomics Environmental Food safety Biomedical Semiconductor Energy Environmental Forensics Geochemistry Ecology & metabolic study Food authenticity Geology Climatology Geochronology Nuclear fuel Nuclear safety LSMS, San Jose and Bremen LC-MS & GC-MS, San Jose, Bremen, & Austin ICP-MS & HR- ICP-MS, Bremen IRMS Bremen TIMS Bremen 8

9 Increasing App s in Life Sciences Research and Applied Markets Proteomics Biomarker discovery Pathway analysis Protein identification Metabolite ID/Profiling Accelerated drug development and compound assessment BioPharma Biologics discovery and development Expanding Application Base Environmental Water, soil analysis Metabolomics Comprehensive study of metabolites for disease and therapeutic assessment Food Safety Inspection, nutrition Chemical contaminant, microbial detection Clinical/Toxicology Disease markers Pain management Drugs of abuse 9

10 Instrumentation Development Cycle Cool Research Tools with the Highest Performance Routine Qualitative & Quantitative Applications and Workflows Technology Moving to Portable & Point of Use & Personal Technology Moving to Diagnostics and Feed Back to the Research Lab Cool Research Tools: - e.g. High performance LC MS n for protein analysis (Orbitrap Elite) Routine Applications: - e.g. High performance LC MS/MS for small molecule analysis (Q Exactive) New Lab Techniques Clinical Research Diagnostics: - e.g. MS/MS in the clinic (clinical chemistry; anatomical pathology; microbiology) Portable instruments: - e.g. Point of use portable/personal instruments (XRF; Raman; FTIR; MS?) 10

11 Continually Extending MS Technology Dallas Proof-of-the-principle for the Orbitrap mass analyzer Chicago Orbitrap with external accumulation developed LTQ launch Denver Exactive benchtop LC-Orbitrap launch Denver Orbitrap Velos Pro Orbitrap Elite Q Exactive Long Beach Resolving power >100,000 demonstrated on concept instrument San Antonio First Commercial LTQ Orbitrap launch Philadelphia LTQ Orbitrap Velos Original 1999 Orbitrap patent US 5,886,346 ASMS 2011: The biggest launches in Orbitrap history 11

12 The Industry s Leading Portfolio of MS Solutions Non-targeted Analysis ESI-Orbitraps High Resolution Accurate Mass Fast Scanning Hybrid Orbitraps Quantitative Proteomics Metabolomics Bioanalysis Clinical / Toxicology Environmental Food Safety Applied Markets Research Qualitative Proteomics Biomarker Discovery Metabolism Metabolomics Lipididomics PTM Analysis Fast Scanning MS and MSn Triple Quads Targeted Analysis Ion Traps 12

13 Strengthening Our Leading Position in Mass Spectrometry June 2011 ASMS Launches Revolutionary Q Exactive The Quanfirmation Instrument Extending Ion Trap Leadership: Velos Pro OT Elite Quantum Leap in Orbitrap Performance Metabolite profiling, peptide sequencing, toxicology Sensitivity equal to high performance triple quads Identify, quantify and confirm in one analysis 13 Metabolite ID, peptide sequencing Fastest and most sensitive ion trap on market Ideal hybrid front-end New fragmentation capability Diverse Technology Introductions Proteomics, detailed structural analysis, Top Down High field Orbitrap most significant advance since first Orbitrap Resolution and scan speed 4X current Orbitrap

14 Driving Progress in Integrated Workflows Sample Preparation Sample Introduction Data Analysis & Interpretation, Distributed informatics Proteomics Drug Discovery/DMPK Water Testing Clinical testing Food safety Metabolomics. MS Analysis Leveraging total company capabilities and expertise 14

15 New Software Tools to Support Workflows Exactfinder 1.0 Integrated HR/AM qual/quan workflow analysis Targeted and non targeted screening MetQuest 1.0 For HR/AM qual/quan metabolic screening Unbiased full-scan data reveals unexpected metabolites Tracefinder 1.1 Automate environmental, food safety & clinical workflows Supports Triple Quad, Ion Trap and Exactive experiments Xcalibur 2.1 Core software control for all Thermo Scientific MS systems Now supports TLX/multiplexing and Turboflow automation New leading edge software for challenging MS workflows 15

16 New Proteomics Tools Proteome Discoverer 1.3 Comprehensive mass informatics platform for data mining Integrate biological information from multiple sources Seive 2.0 For label-free, semiquantitative, differential expression Expanded to support metabolomic & lipodomic workflows Pinpoint 1.2 Enhances speed and confidence in targeted quantitation. Supports multiple experimental approaches including HRAM Thermo Scientific Pierce Enrichment Kits Enrich, capture and identify proteins, peptides, kinases Peptide Calibration kits and libraries, ActivX kinase probes Easy-nLC 1000 Split-free, nano-flow LC optimized for biomolecule separation Effortless ultra high pressure operation (1000 bar, 15,000 psi) Leading edge tools for proteomics research 16

17 Novel MS Technologies: Applicatios Growth Drivers Advances in Hardware, Software and Reagents Move Applications to Higher Throughput Structural accuracy at high sensitivity results in complete protein sequence determination including PTMs High sensitivity, accuracy, precision multiple protein quantitation in biological media High sensitivity, accuracy, precision multiple protein quantitation in biological media many experiments in one run Qualitative Quantitative Quantitative /Multiplexed Hardware Hardware Hardware Software Software Software Reagents Reagents Reagents Technology improves applications growth follows 17

18 Summary Dionex acquisition: comprehensive HPLC portfolio complements leading MS technologies Velos Pro Ion Trap: leadership extended with high speed quantitative capabilities High field Orbitrap Elite: with >240,000 resolution, the most significant advancement since first Orbitrap Q Exactive: Revolutionary Quanfirmation: screen, identify, confirm and quantify in one run Workflow based software: comprehensive new suites for all applications 18