Curriculum Vitae. Role: Principal Investigator

Transcription

1 Curriculum Vitae Guimin Gao Contact Information Section on Statistical Genetics Department of Biostatistics 327 Ryals Public Health Building 1665 University Boulevard The University of Alabama at Birmingham (UAB) Birmingham AL Phone: Fax: Education and Postdoctoral Training 01/ /2005, Postdoctoral Research Associate (in Statistical Genetics and Bioinformatics), Virginia Bioinformatics Institute and Department of Statistics, Virginia Tech, VA. 01/ /2001, Postdoctoral Research Fellow (in Statistical Genetics) Osteoporosis Research Center, Creighton University, NE. 07/2000, Ph.D. in Biostatistics, Sun Yat-sen University of Medical Sciences, Guangzhou, China. 07/1990, M.S. in Applied Mathematics, the Chinese Academy of Sciences, Beijing; graduated from Department of Mathematics at Hubei University, Wuhan, China. Positions 08/ Present: Research Assistant Professor Section on Statistical Genetics, Department of Biostatistics, University of Alabama at Birmingham School of Public Health. 07/ /2000: Assistant Professor Department of Health Statistics, Sun Yat-sen University of Medical Sciences, China. 07/ /1997: Lecturer Department of Mathematics, Hubei Medical University, China. Research Grants NIH R01 GM A2 (Gao) Period Covered: 06/01/07 05/31/2012 Title: Haplotyping and QTL Mapping in Pedigrees with Missing Data Total Award Amount: $900,000 (direct cost) Role: Principal Investigator NIH R01GM (Allison) Period Covered: 09/01/07-08/31/11 Title: Genome-wide Structured Association Testing & Regional Admixture Mapping Total Award Amount: $1,113,898 Role: Co-Investigator 1

2 NIH R01GM (Liu) Period Covered: 04/01/08-03/31/13 Title: Genome Wide Haplotype Association Analysis Total Award Amount: $800,000 Role: Co-Investigator Research Interests Application of statistical methods and development of computer programs to identify genetic variants that influence complex diseases and quantitative traits Joint linkage and linkage disequilibrium mapping of Quantitative trait loci (QTL) and disease genes using pedigree (family) data Admixture mapping Weighted multiple hypothesis testing in genome-wide association studies Copy number variation analysis Research Experience (Topics) Present: Developing an admixture mapping method and apply the method to the analysis of an African American dataset. Developing weighted multiple hypothesis testing methods for genome-wide association studies, calculating weights for association tests by using prior information (such as Hardy-Weinberg disequilibrium), and applying these methods to the analysis of a Rheumatoid Arthritis dataset. Developing methods of haplotyping and identity-by-descent (IBD) probability calculation for large complex pedigrees; applying these methods to identifying genes that influence complex diseases and traits in a 1623-person Hutterite pedigree. Identifying genetic and environmental determinants of triglycerides- the genetic analysis of lipid lowering drugs and diet network (GOLDN) study. Detecting epistatic interactions contributing to human gene expression using CEPH family data : Estimating deleterious-mutation parameters for outcrossing populations and selfing populations : Developing probability models and Bayesian analysis method for Capture-recapture Data via Markov chain Monte Carlo simulation; applying these methods to the estimation of the number of cancer incidence cases. Computer Skills Operating Systems: Unix, Dos, and Windows. Languages: C/C++, and Fortran. Software: ASReml, Loki, SimWalk2, Merlin, SAS, SPSS, and MATLAB Software Development 2002-Present: developing a computer software program for haplotyping and IBD matrix calculation in large complex pedigrees. 2

