FRAUNHOFER INSTITUTE FOR INTERFACIAL ENGINEERING AND BIOTECHNOLOGY IGB FRAUNHOFER IGB INNOVATION THROUGH INTERFACES

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1 FRAUNHOFER INSTITUTE FOR INTERFACIAL ENGINEERING AND BIOTECHNOLOGY IGB FRAUNHOFER IGB INNOVATION THROUGH INTERFACES 2

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3 RESEARCH THAT CAN BE PUT INTO PRACTICE The Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB is one of 66 institutes and research units of the Fraunhofer-Gesellschaft. With its clearly defined mission of applicated research and its focus on key technologies of relevance to the future, the Fraunhofer-Gesellschaft plays a prominent role in the German and European innovation process. Through their research and development work, the Fraunhofer Institutes help to reinforce the competitive strength of the economy by promoting innovation, strengthening the technological base, improving the acceptance of new technologies, and training the future generation of scientists and engineers. Numerous projects and patents are the result of our successful work. Application-oriented and interdisciplinary Competences Our overriding goal is the translation of scientific and engineering research results into economically efficient and sustainable processes and products. Our strength lies in offering complete solutions from laboratory scale to pilot plant. The success of new products and processes is dependent on interdisciplinary and constructive cooperation between science and engineering. Experts in the fields of chemistry, physics, biology and engineering work effectively together at the Fraunhofer IGB and the Institute of Interfacial Process Engineering and Plasma Technology IGVP, our partner institute at the University of Stuttgart. Customers benefit from the synergies and multidisciplinary potential at our institute, which facilitate novel approaches and innovative solutions in areas such as medical engineering, nanotechnology, industrial biotechnology and environmental technology. Departments in Stuttgart Interfacial Engineering and Materials Science Molecular Biotechnology Physical Process Technology Environmental Biotechnology and Bioprocess Engineering Cell and Tissue Engineering Branches of the institute Fraunhofer Center for Chemical-Biotechnological Processes CBP, Leuna Bio, Electro and Chemocatalysis BioCat, Straubing branch Translational Center Regenerative Therapies for Oncology and Musculoskeletal Diseases, Würzburg branch Guiding principles: mission statement and vision 1 View from the university campus in Vaihingen on the institute buildings. At the Fraunhofer IGB we carry out application-oriented research according to the principles of good scientific practice and on the basis of our competences and guiding principles in the areas of medicine, pharmacy, chemistry, the environment and energy. Through our innovation, we contribute to a sustainable development of the economy, society and the environment. EVER BETTER TOGETHER. 4

4 Promoting young talent Research for a sustainable economy The Fraunhofer-Gesellschaft is interested in encouraging the researchers of tomorrow by introducing them to the exciting world of science and the research opportunities of the future. Thus, the Fraunhofer IGB is active in both promoting young talent and encouraging young students interest in research and technology. We do this through events at the Fraunhofer campus in Stuttgart, e.g. Girls Day, University Science Day, Fraunhofer Talent School, as well as exhibits at various exhibitions to introduce students to the fascinating world of science. Checkpoint Future is a platform for students who want information about a future at Fraunhofer. In addition, it s important for us to support the education of office administrators, lab technicians and IT specialists. History The roots of the Fraunhofer IGB go back to 1953, when the small research lab for interfacial physics and chemistry was founded on private initiative in the Palatinate region (southwest Germany). Integrated into the Fraunhofer-Gesellschaft in 1962, the institute moved to Stuttgart in In 1976 the institute was named Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB. In late 2007, Prof. Thomas Hirth became the director of the Fraunhofer IGB and focused strategy on the needs-oriented business areas of medicine, pharmacy, chemistry, the environment and energy. The securing of the supply of water, raw materials and energy, as well as finding solutions for disease, are the big global challenges we face in the 21 st century. Unrelenting population growth, escalating consumption of resources and increased global warming mean that the development and implementation of sustainable processes and products is becoming ever more significant. We want to contribute to solving these challenges through our research and development, which can significantly contribute to future growth at a fraction of the current consumption of resources and of associated emissions. Therefore our actions are oriented on the principle of sustainability, a concept which meets the needs of current generations without jeopardizing the options of future generations to satisfy their own needs. Central research priorities at our institute are the enhancement of resource efficiency by recycling and reuse of secondary raw materials, the sustainable use of residual and waste materials and biobased raw materials, the development of efficient value chains and processes, whose energy demand can be supplied by renewable energy and waste heat, as well as the development of innovative water treatment processes and water management systems. The Fraunhofer-Gesellschaft supports efforts directed toward the sustainable development of society, industry and the environment. The Fraunhofer Institutes play an active part in such efforts through a responsible approach to the implementation of new technologies and through research and studies conducted on behalf of public-sector clients. Excerpt from mission statement of the Fraunhofer- Gesellschaft 5

5 NETWORKING ACTIVITIES The Fraunhofer IGB is an active participant in numerous national and international research networks. Cooperative ventures with various universities and non-university research institutes, as well as interdisciplinary collaboration with other Fraunhofer Institutes, complement our own competences and enable us to exploit synergies in developing new solutions for the needs of industry. We are also actively engaged in shaping research policy through championing strategic, economic and sustainability standpoints. Cooperation with universities the basis for contract research Basic research is a must for the applications of tomorrow. Thus, the Fraunhofer IGB maintains close contacts with neighboring universities in Stuttgart, Tübingen, Hohenheim und Reutlingen both through scientific cooperation and through the professorial and other teaching commitments of Fraunhofer employees. Our branches have enabled us to extend our scientific network to the university locations Halle- Wittenberg, München and Würzburg. The Institute of Interfacial Process Engineering and Plasma Technology IGVP As an example for networking with universities the Fraunhofer IGB is particularly closely allied to the Institute of Interfacial Process Engineering and Plasma Technology IGVP at the University of Stuttgart, which is headed by Fraunhofer IGB director Prof. Thomas Hirth. This enables the pursuit of research and development projects from the basic research to application. This integrated approach is also reflected in the variety of research funding sources, including the Land Baden-Württemberg, different foundations, various Federal Ministries, the EU, and industry. Fraunhofer Network Value Through its memberships in the Fraunhofer Life Sciences and MATERIALS groups as well as eight Fraunhofer alliances, the Fraunhofer IGB is firmly rooted in the Fraunhofer-Gesellschaft. Thus, we foster interdisciplinary know-how and supply the breeding ground for innovation. Fraunhofer Group for Life Sciences Fraunhofer Group for Materials and Components MATERIALS (associated institute) Fraunhofer Building Innovation Alliance Fraunhofer Big Data Alliance Fraunhofer Energy Alliance Fraunhofer Food Chain Management Alliance Fraunhofer Nanotechnology Alliance Fraunhofer Photocatalysis Alliance Fraunhofer Polymer Surfaces Alliance POLO Fraunhofer Cleaning Technology Alliance Fraunhofer Water Systems Alliance (SysWasser) Fraunhofer Sustainability Network For further information on our networking activities please visit: 6

6 SERVICES AND INFRASTRUCTURE Our contract R&D services range from natural sciences and engineering basic research to the development of new applications in laboratory, technical, and pilot plant scale; including the design, construction, and testing of pilot plants. We also offer patent and market surveys, feasibility studies and comprehensive consultancy in our areas of expertise as well as analysis and testing. Furthermore, we provide seminars and workshops for executives. R&D services spectrum Analytical services offer The Fraunhofer IGB has modern laboratories and technical plants equipped with the latest technology. Our clients are companies of the industrial sectors biotechnology, pharmacy, medicine and medical engineering, food, chemistry, metal processing, environment engineering, and plant engineering, as well as the public sector. Market and technology surveys Feasibility studies Development of processes, technologies and products Optimization of existing technologies and processes Testing of developed processes and plants on site (prototypes, pilot and demonstration plants) Information on suitable funding opportunities (i.e. EU) and partnerships A broad spectrum of analytic services supports our research and development work within projects or by contract: Physicochemical analytics High-resolution 400 MHz NMR analytics Surface and particle analytics Microbial evaluation of surfaces and media Biochemical and molecular biological analytics Cell biology analysis Testing of cell-material interactions (e.g. biocompatibility) Cooperation models The Fraunhofer IGB offers its customers complete solutions from market analysis and research to ready for use development. Whether single orders, complex large-scale projects or a strategic partnership there are no limits for cooperating with the Fraunhofer IGB. Partners benefit from the excellent networking of Fraunhofer scientists. 7