3 Publications (peer-reviewed) 1. Kang G., Ye K., Liu L., Allison D.B., Gao G. (2009) Weighted multiple hypothesis testing procedures. Statistical Applications in Genetics and Molecular Biology. Vol. 8 : Iss. 1, Article 23.* *Most Popular Papers (6/12/09-8/7/09) in the journal (* Based on the average number of full-text downloads per day since the paper was posted, *The 10 Most Popular Articles in Collection of Biostatistics Research Archive (COBRA) on May 27, Kang G., Childers D., Liu L., Zhang K., Gao G. (2009) Application of multiple testing methods for correlated tests to genome-wide association studies. BMC Proceedings. (Accepted) 3. Childers D, Kang G, Liu L, Gao G, Zhang K. (2009) Application of imputation methods for the analysis of genome-wide association studies. BMC Proceedings. (Accepted) 4. Liu Y.J., Ordovas J.M., Gao G., Zhang K., Borecki I., Province, M., Tsai, M., Hixson, J.E., Allison, D.B., Arnett, D. K. (2009) Pharmacogenetic Association of the APOA1/C3/A4/A5 Gene Cluster and Lipid Responses to Fenofibrate - The Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) Study. Pharmacogenetics and Genomics. (In press). 5. Gao G., Allison D.B., Hoeschele I. (2009) Haplotyping methods for pedigrees. Hum. Hered. 67: * *Top 10 articles June 2009 in the journal of Hum Hered. 6. Gao G., Wan W., Zhang S., Redden D., Allison D.B. (2008) Testing for differences in distribution tails to test for differences in maximum lifespan. BMC Medical Research Methodology 8:49 (1-10). 7. Liu Y.J, Ordovas, J.M., Gao G., Zhang K., Borecki I., Province M., Tsai M., Hixson J.E., Allison D.B., Arnett D. K. (2008) The SCARB1 gene is associated with lipid response to dietary and pharmacological interventions. J Hum Genet 53: Gao G., Hoeschele I. (2008) A rapid conditional enumeration haplotyping method in pedigrees. Genet. Sel. Evol. 40: Li H., Gao G., Li J., Page G., Zhang K. (2007) Detecting epistatic interactions contributing to human gene expression using the CEPH family data. BMC Proceedings 1 (Suppl 1):S Yoo Y.J., Gao G., Zhang K. (2007) Case-control association analysis of rheumatoid arthritis with candidate genes using related cases. BMC Proceedings 1 (Suppl 1):S Gao G., Hoeschele I. (2005). Approximating identity-by-descent matrices using multiple haplotype configurations on pedigrees. Genetics 171: Gao G., Hoeschele I., Sorensen P., Du. F.X. (2004) Conditional probability methods for haplotyping in pedigrees. Genetics 167: Deng H.W., Gao G., Li J. L. (2002) Estimation of deleterious genomic mutation parameters in natural populations by accounting for variable mutation effects across loci. Genetics 162: Li J. L., Deng H. L., Lai D. B., Xu F. H., Chen J., Gao G. Recker R. R., Deng.H.W. (2001). Toward high-throughput genotyping: dynamic and automatic software for manipulating large-scale genotype data using fluorescently labeled dinucleotide Markers. Genome Research 11,

4 15. Gao G., Fang J. Q. (2001). Stratified capture-recapture methodology in the estimation on the number of cancer incidence cases. Chinese Journal of Epidemiology (Chinese) 22, Gao G., Fang J. Q. (2000). Applications of log-linear Models for Capture-recapture to the estimation of the number of infant death. Journal of mathematical medicine (Chinese) 13, Presentations: A note on conditional haplotyping methods in pedigrees. Second RECOMB Satellite Workshop on Computational Methods for SNPs and Haplotypes, Feb , 2004, Pittsburgh, PA. Haplotyping methods for pedigrees. Twelfth International Conference on Statistics, Combinatorics, Mathematics and Applications. Dec. 2-4, 2005, Auburn, AL. Identity-by-descent matrix calculation methods for QTL mapping in pedigrees. Statistical Genetics Meeting, April 25, 2006, UT M. D. Anderson Cancer Center, Houston TX. Application of multiple testing methods to genome-wide association studies in RA data. Genetic Analysis Workshop 16, Sept , 2008, St. Louis, MO. Professional Service Reviewer for: Genetics; PLoS Genetics; Behavior Genetics; Human Molecular Genetics; Human Heredity; The Journal of Clinical Endocrinology & Metabolism; BMC Genetics; BMC Medical Genetics; Genetics Selection Evolution; Bioinformatics; Biometrics; Computational Statistics and Data Analysis; Human Genetics Grant reviewer for: NIDDK, 2008 NHLBI, 2009 Leader of the journal club in Section on Statistical Genetics in the Department of Biostatistics at UAB (9/2005 Present). Teaching Experience 7/07 - Present: Mentor for postdoctoral fellow, Guolian Kang (at UAB). 9/06 - Present: Co-mentor for postdoctoral fellow, Mary Wojczynski (at UAB). 9/05-8/06: Co-mentor for a postdoctoral fellow, Yongjun Liu (at UAB). Yongjun is now an assistant professor at the University of Missouri-Kansas City. 2008: Lecturer for Statistics in Pharmacogenetics (for graduate students at UAB) 2005: Lecturer for Statistical Genetics (for graduate students at Virginia Tech) : Instructor for more than 15 courses for undergraduate and graduate students (in China). Memberships The International Genetic Epidemiology Society (IGES) The American Society of Human Genetics (ASHG) 4

5 Continuing Education Advanced Gene Mapping/ Linkage Course (scholarship offered by the Rockefeller University, 2003, New York). The Summer Institute in Statistical Genetics at the North Carolina State University with following modules: 1) Quantitative Trait Locus mapping II, 2) Markov Chain Monte Carlo for Geneticists, 3) Association Mapping, 4) Microarray Analysis, 5) Advanced Pedigree MCMC, and 5) Coalescent in genetics. ( ) Short Course on Mathematical Approaches to the Analysis of Complex Phenotypes (the Jackson Laboratory, 2004). Statistical Genetics Short Course featuring Mendel (UCLA Department of Human Genetics, 2006) The Twentieth International Workshop on Methodology of Twin and Family Studies: the advanced course (Institute for Behavioral Genetics, University of Colorado, 2007) Short Course in FBAT/PBAT (Harvard School of Public Health, 2007) Award The third place for faculty members poster presentation in the school of Public Heath Research Day, University of Alabama at Birmingham. 5