7 Quality through accredited analytical services Our standards: GLP and GMP Our quality management systems ensures that the requirements in our reference laboratories are in accordance with legal regulations as well as with the standard DIN EN ISO / IEC The accreditation of selected testing laboratories and processes in our analytics guarantees that our proprietary, inhouse test methods and procedures are sufficiently validated and that the quality of our tests is assured even where no standardized methods are available. The following analytical methods and test procedures are accredited according to DIN EN ISO / IEC 17025: High-performance liquid chromatography (HPLC) Ion chromatography (IC) Gas chromatography (GC, GC / MS) Atomic emission spectrometry (ICP-OES) Electron spectroscopy for chemical analysis (ESCA / XPS) In-vitro cytotoxicity testing of medical devices In-vitro phototoxicity testing of solutions and substances A quality assurance system ensures that legal requirements of Good Laboratory Practice (GLP) and Good Manufacturing Practice (GMP) are met. Our GLP test facility with the Area of Expertise 9 ( Cell-based test systems for the determination of biological parameters ) is used for investigating different biological parameters of samples / substances using cell-based assays, e.g. biological activity, immunogenicity, screening for TLR agonists / antagonists, detection of pyrogenic or microbial residues. The manufacturing of medical devices, investigational medicinal products (IMPs) and cell-based and tissue engineering products (ATMPs) for clinical trials requires processes according to Good Manufacturing Practice (GMP). We develop GMPcompliant manufacturing processes in our 215 m 2 certified GMP unit in Stuttgart also for collaborative development with partners from industry. We perform tests for in-vitro cytotoxicity of medical devices according to DIN EN ISO using cell lines. With our in-house method in-vitro phototoxicity testing we analyze solutions and substances regarding their phototoxic potential, using our three-dimensional skin model. This testing method is based on the OECD Guideline 432 and the INVITTOX Protocol no For detailed information on our analytical services offer, please visit: 8

8 BUSINESS AREAS Strategically, the Fraunhofer IGB is focused on the five needs-oriented business areas medicine, pharmacy, chemistry, environment and energy with an emphasis on the fields presented below. We develop solutions for the great challenges of the 21 st century such as combating disease as well as securing the supply of water, foodstock, raw materials and energy from regenerative i.e. renewable resources. Our aim is to develop sustainable, market-oriented technologies for the industries addressed by our business areas for the benefit of society and for strengthening of the high-tech location of Germany. Medicine Pharmacy Regenerative medicine Diagnostics Medical engineering Drug screening and validation Development and production of pharmaceutical substances Formulation 9

9 A major strength of the Fraunhofer IGB is the collaboration of technology-oriented competences across the boundaries of its departments and branches. Thus, core competencies organized in departments and branches make a relevant contribution for at least three of the five strategic business areas. Through this synergistic networking, the innovation potential is increased by a multiple, for example when materials science aspects are to be linked with cell-biological or microbiological issues. The strategic and technological solutions in the individual business areas are described in detail in our business area brochures. Chemistry Environment Energy Biobased chemicals and materials Functional surfaces and materials Process intensification and -integration Improvement of resource efficiency Recovery of raw materials Water treatment Sustainable energy conversion Energy-efficiency through process optimization Energy storage 10

10 COMPETENCES Interfacial Engineering and Materials Science Contact Material surface requirements are often very different from the properties intrinsic to the bulk of the material concerned. For many applications, the material surface is of crucial importance, for example in medical engineering or adsorber materials. We offer a variety of processes for film deposition from either the gas or liquid phase. We also develop material systems with large surface areas such as particles, porous membranes, non-woven materials and foams. For the monitoring of processes (process diagnostics) and the characterization of the generated material surfaces, a multitude of analytical tools are available. Technology and expertise Deposition of thin monolayers or multiple films from the gas phase (e.g. plasma) Generation of functional nanoparticles using polymerization methods or spray drying Production of separation membranes by phase inversion process Synthesis of biocompatible polymers, chemical modification of biomolecules, development of bio-inks and bioprinting Determination of interfacial energy, -topography, -adsorption and chemical composition of surfaces Dr. Christian Oehr Head of Department Phone christian.oehr@igb.fraunhofer.de Research focus Functional coatings of polymer, metal and ceramic surfaces: barrier coatings, coatings for reduced friction, minimized interfacial energy for improved empty behavior or reduced ice adhesion, photocatalytic and antimicrobial modifications, control of cell adhesion and hemocompatibility Drug delivery coatings and particles Modification of fibers Plasma cleaning and sterilization processes Membranes for gas separation, pressure-retarded osmosis (PRO), PEM fuel cells and membrane reactors Separation of substances via core-shell particles Biofunctionalization of surfaces 11

11 Molecular Biotechnology Contact The biologization of industrial society is one of the most important issues of this century. Due to the possibilities of new sequencing technologies, proteomics and the targeted modification of organisms as well as of cell-free biosynthesis, new ways for the production of fine and bulk chemicals as well as for the development of therapeutics can be followed. We apply these new technologies for the development of diagnostics in infection research and in personalized medicine as well as in the development of antimicrobial drugs. Furthermore, we optimize microorganisms and cell lines, in order to use them for the production of chemicals or proteins. Technology and expertise Universal microarray platform Gene expression analyses and genome sequencing via Next-Generation Sequencing Quantitative proteomics using high-resolution MS techniques Protein purification and -characterization Productions strains and cell lines for pharmacy and chemistry Cell-based assays, e.g. antiviral assays (GLP) Strain- and enzyme screening Development of bioprocesses and fermentation processes Chemical-physical and biochemical analysis Prof. Dr. Steffen Rupp Head of Department Phone Research focus Diagnostic microarrays Biosensors Cell-based assays and infection models for target- and drug screening Identification of ncrna-based biomarkers Production cell lines for pharmaceutical proteins High-throughput enzyme assays and enzyme screening Fermentation processes for industrial biotechnology (dicarboxylic acids, biosurfactants, epoxides) Upstream processing of raw materials in industrial biotechnology Cell-free protein synthesis 12

12 COMPETENCES Physical Process Technology Contact The Department is involved in developing processes and process components based on physical and physical chemical principles. Tasks include among other things, the treatment of drinking water and industrial process water or the storage of heat as well as integrated treatment, processing, and recycling processes in industrial production. A hallmark of our R&D activities is improving economical efficiency and sustainability at the same time by minimizing material consumption, recovery of high-value substances and energy saving. Technology and expertise Thermal process technology Advanced oxidation processes (AOP) by electrolytic and photolytic (UV) processes for water treatment Electrophysical separation of materials Generation of defined high-frequency electromagnetic fields with specifically designed antennas Stabilization of liquid food and downstream products Numeric simulation and theoretical modeling Design and system integration into industrial applications Dipl.-Ing. Siegfried Egner Head of Department Phone siegfried.egner@igb.fraunhofer.de Research focus Heat storage using thermochemical processes for temporally and spatially decoupled use of waste heat or solar thermal heat Use of sorption systems to remove moisture from gases, in particular from air to provide water Drying in a superheated steam atmosphere with integrated recovery of volatile materials Recycling of inorganic nutrients for the production of fertilizers on demand and of organic residues to soil improving substrates Electrolytic and photolytic oxidation processes for rawand process water treatment Gentle pasteurization and sterilization of liquid foods using microwaves or pressure change technology 13

13 Environmental Biotechnology and Bioprocess Engineering The core areas of the Department are the development of (bio)engineering processes in the fields of water management, bioenergy, environmental technology, algal technology, product recovery from organic raw / waste materials and interfacial biology. Maximum efficiency is achieved through the integration of several steps to establish short process chains. Based on these processes, new approaches to the development of system concepts for energy, waste and water management in industry and for communities are followed. Technology and expertise Isolation and downstream processing of bioproducts (membrane-based filtration processes, liquid-liquid extraction, extraction with supercritical CO 2 ) Bioreactors in laboratory, pilot and technical scale Analysis of substrates and fermentation products, protein analysis, real-time mass spectrometry Demonstration plants for waste water treatment, high-load digestion, bioenergy, algal technology Equipment for handling pathogenic microorganisms Apparatuses for testing antimicrobially finished materials Process simulation and automation (MATLAB, Siemens) Contact Dr.-Ing. Ursula Schließmann Head of Department Phone ursula.schliessmann@igb.fraunhofer.de Research focus Aerobic and anaerobic wastewater purification and water processing methods for industry and communities Concepts for resource-conserving production in companies the ultraefficient factory Digestion processes for producing biogas from a wide range of organic substrates in different temperature ranges Dietary supplements and lipids as energy feedstock from microalgae and cyanobacteria Biotransformation of organic raw and industrial waste materials into basic chemicals, use of biogas as a raw material Real-time monitoring of water using biosensors Evaluation of microbial contaminations Bioleaching, biosorption and bioprecipitation processes for recovery of valuable substances from residues 14

14 COMPETENCES Cell and Tissue Engineering Contact The department creates biomedical solutions using principles from tissue engineering and regenerative medicine. The focus is on the development and testing of biomaterials, bioreactors, and 2D / 3D in-vitro tissue models from isolated primary human cells and induced pluripotent stem cells under GLP (Good Laboratory Practice) or GMP (Good Manufacturing Practice) guidelines for applications in regenerative medicine, tissue engineering, medical device development and cellbased assays for toxicology. Technology and expertise Tissue-specific human primary cell isolation Adult, embryonic and induced-pluripotent stem cells and cell therapy Patented 3D human skin equivalent In-vitro cytotoxicity studies of medical devices (DIN ISO ) Accredited phototoxicity testing Development and modification of biomaterials and bioreactors GMP manufacturing of clinical biologics Non-invasive characterization of cells and tissues Prof. Dr. Katja Schenke-Layland Head of Department Phone katja.schenke-layland@ igb.fraunhofer.de Prof. Dr. Petra Kluger Head of Department Phone petra.kluger@igb.fraunhofer.de Research focus Cardiovascular tissue engineering, bioreactor development Design and modification of biocompatible hybrid materials as substrates Cell-material interaction and biomaterial development (electrospinning, hydrogels) Click chemistry for the coupling of extracellular matrix proteins to surfaces 15

15 Fraunhofer Center for Chemical-Biotechnological Processes CBP The Fraunhofer CBP in Leuna closes the gap between the lab and industrial implementation: By making infrastructure and plants (pilot scale and miniplants) available, the center makes it possible for cooperation partners from research and industry to develop and scale up biotechnological and chemical processes for the utilization of renewable raw materials right up to industrial scale. Technology and expertise The CBP provides modularly usable process capacities of up to 10 m 3 for biotechnological and chemical reactions, as well as a wide range of treatment, purification and reconditioning techniques and methods. This flexibly applicable biorefinery concept facilitates the conversion of raw materials such as vegetable oils, cellulose, lignocellulose, starch and sugar into chemical products. Research focus Pulping of lignocellulose, separation and use of its components to make further products Development of processes to obtain new technical enzymes Contact Fraunhofer Center for Chemical-Biotechnological Processes CBP Dipl.-Chem. (FH) Gerd Unkelbach, Head of CBP Am Haupttor Bau Leuna Germany Phone Fax Manufacturing of biobased alcohols, acids and olefins using fermentation and chemical processes Biotechnological functionalization of plant oils Obtaining high-quality extractives from biogenic raw and residual materials Fraunhofer CBP in Central German BioEconomy Cluster The CBP is a member of the BioEconomy cluster, one of the winners at the third Leading-Edge Cluster Competition of the German Federal Ministry of Education and Research. The cluster s core objective is the sustainable value creation from non-food biomass, such as wood for the production of materials, chemicals and energy. 16

16 COMPETENCES Bio, Electro and Chemocatalysis BioCat, Straubing branch A focus of the BioCat branch of the institute is on the development of new chemical catalysts and biocatalysts and their application in technically relevant synthetic and electrochemical processes. Based on substrates such as biomass, CO 2, organic and inorganic waste streams, the entire spectrum of catalysis is used to develop new sustainable and resourceefficient chemical products. BioCat has also developed new methods of managing electrical energy by binding and converting CO 2 in the storage of chemical energy (power to gas), making it possible to store excess regenerative energy in fuels such as long-chain hydrocarbons. The chemical products and corresponding production processes are provided to companies for the production of bulk and fine chemicals. Technology and expertise Chemical catalysis, biocatalysis (enzymes, whole cells), electrocatalysis, screening for catalysts, organic synthesis Molecular-biological and technical optimization of enzymes and enzyme reactions Analyses of natural materials and chemical reactions (e.g. high-resolution NMR analytics, high-throughput LC-MS and GC-MS) Contact Fraunhofer IGB Bio, Electro and Chemocatalysis BioCat, Straubing branch Prof. Dr. Volker Sieber, Head of BioCat Schulgasse 11a Straubing Germany Phone Fax Research focus Biotechnical, chemical and electro(bio)chemical catalysis Special and fine chemicals from terpenes, lignin and chitin-rich waste Lubricants and biosurfactants from vegetable oils and fatty acids Development of methods for integrating the use of renewable resources in existing processes Exploration of inorganic secondary raw materials Production of medium-chain to long-chain hydrocarbons (as fuels) from methane or CO 2 17

17 Translational Center Regenerative Therapies for Oncology and Musculoskeletal Diseases, Würzburg branch The Translational Center Würzburg develops medical products and cell-based therapies. Therefore, the infrastructure of preclinical and clinical testing, CE certification and approval of new innovative therapies will be established. A main focus is laid on the development of digital, transferable documentation systems. Clinical emphasis is put on new oncological therapies and on defects of the musculoskeletal system. Contact Fraunhofer IGB Translational Center Regenerative Therapies for Oncology and Musculoskeletal Diseases, Würzburg branch Prof. Dr. Heike Walles, Head of Translational Center Röntgenring Würzburg Germany Phone Fax Technology and expertise Initiation of CE certification and approval of implants Consulting of SMEs concerning German Medicines Law and Medical Devices Act Development of GxP processes and documentation systems (transferable) Cell culture techniques: primary cells, stem cells, ips cells Development of technologies for tissue engineering and regenerative medicine Research focus Validation and standardization of human tissue models Development of human disease models and infection models Development of human vascularized tumor models: melanoma, intestine, mamma carcinoma, lung carcinoma Stroma-tumor interaction studies for drug screening Application of in-vitro models within the process development for the optimization of drugs, medical products or implants GMP process development, documentation and preparation of the approval process 18

18 INFORMATION SERVICE Would you like to receive further information? We would be happy to inform you! Please mark the relevant field on this page and and send us per fax or post: Periodicals Sender Annual Report CD Annual Report Online newsletter Name, First Name, Title Business area brochures Medicine Pharmacy Chemistry Environment Energy Topic-specific brochures and product leaflets Medicine Pharmacy Chemistry Environment Energy Company / Department Street / P. O. Box Postal code, City, Country Phone Fax Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB Press and Public Relations Nobelstrasse Stuttgart Germany Phone Fax info@igb.fraunhofer.de Visit our online ordering service and download area: publications 19

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20 Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB Nobelstrasse Stuttgart Germany Phone Fax Director Prof. Dr. Thomas Hirth Phone Stay in contact: 1506 BR allg institut en printed on paper from responsible sources Fraunhofer IGB 1